US3340873A - Compartmented medical container having a rupturable diaphragm between compartments - Google Patents
Compartmented medical container having a rupturable diaphragm between compartments Download PDFInfo
- Publication number
- US3340873A US3340873A US54991366A US3340873A US 3340873 A US3340873 A US 3340873A US 54991366 A US54991366 A US 54991366A US 3340873 A US3340873 A US 3340873A
- Authority
- US
- United States
- Prior art keywords
- diaphragm
- plunger
- compartmented
- barrel
- compartments
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Expired - Lifetime
Links
Images
Classifications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61J—CONTAINERS SPECIALLY ADAPTED FOR MEDICAL OR PHARMACEUTICAL PURPOSES; DEVICES OR METHODS SPECIALLY ADAPTED FOR BRINGING PHARMACEUTICAL PRODUCTS INTO PARTICULAR PHYSICAL OR ADMINISTERING FORMS; DEVICES FOR ADMINISTERING FOOD OR MEDICINES ORALLY; BABY COMFORTERS; DEVICES FOR RECEIVING SPITTLE
- A61J1/00—Containers specially adapted for medical or pharmaceutical purposes
- A61J1/14—Details; Accessories therefor
- A61J1/20—Arrangements for transferring or mixing fluids, e.g. from vial to syringe
- A61J1/2093—Containers having several compartments for products to be mixed
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61M—DEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
- A61M5/00—Devices for bringing media into the body in a subcutaneous, intra-vascular or intramuscular way; Accessories therefor, e.g. filling or cleaning devices, arm-rests
- A61M5/178—Syringes
- A61M5/19—Syringes having more than one chamber, e.g. including a manifold coupling two parallelly aligned syringes through separate channels to a common discharge assembly
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61M—DEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
- A61M5/00—Devices for bringing media into the body in a subcutaneous, intra-vascular or intramuscular way; Accessories therefor, e.g. filling or cleaning devices, arm-rests
- A61M5/178—Syringes
- A61M5/28—Syringe ampoules or carpules, i.e. ampoules or carpules provided with a needle
- A61M5/284—Syringe ampoules or carpules, i.e. ampoules or carpules provided with a needle comprising means for injection of two or more media, e.g. by mixing
-
- B—PERFORMING OPERATIONS; TRANSPORTING
- B65—CONVEYING; PACKING; STORING; HANDLING THIN OR FILAMENTARY MATERIAL
- B65D—CONTAINERS FOR STORAGE OR TRANSPORT OF ARTICLES OR MATERIALS, e.g. BAGS, BARRELS, BOTTLES, BOXES, CANS, CARTONS, CRATES, DRUMS, JARS, TANKS, HOPPERS, FORWARDING CONTAINERS; ACCESSORIES, CLOSURES, OR FITTINGS THEREFOR; PACKAGING ELEMENTS; PACKAGES
- B65D25/00—Details of other kinds or types of rigid or semi-rigid containers
- B65D25/02—Internal fittings
- B65D25/04—Partitions
- B65D25/08—Partitions with provisions for removing or destroying, e.g. to facilitate mixing of contents
- B65D25/082—Partitions with provisions for removing or destroying, e.g. to facilitate mixing of contents the partition being in the form of a plug or the like which is removed by increasing or decreasing the pressure within the container
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61J—CONTAINERS SPECIALLY ADAPTED FOR MEDICAL OR PHARMACEUTICAL PURPOSES; DEVICES OR METHODS SPECIALLY ADAPTED FOR BRINGING PHARMACEUTICAL PRODUCTS INTO PARTICULAR PHYSICAL OR ADMINISTERING FORMS; DEVICES FOR ADMINISTERING FOOD OR MEDICINES ORALLY; BABY COMFORTERS; DEVICES FOR RECEIVING SPITTLE
- A61J1/00—Containers specially adapted for medical or pharmaceutical purposes
- A61J1/14—Details; Accessories therefor
- A61J1/20—Arrangements for transferring or mixing fluids, e.g. from vial to syringe
- A61J1/2003—Accessories used in combination with means for transfer or mixing of fluids, e.g. for activating fluid flow, separating fluids, filtering fluid or venting
- A61J1/202—Separating means
- A61J1/2027—Separating means having frangible parts
-
- Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
- Y10—TECHNICAL SUBJECTS COVERED BY FORMER USPC
- Y10S—TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
- Y10S215/00—Bottles and jars
- Y10S215/08—Mixing
Definitions
- My invention is directed toward a hypodermic syringe which can contain two or more medicinal ingredients which are mixed only 'at the time of injection and in addition relates to bottles or vials containing two or more medicinal ingredients which are held isolated from each other until mixing is desired.
