KEGG ENZYME: 1.1.1.350

ENZYME: 1.1.1.350

Entry

EC 1.1.1.350                Enzyme

Name

ureidoglycolate dehydrogenase (NAD+)

Class

Oxidoreductases;
Acting on the CH-OH group of donors;
With NAD+ or NADP+ as acceptor

Sysname

(S)-ureidoglycolate:NAD+ oxidoreductase

Reaction(IUBMB)

(S)-ureidoglycolate + NAD+ = N-carbamoyl-2-oxoglycine + NADH + H+ [RN:R02935]

Reaction(KEGG)

R02935

Substrate

(S)-ureidoglycolate [CPD:C00603];
NAD+ [CPD:C00003]

Product

N-carbamoyl-2-oxoglycine [CPD:C00802];
NADH [CPD:C00004];
H+ [CPD:C00080]

Comment

Involved in catabolism of purines. The enzyme from the bacterium Escherichia coli is specific for NAD+ [2]. cf. EC 1.1.1.154, ureidoglycolate dehydrogenase [NAD(P)+].

History

EC 1.1.1.350 created 2013

Pathway

ec00230

Purine metabolism

ec01100

Metabolic pathways

ec01120

Microbial metabolism in diverse environments

Orthology

K00073

ureidoglycolate dehydrogenase (NAD+)

Genes

ECO:	b0517(allD)

ECJ:	JW0505(allD)

ECD:	ECDH10B_0473(allD)

EBW:	BWG_0393(allD)

ECOK:

ECMDS42_0410(allD)

ECOC:

C3026_02535

ECE:	Z0672(ylbC)

ECS:	ECs_0579(allD)

ECF:	ECH74115_0618(allD)

ETW:	ECSP_0591(allD)

ELX:	CDCO157_0562

EOI:	ECO111_0549(allD)

EOJ:	ECO26_0550(allD)

EOH:	ECO103_0489(allD)

ECOO:

ECRM13514_0319(ylbC)

ECOH:

ECRM13516_0506(ylbC)

ESL:

O3K_18915

ESO:

O3O_06380

ESM:

O3M_18890

ECK:	EC55989_0531(allD)

ECG:	E2348C_0450(allD)

EOK:	G2583_0637(allD)

ELR:	ECO55CA74_03110

ELH:

ETEC_0569

ECW:	EcE24377A_0555(allD)

EUN:	UMNK88_567(allD)

ECP:

ECP_0577

ENA:	ECNA114_0494(allD)

ECOS:

EC958_0655(allD)

ECV:	APECO1_1498(allD)

ECOA:

APECO78_06080

ECX:	EcHS_A0591(allD)

ECM:	EcSMS35_0562(allD)

ECY:

ECSE_0542

ECR:	ECIAI1_0519(allD)

ECQ:	ECED1_0536(allD)

EUM:	ECUMN_0557(allD)

ECT:	ECIAI39_0480(allD)

EOC:	CE10_0491(allD)

EBR:	ECB_00467(allD)

ECOB:

C3029_06185

EBL:	ECD_00467(allD)

EBE:	B21_00472(allD)

EBD:

ECBD_3141

ECI:	UTI89_C0545(allD)

EIH:	ECOK1_0499(allD)

ECZ:	ECS88_0516(allD)

ECC:

c0631

ELO:	EC042_0560(allD)

ELN:	NRG857_02445

ESE:

ECSF_0479

ECL:	EcolC_3105

EKF:	KO11_21005(allD)

EAB:	ECABU_c05960(allD)

EDH:	EcDH1_3096

EDJ:	ECDH1ME8569_0501(allD)

ELU:	UM146_14775

ELW:	ECW_m0588(allD)

ELL:	WFL_02915(allD)

ELC:

i14_0607

ELD:

i02_0607

ELP:	P12B_c0530(allD)

ELF:	LF82_0071(allD)

ECOL:

LY180_02915

ECOI:

ECOPMV1_00505(allD_1)

ECOJ:

P423_02630

EMA:	C1192_09985

ESZ:	FEM44_17155(allD)

ERUY:

OSH18_06890(allD)

STY:	STY0576(allD)

STT:	t2333(allD)

SEX:	STBHUCCB_24670

SENT:

TY21A_11820

STM:	STM0528(allD)

SEO:	STM14_0618(allD)

SEV:	STMMW_05961

SEY:	SL1344_0521(allD)

SEM:	STMDT12_C05920

SEJ:	STMUK_0535(allD)

SEB:	STM474_0549(allD)

SEF:	UMN798_0574(allD)

SETU:

STU288_11730

SETC:

CFSAN001921_14390

SENR:

STMDT2_05231(allD)

SEEN:

SE451236_08665

SPT:	SPA2195(allD)

