Entry
Name
quinate/shikimate dehydrogenase (NAD+);
quinate dehydrogenase (ambiguous);
quinic dehydrogenase (ambiguous);
quinate:NAD oxidoreductase;
quinate 5-dehydrogenase (ambiguous);
quinate:NAD+ 5-oxidoreductase
Class
Oxidoreductases;
Acting on the CH-OH group of donors;
With NAD+ or NADP+ as acceptor
BRITE hierarchy
Sysname
L-quinate:NAD+ 3-oxidoreductase
Reaction(IUBMB)
L-quinate + NAD+ = 3-dehydroquinate + NADH + H+ [RN:
R01872 ]
Reaction(KEGG)
Substrate
Product
Comment
The enzyme, found mostly in bacteria (mostly, but not exclusively in Gram-positive bacteria), fungi, and plants, participates in the degradation of quinate and shikimate with a strong preference for NAD+ as a cofactor. While the enzyme can act on both quinate and shikimate, activity is higher with the former. cf. EC
1.1.5.8 , quinate/shikimate dehydrogenase (quinone), EC
1.1.1.282 , quinate/shikimate dehydrogenase [NAD(P)+], and EC
1.1.1.25 , shikimate dehydrogenase (NADP+).
History
EC 1.1.1.24 created 1961, modified 1976, modified 2004, modified 2021
Pathway
ec00400 Phenylalanine, tyrosine and tryptophan biosynthesis
Orthology
K25901 quinate/shikimate dehydrogenase (NAD+)
Genes
CTEN : 18250123(PSN45_002665)
ASAU : 88173289(PUMCH_002224)
NTE : NEUTE1DRAFT46730(NEUTE1DRAFT_46730)
SMP : 10802440(SMAC4_07403)
SSCK : SPSK_00849 SPSK_06463
FGR : FGSG_05704 FGSG_12357
FPU : FPSE_06307 FPSE_06601
FPOA : FPOAC1_006297 FPOAC1_008652(QA3)
FVN : FVRRES_06901 FVRRES_09249
TATV : 25782657(TrAtP1_012341)
MAW : 19248844(QA3_2) 90964081(QA3_3)
PLJ : 28892416(PLICBS_000125)
CDET : 87949385(CDEST_12885)
ELA : UCREL1_1141 UCREL1_7618
PFY : PFICI_03111 PFICI_15086
PSCO : LY89DRAFT_680000 LY89DRAFT_698602
AOR : AO090038000263 AO090103000431
AFV : AFLA_008750 AFLA_013099
APUU : APUU_30054A APUU_50617S
PTRR : 6347415(PtrM4_036200)
ADAC : 96082890(ACET3X_002568)
ZTR : MYCGRDRAFT_84424(qa-3)
CCAC : CcaHIS019_0606160(CcaverHIS019_0606160)
POJ : PtoMrB4_30530(aroE_2)
PAEB : NCGM1900_0235(aroE)
PCQ : PcP3B5_36090(aroE_2)
PPB : PPUBIRD1_3278(aroE_3)
PVD : CFBP1590__2183(aroE)
PPRC : PFLCHA0_c53540(aroE2)
PMUD : NCTC8068_04581(aroE2)
PFW : PF1751_v1c47820(aroE)
PPUU : PputUW4_04721(aroE2)
PSEC : CCOS191_3120(aroE2)
PTW : TUM18999_29460(aroE_3)
PTAE : NCTC10697_00709(aroE_2)
PSKU : KUIN1_21230(aroE_2)
PSKP : KU43P_32450(aroE_2)
HAAH : HALA3H3_360164 HALA3H3_370002
HABD : OM794_22395 OM794_22470 OM794_22575
HTX : EKK97_10020 EKK97_21495
MARS : A8C75_03190 A8C75_03735
BPM : BURPS1710b_A1897(aroE)
BPL : BURPS1106A_A0483(aroE)
BPD : BURPS668_A0580(aroE)