- Another object is to provide a new and improved medicinal vial of the character indicated.
- Still another object is to provide a new and improved medicinal bottle of the character indicated.
- FIGURE 1 is a perspective view of my syringe
- FIGURE 2 is a cross sectional view of a modification thereof
- FIGURE 3 is a detail view of a portion of the syringe after an injection has been given;
- FIGURE 4 is a cross sectional view of another modification
- FIGURE 5 is a cross sectional view of my bottle
- FIGURES 6 and 7 are partial sectional views of a further modification.
- FIGURE 1 there is shown a hypodermic syringe having a barrel 10 with an open end 12 which accommodates a plunger 14.
- Barrel 10 has a tip 16 at the other end arranged for hypodermic needle attachment.
- Tip 16 has the conventional small orifice through which the medicine ejected from the barrel flows into the needle, and when not in use the tip is sealed by cap 18.
- the portion of the barrel adjacent tip 16 is filled with a first medicinal ingredient either in powder form (to which liquid is added) or in liquid form.
- a hollow rubber cylinder 20 having a diaphragm of very thin rubber 22 is then press fitted snugly into the barrel until the diaphragm just touches the top of the liquid level of the first ingredient.
- the portion of the barrel adjacent the other side of the diaphragm and extending toward the open end is then filled with a second ingredient.
- the plunger is inserted to rest on top of the second or top layer ingredient.
- the head 26 of the plunger (which is contoured to conform to the inside of cylinder 20) moves downward into the second ingredient, and the pressure causes a ruptured diaphragm 22 and permits the two ingredients to mix. Thereafter, the head 26 and shoulder engages the cylinder and the head and the cylinder move downward together toward the tip ejecting the mixture thru the syringe.
- a stop 14a can be provided at the open end 12, as seen in FIG- URE 2.
- FIGURE 4 shows a vial having an upper chamber 30 containing one ingredient, a lower chamber 32 having a second ingredient, a hollow section 34 open at both ends interconnecting these chambers.
- a rubber cylinder 20 having a diaphragm 22 is fitted in section 34.
- a conventional syringe can then be filled in conventional manner by inserting the hypodermic needle through plunger 36 into the chamber.
- a sharp ridge 23 is provided under diaphragm 22 to help puncture the diaphragm.
- FIGURE 5 shows an arrangement similar to FIG- URE 4, except that the top of chamber 30 carries a screwon cover 40 having a hole 42 through which a portion of a plunger 44 extends. In this case, the plunger cannot go through the cover and the plunger is reciprocated through the cover 40 to generate pressure on the diaphragm.
- the diaphragm 22 of the above said devices can be fabricated from any suitable thin flexible material.
- a diaphragm 40 is used which is cup shaped but includes a relatively thin flexible band 41 which is normally spaced from barrel 10.
- the band 41 expands radially into sealing engagement with barrel 10 because of the increase in pressure.
- the diaphragm cup will cling more firmly to the barrel and the fluid pressure will build up more rapidly to cause a more efiective rupturing of the diaphragm.
