CU23411B6 - Uso tópico del factor de crecimiento epidérmico en liposomas para prevenir la amputación del pie diabético - Google Patents

Uso tópico del factor de crecimiento epidérmico en liposomas para prevenir la amputación del pie diabético

Info

Publication number
CU23411B6
CU23411B6 CU20050282A CU20050282A CU23411B6 CU 23411 B6 CU23411 B6 CU 23411B6 CU 20050282 A CU20050282 A CU 20050282A CU 20050282 A CU20050282 A CU 20050282A CU 23411 B6 CU23411 B6 CU 23411B6
Authority
CU
Cuba
Prior art keywords
growth factor
epidermal growth
prevent
diabetic foot
ambutation
Prior art date
Application number
CU20050282A
Other languages
English (en)
Inventor
Rodriguez Blas Yamir Betancourt
Meireles Rolando Paez
Acosta Jorge Amador Berlanga
Escalona Elder Pupo
Original Assignee
Ct Ingenieria Genetica Biotech
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Ct Ingenieria Genetica Biotech filed Critical Ct Ingenieria Genetica Biotech
Priority to CU20050282A priority Critical patent/CU23411B6/es
Priority to ARP060105657A priority patent/AR058590A1/es
Priority to CN201510005113.5A priority patent/CN104623632A/zh
Priority to JP2008547843A priority patent/JP5715326B2/ja
Priority to AU2006331223A priority patent/AU2006331223B2/en
Priority to PCT/CU2006/000018 priority patent/WO2007073704A1/es
Priority to US12/159,159 priority patent/US20090074850A1/en
Priority to BRPI0620733-2A priority patent/BRPI0620733A2/pt
Priority to PL06828470T priority patent/PL1970071T3/pl
Priority to RU2008131070/15A priority patent/RU2394590C2/ru
Priority to KR1020087018604A priority patent/KR20080083033A/ko
Priority to CNA2006800529574A priority patent/CN101374541A/zh
Priority to MYPI20082429A priority patent/MY184122A/en
Priority to EP06828470.2A priority patent/EP1970071B1/en
Priority to CA2635013A priority patent/CA2635013C/en
Priority to ZA200806112A priority patent/ZA200806112B/xx
Publication of CU23411B6 publication Critical patent/CU23411B6/es
Priority to JP2013050061A priority patent/JP2013107912A/ja

Links

Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00—Medicinal preparations containing peptides
    • A61K38/16—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • A61K38/17—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • A61K38/18—Growth factors; Growth regulators
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/10—Dispersions; Emulsions
    • A61K9/127—Synthetic bilayered vehicles, e.g. liposomes or liposomes with cholesterol as the only non-phosphatidyl surfactant
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00—Medicinal preparations containing peptides
    • A61K38/16—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • A61K38/17—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • A61K38/18—Growth factors; Growth regulators
    • A61K38/1808—Epidermal growth factor [EGF] urogastrone
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P17/00—Drugs for dermatological disorders
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P17/00—Drugs for dermatological disorders
    • A61P17/02—Drugs for dermatological disorders for treating wounds, ulcers, burns, scars, keloids, or the like
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P3/00—Drugs for disorders of the metabolism
    • A61P3/08—Drugs for disorders of the metabolism for glucose homeostasis
    • A61P3/10—Drugs for disorders of the metabolism for glucose homeostasis for hyperglycaemia, e.g. antidiabetics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system

Landscapes

  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Veterinary Medicine (AREA)
  • Public Health (AREA)
  • General Health & Medical Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Engineering & Computer Science (AREA)
  • Epidemiology (AREA)
  • Organic Chemistry (AREA)
  • General Chemical & Material Sciences (AREA)
  • Gastroenterology & Hepatology (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Dispersion Chemistry (AREA)
  • Diabetes (AREA)
  • Immunology (AREA)
  • Zoology (AREA)
  • Dermatology (AREA)
  • Obesity (AREA)
  • Heart & Thoracic Surgery (AREA)
  • Cardiology (AREA)
  • Hematology (AREA)
  • Endocrinology (AREA)
  • Emergency Medicine (AREA)
  • Medicinal Preparation (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)

