KEGG ENZYME: 1.1.1.130

ENZYME: 1.1.1.130

Entry

EC 1.1.1.130                Enzyme

Name

3-dehydro-L-gulonate 2-dehydrogenase;
3-keto-L-gulonate dehydrogenase;
3-ketogulonate dehydrogenase;
3-keto-L-gulonate dehydrogenase;
3-ketogulonate dehydrogenase

Class

Oxidoreductases;
Acting on the CH-OH group of donors;
With NAD+ or NADP+ as acceptor

Sysname

3-dehydro-L-gulonate:NAD(P)+ 2-oxidoreductase

Reaction(IUBMB)

3-dehydro-L-gulonate + NAD(P)+ = (4R,5S)-4,5,6-trihydroxy-2,3-dioxohexanoate + NAD(P)H + H+ [RN:R02637 R02639]

Reaction(KEGG)

R02637 R02639

Substrate

3-dehydro-L-gulonate [CPD:C00618];
NAD+ [CPD:C00003];
NADP+ [CPD:C00006]

Product

(4R,5S)-4,5,6-trihydroxy-2,3-dioxohexanoate [CPD:C04575];
NADH [CPD:C00004];
NADPH [CPD:C00005];
H+ [CPD:C00080]

History

EC 1.1.1.130 created 1972

Pathway

ec00040

Pentose and glucuronate interconversions

ec00053

Ascorbate and aldarate metabolism

ec01100

Metabolic pathways

Orthology

K08092

3-dehydro-L-gulonate 2-dehydrogenase

Genes

ECO:	b3575(yiaK)

ECJ:	JW3547(yiaK)

ECD:	ECDH10B_3756(yiaK)

EBW:	BWG_3265(yiaK)

ECOK:

ECMDS42_3012(yiaK)

ECOC:

C3026_19385

EOI:	ECO111_4395(yiaK)

EOJ:	ECO26_5026(yiaK)

EOH:	ECO103_4659(yiaK)

ESL:

O3K_00975

ESO:

O3O_24700

ESM:

O3M_01005

ECK:	EC55989_4032(yiaK)

ECG:	E2348C_3827(yiaK)

ELH:

ETEC_3818

ECW:	EcE24377A_4072(dlgD)

EUN:	UMNK88_4360

ECP:

ECP_3679

ENA:	ECNA114_3727(yiaK)

ECOS:

EC958_3982(yiaK)

ECV:	APECO1_2875(yiaK)

ECOA:

APECO78_21690

ECX:	EcHS_A3779(dlgD)

ECM:	EcSMS35_3898(dlgD)

ECY:

ECSE_3851

ECR:	ECIAI1_3742(yiaK)

ECQ:	ECED1_4263(yiaK)

EUM:	ECUMN_4088(yiaK)

ECT:	ECIAI39_4087(yiaK)

EOC:	CE10_4129(yiaK)

EBR:	ECB_03427(yiaK)

ECOB:

C3029_21970

EBL:	ECD_03427(yiaK)

EBE:	B21_03378(yiaK)

EBD:

ECBD_0159

ECI:	UTI89_C4117(yiaK)

EIH:	ECOK1_4022(dlgD)

ECZ:	ECS88_3994(yiaK)

ECC:	c4396(yiaK)

ELO:	EC042_3881(dlgD)

ELN:	NRG857_17800

ESE:

ECSF_3410

ECL:	EcolC_0139

EKF:	KO11_04845(yiaK)

EAB:	ECABU_c40180(dlgD)

EDH:	EcDH1_0135

EDJ:	ECDH1ME8569_3456(yiaK)

ELU:	UM146_18045

ELW:	ECW_m3849(yiaK)

ELL:	WFL_18795(yiaK)

ELC:	i14_4063(yiaK)

ELD:	i02_4063(yiaK)

ELP:	P12B_c3704(yiaK)

ELF:	LF82_3339(yiaK)

ECOL:

LY180_18385

ECOI:

ECOPMV1_03913(dlgD)

ECOJ:

P423_19890

EFE:	EFER_3573(yiaK)

EAL:	EAKF1_ch2371c

EMA:	C1192_15920

ESZ:	FEM44_09065

ERUY:

OSH18_12085(yiaK)

STY:

STY4130

STT:

t3851

SEX:	STBHUCCB_40640

SENT:

TY21A_19565

STM:	STM3668(yiaK)

SEO:	STM14_4425(yiaK)

SEV:	STMMW_36561

SEY:	SL1344_3633(yiaK)

SEM:	STMDT12_C37250

SEJ:	STMUK_3654(yiaK)

SEB:	STM474_3840(yiaK)

SEF:	UMN798_3985

SETU:

STU288_18530

SETC:

CFSAN001921_22105

SENR:

STMDT2_35521

SEND:

DT104_36511

SENI:

CY43_19040

SEEN:

SE451236_02580

SPT:	SPA3519(yiaK)

SEK:

SSPA3286

SPQ:	SPAB_04559

SEI:	SPC_3748(yiaK)

SEH:	SeHA_C3991

SHB:

SU5_04145

SENH:

CFSAN002069_13700

SEEH:

SEEH1578_04425

SEE:	SNSL254_A3946

SENN:

SN31241_2150

SEW:	SeSA_A3866

SEA:	SeAg_B3882

SENS:

Q786_17920

SED:

SeD_A4053

SEG:	SG3763(yiaK)

SEL:	SPUL_3897(yiaK)

SEGA:

SPUCDC_3883(yiaK)

SET:	SEN3490(yiaK)

SENA:

AU38_17830

SENO:

AU37_18020

SENV:

AU39_18025

SENQ:

AU40_20080

SENL:

IY59_18465

SENJ:

CFSAN001992_15305

SEEC:

CFSAN002050_25310

SEEB:

SEEB0189_001535

SEEP:

I137_18700

SENB:

BN855_37560

SENE:

IA1_17815

SENC:

SEET0819_02100

SALZ:

EOS98_00910

SFL:	SF3619(yiaK)

SFX:	S4150(yiaK)

SFV:	SFV_3965(yiaK)

SFE:	SFxv_3943(yiaK)

SFN:

SFy_5156

SFS:

SFyv_5232

SFT:	NCTC1_03914(yiaK)

SBO:	SBO_3583(yiaK)

SBC:	SbBS512_E3947(dlgD)

SHQ:	A0259_21705

SHIG:

LXH19_00760(yiaK)

ENC:

ECL_00191

ENL:	A3UG_00985

ECLG:

EC036_01840

ECLE:

ECNIH2_22595

ECLI:

ECNIH5_21115

ECLX:

LI66_21885

ECLY:

LI62_23905

ECLO:

ENC_47440

EHM:	AB284_02935

EXF:	BFV63_21225

ECLA:

ECNIH3_21195

ECLC:

ECR091_21125

EEC:	EcWSU1_00160(dlgD)

ELG:	BH714_15955

ECAN:

CWI88_00910

ERN:	BFV67_00725

ECLS:

LI67_001705

ECHG:

FY206_00880

ESH:	C1N69_00775

EAS:	Entas_0167

ENF:	AKI40_2078(yiaK)

LNI:	CWR52_11755

EBG:	FAI37_05810

ENS:	HWQ15_07205(yiaK)

ENK:	LOC22_09765(yiaK)

EHU:	D5067_0022360

EMOR:

L6Y89_21365(yiaK)

EQU:	OM418_00745(yiaK)

EPU:	QVH39_00765(yiaK)

EAX:	AAHF05_00825(yiaK)

KPE:	KPK_0166(dlgD)

KVD:	KR75_07255

KQV:	B8P98_00955

KOX:

KOX_05675

KOE:

A225_5605

KOY:	J415_04080

KOM:	HR38_04170

KOK:	KONIH1_28205

KOC:	AB185_08195

KLL:	BJF97_27840

KLW:	DA718_01050

KAR:	LGL98_00900(yiaK)

KGR:	JJJ10_00975(yiaK)

KPAS:

LUW96_05610(yiaK)

KLC:	K7H21_00915(yiaK)

KLM:	BWI76_27080

REE:	electrica_00162(dlgD)

KLP:	GUC22_00905

ROR:	RORB6_19620

RON:	TE10_01345

RAO:	DSD31_00925

CKO:

