CU23411B6 - Uso tópico del factor de crecimiento epidérmico en liposomas para prevenir la amputación del pie diabético - Google Patents
Uso tópico del factor de crecimiento epidérmico en liposomas para prevenir la amputación del pie diabéticoInfo
- Publication number
- CU23411B6 CU23411B6 CU20050282A CU20050282A CU23411B6 CU 23411 B6 CU23411 B6 CU 23411B6 CU 20050282 A CU20050282 A CU 20050282A CU 20050282 A CU20050282 A CU 20050282A CU 23411 B6 CU23411 B6 CU 23411B6
- Authority
- CU
- Cuba
- Prior art keywords
- growth factor
- epidermal growth
- prevent
- diabetic foot
- ambutation
- Prior art date
Links
- 102000009024 Epidermal Growth Factor Human genes 0.000 title abstract 3
- 101800003838 Epidermal growth factor Proteins 0.000 title abstract 3
- 229940116977 epidermal growth factor Drugs 0.000 title abstract 3
- VBEQCZHXXJYVRD-GACYYNSASA-N uroanthelone Chemical compound C([C@@H](C(=O)N[C@H](C(=O)N[C@@H](CS)C(=O)N[C@@H](CC(N)=O)C(=O)N[C@@H](CS)C(=O)N[C@H](C(=O)N[C@@H]([C@@H](C)CC)C(=O)NCC(=O)N[C@@H](CC=1C=CC(O)=CC=1)C(=O)N[C@@H](CO)C(=O)NCC(=O)N[C@@H](CC(O)=O)C(=O)N[C@@H](CCCNC(N)=N)C(=O)N[C@@H](CS)C(=O)N[C@@H](CCC(N)=O)C(=O)N[C@@H]([C@@H](C)O)C(=O)N[C@@H](CCCNC(N)=N)C(=O)N[C@@H](CC(O)=O)C(=O)N[C@@H](CC(C)C)C(=O)N[C@@H](CCCNC(N)=N)C(=O)N[C@@H](CC=1C2=CC=CC=C2NC=1)C(=O)N[C@@H](CC=1C2=CC=CC=C2NC=1)C(=O)N[C@@H](CCC(O)=O)C(=O)N[C@@H](CC(C)C)C(=O)N[C@@H](CCCNC(N)=N)C(O)=O)C(C)C)[C@@H](C)O)NC(=O)[C@H](CO)NC(=O)[C@H](CC(O)=O)NC(=O)[C@H](CC(C)C)NC(=O)[C@H](CO)NC(=O)[C@H](CCC(O)=O)NC(=O)[C@@H](NC(=O)[C@H](CC=1NC=NC=1)NC(=O)[C@H](CCSC)NC(=O)[C@H](CS)NC(=O)[C@@H](NC(=O)CNC(=O)CNC(=O)[C@H](CC(N)=O)NC(=O)[C@H](CC(C)C)NC(=O)[C@H](CS)NC(=O)[C@H](CC=1C=CC(O)=CC=1)NC(=O)CNC(=O)[C@H](CC(O)=O)NC(=O)[C@H](CC=1C=CC(O)=CC=1)NC(=O)[C@H](CO)NC(=O)[C@H](CO)NC(=O)[C@H]1N(CCC1)C(=O)[C@H](CS)NC(=O)CNC(=O)[C@H]1N(CCC1)C(=O)[C@H](CC=1C=CC(O)=CC=1)NC(=O)[C@H](CO)NC(=O)[C@@H](N)CC(N)=O)C(C)C)[C@@H](C)CC)C1=CC=C(O)C=C1 VBEQCZHXXJYVRD-GACYYNSASA-N 0.000 title abstract 3
- 208000008960 Diabetic foot Diseases 0.000 title abstract 2
- 230000000699 topical effect Effects 0.000 title 1
- 238000002266 amputation Methods 0.000 abstract 1
- 230000001684 chronic effect Effects 0.000 abstract 1
- 238000009472 formulation Methods 0.000 abstract 1
- 230000000302 ischemic effect Effects 0.000 abstract 1
- 230000003902 lesion Effects 0.000 abstract 1
- 239000002502 liposome Substances 0.000 abstract 1
- 239000000203 mixture Substances 0.000 abstract 1
- 206010040882 skin lesion Diseases 0.000 abstract 1
- 231100000444 skin lesion Toxicity 0.000 abstract 1
- 239000012049 topical pharmaceutical composition Substances 0.000 abstract 1
Classifications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K38/00—Medicinal preparations containing peptides
- A61K38/16—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
- A61K38/17—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
- A61K38/18—Growth factors; Growth regulators
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/10—Dispersions; Emulsions
- A61K9/127—Synthetic bilayered vehicles, e.g. liposomes or liposomes with cholesterol as the only non-phosphatidyl surfactant
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K38/00—Medicinal preparations containing peptides
- A61K38/16—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
- A61K38/17—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
- A61K38/18—Growth factors; Growth regulators