BURT : BTHE68_07680(aroE_1)
PDIO : PDMSB3_2300.1(aroE)
PANN : PanNE5_18940(aroE_1)
PLG : NCTC10937_03700(aroE_2)
BUE : BRPE67_ACDS07620(aroE)
SMIO : CATMQ487_25800(aroE_1)
MESM : EJ066_01655 EJ066_30260
MEAA : ACG873_08065 ACG873_12360 ACG873_21090
PHT : BLM14_17570 BLM14_19965
SMEL : SM2011_b20037(aroE2)
RHI : NGR_b00200 NGR_b06000
SFD : USDA257_c22240(aroE1) USDA257_c56320(aroE2)
SAME : SAMCFNEI73_pC0018(aroE)
SINO : SS05631_b49820 SS05631_b63110
ESJ : SJ05684_b47210 SJ05684_b53920
EAK : EKH55_1601 EKH55_4826
EAW : ACEP9W_26355 ACEP9W_26535
AVV : RvVAT039_38280(aroE)
AVF : RvVAR031_41320(aroE)
RET : RHE_CH02291(aroEch2) RHE_PC00214(aroEc)
REL : REMIM1_CH02301(aroE-2) REMIM1_PB00219(aroE-3)
REP : IE4803_CH01956(aroE-2) IE4803_PD00660(aroE-3)
REI : IE4771_CH02031(aroE-2) IE4771_PE00684(aroE-3)
RTR : RTCIAT899_PC05330 RTCIAT899_PC07925
RGA : RGR602_PC02220(aroE-2)
RHN : AMJ98_CH02346(aroE-2) AMJ98_PB00285(aroE-3)
RPHA : AMC79_CH03887(aroE-2) AMC79_PA00326(aroE-3)
RHX : AMK02_CH02362(aroE-2) AMK02_PB00300(aroE-3)
RHK : Kim5_CH02056(aroE-2) Kim5_PD00633(aroE-3)
REZ : AMJ99_CH02424(aroE-2) AMJ99_PA00285(aroE-3)
RBQ : J2J99_09965 J2J99_26870
RLN : J0663_20970 J0663_29630
SOJ : K6301_18725 K6301_20725 K6301_22005
SSUM : Q9314_19400 Q9314_21180 Q9314_26130
BJA : bll1059(aroE) bll6391(aroE)
BRO : BRAD285_1609(aroE) BRAD285_3019(aroE)
BGQ : X265_05330 X265_34730
BGZ : XH91_05355 XH91_33120
BVZ : BRAD3257_6024(aroE) BRAD3257_8666(aroE)
BRAZ : LRP30_29860 LRP30_42230
BOY : LQG66_01260 LQG66_33160
VGO : GJW-30_1_01140(aroE_2)
MAQU : Maq22A_c10215(aroE) Maq22A_c19135(aroE)
MEE : DA075_08870 DA075_24535
MTEA : DK419_05545 DK419_21185
MIND : mvi_02410(aroE_1) mvi_33050(aroE_3)
MOC : BB934_22135 BB934_24965
LAP : ACP90_08185 ACP90_08360
YPAC : CEW88_16985 CEW88_22640
SPSE : SULPSESMR1_00067(aroE)
PMAU : CP157_03022(aroE_2)
MANH : LA6_000510(aroE_1) LA6_005499(aroE_3) LA6_005712(aroE_4)
SBIN : SBA_ch2_1490(aroE_1) SBA_ch2_3400(aroE_2)
SPYG : YGS_C2P0952 YGS_C2P1151
SPAG : sphantq_03772(aroE_2) sphantq_04115(aroE_3)
MGAU : MGALJ_11380(aroE_2)
MMAT : MMAGJ_48380(aroE_1)
MSEI : MSEDJ_10090(aroE_1)
RHA : RHA1_ro01342(aroE1) RHA1_ro01853(aroE3)
REB : XU06_17790 XU06_22275
RQI : C1M55_18770 C1M55_23615
ROP : ROP_10580(aroE) ROP_15380(aroE) ROP_21990(aroE)
ROA : Pd630_LPD05461 Pd630_LPD06023
RPY : Y013_09920 Y013_14040
RAV : AAT18_10970 AAT18_25260
RRZ : CS378_00720 CS378_14840
RHOD : AOT96_03650 AOT96_29400
RRT : 4535765_03803(aroE_2)
RKO : JWS14_06905 JWS14_09520 JWS14_12960
RGO : KYT97_26160 KYT97_30380