CKO_05033

CFD:	CFNIH1_05490

CBRA:

A6J81_18070

CWE:	CO701_22940

CFQ:	C2U38_26735

CIF:	AL515_00420

CIE:	AN232_05315

CPAR:

CUC49_18435

CITZ:

E4Z61_17830

CARS:

E1B03_25335

CIX:	M4I31_00840(yiaK)

CITR:

GUC46_00815

CIQ:	FD428_00695

ESC:	Entcl_0163

KLE:	AO703_20620

KOR:	AWR26_18130(yiaK)

KRD:	A3780_06125

KOO:	O9K67_17730(yiaK)

KOU:	C0557_06555

KAS:	KATP_01750(dlgD_1) KATP_21200(dlgD_2)

LAZ:	A8A57_00930

LEF:	LJPFL01_0151

LEW:	DAI21_03610

BFT:	MNO13_13410(yiaK)

BSEL:

RHD99_07420(yiaK)

KIN:	AB182_26300

PDZ:	HHA33_03015(yiaK)

METY:

MRY16398_01670(dlgD)

IZH:	FEM41_13790

PSGC:

G163CM_37550(dlgD)

SUPE:

P0H77_01115(yiaK) P0H77_19615(yiaK)

MPHG:

MPHASIOC01_000127(yiaK)

EBF:

D782_0150

EBC:	C2U52_09105

EBB:	F652_2161 F652_2795

YIN:	CH53_4238(dlgD)

YMA:	DA391_10455

SMAC:

SMDB11_3331(dlgD)

SPE:

Spro_3933

SRR:	SerAS9_4139

SRL:	SOD_c38930(dlgD)

SRY:	M621_20900

SPLY:

Q5A_020880(dlgD)

SRS:	SerAS12_4140

SRA:	SerAS13_4140

SLQ:	M495_20535

SFW:	WN53_21580

SFG:	AV650_17370

SQU:	E4343_20725

SNEM:

NLX84_20500(yiaK)

SGRI:

SGBXF1_04033(dlgD)

SSAR:

SSARUM_003932(yiaK)

SFO:	Z042_06785

RAH:	Rahaq_1074

RACE:

JHW33_22085(yiaK)

RAQ:	Rahaq2_1145

RAA:

Q7S_05145

ROX:	BV494_00640 BV494_15210

RBON:

QNM34_05475(yiaK)

SERA:

Ser39006_020885 Ser39006_022675

SERQ:

CWC46_20890 CWC46_22685

PROD:

PCO85_02485(yiaK) PCO85_04565(yiaK)

PCT:

PC1_3692

PWA:	Pecwa_3889

PPAR:

A8F97_22060

PEC:

W5S_4035

PWS:	A7983_04500 A7983_12495 A7983_12510

PPUJ:

E2566_18665

PARI:

I2D83_03340(yiaK)

PAQU:

DMB82_0017635(yiaK)

PQU:	IG609_017415(yiaK)

PPOO:

LW347_18720(yiaK)

PACB:

M9782_06655(yiaK)

PARL:

PEC302110_08100(yiaK)

BGJ:	AWC36_17715

SOD:

Sant_1948

EPE:	CI789_16640

ETP:	LU633_19545(yiaK)

ERP:	LJN55_21155(yiaK)

ERWE:

GKQ23_21565

PAM:	PANA_0364(dlgD)

PLF:	PANA5342_4050(dlgD)

PAJ:	PAJ_3520(dlgD)

PAQ:	PAGR_g3913

PAO:	Pat9b_1877

PSTW:

DSJ_03410

PPHO:

CTZ24_09875

PANZ:

NR302_22700(yiaK)

TCI:	A7K98_02595

EHO:	A9798_02100

HAV:	AT03_19190

HPAR:

AL518_07400 AL518_10545

OPO:	DSM2777_06205

HIN:

HI_1031

HIQ:	CGSHiGG_08775

HPAK:

JT17_07790

HSO:	HS_0759(mdh)

HSM:

HSM_1226

PMU:

PM1256

PMV:	PMCN06_1920(dlgD)

PUL:	NT08PM_2210

PMP:	Pmu_19160(dlgD)

PMUL:

DR93_499(dlgD)

PDAG:

4362423_01625(dlgD)

PSKY:

A6B44_10495

PATL:

KGI96_10570(yiaK)

PCAI:

K7G93_001845(yiaK)

MSU:

MS0054

BSUN:

A4G13_09070

MHT:

D648_390

MHQ:

D650_370

MHAT:

B824_1140(yiaK)

MHX:	MHH_c05720(dlgD)

MHAE:

F382_07945

MHAM:

J450_07145

MHAO:

J451_08025

MHAL:

N220_00120

MHAQ:

WC39_00180

MHAY:

VK67_00185

MVR:

X781_670

MVI:

X808_820

MVG:

X874_790

MVE:	X875_20260

MGRA:

A4G16_09800

MBOS:

ICJ55_02005(yiaK)

MPEG:

HV560_02710(yiaK)

MANN:

GM695_02540

APL:

APL_1573

APJ:	APJL_1604 APJL_1605

APA:

APP7_1635

ASU:

Asuc_0268

ASI:	ASU2_10040

ASS:	ASU1_10085

AEU:	ACEE_10335

APOR:

DDU33_01580

ALIG:

NCTC10568_01932(dlgD)

AGP:	NYR63_08455(yiaK)

AGK:	NYR60_07035(yiaK)

GSS:	NYR30_10705(yiaK)

BTO:

WQG_22320

BTRE:

F542_290

BTRH:

F543_300

BTRA:

F544_22850

RPNE:

NCTC8284_03314(dlgD_2)

RHEY:

FEE42_11320

RHAE:

IHV77_10320(yiaK)

OOI:	A6A10_00695 A6A10_00745

FCL:	A4G17_03000

BHUD:

A6A11_09075

PAET:

NCTC13378_00072(dlgD)

PBAN:

AC062_1774

VSP:

VS_II0146

VGA:	BSQ33_11610

VSH:	BSZ05_18275

VSR:	Vspart_00567(dlgD)

VLE:	ISX51_21815(yiaK)

VRU:	RND59_03335(yiaK)

VIO:	AB2S62_00515(yiaK)

VIH:	AB0763_12110(yiaK)

MKE:	OOT55_06440(yiaK)

HHU:	AR456_18335

HPRO:

LMS44_04965(yiaK)

HBH:	E4T21_20090(yiaK)

HALF:

QEN58_04320(yiaK)

HAAH:

HALA3H3_50019(dlgD)

HABD:

OM794_04790(yiaK)

HOL:	HORIV_15110(dlgD)

HNP:	SR894_04265(yiaK)

HTT:	HZS52_23275(yiaK)

HAA:	A5892_03140

KUS:	B9G99_15925

KMA:	B9H00_15710

MARS:

A8C75_18935

BCT:

GEM_3243

BPYR:

ABD05_23400

BANN:

JFN94_16455(yiaK)

BURK:

DM992_23800

PTS:	CUJ90_31490

MARU:

FIU81_09120(dlgD)

PZH:	CX676_12965

PARO:

CUV01_08870

SLOM:

PXH66_21015(yiaK)

TPAV:

HRQ91_07735(yiaK)

SBU:	SpiBuddy_2240

SGP:	SpiGrapes_1800 SpiGrapes_2576

SASS:

MUG09_12345(yiaK) MUG09_13745(yiaK)

ACA:

ACP_1954

ACM:	AciX9_1752

GMA:	AciX8_0342

GRB:	GOB94_08635

TSA:	AciPR4_0567

TALB:

FTW19_15705

EDA:	GWR55_06525(yiaK)

EDG:	H7846_13235(yiaK)

EPL:	P4G45_07295(yiaK)

ORP:	MOP44_12565(yiaK)

TEMP:

RBB75_16235(yiaK)

PFER:

IRI77_25355(yiaK)

GBA:

J421_0713

DRC:	G0Q07_19910(yiaK)

MCOS:

GM418_15300

ANF:

AQPE_3768

CHF:	KTO58_24915(yiaK)

CSAC:

SIO70_18050(yiaK)

CHIM:

CK934_03855

NKO:	Niako_3650

FGG:	FSB75_04805

HHY:	Halhy_6468

PHE:

Phep_3438

PGS:	CPT03_01000

PEJ:	FYC62_04300

PSN:	Pedsa_2698

MUP:	A0256_23975

MUC:

MuYL_3799

MGOT:

MgSA37_04096(dlgD)

MUH:	HYN43_028665

MGIN:

FRZ54_22780

MGK:	FSB76_05645

MRUB:

DEO27_030395

MGOS:

DIU38_032655

MMAB:

HQ865_17775(yiaK)

MDJ:	LLH06_05880(yiaK)

MJJ:	PQO05_04185(yiaK)

MSAB:

SNE25_06615(yiaK)

MUY:	SNE26_18145(yiaK)

CMR:	Cycma_3367

CAMU:

CA2015_3203

CXI:	ABWH99_19030(yiaK)

EVI:	Echvi_3091

EST:	DN752_22295

ECHI:

FKX85_14620

EMAI:

KZP23_19675(yiaK)

AHAO:

OM944_08430(yiaK)

AHAP:

V8V91_21165

RHOZ:

GXP67_33145(yiaK)

PSEZ:

HME7025_02598(dpkA)

EOL:	Emtol_1032

RSI:	Runsl_5467

RUP:	DTQ70_01990

FIB:	A6C57_03190

HYZ:	AXW84_03380

HYJ:	FHG12_13530

PKO:	PKOR_07140

PACT:

CA264_18075

PONT:

C1N53_18440

RUF:	TH63_05215

CLIT:

OQ292_23085(yiaK)

IRO:	RT717_14585(yiaK)

FBT:	D770_00610

CHK:	D4L85_18090

MARM:

YQ22_10005

MART:

BTR34_10075

MARE:

EJ994_10305

SEON:

BWZ22_15620

AALG:

AREALGSMS7_03762(dlgD)

MARF:

CJ739_2488

EMAR:

D1013_18825

ASAG:

FGM00_11440

TSX:	RHP49_03490(yiaK)

RBAR:

AWN76_004040

MRO:

MROS_2339

OCN:	CUC15_16400

NCM:	QNK12_13515(yiaK)

PHEX:

L0M14_06415(yiaK)

SPAE:

E2C16_10285

CBEI:

LF65_03926

CPAS:

Clopa_1614

CPAT:

CLPA_c27020(dlgD)

CPAE:

CPAST_c27020(dlgD)

CEU:	A7L45_01920

FTK:	PXT33_010115(yiaK)

OKO:	Ruko_19700(yiaK)

ALKA:

J0B03_03745(yiaK) J0B03_03860(yiaK)

BLIQ:

INP51_13510(yiaK)

CPY:

Cphy_1597

LACY:

A4V08_05145 A4V08_19720 A4V08_26375

LXA:	OW255_01530(yiaK)

LSIA:

VIG27_01940(yiaK)

RGN:	RGna_04580

CBOL:

CGC65_17835 CGC65_28090

CASP:

NQ535_05220(yiaK) NQ535_09435(yiaK) NQ535_23280(yiaK)

ECLF:

QMP25_13810(yiaK) QMP25_32135(yiaK)

DFM:	NQ560_12490(yiaK)

QDO:	H9Q78_10435(yiaK)

MFOR:

NQ534_12200(yiaK)

CBAR:

PATL70BA_2571(yiaK)

GFE:	Gferi_07860

HALS:

D7D81_01315

IFN:	GM661_17375

APR:

Apre_0576

MHAP:

JFY71_00655(yiaK)

PUF:

UFO1_3871

ERB:	A4V01_00980

APAL:

BN85403770

GEZ:	FE251_05235

» show all

Reference

1 [PMID:13926592]

Authors

VOLK WA, LARSEN JL.

Title

beta-Keto-L-gulonic acid as an intermediate in the bacterial metabolism of ascorbic acid.

Journal

J Biol Chem 237:2454-7 (1962)

Other DBs

ExplorEnz - The Enzyme Database:

1.1.1.130

IUBMB Enzyme Nomenclature:

1.1.1.130

ExPASy - ENZYME nomenclature database:

1.1.1.130

BRENDA, the Enzyme Database:

1.1.1.130

CAS:	37250-61-6

LinkDB

DBGET integrated database retrieval system