- a medical mixing container having upper and lower chambers sealingly separated by a thin rupturable diaphragm transversely mounted sealingly and longitudinally movable within the container, said diaphragm being in the form of an expandable cylinder having a circumferential barrel and a transverse bottom, said barrel having a portion normally spaced from the container and having an upper shoulder, in combination with a plunger longitudinally movable within one of said chambers and being contoured to fit snugly within the said chambers, including ingredients which are mixed when the diaphragm is ruptured, said plunger having surfaces adapted to sealingly engage the barrel, bottom and shoulder of the diaphragm, whereby axial movement of the plunger will first cause the barrel to expand towards the container, whereby complete engagement with the wall being then eifected when the plunger has entered the cylinder to contact the barrel and snap the said portion against the container, whereby the diaphragm bottom is ruptured during the axial movement of the plunger, further movement of the plunger causing the plunger surfaces to
Landscapes
- Health & Medical Sciences (AREA)
- Public Health (AREA)
- Engineering & Computer Science (AREA)
- Veterinary Medicine (AREA)
- Life Sciences & Earth Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- General Health & Medical Sciences (AREA)
- Vascular Medicine (AREA)
- Anesthesiology (AREA)
- Biomedical Technology (AREA)
- Heart & Thoracic Surgery (AREA)
- Hematology (AREA)
- Pharmacology & Pharmacy (AREA)
- Mechanical Engineering (AREA)
- Medical Preparation Storing Or Oral Administration Devices (AREA)
Description
.Sept. 12. 1967 SOLQWEY COMPARTMENTED MEDICAL CONTAINER HAVING A RUP'IURABLE DIAPHRAGM BETWEEN COMPARTMENTS Filed May 13 1966 E i 0mm;
)24 azowgy United States Patent 3,340,873 COMPARTMENTED MEDICAL CONTAINER HAV- ING A RUPTURABLE DIAPHRAGM BETWEEN COMPARTMENTS Ida Solowey, P.0. Box 34, Fresh Meadows Station,
Flushing, N.Y. 11365 Filed May 13, 1966, Ser. No. 549,913 1 Claim. (Cl. 128-272) My invention is directed toward a hypodermic syringe which can contain two or more medicinal ingredients which are mixed only 'at the time of injection and in addition relates to bottles or vials containing two or more medicinal ingredients which are held isolated from each other until mixing is desired.
It is an object of my invention to provide a new and improved syringe of the character indicated.
Another object is to provide a new and improved medicinal vial of the character indicated.
Still another object is to provide a new and improved medicinal bottle of the character indicated.
All of the foregoing and still further objects and advantages of my invention will now be explained with reference both to this specification and to the drawings wherein:
FIGURE 1 is a perspective view of my syringe;
FIGURE 2 is a cross sectional view of a modification thereof;
FIGURE 3 is a detail view of a portion of the syringe after an injection has been given;
FIGURE 4 is a cross sectional view of another modification;
FIGURE 5 is a cross sectional view of my bottle;
FIGURES 6 and 7 are partial sectional views of a further modification.
Referring now to FIGURE 1, there is shown a hypodermic syringe having a barrel 10 with an open end 12 which accommodates a plunger 14. Barrel 10 has a tip 16 at the other end arranged for hypodermic needle attachment. Tip 16 has the conventional small orifice through which the medicine ejected from the barrel flows into the needle, and when not in use the tip is sealed by cap 18.
In use, the portion of the barrel adjacent tip 16 is filled with a first medicinal ingredient either in powder form (to which liquid is added) or in liquid form. A hollow rubber cylinder 20 having a diaphragm of very thin rubber 22 is then press fitted snugly into the barrel until the diaphragm just touches the top of the liquid level of the first ingredient. The portion of the barrel adjacent the other side of the diaphragm and extending toward the open end is then filled with a second ingredient. The plunger is inserted to rest on top of the second or top layer ingredient. As the operator presses the plunger arm 24, the head 26 of the plunger (which is contoured to conform to the inside of cylinder 20) moves downward into the second ingredient, and the pressure causes a ruptured diaphragm 22 and permits the two ingredients to mix. Thereafter, the head 26 and shoulder engages the cylinder and the head and the cylinder move downward together toward the tip ejecting the mixture thru the syringe.
To prevent the plunger 14 from slipping out, a stop 14a can be provided at the open end 12, as seen in FIG- URE 2.