Abstract

La presente invención está relacionada con el uso de formulaciones tópicas que contienen Factor de Crecimiento Epidérmico encapsulado o asociado a liposomas deformables o convencionales para ser aplicadas en la superficie y alrededor de lesiones cutáneas isquémicas crónicas. Las formulaciones de la presente invención, en contraste al estado de la técnica anterior, son útiles porque permiten una alta biodisponibilidad del Factor de Crecimiento Epidérmico en el tejido profundo debajo de la lesión y para prevenir la amputación del pie diabético.
CU20050282A 2005-12-29 2005-12-29 Uso tópico del factor de crecimiento epidérmico en liposomas para prevenir la amputación del pie diabético CU23411B6 (es)

Priority Applications (17)

Application Number Priority Date Filing Date Title
CU20050282A CU23411B6 (es) 2005-12-29 2005-12-29 Uso tópico del factor de crecimiento epidérmico en liposomas para prevenir la amputación del pie diabético
ARP060105657A AR058590A1 (es) 2005-12-29 2006-12-20 Uso topico del factor de crecimiento epidermico en liposomas para prevenir la amputacion del pie diabetico
BRPI0620733-2A BRPI0620733A2 (pt) 2005-12-29 2006-12-28 uso de uma quantidade efetiva de fator de crescimento epidérmico encapsulado ou associado a lipossomas deformáveis ou convencionais e formulação farmacêutica tópica
RU2008131070/15A RU2394590C2 (ru) 2005-12-29 2006-12-28 Применение местной композиции, содержащей эпидермальный фактор роста (еgf), для профилактики ампутации по поводу диабетической стопы
AU2006331223A AU2006331223B2 (en) 2005-12-29 2006-12-28 Use of a topical composition containing epidermal growth factor (EGF) for diabetic foot amputation prevention
PCT/CU2006/000018 WO2007073704A1 (es) 2005-12-29 2006-12-28 Uso tópico del factor de crecimiento epidermico en liposomas para prevenir la amputacion del pie diabético
US12/159,159 US20090074850A1 (en) 2005-12-29 2006-12-28 Use of a topical composition containing epidermal growth factor (egf) for diabetic foot amputation prevention
CN201510005113.5A CN104623632A (zh) 2005-12-29 2006-12-28 包含表皮生长因子(egf)的局部用组合物用于预防糖尿病性截足的应用
PL06828470T PL1970071T3 (pl) 2005-12-29 2006-12-28 Wykorzystanie stosowanej zewnętrznie kompozycji zawierającej nabłonkowy czynnik wzrostu (EGF) w celu zapobiegania amputacji stopy cukrzycowej
JP2008547843A JP5715326B2 (ja) 2005-12-29 2006-12-28 糖尿病による足切断を予防するための、上皮成長因子（ｅｇｆ）を含有する局所組成物の使用
KR1020087018604A KR20080083033A (ko) 2005-12-29 2006-12-28 당뇨병성 발 절단 예방을 위한 상피 성장 인자(ｅｇｆ)를포함하는 국소 조성물의 용도
CNA2006800529574A CN101374541A (zh) 2005-12-29 2006-12-28 包含表皮生长因子（egf）的局部用组合物用于预防糖尿病性截足的应用
MYPI20082429A MY184122A (en) 2005-12-29 2006-12-28 Use of topical composition containing epidermal growth factor (egf) for diabetic foot amputation prevention
EP06828470.2A EP1970071B1 (en) 2005-12-29 2006-12-28 Use of a topical composition containing epidermal growth factor (egf) for diabetic foot amputation prevention
CA2635013A CA2635013C (en) 2005-12-29 2006-12-28 Use of a topical composition containing epidermal growth factor (egf) for diabetic foot amputation prevention
ZA200806112A ZA200806112B (en) 2005-12-29 2008-07-14 Use of a topical composition containing epidermal growth factor (EGF) for diabetic foot amputation prevention
JP2013050061A JP2013107912A (ja) 2005-12-29 2013-03-13 糖尿病による足切断を予防するための、上皮成長因子（ｅｇｆ）を含有する局所組成物の使用

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
CU20050282A CU23411B6 (es) 2005-12-29 2005-12-29 Uso tópico del factor de crecimiento epidérmico en liposomas para prevenir la amputación del pie diabético

Publications (1)

Publication Number Publication Date
CU23411B6 true CU23411B6 (es) 2009-09-08

Family

ID=37831654

Family Applications (1)

