Entry Name 5-formyl-3-hydroxy-2-methylpyridine 4-carboxylic acid 5-dehydrogenase;
Class Oxidoreductases;BRITE hierarchy
Sysname 5-formyl-3-hydroxy-2-methylpyridine-4-carboxylate:NAD+ 5-oxidoreductase
Reaction(IUBMB) 5-formyl-3-hydroxy-2-methylpyridine-4-carboxylate + NAD+ + H2O = 3-hydroxy-2-methylpyridine-4,5-dicarboxylate + NADH + H+ [RN:
R04524 ]
Reaction(KEGG) Substrate 5-formyl-3-hydroxy-2-methylpyridine-4-carboxylate [CPD:
C06050 ];
NAD+ [CPD:
C00003 ];
H2O [CPD:
C00001 ]
Product 3-hydroxy-2-methylpyridine-4,5-dicarboxylate [CPD:
C04604 ];
NADH [CPD:
C00004 ];
H+ [CPD:
C00080 ]
Comment The enzyme, characterized from the bacteria Pseudomonas sp. MA-1 and Mesorhizobium loti, participates in the degradation of pyridoxine (vitamin B6).
History EC 1.2.1.100 created 2018
Pathway ec01120 Microbial metabolism in diverse environments
Orthology K18612 5-formyl-3-hydroxy-2-methylpyridine 4-carboxylic acid 5-dehydrogenase
Genes MESS : ABSY17_02605(fhmpcd1)
OST : ABWH87_14800(fhmpcd1)
» show all Taxonomy Reference Authors Lee YC, Nelson MJ, Snell EE.
Title Enzymes of vitamin B6 degradation. Purification and properties of isopyridoxal dehydrogenase and 5-formyl-3-hydroxy-2-methylpyridine-4-carboxylic-acid dehydrogenase.
Journal J Biol Chem 261:15106-11 (1986)
Reference Authors Yokochi N, Yoshikane Y, Matsumoto S, Fujisawa M, Ohnishi K, Yagi T
Title Gene identification and characterization of 5-formyl-3-hydroxy-2-methylpyridine 4-carboxylic acid 5-dehydrogenase, an NAD+-dependent dismutase.
Journal Sequence Reference Authors Mugo AN, Kobayashi J, Mikami B, Yoshikane Y, Yagi T, Ohnishi K
Title Crystal structure of 5-formyl-3-hydroxy-2-methylpyridine 4-carboxylic acid 5-dehydrogenase, an NAD(+)-dependent dismutase from Mesorhizobium loti.
Journal Sequence Other DBs ExPASy - ENZYME nomenclature database: 1.2.1.100
LinkDB All DBs