SEK:

SSPA2040

SPQ:	SPAB_03036

SEI:	SPC_0542(allD)

SEC:	SCH_0567(allD)

SEH:	SeHA_C0635(allD)

SHB:

SU5_01221

SENH:

CFSAN002069_06200

SEEH:

SEEH1578_12075

SEE:	SNSL254_A0581(allD)

SENN:

SN31241_15330

SEA:	SeAg_B0574(allD)

SENS:

Q786_02605

SED:	SeD_A0576(allD)

SEG:	SG0540(allD)

SET:	SEN0509(allD)

SENA:

AU38_02595

SENO:

AU37_02590

SENV:

AU39_02595

SENQ:

AU40_02850

SENL:

IY59_02645

SEEC:

CFSAN002050_09250

SEEB:

SEEB0189_016660

SENB:

BN855_5270(allD)

SENE:

IA1_02785

SENC:

SEET0819_09595

SALZ:

EOS98_16460

SHQ:	A0259_06250

SHIG:

LXH19_16125(allD)

KPU:	KP1_1373(ylbC)

KPP:

A79E_3790

KOC:	AB185_29050

KGR:	JJJ10_20955(allD)

KPAS:

LUW96_13565(allD)

KLC:	K7H21_21260(allD)

KLM:	BWI76_07040

KLP:	GUC22_20245(allD)

CFD:	CFNIH1_12730

CBRA:

A6J81_10550

CIE:	AN232_23700

CARS:

E1B03_07350(allD)

CIX:	M4I31_17310(allD)

BAGE:

BADSM9389_31190

EBU:	CUC76_09105

YIN:	CH53_61(allD)

SMAR:

SM39_0495(allD)

SMW:	SMWW4_v1c11190(allD)

SRY:	M621_05540

SERF:

L085_22955

SFW:	WN53_14690

SFG:	AV650_10210

SSUR:

ATE40_002310

SURI:

J0X03_18265(allD)

SNEV:

OI978_01085(allD)

SFO:	Z042_06890

RAH:	Rahaq_0302

RACE:

JHW33_18115(allD)

RAQ:	Rahaq2_0319

RAA:

Q7S_01500

EAME:

GXP68_18225(allD)

ERWI:

GN242_15840(allD)

TCI:	A7K98_20490

TPTY:

NCTC11468_00687(allD)

PMR:	PMI0702(allD)

PMIB:

BB2000_0774(allD)

PVL:	AOB99_05905

PVG:	CRN77_16325

PHAU:

PH4a_13000

PROT:

BTA34_04755

PCOL:

F1325_05980(allD)

PCIB:

F9282_05750(allD)

PPEE:

I6G31_03530(allD)

PAPP:

QQS39_06255(allD)

PFQ:	QQ39_10725

LRI:	NCTC12151_02780(allD)

LGB:	V8L73_14610(allD)

MHAT:

B824_16610(allD)

MHAM:

J450_02305

MVI:	X808_13020

MVG:	X874_12010

MVE:

X875_8750

MGRA:

A4G16_03105

MBOS:

ICJ55_06420(allD)

MPEG:

HV560_08520(allD)

MANN:

GM695_08175(allD)

AVT:	NCTC3438_00702(allD)

PGB:	H744_1c1498

EMO:	DM558_12020

HAA:	A5892_02585

ILV:	WMO13_07360(allD)

GAP:	GAPWK_1756

GAQ:	RAM11_06065(allD)

OMO:	RHO11_01340(allD)

PLAD:

PPGU16_81170

GYJ:	AADW23_12500

BLI:	BL01097 BL01098(yjmC)

BLD:	BLi01129 BLi01130

BLH:	BaLi_c12540 BaLi_c12550

BSON:

S101395_03699(allD) S101395_03700

BACF:

AM500_03320 AM500_03325

CSOA:

LIS82_01135(allD)

LSP:

Bsph_2900

LFU:	HR49_12215

LYQ:	MY533_11190(allD)

VNE:	CFK40_17830 CFK40_17835

LAO:	AOX59_07645 AOX59_07650

NNV:	QNH39_21420(allD) QNH39_21425(allD)

BOU:	I5818_06520(allD) I5818_06525(allD)

ACHP:

QR721_10180(allD)

SCA:	SCA_2053(allD) SCA_2054(allD)

SXY:	BE24_13540 BE24_13545

SXL:	SXYLSMQ121_2325 SXYLSMQ121_2326

SXO:	SXYL_02492(allD1) SXYL_02493(allD2)

SSIF:

AL483_12085 AL483_12090(allD)

SCOH:

BZ166_03585

SURY:

MUA21_12110(allD) MUA21_12115(allD)

