Entry Name sulfoacetaldehyde reductase (NADH);
Class Oxidoreductases;BRITE hierarchy
Sysname isethionate:NAD+ oxidoreductase
Reaction(IUBMB) isethionate + NAD+ = 2-sulfoacetaldehyde + NADH + H+ [RN:
R13009 ]
Reaction(KEGG) Substrate Product Comment The enzymes from the bacteria Bilophila wadsworthia and Clostridium sp. MSTE9 catalyse the reaction only in the reduction direction. In the bacterium Bifidobacterium kashiwanohense the optimal reaction pH for sulfoacetaldehyde reduction is 7.5, while that for isethionate oxidation is 10.0. cf. EC
1.1.1.313 , sulfoacetaldehyde reductase (NADPH).
History EC 1.1.1.433 created 2022
Pathway ec00430 Taurine and hypotaurine metabolism
Orthology K25985 sulfoacetaldehyde reductase (NADH)
Genes » show all Taxonomy Reference Authors Peck SC, Denger K, Burrichter A, Irwin SM, Balskus EP, Schleheck D.
Title A glycyl radical enzyme enables hydrogen sulfide production by the human intestinal bacterium Bilophila wadsworthia.
Journal Sequence Reference Authors Xing M, Wei Y, Zhou Y, Zhang J, Lin L, Hu Y, Hua G, N Nanjaraj Urs A, Liu D, Wang F, Guo C, Tong Y, Li M, Liu Y, Ang EL, Zhao H, Yuchi Z, Zhang Y.
Title Radical-mediated C-S bond cleavage in C2 sulfonate degradation by anaerobic bacteria.
Journal Reference Authors Zhou Y, Wei Y, Nanjaraj Urs AN, Lin L, Xu T, Hu Y, Ang EL, Zhao H, Yuchi Z, Zhang Y.
Title Identification and characterization of a new sulfoacetaldehyde reductase from the human gut bacterium Bifidobacterium kashiwanohense.
Journal Sequence Reference 4
Authors Liu J, Wei Y, Ma K, An J, Liu X, Liu Y, Ang EL, Zhao H, Zhang Y.
Title Mechanistically diverse pathways for sulfoquinovose degradation in bacteria.
Journal ACS Catal 11:14740-14750 (2021)
Other DBs ExPASy - ENZYME nomenclature database: 1.1.1.433
LinkDB All DBs