FIGURE 4 shows a vial having an upper chamber 30 containing one ingredient, a lower chamber 32 having a second ingredient, a hollow section 34 open at both ends interconnecting these chambers. A rubber cylinder 20 having a diaphragm 22 is fitted in section 34. When a rubber plunger 36 in the top of the chamber 30 is depressed, the diaphragm is ruptured and the ingredients are mixed. A conventional syringe can then be filled in conventional manner by inserting the hypodermic needle through plunger 36 into the chamber. A sharp ridge 23 is provided under diaphragm 22 to help puncture the diaphragm.
FIGURE 5 shows an arrangement similar to FIG- URE 4, except that the top of chamber 30 carries a screwon cover 40 having a hole 42 through which a portion of a plunger 44 extends. In this case, the plunger cannot go through the cover and the plunger is reciprocated through the cover 40 to generate pressure on the diaphragm. The diaphragm 22 of the above said devices can be fabricated from any suitable thin flexible material.
In FIGURES 6 and 7 a diaphragm 40 is used which is cup shaped but includes a relatively thin flexible band 41 which is normally spaced from barrel 10. When the plunger 14 is depressed towards the diaphragm the band 41 expands radially into sealing engagement with barrel 10 because of the increase in pressure. Thus the diaphragm cup will cling more firmly to the barrel and the fluid pressure will build up more rapidly to cause a more efiective rupturing of the diaphragm.
It is to be noted that the engagement between the plunger and diaphragm and their combined further movement causes a simultaneous ejecting pressure and further mixing of the ingredients.
Having thus described my invention, I claim as new and desire to secure by Letters Patent:
A medical mixing container having upper and lower chambers sealingly separated by a thin rupturable diaphragm transversely mounted sealingly and longitudinally movable within the container, said diaphragm being in the form of an expandable cylinder having a circumferential barrel and a transverse bottom, said barrel having a portion normally spaced from the container and having an upper shoulder, in combination with a plunger longitudinally movable within one of said chambers and being contoured to fit snugly within the said chambers, including ingredients which are mixed when the diaphragm is ruptured, said plunger having surfaces adapted to sealingly engage the barrel, bottom and shoulder of the diaphragm, whereby axial movement of the plunger will first cause the barrel to expand towards the container, whereby complete engagement with the wall being then eifected when the plunger has entered the cylinder to contact the barrel and snap the said portion against the container, whereby the diaphragm bottom is ruptured during the axial movement of the plunger, further movement of the plunger causing the plunger surfaces to sealingly engage the diaphragm thereby moving the diaphragm axially, including means mounted on the end of the container opposite the plunger adapted to receive a hypodermic needle and wherein the plunger extends through an open end of the container having a perforated closure wherein said closure functions as a stop to prevent complete removal of the plunger from the container.
References Cited UNITED STATES PATENTS 1,943,120 1/ 1934 Kabnick 128-218 2,590,900 4/ 1952 Sommerstein 128272 2,591,706 4/1952 Lockhart 128-218 2,705,956 4/ 1955 McLaughlin 128-272 FOREIGN PATENTS 961,289 4/ 1957 Germany.
RICHARD A. GAUDET, Primary Examiner.
DALTON L. TRULUCK, Examiner.
