Entry
Name
decaprenylphospho-beta-D-erythro-pentofuranosid-2-ulose 2-reductase;
decaprenylphospho-beta-D-ribofuranose 2'-epimerase;
Rv3791;
DprE2
Class
Oxidoreductases;
Acting on the CH-OH group of donors;
With NAD+ or NADP+ as acceptor
BRITE hierarchy
Sysname
trans,octacis-decaprenylphospho-beta-D-arabinofuranose:NAD+ 2-oxidoreductase
Reaction(IUBMB)
trans,octacis-decaprenylphospho-beta-D-arabinofuranose + NAD+ = trans,octacis-decaprenylphospho-beta-D-erythro-pentofuranosid-2-ulose + NADH + H+ [RN:
R10113 ]
Reaction(KEGG)
Substrate
trans,octacis-decaprenylphospho-beta-D-arabinofuranose [CPD:
C20370 ];
NAD+ [CPD:
C00003 ]
Product
trans,octacis-decaprenylphospho-beta-D-erythro-pentofuranosid-2-ulose [CPD:
C20369 ];
NADH [CPD:
C00004 ];
H+ [CPD:
C00080 ]
Comment
The reaction is catalysed in the reverse direction. The enzyme, isolated from the bacterium Mycobacterium smegmatis, is involved, along with EC
1.1.98.3 , decaprenylphospho-beta-D-ribofuranose 2-oxidase, in the epimerization of trans,octacis-decaprenylphospho-beta-D-ribofuranose to trans,octacis-decaprenylphospho-beta-D-arabinoofuranose, the arabinosyl donor for the biosynthesis of mycobacterial cell wall arabinan polymers.
History
EC 1.1.1.333 created 2012
Orthology
K16652 decaprenylphospho-beta-D-erythro-pentofuranosid-2-ulose 2-reductase
Genes
MBO : BQ2027_MB3820(dpre2)
MAVM : MAA44156_00240(actIII_1)
MBAI : MB901379_04791(fabG1_2)
MHEK : JMUB5695_00223(dprE2)
MKY : IWGMT90018_61330(dprE2)
MPHL : MPHLCCUG_00214(phbB_1)
MAUU : NCTC10437_05392(fabG1)
MFLV : NCTC10271_00223(sdh_1)
MSAL : DSM43276_00168(phbB)
MTER : 4434518_04037(actIII)
CUC : CULC809_00150(dprE2)
CUN : Cul210932_0151(dprE2)
CUQ : Cul210931_0145(dprE2)
CUZ : Cul05146_0151(dprE2)
CUJ : CUL131002_0135c(dprE2)
CUS : CulFRC11_0146(dprE2)
CMIN : NCTC10288_02446(fabG3)
CRL : NCTC7448_00916(actIII_2)
CAUS : CAURIC_11120(fabG3)
NFR : ERS450000_04042(fabG_23)
NSPU : IFM12276_65810(dprE2)
RRT : 4535765_00239(fabG1_1)
TPUL : TPB0596_44970(dprE2)
SLE : sle_28330(sle_28330)
PAUS : NCTC13651_00709(fabG_3)
ACTU : Actkin_00163(fabG_2)
DHI : LH044_19675 LH044_20390
» show all
Taxonomy
Reference
Authors
Trefzer C, Skovierova H, Buroni S, Bobovska A, Nenci S, Molteni E, Pojer F, Pasca MR, Makarov V, Cole ST, Riccardi G, Mikusova K, Johnsson K
Title
Benzothiazinones are suicide inhibitors of mycobacterial decaprenylphosphoryl-beta-D-ribofuranose 2'-oxidase DprE1.
Journal
Sequence
Other DBs
ExPASy - ENZYME nomenclature database: 1.1.1.333
LinkDB
All DBs