KEGG   ENZYME: 1.1.1.337
Entry
EC 1.1.1.337                Enzyme                                 
Name
L-2-hydroxycarboxylate dehydrogenase (NAD+);
(R)-sulfolactate:NAD+ oxidoreductase;
L-sulfolactate dehydrogenase;
(R)-sulfolactate dehydrogenase;
L-2-hydroxyacid dehydrogenase (NAD+);
ComC
Class
Oxidoreductases;
Acting on the CH-OH group of donors;
With NAD+ or NADP+ as acceptor
Sysname
(2S)-2-hydroxycarboxylate:NAD+ oxidoreductase
Reaction(IUBMB)
a (2S)-2-hydroxycarboxylate + NAD+ = a 2-oxocarboxylate + NADH + H+ [RN:R10189]
Reaction(KEGG)
R10189 > R07136
Substrate
(2S)-2-hydroxycarboxylate [CPD:C15565];
NAD+ [CPD:C00003]
Product
2-oxocarboxylate [CPD:C00161];
NADH [CPD:C00004];
H+ [CPD:C00080]
Comment
The enzyme from the archaeon Methanocaldococcus jannaschii acts on multiple (S)-2-hydroxycarboxylates including (2R)-3-sulfolactate, (S)-malate, (S)-lactate, and (S)-2-hydroxyglutarate [3]. Note that (2R)-3-sulfolactate has the same stereo configuration as (2S)-2-hydroxycarboxylates.
History
EC 1.1.1.337 created 2012
Pathway
ec00680  Methane metabolism
ec01100  Metabolic pathways
ec01120  Microbial metabolism in diverse environments
Orthology
K05884  L-2-hydroxycarboxylate dehydrogenase (NAD+)
Genes
VSH: BSZ05_08715
VCK: PG915_14325
TFT: RI844_15805
AGAR: OAG1_18420
WBO: MIS45_08080
CNC: CNE_BB1p05710(comC)
CUH: BJN34_35490
PACS: FAZ98_33455
PTRP: DCO17_04195
PWU: A8O14_06820
PARD: DN92_02155
POLY: PSHI2_17910
POLN: PSHI8_17920
POLT: TUM22923_05110
PNR: AT302_16585
BFZ: BAU07_07535
BGV: CAL12_19730
ADY: HLG70_07725
PUS: CKA81_13830
PIG: EGT29_10430
RHOB: HTY51_03820
LIM: L103DPR2_01654(yjmC)
HYN: F9K07_00765
HGR: DW355_02340
XYG: R9X41_06580
BPRC: D521_0584
SMK: Sinme_5353
SMQ: SinmeB_5546
SMX: SM11_pC1598
SMI: BN406_04935
SMEG: C770_GR4pC1290
SMEL: SM2011_a0265
SMER: DU99_24705
SFH: SFHH103_06683(mdh)
SIX: BSY16_5575
RIR: BN877_p0363
RJG: CCGE525_30300
SHZ: shn_26825
BROS: QUH67_25525
APOL: K9D25_08275
RHZ: RHPLAN_59280
DEQ: XM25_09010
DEI: C4375_14185
YTI: FNA67_12740
MMED: Mame_04860(yjmC_2)
JAV: OXU80_24995
PSIN: CAK95_00810
OTM: OSB_08100(yjmC)
SUAM: BOO69_02845
DAA: AKL17_3266
YAG: AABB28_16175
SEDI: EBB79_05045
LIT: FPZ52_15805
PALW: PSAL_017020(allD)
GCE: KYE46_09560
MTAR: DF168_01575(yjmC_4)
LCRE: Pla8534_16970(yjmC)
SDYN: Mal52_06970(yjmC)
TAER: GT409_05910
TPI: TREPR_3329
SPER: EW093_13865
OCK: EXM22_12545
SBU: SpiBuddy_0633
SGP: SpiGrapes_1364
SASS: MUG09_03720 MUG09_13845
SCC: Spico_1555
TAZ: TREAZ_1631
TAQU: KDW03_08540
MSIL: METEAL_16280
MSEA: METESE_14790
ANF: AQPE_3448
CBAE: COR50_00710
CHIT: FW415_08115
COY: HF329_20415
CFIL: MYF79_30070
CHOR: MKQ68_17325
CSAC: SIO70_31215
CPOL: WJU16_09045
CHIM: CK934_28440
NKO: Niako_5052
NSO: NIASO_00405
NYN: U0035_08525
FGG: FSB75_01485
AGI: FSB73_14960
ATEE: K9M52_14285
PGIN: FRZ67_22035
LACS: H4075_07420
FEI: K9M53_13855
FLP: LK994_01670
FLC: KJS93_10890
FLV: KJS94_08280
THEO: IMW88_12050
PSN: Pedsa_2198
CAMU: CA2015_1167
