KEGG ENZYME: 1.1.1.240

ENZYME: 1.1.1.240

Entry

EC 1.1.1.240                Enzyme

Name

N-acetylhexosamine 1-dehydrogenase;
N-acetylhexosamine dehydrogenase;
N-acetyl-D-hexosamine dehydrogenase

Class

Oxidoreductases;
Acting on the CH-OH group of donors;
With NAD+ or NADP+ as acceptor

Sysname

N-acetyl-D-hexosamine:NAD+ 1-oxidoreductase

Reaction(IUBMB)

N-acetyl-alpha-D-glucosamine + NAD+ = N-acetyl-D-glucosaminate + NADH + H+ [RN:R01202]

Reaction(KEGG)

R01202

Substrate

N-acetyl-alpha-D-glucosamine [CPD:C20328];
NAD+ [CPD:C00003]

Product

N-acetyl-D-glucosaminate [CPD:C01133];
NADH [CPD:C00004];
H+ [CPD:C00080]

Comment

Also acts on N-acetylgalactosamine and, more slowly, on N-acetylmannosamine. Anomeric specificity was tested with N-acetyl-D-glucosamine, and it was shown that the enzyme is specific for the alpha anomer.

History

EC 1.1.1.240 created 1992

Reference

Authors

Horiuchi T, Kurokawa T.

Title

Purification and characterization of N-acetyl-D-hexosamine dehydrogenase from Pseudomonas sp no 53.

Journal

Agric Biol Chem 53:1919-1925 (1989)

Other DBs

ExplorEnz - The Enzyme Database:

1.1.1.240

IUBMB Enzyme Nomenclature:

1.1.1.240

ExPASy - ENZYME nomenclature database:

1.1.1.240

BRENDA, the Enzyme Database:

1.1.1.240

CAS:	122785-18-6

LinkDB

DBGET integrated database retrieval system