KEGG ENZYME: 1.1.3.41

ENZYME: 1.1.3.41

Entry

EC 1.1.3.41                 Enzyme

Name

alditol oxidase;
xylitol oxidase;
xylitol:oxygen oxidoreductase;
AldO

Class

Oxidoreductases;
Acting on the CH-OH group of donors;
With oxygen as acceptor

Sysname

alditol:oxygen oxidoreductase

Reaction(IUBMB)

an alditol + O2 = an aldose + H2O2 [RN:R11618]

Reaction(KEGG)

R11618 > R07152 R11620

Substrate

alditol [CPD:C00717];
O2 [CPD:C00007]

Product

aldose [CPD:C01370];
H2O2 [CPD:C00027]

Comment

The enzyme from Streptomyces sp. IKD472 and from Streptomyces coelicolor is a monomeric oxidase containing one molecule of FAD per molecule of protein [1,2]. While xylitol (five carbons) and sorbitol (6 carbons) are the preferred substrates, other alditols, including L-threitol (four carbons), D-arabinitol (five carbons), D-galactitol (six carbons) and D-mannitol (six carbons) can also act as substrates, but more slowly [1,2]. Belongs in the vanillyl-alcohol-oxidase family of enzymes [2].

History

EC 1.1.3.41 created 2002, modified 2008

Pathway

ec00040

Pentose and glucuronate interconversions

ec00051

Fructose and mannose metabolism

ec01100

Metabolic pathways

Orthology

K00594

alditol oxidase

Genes

RHL:	LPU83_2792(xyoA)

RGR:	FZ934_21205

DEI:	C4375_16190

DSAL:

K1X15_10040

DEVO:

H4N61_10425

DOY:	JI749_10550

DRH:	JI748_05300

NSM:	JO391_00330

SUR:	STAUR_8333

ACA:	ACP_1928(sox)

ACM:	AciX9_2118

GMA:	AciX8_2661

GRW:	FTO74_13100

GRB:	GOB94_08210

TSA:	AciPR4_3451

TRS:	Terro_0916

TALB:

FTW19_07175 FTW19_13810

ABAS:

ACPOL_5628

EDA:	GWR55_02480

EDG:	H7846_14155

EPL:	P4G45_03085

ADIN:

H7849_12695

ORP:	MOP44_09445

TGI:	RBB81_23115

TEMP:

RBB75_12095

TPSC:

RBB77_07080

PFER:

IRI77_14560

ABAC:

LuPra_00940(xyoA)

MICA:

P0L94_11540

PSEG:

D3H65_01375

PGIN:

FRZ67_06325

FLC:	KJS93_03690

HHY:	Halhy_6020

MGOT:

MgSA37_01412(xyoA)

MUH:	HYN43_006085

MGIN:

FRZ54_19475

MGK:	FSB76_09950

MRUB:

DEO27_006170

MGOS:

DIU38_013740

MSAB:

SNE25_22435

MUY:	SNE26_12760

CXI:	ABWH99_10195

ALM:	AO498_13110

AHAP:

V8V91_15185

SLI:

Slin_6373

SRD:	SD10_21470

SMON:

AWR27_19060

SPIR:

CWM47_23165

SPIK:

EXU85_31715

SPIB:

G8759_27035

STAE:

HNV11_03600

SRHO:

HH216_01275

SOQ:	LQ777_17405

SFOL:

H3H32_33550

SENF:

GJR95_38930

RHOZ:

GXP67_34265

PSEZ:

HME7025_01300(xyoA)

EOL:	Emtol_3160

EMZ:	MB380_06195

MAQA:

LAG90_15890

DFE:

Dfer_3313

DSN:	HWI92_21455

DYC:	NFI80_20955

DFQ:	NFI81_22110

DCN:	MUK70_26355

DPF:	ON006_22295

RSI:	Runsl_5602

RUN:	DR864_25645

RUP:	DTQ70_04755

FAE:

FAES_2542

FIB:	A6C57_08695

PONT:

C1N53_03930

RTI:	DC20_00345

ADD:	HUW48_14060

ASWU:

HUW51_11355

CLIT:

OQ292_21005

IRO:	RT717_08685

CHK:	D4L85_02920

PRHO:

PZB74_14385

MARB:

CJ263_03980

EMAR:

D1013_02530

BCIR:

C2I06_21335

NTGC:

AB3U99_02485

GRC:	GI584_06435

GCS:	MUN88_07280

GSM:	MUN87_11645

NDT:	L1999_13670

ALKL:

MM271_23545

PUK:	PU629_20355

PJD:	Pjdr2_3940

GYM:	GYMC10_3259

PBV:	AR543_14140

PYG:	AWM70_16255

PLW:	D5F53_13875

PPSC:

EHS13_31635

PALB:

EJC50_27860

PPRT:

ET464_13645

PRZ:	GZH47_03155

PLYC:

GXP70_13305

PCEL:

HUB94_15845

PALR:

HGI30_02665

PSPN:

L1F29_23665

PAUN:

MJA45_24360

PHK:	SK066_11715

PKP:	SK3146_00271(xyoA)

COH:	EAV92_20955

CHEB:

HH215_15340

COHL:

J4772_11885

AFX:	JZ786_23950

MLJ:	MLAC_02150(xyoA)

RANT:

RHODO2019_17710

SCO:	SCO6147(SC1A9.11c)

SMA:	SAVERM_2090

SGRF:

SGFS_032920

SCB:	SCAB_19421

SSX:	SACTE_6464

SVL:	Strvi_3645

SHY:

SHJG_7217

SHO:	SHJGH_6977

SRC:	M271_07275

SMAL:

SMALA_6973

SSOI:

I1A49_38635

SFA:

Sfla_0209

SBH:

SBI_09106

SDV:	BN159_2173(xyoA)

STRP:

F750_6808

SCI:	B446_28865

SLV:	SLIV_07400(xyoA)

SGU:	SGLAU_26465(xyoA)

SCW:	TU94_26360

SXI:	SXIM_48790

SAMB:

SAM23877_5861(xyoA)

SCX:	AS200_11600

SRW:	TUE45_06783(xyoA)

STRF:

ASR50_28020

SLE:	sle_15280(sle_15280)

SPAV:

Spa2297_25990

STRT:

A8713_25540

SGS:	AVL59_12365

STSI:

A4E84_31690

SGM:	GCM10017557_16380(xyoA)

SCAD:

DN051_10280

SPHW:

NFX46_10295

SGRS:

V9K83_06415

SLS:	SLINC_6662

STRD:

NI25_08645

SNW:	BBN63_04915

SAUO:

BV401_38490

SPUN:

BFF78_10425

SALF:

SMD44_01119

SNZ:	DC008_27635

SGE:	DWG14_01922(xyoA)

SRJ:

SRO_1690

SDX:	C4B68_08815

SGD:	ELQ87_08415

SCYA:

EJ357_36765

SAST:

CD934_05730

SNQ:	CP978_26600

SNK:	CP967_33445

SHAW:

CEB94_32340

SGAL:

CP966_28775

SFY:	GFH48_10640

SAQU:

EJC51_36855

SGF:	HEP81_01873

SSEO:

D0Z67_23350

SPHV:

F9278_38515

SFUG:

CNQ36_26325

SPAC:

B1H29_07660

SCHA:

CP983_09330

SCOE:

CP976_34260

SBAT:

G4Z16_03155

SBRO:

GQF42_33160

STUI:

GCM10017668_56430(xyoA)

SATA:

C5746_03840

SCHF:

IPT68_28830

SHAR:

HUT13_24560

SCYG:

S1361_30790(xyoA)

SFEU:

IM697_32150

SLIA:

HA039_32885

SVD:	CP969_29735

SPRA:

CP972_28580

SROI:

IAG44_08270

SDD:	D9753_07380

SACT:

DMT42_30285

SMAO:

CAG99_02390

SLF:	JEQ17_11545

SDEC:

L3078_36060

SDUR:

M4V62_37135

SAKB:

K1J60_09950

SCAE:

IHE65_09440

STUB:

MMF93_02050

SSPN:

LXH13_31015

SCIR:

STRCI_006405

SLON:

LGI35_07170

SDRZ:

NEH16_28990

STEE:

F3L20_12920

SANT:

QR300_06350

SARG:

HKX69_07030

SJN:	RI060_08345

SCYN:

N8I84_31030

SFIY:

F0344_31815

SKG:	KJK29_06485

SCOA:

QU709_08000

SLAI:

P8A22_35775

SFP:	QUY26_35595

SINN:

ABB07_07695

SCAY:

PYS65_07355

KBU:	Q4V64_41105

SARM:

DVA86_33455

SPRF:

K4G22_26120

SLUO:

PS467_05085

STPB:

QR97_23160

SMIB:

SMIR_06470

SCAJ:

O1G22_09455

STRW:

QHG49_07900

STRL:

HEP84_39065

STSD:

HEP87_39850

SRPZ:

HEP85_30680

SGLY:

P8A20_00875

SCAT:

P8A18_01430

SABD:

N8I86_29350

STRV:

EZV63_29045

SPIH:

ABXR15_12480

SMOD:

POD33_24565

SCT:	SCAT_p1150(xyoA)

SCY:	SCATT_p05820

KSK:

KSE_59540

KIT:	CFP65_7303

KIS:	HUT16_27820

STRI:

C7M71_018365

STRH:

GXP74_27500

ABRY:

NYE86_12660

AGLA:

OIE69_32310

AREV:

RVR_1015

LXL:	KDY119_00127(xyoA)

LEIF:

HF024_17225

LSE:	F1C12_15575 F1C12_16665

LEIZ:

IT072_18120

CMI:

CMM_2110

CMH:	VO01_09800

CMS:	CMS1111(xyoA)

CMC:

CMN_02075

CCAP:

AES38_10310

CZH:	H9X71_10615

CPHA:

FGI33_02565

CCAF:

FGD68_13020

MTS:

MTES_2201

MIM:	AKG07_10745

MIX:	AB663_000424

MCW:	A8L33_01875

MPAL:

BO218_07510

MIH:	BJP65_11875

MICR:

BMW26_15485

MFOL:

DXT68_14915

MOO:	BWL13_02828(xyoA)

MLV:	CVS47_02873(xyoA)

MWA:	E4K62_02105

MPRT:

ET475_10055

MSF:	IT882_14350

MCAW:

F6J84_06005

MLZ:	F6J85_01905

MICS:

C1N74_03445

MBIN:

LXM64_06975

MTEC:

OAU46_02215

MAZA:

NFX31_14915

MSUW:

GCM10025863_29740

MARK:

QUC20_03305

MRG:	SM116_03525

MINV:

T9R20_04045

MOJ:	D7D94_12815

MPLN:

VC184_03160

MLIY:

RYJ27_11835

MICE:

EHF32_05950

MAUG:

KV397_02650

MHOT:

PU630_02935

MGAB:

KV396_04240

MBET:

N8K70_02765

MICM:

CHE218_26790(aldO)

MCHN:

HCR76_12005

RTN:	A6122_2557

RRY:	C1O28_12095

RIA:	C7V51_13870

RFS:	C1I64_14595

RTE:	GSU10_01560

ROE:	Q0F99_09875

RATH:

GSU68_01710

CUM:	NI26_11435 NI26_12010

CUB:	BJK06_12730 BJK06_13355

CUG:	C1N91_11615 C1N91_12175

CQF:	GBG65_01645 GBG65_02425

CCIT:

QPK07_11855 QPK07_12365

CUF:	KM842_01425 KM842_01910

CUY:	I8920_11360 I8920_11855

CPOI:

OE229_15200 OE229_15855

CURT:

LCG91_11415 LCG91_11955

CURZ:

LQK89_11830 LQK89_12350

FRP:	AX769_01755 AX769_13540

FSB:	GCM10025867_03010

AGY:	ATC03_05180

AGF:	ET445_16960

AMAV:

GCM10025877_25590

ALAV:

MTO99_00170

AIL:	FLP10_04270

CART:

PA27867_0885

CRY:	B7495_04410

MALK:

MalAC0309_2521

CHRE:

IE160_10800

MDB:	OVN18_03055

MYL:	C3E77_02515

SALA:

ESZ53_09415

SALD:

FVA74_03270

HUW:	FPZ11_11120

GRY:	D7I44_06630

LYD:	D7I47_12535

LYK:	FLP23_08300

PLAP:

EAO79_08890

PFLU:

BWO91_04980

MANT:

BHD05_05825

HEA:	HL652_16660 HL652_17815

HEH:	L3i23_18880

FRN:	F1C15_12780

GLN:	F1C58_12355

AGX:	AGREI_0238(xyoA)

SUBT:

KPL76_13785

SUBA:

LQ955_13460

HOM:	OF852_05130

NAEI:

GCM126_30400

AOG:	LH407_13335

ART:

Arth_4010

ARR:	ARUE_c00520

ARM:

ART_0047

ARW:	MB46_06040

ARH:	AHiyo8_36770

ARU:	ASPU41_02055

ARQ:	BWQ92_09045

ARN:	CGK93_00345

ARX:	ARZXY2_3844

ARTH:

C3B78_00380

AAGI:

NCTC2676_1_02496(xyoA)

ASUN:

KG104_09145

ARTY:

AHiyo4_22180

AZH:	MUK71_06755

AGEG:

MUG94_08470

AOD:	Q8Z05_07180

AZX:	N2K95_07835

ARTM:

MN0502_27170

ARTZ:

FCN77_25010

ARTA:

OL239_10295

AAU:

AAur_0055

PUE:	FV140_00250

PNV:	JMY29_00295

PAYJ:

HMI59_20815

PAGO:

IRJ34_00255

PAYN:

HMI60_00350

PHRZ:

QN084_11065

ARZ:	AUT26_00260

ACH:

Achl_0055

APN:	Asphe3_00510

PSUL:

AU252_13120 AU252_22385

PSNI:

NIBR502771_05040

PSEY:

GU243_13705 GU243_13780

PDEL:

JCQ34_00240

POK:	SMD14_00570

PSLS:

KTR40_00255

PSFE:

NG819_03210

PQA:	WHH00_18285

AAI:	AARI_02190

GAR:	AOZ07_01250

GMI:	NMP99_01425

GLM:	N6V40_01380

GEY:	QMQ05_01210

SATK:

SA2016_0475

CCYC:

SCMU_05010

BCV:

Bcav_2879

BFA:	Bfae_29560

BRX:	BH708_10460 BH708_11690

BGG:	CFK41_01560

BSAU:

DWV08_12335

BRR:	C1N80_04225

BKI:	M4486_15410

BRHA:

NLU66_00265 NLU66_04800

BHH:	Bra3105_12330

BHQ:	BRM3_03850

JDE:

Jden_2461

DAY:	FV141_00960

DERM:

H7F30_01930

ALX:	LVQ62_12740

BEI:	GCM100_05210

IVA:	Isova_0124

IDO:	I598_2577(xyoA)

CET:	B8281_05070

CCEU:

CBR64_06400

PROU:

AB1046_16050

SKE:	Sked_35760

SBIL:

SANBI_003487

CFL:

Cfla_0930

CFI:

Celf_2955

CELZ:

E5225_13340

CEJ:	GC089_14000

CELH:

GXP71_01040

CIRA:

LFM56_13670

CELC:

K5O09_04080

CDON:

KKR89_04585

CWAN:

KG103_04910

CFEN:

KG102_03255

CWN:	NP075_04795

CXIE:

NP048_04805

CELE:

P9841_06140

PSEK:

GCM125_15300

TEH:	GKE56_07425

PHW:	G7075_12550

TED:	U5C87_21685

SERJ:

SGUI_0471

ORD:	L0A91_09245

GEZ:	FE251_06345

GEW:	MF406_13385

HALT:

IM660_05855

RHAL:

LQF10_14005

RSUA:

LQF12_05000

DSS:	GCM25873_25370

TES:	BW730_04600

TEZ:	BKM78_03360

TDF:	H9L22_06490

TLA:	TLA_TLA_00684(xyoA)

PRV:	G7070_07435

PSOI:

PCC79_04120

NANO:

G5V58_03670

NAQU:

ENKNEFLB_00345(xyoA_1)

NRN:	SHK17_02005

AER:	AERYTH_15315

AEZ:	C3E78_12990

AEB:	C6I20_11465

AEF:	GEV26_13040

AWN:	NQV15_04300

SGRG:

L0C25_00405

KFL:

Kfla_1819

KQI:	F1D05_28925

KSL:	OG809_20890

KRI:	OX958_27290

NDA:

Ndas_4763

NGV:	CDO52_16650

NEX:	NE857_01415

NAKE:

KGD83_01325

NCG:	KGD84_29615

STRR:

EKD16_11800(xyoA)

SNAH:

OUQ99_13310

AMAZ:

LUW76_37470

ACTQ:

OG417_49195

SRO:

Sros_2313

NOA:	BKM31_57625

NOW:	GBF35_38755

NCX:	Nocox_31680(xyoA)

NGN:	LCN96_43235

NFS:	OIE67_06000

MHAI:

OHB01_35610

FRI:	FraEuI1c_5969

ACE:

Acel_0723

NAKA:

H7F38_21880

GOB:

Gobs_2565

BSD:	BLASA_2793(xyoA)

BLAP:

MVA48_03230

BBRG:

U6N30_15505

BMON:

ABDB74_10645

MMAR:

MODMU_2272

MOM:	KUM42_01180

KRA:

Krad_3634

AMD:

AMED_4426

AMN:

RAM_22540

AMM:

AMES_4372

AMZ:

B737_4372

AOI:

AORI_3521

AJA:	AJAP_21525(xyoA)

AMYC:

CU254_14050

AMYB:

BKN51_14880

AORI:

SD37_18195

APRT:

MUY14_15230

AROO:

NQK81_04905 NQK81_43810

ARHD:

VSH64_06280

AMOG:

QRX60_36325

ACOR:

LCL61_27100

ACAB:

QRX50_40170

ANW:	QP939_41595

AMYD:

K1T34_36410

AMYE:

MJQ72_10690

AMYS:

CVV72_12025

PBRO:

HOP40_16670

PPEL:

H6H00_16290

PSDS:

K1T35_12810

APRE:

CNX65_11710

AMI:

Amir_2301

SESP:

BN6_41440

SSYI:

EKG83_23125

KUT:	JJ691_32280

KBR:	Q4V65_04325

LED:	BBK82_04005 BBK82_29275

AHM:	TL08_13395

ACTI:

UA75_14945

ACAD:

UA74_14355

AHG:	AHOG_13485(xyoA)

UME:	RM788_11605

MAU:	Micau_4754

MIL:

ML5_3543

MICB:

MicB006_3765

MTUA:

CSH63_00775

MICH:

FJK98_25225

MTEM:

GCE86_18290

MCAB:

HXZ27_24090

MSAG:

GCM10017556_09770(xyoA)

VMA:	VAB18032_27936

MCRA:

ID554_22805

VER:	HUT12_25600

MENO:

Jiend_43330(xyoA)

MCHL:

PVK74_13985

MFEU:

H1D33_29355

MPRN:

Q3V37_14260

MHAW:

RMN56_19080

MCAY:

PVK37_30200

MICF:

QQG74_24675

ASE:	ACPL_1234(xyoA)

AMS:	AMIS_10070

ACTN:

L083_5339(xyoA)

ACTS:

ACWT_1115

AIH:	Aiant_54240(xyoA)

ACTR:

Asp14428_77070(xyoA)

ACTL:

L3i22_011130(xyoA)

ASIC:

Q0Z83_077860(aldO)

AOU:	ACTOB_001044

ACTE:

ACTI_30740(xyoA)

AFS:

AFR_25135

PLK:	CIK06_14920

PLAB:

C6361_33815

PLAT:

C6W10_27480

PFLA:

Pflav_087590(xyoA)

PSUU:

Psuf_050580(xyoA)

PRY:	Prubr_10810(xyoA)

CATI:

CS0771_38420(xyoA)

DVC:	Dvina_08045

DFU:	Dfulv_07460

DAUR:

Daura_07430

DMAT:

Dmats_07555

DACT:

KZZ52_07285

NHY:	JQS43_17000

CCAZ:

COUCH_17345

CAI:

Caci_1977

GLY:	K3N28_20915

PLAN:

A1s21148_01715

PSUF:

A1sIA56_06595

JTL:	M6D93_05395

JCY:	M6B22_00800

RMAR:

GBA65_09685

PMET:

G4Y79_20175

FGI:	OP10G_3204

DPD:	Deipe_4064

DAH:	DAETH_40570(xyoA)

DSC:	ABOD76_01230

» show all

Reference

1 [PMID:16232758]

Authors

Yamashita M, Omura H, Okamoto E, Furuya Y, Yabuuchi M, Fukahi K, Murooka Y

Title

Isolation, characterization, and molecular cloning of a thermostable xylitol oxidase from Streptomyces sp. IKD472.

Journal

J Biosci Bioeng 89:350-60 (2000)
DOI:10.1016/S1389-1723(00)88958-6

Sequence

[ag:BAA95146]

Reference

2 [PMID:17517896]

Authors

Heuts DP, van Hellemond EW, Janssen DB, Fraaije MW

Title

Discovery, characterization, and kinetic analysis of an alditol oxidase from Streptomyces coelicolor.

Journal

J Biol Chem 282:20283-91 (2007)
DOI:10.1074/jbc.M610849200

Reference

3 [PMID:18154360]

Authors

Forneris F, Heuts DP, Delvecchio M, Rovida S, Fraaije MW, Mattevi A

Title

Structural analysis of the catalytic mechanism and stereoselectivity in Streptomyces coelicolor alditol oxidase.

Journal

Biochemistry 47:978-85 (2008)
DOI:10.1021/bi701886t

Sequence

[sco:SCO6147]

Other DBs

ExplorEnz - The Enzyme Database:

1.1.3.41

IUBMB Enzyme Nomenclature:

1.1.3.41

ExPASy - ENZYME nomenclature database:

1.1.3.41

BRENDA, the Enzyme Database:

1.1.3.41

CAS:	177322-52-0

LinkDB

DBGET integrated database retrieval system