Application Number Title Priority Date Filing Date
CU20050282A CU23411B6 (es) 2005-12-29 2005-12-29 Uso tópico del factor de crecimiento epidérmico en liposomas para prevenir la amputación del pie diabético

Country Status (15)

Country Link
US (1) US20090074850A1 (es)
EP (1) EP1970071B1 (es)
JP (2) JP5715326B2 (es)
KR (1) KR20080083033A (es)
CN (2) CN101374541A (es)
AR (1) AR058590A1 (es)
AU (1) AU2006331223B2 (es)
BR (1) BRPI0620733A2 (es)
CA (1) CA2635013C (es)
CU (1) CU23411B6 (es)
MY (1) MY184122A (es)
PL (1) PL1970071T3 (es)
RU (1) RU2394590C2 (es)
WO (1) WO2007073704A1 (es)
ZA (1) ZA200806112B (es)

Families Citing this family (11)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CU23388B6 (es) * 2006-01-31 2009-07-16 Ct Ingenieria Genetica Biotech Composición farmacéutica de microesferas para prevenir la amputación del pie diabético
US20110308985A1 (en) * 2009-02-26 2011-12-22 Gina Van Bogaert Composition of a liposomal gel containing hydrocortisone, its metabolites, precursors or mixtures thereof and the use thereof
CN102247300A (zh) * 2010-12-24 2011-11-23 天津天狮生物发展有限公司 人表皮生长因子纳米脂质体及其制备方法
CN102302416B (zh) * 2011-08-26 2012-12-05 广东丸美生物技术股份有限公司 一种辅酶q-10/egf脂质体、制备方法和应用
CN102949345A (zh) * 2012-06-15 2013-03-06 深圳职业技术学院 重组人表皮生长因子阳离子脂质体及其制备方法
CU24121B1 (es) 2012-08-02 2015-08-27 Ct De Ingeniería Genética Y Biotecnología Vesículas que comprenden factor de crecimiento epidérmico y composiciones que las contienen
WO2019010304A1 (en) * 2017-07-05 2019-01-10 Wisconsin Alumni Research Foundation MICROPARTICLES COATED WITH MINERALS FOR GENES ADMINISTRATION IN CHRONIC WOUND THERAPY
KR101973960B1 (ko) 2017-09-29 2019-04-30 티앤에이치바이오(주) 글루타티온이 함유된 캡슐형 표피 성장 인자의 조성물 및 이로 제조되는 글루타티온이 함유된 캡슐형 표피 성장 인자
KR101964156B1 (ko) 2017-12-27 2019-08-07 티앤에이치바이오(주) 표피 성장 인자(egf) 기능 활성화 및 구조 안정화 조성물
CN111195230B (zh) * 2018-11-19 2024-01-12 奥维嘉生物科技（北京）有限公司 一种制备柔性脂质体的方法
WO2024005144A1 (ja) 2022-07-01 2024-01-04 国立大学法人東京大学 体表面潰瘍治癒促進装置

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HK1077740A1 (en) * 2001-12-20 2006-02-24 Ct Ingenieria Genetica Biotech Use of epidermal growth factor in the manufacture of a pharmaceutical injection composition for preventing diabetic limb amputation
WO2003075849A2 (en) * 2002-03-06 2003-09-18 Arizona Board Of Regents Composition and method for enhancing immune response
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Also Published As

Publication number Publication date
CN101374541A (zh) 2009-02-25
RU2394590C2 (ru) 2010-07-20
AU2006331223A8 (en) 2008-09-11
EP1970071B1 (en) 2014-12-17
AR058590A1 (es) 2008-02-13
JP2009522213A (ja) 2009-06-11
EP1970071A1 (en) 2008-09-17
BRPI0620733A2 (pt) 2011-11-22
ZA200806112B (en) 2009-10-28
RU2008131070A (ru) 2010-02-10
CA2635013A1 (en) 2007-07-05
AU2006331223B2 (en) 2011-12-22
KR20080083033A (ko) 2008-09-12
JP5715326B2 (ja) 2015-05-07
CN104623632A (zh) 2015-05-20
CA2635013C (en) 2015-09-29
WO2007073704A1 (es) 2007-07-05
PL1970071T3 (pl) 2015-05-29
AU2006331223A1 (en) 2007-07-05
US20090074850A1 (en) 2009-03-19
MY184122A (en) 2021-03-19
JP2013107912A (ja) 2013-06-06

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