Priority Applications (3)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
US54991366 US3340873A (en) | 1966-05-13 | 1966-05-13 | Compartmented medical container having a rupturable diaphragm between compartments |
FR110931A FR1550103A (en) | 1966-05-13 | 1967-06-19 | Two or more compartment hypodermic syringe. |
BE706004D BE706004A (en) | 1966-05-13 | 1967-11-03 |
Applications Claiming Priority (1)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
US54991366 US3340873A (en) | 1966-05-13 | 1966-05-13 | Compartmented medical container having a rupturable diaphragm between compartments |
Publications (1)
Publication Number | Publication Date |
---|---|
US3340873A true US3340873A (en) | 1967-09-12 |
Family
ID=24194888
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
US54991366 Expired - Lifetime US3340873A (en) | 1966-05-13 | 1966-05-13 | Compartmented medical container having a rupturable diaphragm between compartments |
Country Status (3)
Country | Link |
---|---|
US (1) | US3340873A (en) |
BE (1) | BE706004A (en) |
FR (1) | FR1550103A (en) |
Cited By (28)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US3870147A (en) * | 1972-04-28 | 1975-03-11 | Wolf Geraete Gmbh | Container for storage and preparation of a plant protective material containing at least two components |
US4159570A (en) * | 1977-10-31 | 1979-07-03 | Dentipressions Incorporated | Disposable mixing syringe |
US4191254A (en) * | 1978-01-16 | 1980-03-04 | Baughman Kenneth E | Apparatus and method for plugging voids in a ground stratum |
US4693706A (en) * | 1986-08-11 | 1987-09-15 | Mark L. Anderson | Two compartment mixing syringe |
US4983164A (en) * | 1987-04-14 | 1991-01-08 | Astra Meditec Ab | Automatic two-chamber injector |
US5002206A (en) * | 1989-10-25 | 1991-03-26 | Merck & Co., Inc. | Double tip drug dispensing and metering device |
US5137528A (en) * | 1990-11-26 | 1992-08-11 | Crose Virginia W | Ampoule for administering a liquid local anaesthetic |
US5196001A (en) * | 1991-03-05 | 1993-03-23 | Ti Kao | Devices and methods for preparing pharmaceutical solutions |
US5217433A (en) * | 1991-05-24 | 1993-06-08 | Merck & Co., Inc. | Medication container for mixing two components |
US5322800A (en) * | 1991-06-26 | 1994-06-21 | The United States Of America As Represented By The Secretary Of The Interior | Method and device for safely preserving aqueous field samples using acid or base |
US6372270B1 (en) * | 1999-05-26 | 2002-04-16 | Sean P. Denny | Drink mix apparatus for making personal quantities of beverage |
US6419414B1 (en) | 2001-04-20 | 2002-07-16 | 3M Innovative Properties Company | Container for multiple-component compositions |
WO2003022696A1 (en) * | 2001-09-10 | 2003-03-20 | Den-Mat Corporation | Unit-dose packaging system |
US6543612B2 (en) | 2001-05-21 | 2003-04-08 | 3M Innovative Properties Company | Container for compositions made of two or more components |
US6544213B1 (en) | 1999-09-13 | 2003-04-08 | Merck & Co., Inc. | Dual compartment mixing and dispensing device |
US20050113768A1 (en) * | 2003-11-24 | 2005-05-26 | Carlos Patrickson | Pain-alleviating injection needle |
WO2006118697A3 (en) * | 2005-04-29 | 2007-01-25 | Ipifini | Programmable liquid containers |
US20100240004A1 (en) * | 2009-03-23 | 2010-09-23 | Moshe Zalsman | Capsule for mixing together two flowable materials, and kits including such capsules, particularly useful in dentistry |
WO2011071463A1 (en) * | 2009-12-07 | 2011-06-16 | Merenkov Aleksandr Vladimirovich | Container, container for packaging and storing two components, and container manufacturing method |
AU2010101255B4 (en) * | 2010-11-15 | 2011-09-22 | Lumsden, Andrew | A prefilled syringe for administering buffered lignocaine |
WO2014180902A1 (en) * | 2013-05-07 | 2014-11-13 | Auxin Surgery Sa | Device for chemically assisted dissection |