ROZ : CBI38_11155 CBI38_24855
RPSK : JWS13_32905 JWS13_36315 JWS13_39525
RHOO : RA302_18265 RA302_22930
RHOU : KZJ41_12070 KZJ41_26740
RHOW : A4U64_13765 A4U64_25910
RHOJ : JVH1_28065 JVH1_30635
RHOS : QWW67_00640 QWW67_15725
RHOQ : QWW98_00645 QWW98_15730
RHOY : QNA09_08485 QNA09_22350
RHOH : CPI83_06805 CPI83_11195
RHOX : RBB84_00335 RBB84_14655
RHJS : OYT95_29445 OYT95_32055
SAMB : SAM23877_6314(aroE)
SLE : sle_11670(sle_11670)
SGM : GCM10017557_12750(aroE)
SPHV : F9278_40145 F9278_41605
STUI : GCM10017668_59870(aroE)
MHOS : CXR34_05715 CXR34_10865
AMAV : GCM10025877_22880(aroE_2)
LTN : KVY00_10585 KVY00_10615
ARL : AFL94_05075 AFL94_14405
ARY : ATC04_03530 ATC04_12810
ARTP : E5206_03525 E5206_14090
ACAO : NF551_08110 NF551_14275
PNV : JMY29_13025 JMY29_19420
PAYN : HMI60_13120 HMI60_19460
PSLS : KTR40_08320 KTR40_18605
GPR : JQN66_05515 JQN66_14430
SATK : SA2016_3914 SA2016_3943
CCYC : SCMU_39920(aroE_2) SCMU_40300(aroE_3)
NAQU : ENKNEFLB_00208(aroE_1)
PSEH : XF36_10740 XF36_13835
PSDS : K1T35_34450 K1T35_37320
ACTY : OG774_13365 OG774_28610
ASIC : Q0Z83_040480 Q0Z83_102990
ACTE : ACTI_07260(aroE_2) ACTI_69120(aroE_3)
» show all
Taxonomy
Reference
Authors
MITSUHASHI S, DAVIS BD.
Title
Aromatic biosynthesis. XIII. Conversion of quinic acid to 5-dehydroquinic acid by quinic dehydrogenase.
Journal
Reference
2
Authors
Gamborg OL.
Title
Aromatic metabolism in plants. III. Quinate dehydrogenase from mung bean cell suspension cultures.
Journal
Biochim Biophys Acta 128:483-491 (1966)
Reference
Authors
Hawkins AR, Giles NH, Kinghorn JR.
Title
Genetical and biochemical aspects of quinate breakdown in the filamentous fungus Aspergillus nidulans.
Journal
Reference
Authors
Singh S, Stavrinides J, Christendat D, Guttman DS.
Title
A phylogenomic analysis of the shikimate dehydrogenases reveals broadscale functional diversification and identifies one functionally distinct subclass.
Journal
Reference
Authors
Teramoto H, Inui M, Yukawa H.
Title
Regulation of expression of genes involved in quinate and shikimate utilization in Corynebacterium glutamicum.
Journal
Sequence
Reference
Authors
Kubota T, Tanaka Y, Hiraga K, Inui M, Yukawa H.
Title
Characterization of shikimate dehydrogenase homologues of Corynebacterium glutamicum.
Journal
Sequence
Reference
Authors
Peek J, Christendat D.
Title
The shikimate dehydrogenase family: functional diversity within a conserved structural and mechanistic framework.
Journal
Other DBs
ExplorEnz - The Enzyme Database: 1.1.1.24
ExPASy - ENZYME nomenclature database: 1.1.1.24
LinkDB
All DBs