CXI: ABWH99_04195 ABWH99_06195
BBD: Belba_1791
EVI: Echvi_0162
EST: DN752_07350
ECHI: FKX85_00785
ALGO: GYM62_13805
AHAO: OM944_09430
AHAP: V8V91_11455
MDA: IPZ59_00985
SPIK: EXU85_28470
SPIB: G8759_30960
SRHO: HH216_11020
SOQ: LQ777_19275
SFOL: H3H32_24840
SENF: GJR95_20605
EMZ: MB380_09155
DSN: HWI92_12955
DFQ: NFI81_13340
DCN: MUK70_16695
DPF: ON006_18525
RSI: Runsl_0559
RUN: DR864_22800
RUP: DTQ70_27545
HSW: Hsw_3558
HYM: N008_11585
HYG: AUC43_08190
HYP: A0257_10070
HYZ: AXW84_17735
HNV: DDQ68_12555
HRS: HER32_07605
HTS: HMJ29_03810
HMT: MTP16_02030
HTB: MTX78_19255
HYK: O9Z63_13890
HSK: H4317_03670
HCW: O3303_11905
HSB: MWH26_14695
HAEI: MUN82_20995
HCU: MUN79_00150
HCF: MUN80_00740
PONT: C1N53_14500
RUF: TH63_01270
RTI: DC20_19730
RUD: TH61_09780
ADD: HUW48_20385
ASWU: HUW51_03165
MHAA: Q3Y49_09305
MARP: QYS47_06980
MSAA: QYS49_11240
FPF: DCC35_04490
FLM: MY04_2484 MY04_2897
FYA: KMW28_01625 KMW28_03820
FKA: KM029_13735 KM029_15620
CLIT: OQ292_06510
IRO: RT717_18950
CHK: D4L85_06045
FUV: JR347_01350
FMM: LVD15_12685
FUA: LVD17_13565
FLW: LVD16_07150
RCG: N7E81_11175
PRHO: PZB74_01255
TPEL: P0M28_24940
RSR: T7867_10340
FAX: FUAX_10320
PPSV: PEPS_23260
ATK: AUTU_05100
LUY: QZH61_12165
SHYR: LA303_06570
CACI: CLOAM1159(mdh)
SCIB: HUG20_05110
SCIA: HUG15_07015
MENL: MVE64_18720 MVE64_18725
PAUN: MJA45_24680
LMUL: PUW59_04940
LRU: HMPREF0538_21967
LRT: LRI_1196
LRR: N134_04225
LMU: LBLM1_05130
LOR: AYI71_01210
LALO: ABC765_04535
LCY: LC20004_10680
THL: TEH_05010(mdh)
TOO: C7K38_02045
TKR: C7K43_11960
VIE: OL234_00735
RTF: VQP54_05570
CRN: CAR_c14810(mdh)
CVD: LHA31_11755
DINC: QNK01_01660
CAC: CA_C0566
CAE: SMB_G0579(mdh)
CAY: CEA_G0580
CKL: CKL_2769(mdh)
CKR: CKR_2460
CLJ: CLJU_c05920(mdh)
CLS: CXIVA_05030
CPAS: Clopa_1152
CPAT: CLPA_c31190(mdh)
CPAE: CPAST_c31190(mdh)
CAH: CAETHG_2689
CTYK: CTK_C26970(mdh)
CARG: RSJ17_10995
CFER: D4Z93_02490
CLOS: DMR38_02690
PROQ: P6M73_04985
RUM: CK1_23260 CK1_39560
PFAA: MM59RIKEN_02120
FWA: DCMF_19385
AWO: Awo_c16770(mdh)
AWI: CHL1_001481
ALKA: J0B03_10230
CCT: CC1_29650
ROB: CK5_14170
BYL: A4V09_10375
BHAN: CGC63_01920
BPRO: PMF13cell1_03197(yjmC_2)
BLAB: EYS05_03090
BWX: NQ550_21270
BMAS: LK422_14620
BLAR: LC508_08005
BLUI: Blut17040_23370
BCOC: BLCOC_22890(yjmC)
CSH: Closa_3084
ACHT: bsdcttw_20390
WHJ: H9Q79_05195
CBAR: PATL70BA_1096(mdh)
MDV: C5Q96_04090
MNL: QU661_05675
AHAD: FRZ06_06310
PEB: O0R46_08030
EAC: EAL2_808p02730(mdh)
TEP: TepRe1_1808
TAE: TepiRe1_1949(mdh)
VNK: VEIT17_15940
VRG: OKW85_08395
VOR: VEIS_15810
ERM: EYR00_09930
TSF: NQ543_04255
FBS: N510_002328(yjmC)
TBK: HF295_08465
OLS: Olsu_0270
DDT: AAY81_05455
MYJ: BCA37_23555
MTY: MTOK_02180
SLE: sle_01170(sle_01170)
SGE: DWG14_06080(dpkA)
SVD: CP969_00545
AREV: RVR_521
ACOR: LCL61_28810
LMAJ: GKN94_06375
CALL: OZ401_001371
VAB: WPS_25360 WPS_25370
ACO: Amico_1325 Amico_1663
AMIZ: RBH88_01185 RBH88_03665
PYY: RAH42_07425
ARAM: KAR29_04645
KPF: IX53_06400
MPG: Theba_0594
