ES419019A1 - Indolo-2,3-c quinolinone derivatives - Google Patents

Indolo-2,3-c quinolinone derivatives

Info

Publication number
ES419019A1
ES419019A1 ES419019A ES419019A ES419019A1 ES 419019 A1 ES419019 A1 ES 419019A1 ES 419019 A ES419019 A ES 419019A ES 419019 A ES419019 A ES 419019A ES 419019 A1 ES419019 A1 ES 419019A1
Authority
ES
Spain
Prior art keywords
formula
lower alkyl
hydrogen
compounds
see formula
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired
Application number
ES419019A
Other languages
Spanish (es)
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
F Hoffmann La Roche AG
Original Assignee
F Hoffmann La Roche AG
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by F Hoffmann La Roche AG filed Critical F Hoffmann La Roche AG
Publication of ES419019A1 publication Critical patent/ES419019A1/en
Expired legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D215/00—Heterocyclic compounds containing quinoline or hydrogenated quinoline ring systems
    • C07D215/02—Heterocyclic compounds containing quinoline or hydrogenated quinoline ring systems having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen atoms or carbon atoms directly attached to the ring nitrogen atom
    • C07D215/16—Heterocyclic compounds containing quinoline or hydrogenated quinoline ring systems having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen atoms or carbon atoms directly attached to the ring nitrogen atom with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
    • C07D215/38—Nitrogen atoms
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C251/00—Compounds containing nitrogen atoms doubly-bound to a carbon skeleton
    • C07C251/72—Hydrazones
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D209/00—Heterocyclic compounds containing five-membered rings, condensed with other rings, with one nitrogen atom as the only ring hetero atom
    • C07D209/02—Heterocyclic compounds containing five-membered rings, condensed with other rings, with one nitrogen atom as the only ring hetero atom condensed with one carbocyclic ring
    • C07D209/04—Indoles; Hydrogenated indoles
    • C07D209/30—Indoles; Hydrogenated indoles with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, directly attached to carbon atoms of the hetero ring
    • C07D209/42—Carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D471/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00
    • C07D471/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00 in which the condensed system contains two hetero rings
    • C07D471/04—Ortho-condensed systems

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Nitrogen Condensed Heterocyclic Rings (AREA)
  • Indole Compounds (AREA)
  • Quinoline Compounds (AREA)

Abstract

Procedure for the preparation of polycyclic compounds of the formula **(See formula)** in which R2 and R4 are hydrogen, lower alkyl, lower alkenyl, or a radical of the formula **(See formula)** where S is a straight-chain lower alkylene with 1 to 7 carbon atoms which may contain one or more lower alkyl substituents, R6 and R7 are hydrogen, lower alkyl, hydroxy-lower alkyl or halo-lower alkyl, or taken together with the nitrogen atom, are a 5- or 6-membered heterocyclic group with another heteroatom, at most, which can be sulfur, oxygen or nitrogen and B is hydrogen, lower alkyl or lower alkanoyl; provided that at least one of R2 or R4 is a radical of the formula **(See formula)** R1 and R5 are hydrogen, trifluoromethyl, halogen, lower alkyl, lower alkoxy, amino, cyano or nitro; as well as the omega-N-oxides of these compounds and the addition salts of these compounds with acids, characterized in that a compound of the formula is reacted **(See formula)** in which Y is a part group and R1, R2, R3 and R5 have the aforementioned meaning, and because, if desired, a compound of formula I is converted into an omega-N-oxide or an addition salt with an acid. (Machine-translation by Google Translate, not legally binding)
ES419019A 1972-09-25 1974-09-24 Indolo-2,3-c quinolinone derivatives Expired ES419019A1 (en)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
US29219372A 1972-09-25 1972-09-25

Publications (1)

Publication Number Publication Date
ES419019A1 true ES419019A1 (en) 1976-06-16

Family

ID=23123617

Family Applications (1)

Application Number Title Priority Date Filing Date
ES419019A Expired ES419019A1 (en) 1972-09-25 1974-09-24 Indolo-2,3-c quinolinone derivatives

Country Status (17)

Country Link
JP (1) JPS4969698A (en)
AR (1) AR205437A1 (en)
AT (1) AT340425B (en)
BE (1) BE805199A (en)
CH (1) CH587274A5 (en)
DD (1) DD109388A5 (en)
DE (1) DE2348149A1 (en)
ES (1) ES419019A1 (en)
FR (1) FR2200004B1 (en)
GB (1) GB1400934A (en)
HU (1) HU168788B (en)
IE (1) IE38331B1 (en)
IL (1) IL43283A (en)
LU (1) LU68486A1 (en)
NL (1) NL7313186A (en)
SU (1) SU525428A3 (en)
ZA (1) ZA735679B (en)

Families Citing this family (6)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO2004108671A1 (en) * 2003-06-06 2004-12-16 Suven Life Sciences Limited Substituted indoles with serotonin receptor affinity, process for their preparation and pharmaceutical compositions containing them
US20050089936A1 (en) * 2003-10-23 2005-04-28 Jianping Cai Combinatorial library of 3-aryl-1H-indole-2-carboxylic acid amides
ITMI20040874A1 (en) * 2004-04-30 2004-07-30 Ist Naz Stud Cura Dei Tumori INDOLIC AND AZAINDOLIC DERIVATIVES WITH ANTI-TUMORAL ACTION
FR2887881B1 (en) * 2005-07-01 2009-10-09 Pierre Fabre Medicament Sa PROTEIN INHIBITORS KINASES
JP5496877B2 (en) 2007-04-16 2014-05-21 アッヴィ・インコーポレイテッド 7-substituted indole Mcl-1 inhibitors
CN114605407B (en) * 2022-03-14 2024-06-04 澳门科技大学 Indoloquinolinone compound and synthetic method and application thereof

Also Published As

Publication number Publication date
IE38331B1 (en) 1978-02-15
FR2200004A1 (en) 1974-04-19
IE38331L (en) 1974-03-25
AR205437A1 (en) 1976-05-07
DE2348149A1 (en) 1974-04-04
AU6062073A (en) 1975-03-27
GB1400934A (en) 1975-07-16
IL43283A (en) 1976-12-31
NL7313186A (en) 1974-03-27
FR2200004B1 (en) 1976-07-02
HU168788B (en) 1976-07-28
AT340425B (en) 1977-12-12
CH587274A5 (en) 1977-04-29
SU525428A3 (en) 1976-08-15
IL43283A0 (en) 1975-08-31
DD109388A5 (en) 1974-11-05
BE805199A (en) 1974-03-25
ZA735679B (en) 1974-07-31
JPS4969698A (en) 1974-07-05
ATA818873A (en) 1977-04-15
LU68486A1 (en) 1975-06-16

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