| Entry |
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| Name |
pyruvate dehydrogenase (NADP+)
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| Class |
Oxidoreductases;
Acting on the aldehyde or oxo group of donors;
With NAD+ or NADP+ as acceptor
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| Sysname |
pyruvate:NADP+ 2-oxidoreductase (CoA-acetylating)
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| Reaction(IUBMB) |
pyruvate + CoA + NADP+ = acetyl-CoA + CO2 + NADPH [RN: R00210]
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| Reaction(KEGG) |
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| Substrate |
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| Product |
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| Comment |
The Euglena enzyme can also use FAD or methyl viologen as acceptor, more slowly. The enzyme is inhibited by oxygen.
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| History |
EC 1.2.1.51 created 1989
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| Orthology |
| K21682 | pyruvate dehydrogenase (NADP+) |
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| Genes |
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| Reference |
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| Authors |
Inui H, Miyatake K, Nakano Y, Kitaoka S. |
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| Title |
Occurrence of oxygen-sensitive, NADP+-dependent pyruvate dehydrogenase in mitochondria of Euglena gracilis. |
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| Journal |
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| Reference |
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| Authors |
Inui H, Ono K, Miyatake K, Nakano Y, Kitaoka S |
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| Title |
Purification and characterization of pyruvate:NADP+ oxidoreductase in Euglena gracilis. |
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| Journal |
J Biol Chem 262:9130-5 (1987) |
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| Sequence |
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| Other DBs |
| ExplorEnz - The Enzyme Database: | 1.2.1.51 |
| ExPASy - ENZYME nomenclature database: | 1.2.1.51 |
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| LinkDB |
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