KEGG   ENZYME: 1.1.1.258
Entry
EC 1.1.1.258                Enzyme                                 
Name
6-hydroxyhexanoate dehydrogenase
Class
Oxidoreductases;
Acting on the CH-OH group of donors;
With NAD+ or NADP+ as acceptor
Sysname
6-hydroxyhexanoate:NAD+ oxidoreductase
Reaction(IUBMB)
6-hydroxyhexanoate + NAD+ = 6-oxohexanoate + NADH + H+ [RN:R05283]
Reaction(KEGG)
R05283
Substrate
6-hydroxyhexanoate [CPD:C06103];
NAD+ [CPD:C00003]
Product
6-oxohexanoate [CPD:C06102];
NADH [CPD:C00004];
H+ [CPD:C00080]
Comment
Involved in the cyclohexanol degradation pathway in Acinetobacter NCIB 9871.
History
EC 1.1.1.258 created 2000
Pathway
ec00930  Caprolactam degradation
ec01120  Microbial metabolism in diverse environments
Orthology
K19961  6-hydroxyhexanoate dehydrogenase
Reference
1  [PMID:1261]
  Authors
Donoghue NA, Trudgill PW.
  Title
The metabolism of cyclohexanol by Acinetobacter NCIB 9871.
  Journal
Eur J Biochem 60:1-7 (1975)
DOI:10.1111/j.1432-1033.1975.tb20968.x
Reference
2  [PMID:6722936]
  Authors
Hecker LI, Tondeur Y, Farrelly JG.
  Title
Formation of epsilon-hydroxycaproate and epsilon-aminocaproate from N-nitrosohexamethyleneimine: evidence that microsomal alpha-hydroxylation of cyclic nitrosamines may not always involve the insertion of molecular oxygen into the substrate.
  Journal
Chem Biol Interact 49:235-48 (1984)
DOI:10.1016/0009-2797(84)90064-4
Other DBs
ExplorEnz - The Enzyme Database: 1.1.1.258
IUBMB Enzyme Nomenclature: 1.1.1.258
ExPASy - ENZYME nomenclature database: 1.1.1.258
UM-BBD (Biocatalysis/Biodegradation Database): 1.1.1.258
BRENDA, the Enzyme Database: 1.1.1.258
CAS: 77000-03-4
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