- A61K38/1808—Epidermal growth factor [EGF] urogastrone
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P17/00—Drugs for dermatological disorders
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P17/00—Drugs for dermatological disorders
- A61P17/02—Drugs for dermatological disorders for treating wounds, ulcers, burns, scars, keloids, or the like
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P3/00—Drugs for disorders of the metabolism
- A61P3/08—Drugs for disorders of the metabolism for glucose homeostasis
- A61P3/10—Drugs for disorders of the metabolism for glucose homeostasis for hyperglycaemia, e.g. antidiabetics
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
Landscapes
- Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Medicinal Chemistry (AREA)
- Veterinary Medicine (AREA)
- Public Health (AREA)
- General Health & Medical Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- Pharmacology & Pharmacy (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Engineering & Computer Science (AREA)
- Epidemiology (AREA)
- Organic Chemistry (AREA)
- General Chemical & Material Sciences (AREA)
- Gastroenterology & Hepatology (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Proteomics, Peptides & Aminoacids (AREA)
- Dispersion Chemistry (AREA)
- Diabetes (AREA)
- Immunology (AREA)
- Zoology (AREA)
- Dermatology (AREA)
- Obesity (AREA)
- Heart & Thoracic Surgery (AREA)
- Cardiology (AREA)
- Hematology (AREA)
- Endocrinology (AREA)
- Emergency Medicine (AREA)
- Medicinal Preparation (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
Abstract
La presente invención está relacionada con el uso de formulaciones tópicas que contienen Factor de Crecimiento Epidérmico encapsulado o asociado a liposomas deformables o convencionales para ser aplicadas en la superficie y alrededor de lesiones cutáneas isquémicas crónicas. Las formulaciones de la presente invención, en contraste al estado de la técnica anterior, son útiles porque permiten una alta biodisponibilidad del Factor de Crecimiento Epidérmico en el tejido profundo debajo de la lesión y para prevenir la amputación del pie diabético.
Priority Applications (17)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
CU20050282A CU23411B6 (es) | 2005-12-29 | 2005-12-29 | Uso tópico del factor de crecimiento epidérmico en liposomas para prevenir la amputación del pie diabético |
ARP060105657A AR058590A1 (es) | 2005-12-29 | 2006-12-20 | Uso topico del factor de crecimiento epidermico en liposomas para prevenir la amputacion del pie diabetico |
BRPI0620733-2A BRPI0620733A2 (pt) | 2005-12-29 | 2006-12-28 | uso de uma quantidade efetiva de fator de crescimento epidérmico encapsulado ou associado a lipossomas deformáveis ou convencionais e formulação farmacêutica tópica |
RU2008131070/15A RU2394590C2 (ru) | 2005-12-29 | 2006-12-28 | Применение местной композиции, содержащей эпидермальный фактор роста (еgf), для профилактики ампутации по поводу диабетической стопы |
AU2006331223A AU2006331223B2 (en) | 2005-12-29 | 2006-12-28 | Use of a topical composition containing epidermal growth factor (EGF) for diabetic foot amputation prevention |
PCT/CU2006/000018 WO2007073704A1 (es) | 2005-12-29 | 2006-12-28 | Uso tópico del factor de crecimiento epidermico en liposomas para prevenir la amputacion del pie diabético |