US10335548B1 (en) | 2017-06-09 | 2019-07-02 | Cinti Medical, Inc. | Syringe assembly |
US20210069062A1 (en) * | 2018-01-05 | 2021-03-11 | Pacifi Limited | Method and apparatus |
US11284867B2 (en) | 2019-06-20 | 2022-03-29 | Spectrum Solutions L.L.C. | Sample collection system including a sample collection vessel, sealing cap, and reagent chamber and valve assembly in the sealing cap |
US11364095B2 (en) * | 2015-12-23 | 2022-06-21 | Medmix Switzerland Ag | Discharger |
US11536632B2 (en) | 2011-06-19 | 2022-12-27 | DNA Genotek, Inc. | Biological collection system |
US11572581B2 (en) | 2002-06-07 | 2023-02-07 | DNA Genotek, Inc. | Compositions and methods for obtaining nucleic acids from sputum |
US11712692B2 (en) | 2018-11-20 | 2023-08-01 | Spectrum Solutions L.L.C. | Sample collection system including sealing cap and valve |
Citations (5)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US1943120A (en) * | 1930-05-21 | 1934-01-09 | Kabnick Stuart | Hypodermic syringe |
US2590900A (en) * | 1949-03-23 | 1952-04-01 | Sommerstein Cwi | Ampoule |
US2591706A (en) * | 1950-09-29 | 1952-04-08 | Compule Corp | Plural-compartment admixing hypodermic syringe ampoule for segregated storage of ingredients of liquid medicinal solutions and therapeutic preparations |
US2705956A (en) * | 1952-03-10 | 1955-04-12 | Howard J Mclaughlin | Means of administering procaine and like preparations |
DE961289C (en) * | 1952-10-05 | 1957-04-04 | Dr Med Dent Wilhelm Eisenberg | Two-chambered ampoule designed for separate storage and for mixing the components of an agent to be sprayed |
-
1966
- 1966-05-13 US US54991366 patent/US3340873A/en not_active Expired - Lifetime
-
1967
- 1967-06-19 FR FR110931A patent/FR1550103A/en not_active Expired
- 1967-11-03 BE BE706004D patent/BE706004A/xx unknown
Patent Citations (5)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US1943120A (en) * | 1930-05-21 | 1934-01-09 | Kabnick Stuart | Hypodermic syringe |
US2590900A (en) * | 1949-03-23 | 1952-04-01 | Sommerstein Cwi | Ampoule |
US2591706A (en) * | 1950-09-29 | 1952-04-08 | Compule Corp | Plural-compartment admixing hypodermic syringe ampoule for segregated storage of ingredients of liquid medicinal solutions and therapeutic preparations |
US2705956A (en) * | 1952-03-10 | 1955-04-12 | Howard J Mclaughlin | Means of administering procaine and like preparations |
DE961289C (en) * | 1952-10-05 | 1957-04-04 | Dr Med Dent Wilhelm Eisenberg | Two-chambered ampoule designed for separate storage and for mixing the components of an agent to be sprayed |
Cited By (40)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US3870147A (en) * | 1972-04-28 | 1975-03-11 | Wolf Geraete Gmbh | Container for storage and preparation of a plant protective material containing at least two components |
US4159570A (en) * | 1977-10-31 | 1979-07-03 | Dentipressions Incorporated | Disposable mixing syringe |
US4191254A (en) * | 1978-01-16 | 1980-03-04 | Baughman Kenneth E | Apparatus and method for plugging voids in a ground stratum |
US4693706A (en) * | 1986-08-11 | 1987-09-15 | Mark L. Anderson | Two compartment mixing syringe |
US4983164A (en) * | 1987-04-14 | 1991-01-08 | Astra Meditec Ab | Automatic two-chamber injector |
US5002206A (en) * | 1989-10-25 | 1991-03-26 | Merck & Co., Inc. | Double tip drug dispensing and metering device |
US5137528A (en) * | 1990-11-26 | 1992-08-11 | Crose Virginia W | Ampoule for administering a liquid local anaesthetic |
US5196001A (en) * | 1991-03-05 | 1993-03-23 | Ti Kao | Devices and methods for preparing pharmaceutical solutions |
US5217433A (en) * | 1991-05-24 | 1993-06-08 | Merck & Co., Inc. | Medication container for mixing two components |
US5322800A (en) * | 1991-06-26 | 1994-06-21 | The United States Of America As Represented By The Secretary Of The Interior | Method and device for safely preserving aqueous field samples using acid or base |