MINF: MESINF_0035(mdh) MESINF_1540(mdh)
BANA: BARAN1_1319(mdh)
MJA: MJ_1425
MFE: Mefer_1396
MVU: Metvu_0738
MFS: MFS40622_0628
MIF: Metin_0176
MJH: JH146_0548
MESG: MLAUSG7_0644(comC)
MESA: MLASG1_0181(comC)
MIG: Metig_0716
MMP: MMP1133(comC)
MMQ: MmarC5_0451
MMX: MmarC6_1534
MMZ: MmarC7_0385
MMD: GYY_06515
MMAK: MMKA1_13120(comC)
MMAO: MMOS7_12420(comC)
MMAD: MMJJ_17120(yjmC)
MAE: Maeo_1015
MVN: Mevan_0455
MVO: Mvol_0905
MOK: Metok_0546
METF: CFE53_04010
MTH: MTH_1205
MMG: MTBMA_c15830(comC)
MWO: MWSIV6_1598(comC)
MTEE: MTTB_02220
METC: MTCT_1098
METE: tca_01162(yjmC)
METZ: METMT2_1207
METK: FVF72_05595
MTHM: FZP57_07660
METJ: FZP68_03015
MST: Msp_0279(comC)
METB: AW729_05750
MEIS: PXD04_05160(comC)
MRU: mru_1980(comC)
MSI: Msm_1040
MEB: Abm4_1552(comC)
MMIL: sm9_2052(comC)
MEYE: TL18_09445
MOL: YLM1_1417
MARO: MarbSA_15040
METV: K4897_06265
MEL: Metbo_0320
MEW: MSWAN_2101
METH: MBMB1_1726(comC)
MFC: BRM9_0342(comC)
MFI: DSM1535_0956(comC)
MCUB: MCBB_2038(comC)
MSUB: BK009_07660
METN: BK008_03315
METT: CIT01_03895
METO: CIT02_09230
MEME: HYG87_05175
MFEG: GCM10025860_03460
MEER: NKF70_05390(comC)
MRID: FGU46_06210
MFV: Mfer_0389
MKA: MK0392(comC)
HALX: M0R89_21370
NARA: QQ977_15230
STO: STK_20900
SOH: D1869_11455
SJV: SJAV_10250
SULL: EWF20_12610
AMAN: B6F84_09265
ABRI: DFR85_02480 DFR85_02750
ASUL: DFR86_07970
AAMB: D1866_00065 D1866_09410
ACIH: HS5_24340
SACD: HS1genome_1813
SAZO: D1868_06535
CSTY: KN1_08830
STEP: IC006_0144
LOKI: Lokiarch_23620(mdh_3) Lokiarch_23630(mdh_4)
LOB: NEF87_004182
PSYT: DSAG12_01758
 » show all
Reference
1  [PMID:10850983]
  Authors
Graupner M, Xu H, White RH
  Title
Identification of an archaeal 2-hydroxy acid dehydrogenase catalyzing reactions involved in coenzyme biosynthesis in methanoarchaea.
  Journal
J Bacteriol 182:3688-92 (2000)
DOI:10.1128/JB.182.13.3688-3692.2000
  Sequence
[mja:MJ_1425]
Reference
2  [PMID:11451450]
  Authors
Graupner M, White RH.
  Title
The first examples of (S)-2-hydroxyacid dehydrogenases catalyzing the transfer of the pro-4S hydrogen of NADH are found in the archaea.
  Journal
Biochim Biophys Acta 1548:169-73 (2001)
DOI:10.1016/S0167-4838(01)00220-5
  Sequence
[mja:MJ_1425]
Reference
3  [PMID:12013276]
  Authors
Graham DE, White RH.
  Title
Elucidation of methanogenic coenzyme biosyntheses: from spectroscopy to genomics.
  Journal
Nat Prod Rep 19:133-47 (2002)
DOI:10.1039/b103714p
Reference
4  [PMID:15758220]
  Authors
Rein U, Gueta R, Denger K, Ruff J, Hollemeyer K, Cook AM
  Title
Dissimilation of cysteate via 3-sulfolactate sulfo-lyase and a sulfate exporter in Paracoccus pantotrophus NKNCYSA.
  Journal
Microbiology 151:737-47 (2005)
DOI:10.1099/mic.0.27548-0
Other DBs
ExplorEnz - The Enzyme Database: 1.1.1.337
IUBMB Enzyme Nomenclature: 1.1.1.337
ExPASy - ENZYME nomenclature database: 1.1.1.337
BRENDA, the Enzyme Database: 1.1.1.337
CAS: 81210-65-3
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