US12/159,159 US20090074850A1 (en) | 2005-12-29 | 2006-12-28 | Use of a topical composition containing epidermal growth factor (egf) for diabetic foot amputation prevention |
CN201510005113.5A CN104623632A (zh) | 2005-12-29 | 2006-12-28 | 包含表皮生长因子(egf)的局部用组合物用于预防糖尿病性截足的应用 |
PL06828470T PL1970071T3 (pl) | 2005-12-29 | 2006-12-28 | Wykorzystanie stosowanej zewnętrznie kompozycji zawierającej nabłonkowy czynnik wzrostu (EGF) w celu zapobiegania amputacji stopy cukrzycowej |
JP2008547843A JP5715326B2 (ja) | 2005-12-29 | 2006-12-28 | 糖尿病による足切断を予防するための、上皮成長因子(egf)を含有する局所組成物の使用 |
KR1020087018604A KR20080083033A (ko) | 2005-12-29 | 2006-12-28 | 당뇨병성 발 절단 예방을 위한 상피 성장 인자(egf)를포함하는 국소 조성물의 용도 |
CNA2006800529574A CN101374541A (zh) | 2005-12-29 | 2006-12-28 | 包含表皮生长因子(egf)的局部用组合物用于预防糖尿病性截足的应用 |
MYPI20082429A MY184122A (en) | 2005-12-29 | 2006-12-28 | Use of topical composition containing epidermal growth factor (egf) for diabetic foot amputation prevention |
EP06828470.2A EP1970071B1 (en) | 2005-12-29 | 2006-12-28 | Use of a topical composition containing epidermal growth factor (egf) for diabetic foot amputation prevention |
CA2635013A CA2635013C (en) | 2005-12-29 | 2006-12-28 | Use of a topical composition containing epidermal growth factor (egf) for diabetic foot amputation prevention |
ZA200806112A ZA200806112B (en) | 2005-12-29 | 2008-07-14 | Use of a topical composition containing epidermal growth factor (EGF) for diabetic foot amputation prevention |
JP2013050061A JP2013107912A (ja) | 2005-12-29 | 2013-03-13 | 糖尿病による足切断を予防するための、上皮成長因子(egf)を含有する局所組成物の使用 |
Applications Claiming Priority (1)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
CU20050282A CU23411B6 (es) | 2005-12-29 | 2005-12-29 | Uso tópico del factor de crecimiento epidérmico en liposomas para prevenir la amputación del pie diabético |
Publications (1)
Publication Number | Publication Date |
---|---|
CU23411B6 true CU23411B6 (es) | 2009-09-08 |
Family
ID=37831654
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
CU20050282A CU23411B6 (es) | 2005-12-29 | 2005-12-29 | Uso tópico del factor de crecimiento epidérmico en liposomas para prevenir la amputación del pie diabético |
Country Status (15)
Country | Link |
---|---|
US (1) | US20090074850A1 (es) |
EP (1) | EP1970071B1 (es) |
JP (2) | JP5715326B2 (es) |
KR (1) | KR20080083033A (es) |
CN (2) | CN101374541A (es) |
AR (1) | AR058590A1 (es) |
AU (1) | AU2006331223B2 (es) |
BR (1) | BRPI0620733A2 (es) |
CA (1) | CA2635013C (es) |
CU (1) | CU23411B6 (es) |
MY (1) | MY184122A (es) |
PL (1) | PL1970071T3 (es) |
RU (1) | RU2394590C2 (es) |
WO (1) | WO2007073704A1 (es) |
ZA (1) | ZA200806112B (es) |
Families Citing this family (11)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
CU23388B6 (es) * | 2006-01-31 | 2009-07-16 | Ct Ingenieria Genetica Biotech | Composición farmacéutica de microesferas para prevenir la amputación del pie diabético |
US20110308985A1 (en) * | 2009-02-26 | 2011-12-22 | Gina Van Bogaert | Composition of a liposomal gel containing hydrocortisone, its metabolites, precursors or mixtures thereof and the use thereof |
CN102247300A (zh) * | 2010-12-24 | 2011-11-23 | 天津天狮生物发展有限公司 | 人表皮生长因子纳米脂质体及其制备方法 |
CN102302416B (zh) * | 2011-08-26 | 2012-12-05 | 广东丸美生物技术股份有限公司 | 一种辅酶q-10/egf脂质体、制备方法和应用 |
CN102949345A (zh) * | 2012-06-15 | 2013-03-06 | 深圳职业技术学院 | 重组人表皮生长因子阳离子脂质体及其制备方法 |
CU24121B1 (es) | 2012-08-02 | 2015-08-27 | Ct De Ingeniería Genética Y Biotecnología | Vesículas que comprenden factor de crecimiento epidérmico y composiciones que las contienen |