SNL:	BJD96_12915 BJD96_12920

SARL:

SAP2_02420(allD_1) SAP2_02430(allD_2)

SSIM:

SAMEA4384339_0261(allD_1) SAMEA4384339_0262(allD_2)

SPSD:

JMB28_12670(allD) JMB28_12675(allD)

SCAQ:

QMO72_12310(allD) QMO72_12315(allD)

SGAI:

K3U27_12085(allD) K3U27_12090(allD)

SSCU:

CEP64_13225 CEP64_13230(allD)

SSTE:

SAMEA4384403_0162(allD_1) SAMEA4384403_0163(allD_2)

JEA:	JEM45_03075(allD) JEM45_03080(allD)

LWI:	UE46_03775 UE46_03780

LNW:	OTR81_01125(allD) OTR81_01130(allD)

BLR:	BRLA_c022460 BRLA_c022470

BRW:	GOP56_04135(allD) GOP56_04140(allD)

PTA:	HPL003_13020

PKB:	B4V02_20120

PLUT:

EI981_02235

PTHI:

NDS46_06670(allD)

PDY:	QJQ58_15845(allD)

SPOO:

J3U78_13330(allD)

STHO:

QNH10_06975(allD) QNH10_06980(allD)

STRB:

QWT68_12570(allD)

SJT:	PGH26_15525(allD)

RST:	ATY39_05550 ATY39_05555

LFE:

LAF_0163

LFR:

LC40_0123

LHIL:

G8J22_00247(allD)

LZY:	LZ3411_0459

EFA:	EF0388(allD)

EFL:	EF62_0721(allD)

EFI:	OG1RF_10276(allD)

EFD:	EFD32_0322

EFS:

EFS1_0271

EFN:	DENG_00376(allD)

EFQ:	DR75_2381(allD)

ENE:

ENT_25980

ECAS:

ECBG_00215 ECBG_00233

EGA:	AL523_00065(allD) AL523_17300(allD)

ESS:	ATZ33_08475 ATZ33_08480

EGV:	EGCR1_17800(allD) EGCR1_17820(allD)

EIE:	ENLAB_08150 ENLAB_08330

ENI:	CXM95_12950(allD) CXM95_13040(allD)

ERX:	ATZ35_00300 ATZ35_00305

TOO:	C7K38_01850(allD) C7K38_01865(allD)

VTE:	BHY08_06460

VPI:	BW732_07880

VCP:	H9L18_06540(allD)

VHY:	G7082_14395(allD)

VLU:	M2919_06885(allD)

AUI:	APT62_03875

ABAE:

CL176_02815

FCT:	NRE15_06660(allD)

FHM:	R0V13_09215(allD)

CRN:	CAR_c17740(allD)

CML:	BN424_1730(allD) BN424_1731(allD)

CARC:

NY10_1796 NY10_821

CDJ:	BFC22_07250 BFC22_07255

JDA:	BW727_101585(allD)

JEH:	EJN90_04090(allD)

CSQ:

CSCA_5012

CCK:	Ccar_15715

CARG:

RSJ17_17100

CDRK:

B9W14_19750

BLIQ:

INP51_01735(allD)

LACY:

A4V08_02865

CHYL:

CE91St63_15320(allD)

CBOL:

CGC65_17075

DFM:	NQ560_10850(allD)

SINT:

K5I26_04190(allD)

SCAG:

ACI3DM_05845(allD)

SCAZ:

ACI3DN_06320(allD)

MDV:	C5Q96_03700

MNL:	QU661_05250(allD)

SELM:

TAMA11512_01860(allD)

PUF:

UFO1_0268

STED:

SPTER_11400(allD)

SSPH:

SPSPH_035700(allD)

SSID:

SPSIL_034110(allD)

OLS:

Olsu_1381

CGO:	Corgl_1632

COLL:

KPC83_02180(allD)

LLUT:

K1X41_00900

LGO:	JCM16774_0854

» show all

Reference

1 [PMID:10601204]

Authors

Cusa E, Obradors N, Baldoma L, Badia J, Aguilar J.

Title

Genetic analysis of a chromosomal region containing genes required for assimilation of allantoin nitrogen and linked glyoxylate metabolism in Escherichia coli.

Journal

J Bacteriol 181:7479-84 (1999)
DOI:10.1128/JB.181.24.7479-7484.1999

Sequence

[eco:b0517]

Reference

2 [PMID:23284870]

Authors

Kim MI, Shin I, Cho S, Lee J, Rhee S

Title

Structural and functional insights into (S)-ureidoglycolate dehydrogenase, a metabolic branch point enzyme in nitrogen utilization.

Journal

PLoS One 7:e52066 (2012)
DOI:10.1371/journal.pone.0052066