US6372270B1 (en) * | 1999-05-26 | 2002-04-16 | Sean P. Denny | Drink mix apparatus for making personal quantities of beverage |
US20020090426A1 (en) * | 1999-05-26 | 2002-07-11 | Denny Sean P. | Methods and apparatus for making personal quantities of beverage |
US6544213B1 (en) | 1999-09-13 | 2003-04-08 | Merck & Co., Inc. | Dual compartment mixing and dispensing device |
US6419414B1 (en) | 2001-04-20 | 2002-07-16 | 3M Innovative Properties Company | Container for multiple-component compositions |
US6543612B2 (en) | 2001-05-21 | 2003-04-08 | 3M Innovative Properties Company | Container for compositions made of two or more components |
WO2003022696A1 (en) * | 2001-09-10 | 2003-03-20 | Den-Mat Corporation | Unit-dose packaging system |
US11572581B2 (en) | 2002-06-07 | 2023-02-07 | DNA Genotek, Inc. | Compositions and methods for obtaining nucleic acids from sputum |
US20050113768A1 (en) * | 2003-11-24 | 2005-05-26 | Carlos Patrickson | Pain-alleviating injection needle |
WO2006118697A3 (en) * | 2005-04-29 | 2007-01-25 | Ipifini | Programmable liquid containers |
US20090206084A1 (en) * | 2005-04-29 | 2009-08-20 | Ipifini, Inc. | Programmable liquid containers |
US20100240004A1 (en) * | 2009-03-23 | 2010-09-23 | Moshe Zalsman | Capsule for mixing together two flowable materials, and kits including such capsules, particularly useful in dentistry |
WO2011071463A1 (en) * | 2009-12-07 | 2011-06-16 | Merenkov Aleksandr Vladimirovich | Container, container for packaging and storing two components, and container manufacturing method |
AU2010101255B4 (en) * | 2010-11-15 | 2011-09-22 | Lumsden, Andrew | A prefilled syringe for administering buffered lignocaine |
US11536632B2 (en) | 2011-06-19 | 2022-12-27 | DNA Genotek, Inc. | Biological collection system |
US11592368B2 (en) | 2011-06-19 | 2023-02-28 | DNA Genotek, Inc. | Method for collecting and preserving a biological sample |
US11549870B2 (en) | 2011-06-19 | 2023-01-10 | DNA Genotek, Inc. | Cell preserving solution |
US11116536B2 (en) | 2013-05-07 | 2021-09-14 | Auxin Surgery Sa | Device for chemically assisted dissection |
WO2014180902A1 (en) * | 2013-05-07 | 2014-11-13 | Auxin Surgery Sa | Device for chemically assisted dissection |
US10092312B2 (en) | 2013-05-07 | 2018-10-09 | Auxin Surgery Sa | Device for chemically assisted dissection |
US11364095B2 (en) * | 2015-12-23 | 2022-06-21 | Medmix Switzerland Ag | Discharger |
US10335548B1 (en) | 2017-06-09 | 2019-07-02 | Cinti Medical, Inc. | Syringe assembly |
US20210069062A1 (en) * | 2018-01-05 | 2021-03-11 | Pacifi Limited | Method and apparatus |
US12090119B2 (en) * | 2018-01-05 | 2024-09-17 | Pacifi Limited | Method of packaging a two component composition into a dual vial |
US11712692B2 (en) | 2018-11-20 | 2023-08-01 | Spectrum Solutions L.L.C. | Sample collection system including sealing cap and valve |
US11547392B2 (en) | 2019-06-20 | 2023-01-10 | Spectrum Solutions L.L.C. | Method of collecting and preserving a biological sample |
US11284867B2 (en) | 2019-06-20 | 2022-03-29 | Spectrum Solutions L.L.C. | Sample collection system including a sample collection vessel, sealing cap, and reagent chamber and valve assembly in the sealing cap |
US11701094B2 (en) | 2019-06-20 | 2023-07-18 | Spectrum Solutions L.L.C. | Sample collection system including valve and plug assemblies |
US12053167B2 (en) | 2019-06-20 | 2024-08-06 | Spectrum Solutions Llc | Sample collection system including plug assembly |
US12075987B2 (en) | 2019-06-20 | 2024-09-03 | Spectrum Solutions, Llc | Sample collection system including valve assembly |
US12075986B2 (en) | 2019-06-20 | 2024-09-03 | Spectrum Solutions Llc | Sample collection system including valve assembly |
Also Published As
Publication number | Publication date |
---|---|
FR1550103A (en) | 1968-12-20 |
BE706004A (en) | 1968-03-18 |
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