WO2019010304A1 (en) * | 2017-07-05 | 2019-01-10 | Wisconsin Alumni Research Foundation | MICROPARTICLES COATED WITH MINERALS FOR GENES ADMINISTRATION IN CHRONIC WOUND THERAPY |
KR101973960B1 (ko) | 2017-09-29 | 2019-04-30 | 티앤에이치바이오(주) | 글루타티온이 함유된 캡슐형 표피 성장 인자의 조성물 및 이로 제조되는 글루타티온이 함유된 캡슐형 표피 성장 인자 |
KR101964156B1 (ko) | 2017-12-27 | 2019-08-07 | 티앤에이치바이오(주) | 표피 성장 인자(egf) 기능 활성화 및 구조 안정화 조성물 |
CN111195230B (zh) * | 2018-11-19 | 2024-01-12 | 奥维嘉生物科技(北京)有限公司 | 一种制备柔性脂质体的方法 |
WO2024005144A1 (ja) | 2022-07-01 | 2024-01-04 | 国立大学法人東京大学 | 体表面潰瘍治癒促進装置 |
Family Cites Families (13)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US3990445A (en) * | 1975-01-03 | 1976-11-09 | Valleylab, Inc. | Drug injection device |
DE3837450A1 (de) * | 1988-11-04 | 1990-05-10 | Huels Chemische Werke Ag | Verfahren zur herstellung von 1.1-diphenylethan mit guter geruchsqualitaet |
US4944948A (en) | 1989-02-24 | 1990-07-31 | Liposome Technology, Inc. | EGF/Liposome gel composition and method |
EP0465588A4 (en) * | 1989-04-04 | 1992-06-03 | Alcon Laboratories Inc | The use of liposomes for the delivery of therapeutic agents to wounds, cuts and abrasions |
US5130298A (en) * | 1989-05-16 | 1992-07-14 | Ethicon, Inc. | Stabilized compositions containing epidermal growth factor |
WO1991001719A1 (en) * | 1989-08-01 | 1991-02-21 | The University Of Michigan | Topical delivery of peptides/proteins entrapped in dehydration/rehydration liposomes |
US6165500A (en) * | 1990-08-24 | 2000-12-26 | Idea Ag | Preparation for the application of agents in mini-droplets |
US6635674B1 (en) * | 1998-11-06 | 2003-10-21 | Bristol-Myers Squibb Co. | Pharmaceutical preparations for external use containing non-steroidal anti-inflammatory and analgesic agents |
HK1077740A1 (en) * | 2001-12-20 | 2006-02-24 | Ct Ingenieria Genetica Biotech | Use of epidermal growth factor in the manufacture of a pharmaceutical injection composition for preventing diabetic limb amputation |
WO2003075849A2 (en) * | 2002-03-06 | 2003-09-18 | Arizona Board Of Regents | Composition and method for enhancing immune response |
EP1482966B1 (en) * | 2002-03-12 | 2014-05-14 | Bio-Click Technologies Ltd | Method and composition for treating skin wounds with epidermal growth factor |
GB0422439D0 (en) * | 2004-10-08 | 2004-11-10 | European Molecular Biology Lab Embl | Inhibitors of infection |
CU23388B6 (es) * | 2006-01-31 | 2009-07-16 | Ct Ingenieria Genetica Biotech | Composición farmacéutica de microesferas para prevenir la amputación del pie diabético |
-
2005
- 2005-12-29 CU CU20050282A patent/CU23411B6/es unknown
-
2006
- 2006-12-20 AR ARP060105657A patent/AR058590A1/es unknown
- 2006-12-28 BR BRPI0620733-2A patent/BRPI0620733A2/pt not_active Application Discontinuation
- 2006-12-28 AU AU2006331223A patent/AU2006331223B2/en not_active Ceased
- 2006-12-28 CN CNA2006800529574A patent/CN101374541A/zh active Pending
- 2006-12-28 MY MYPI20082429A patent/MY184122A/en unknown
- 2006-12-28 WO PCT/CU2006/000018 patent/WO2007073704A1/es active Application Filing
- 2006-12-28 PL PL06828470T patent/PL1970071T3/pl unknown
- 2006-12-28 KR KR1020087018604A patent/KR20080083033A/ko not_active Application Discontinuation
- 2006-12-28 RU RU2008131070/15A patent/RU2394590C2/ru not_active IP Right Cessation
- 2006-12-28 US US12/159,159 patent/US20090074850A1/en not_active Abandoned
- 2006-12-28 CN CN201510005113.5A patent/CN104623632A/zh active Pending
- 2006-12-28 EP EP06828470.2A patent/EP1970071B1/en not_active Not-in-force
- 2006-12-28 CA CA2635013A patent/CA2635013C/en not_active Expired - Fee Related
- 2006-12-28 JP JP2008547843A patent/JP5715326B2/ja not_active Expired - Fee Related
-
2008
- 2008-07-14 ZA ZA200806112A patent/ZA200806112B/xx unknown
-
2013
- 2013-03-13 JP JP2013050061A patent/JP2013107912A/ja active Pending
Also Published As
Publication number | Publication date |
---|---|
CN101374541A (zh) | 2009-02-25 |
RU2394590C2 (ru) | 2010-07-20 |
AU2006331223A8 (en) | 2008-09-11 |
EP1970071B1 (en) | 2014-12-17 |
AR058590A1 (es) | 2008-02-13 |
JP2009522213A (ja) | 2009-06-11 |
EP1970071A1 (en) | 2008-09-17 |
BRPI0620733A2 (pt) | 2011-11-22 |
ZA200806112B (en) | 2009-10-28 |
RU2008131070A (ru) | 2010-02-10 |
CA2635013A1 (en) | 2007-07-05 |
AU2006331223B2 (en) | 2011-12-22 |
KR20080083033A (ko) | 2008-09-12 |
JP5715326B2 (ja) | 2015-05-07 |
CN104623632A (zh) | 2015-05-20 |
CA2635013C (en) | 2015-09-29 |
WO2007073704A1 (es) | 2007-07-05 |
PL1970071T3 (pl) | 2015-05-29 |
AU2006331223A1 (en) | 2007-07-05 |
US20090074850A1 (en) | 2009-03-19 |
MY184122A (en) | 2021-03-19 |
JP2013107912A (ja) | 2013-06-06 |
Similar Documents
Publication | Publication Date | Title |
---|---|---|
AR058590A1 (es) | Uso topico del factor de crecimiento epidermico en liposomas para prevenir la amputacion del pie diabetico | |
ES2655113T3 (es) | Método de suministro de células progenitoras del folículo piloso a la piel | |
AR055952A1 (es) | Dispositivos medicos para usar con un endoscopio | |
AR049590A1 (es) | Composiciones de limpieza humectantes suaves | |
Gualdi et al. | Surgical treatment of basal cell carcinoma and squamous cell carcinoma | |
CU23388B6 (es) | Composición farmacéutica de microesferas para prevenir la amputación del pie diabético | |
Smith et al. | Eccrine angiomatous hamartoma: report of three patients | |
CL2008002466A1 (es) | Composicion farmaceutica topica anhidra que comprende un vasodilatador y un vehiculo aceptable; uso de la composicion anhidra topica en las areas genitales para obtener bienestar sexual mejorado. | |
Quaba et al. | Superficial acral fibromyxoma | |
BRPI0600326A (pt) | composição fisiologicamente aceitável, usos cosméticos, usos e processos de tratamento cosmético | |
US8550094B2 (en) | Pubic patches | |
Avilés-Izquierdo et al. | Dermoscopic features of cutaneous Rosai-Dorfman disease | |
Abdel-Naser et al. | Common dermatoses in moderately pigmented skin: uncommon presentations | |
AR054361A1 (es) | Uso de acido adamantil metoxidifenil propenoico para el tratamiento de enfermedades dermatologicas | |
TH140643A (th) | การใช้เฉพาะที่ของอีพิเดอมอลโกรทแฟกเตอร์ในไลโปโซมสำหรับการป้องกันการตัดเท้าเบาหวาน | |
BRPI0505988A (pt) | formulação cosmética e/ou dermtólogica e uso da mesma | |
Sakanoue et al. | Nevus lipomatosus cutaneous superficialis associated with trichofolliculoma on the lower leg | |
Veeranna | Linear plaque over the face | |
Veeranna | Quiz-Linear plaque over the face | |
BRPI0514445A (pt) | métodos para cicatrizar feridas administrando il-18 humano | |
CN202552321U (zh) | 割菜鞋 | |
Oza et al. | Giant Trichoblastoma of leg: a rare uncommon site presentation | |
Koh | Multiple acral syringomas involving the hands | |
Campoamor | [Translated article] Frontal Examination of the Distal Nail Unit | |
CN212629921U (zh) | 一种脚趾固定套 |