KEGG ENZYME: 1.2.1.75

ENZYME: 1.2.1.75

Entry

EC 1.2.1.75                 Enzyme

Name

malonyl-CoA reductase (malonate semialdehyde-forming);
NADP-dependent malonyl CoA reductase;
malonyl CoA reductase (NADP);
malonyl CoA reductase (malonate semialdehyde-forming)

Class

Oxidoreductases;
Acting on the aldehyde or oxo group of donors;
With NAD+ or NADP+ as acceptor

Sysname

malonate semialdehyde:NADP+ oxidoreductase (malonate semialdehyde-forming)

Reaction(IUBMB)

malonate semialdehyde + CoA + NADP+ = malonyl-CoA + NADPH + H+ [RN:R00740]

Reaction(KEGG)

R00740

Substrate

malonate semialdehyde [CPD:C00222];
CoA [CPD:C00010];
NADP+ [CPD:C00006]

Product

malonyl-CoA [CPD:C00083];
NADPH [CPD:C00005];
H+ [CPD:C00080]

Comment

Requires Mg2+. Catalyses the reduction of malonyl-CoA to malonate semialdehyde, a key step in the 3-hydroxypropanoate and the 3-hydroxypropanoate/4-hydroxybutanoate cycles, autotrophic CO2 fixation pathways found in some green non-sulfur phototrophic bacteria and some thermoacidophilic archaea, respectively [1,2]. The enzyme from Sulfolobus tokodaii has been purified, and found to contain one RNA molecule per two subunits [3]. The enzyme from Chloroflexus aurantiacus is bifunctional, and also catalyses the next reaction in the pathway, EC 1.1.1.298 [3-hydroxypropionate dehydrogenase (NADP+)] [4].

History

EC 1.2.1.75 created 2009

Pathway

ec00640

Propanoate metabolism

ec00720

Other carbon fixation pathways

ec01100

Metabolic pathways

Orthology

K14468

malonyl-CoA reductase / 3-hydroxypropionate dehydrogenase (NADP+)

K15017

malonyl-CoA/succinyl-CoA reductase (NADPH)

Genes

PAQM:

E0F26_07700

SRAD:

LLW23_04765

BLAS:

BSY18_2663

BFW:	B5J99_04270

PALG:

HFP57_16700

SAND:

H3309_14805

POQ:	KZX46_11630

PMEA:

KTC28_17245

ELQ:	Ga0102493_111748

ERK:	CD351_07810

PNS:	A9D12_09055

ERQ:	PS060_10465

PORL:

BG023_111319

PHZ:	CHX26_07200

POT:	E2E27_15410

PORC:

CBR61_06730

CTM:	Cabther_B0159

CVL:	J8C06_14250

CHLO:

J8C02_13405

GGR:	HKW67_05060

RRS:	RoseRS_3201

RCA:

Rcas_2929

CAU:

Caur_2614

CHL:	Chy400_2826

CAG:

Cagg_1256

STO:	STK_21710(mcr_scr)

SOH:	D1869_11875(asd)

SJV:	SJAV_05170(asd_1)

SSO:	SSO2178(asd-2)

SOL:

Ssol_2908

SSOA:

SULA_2921(asd)

SSOL:

SULB_2921(asd)

SSOF:

SULC_2918(asd)

SSHI:

J5U23_00989

SCAS:

SACC_21720

SIS:	LS215_2961

SIA:	M1425_2796

SIM:	M1627_2848

SID:

M164_2777

SIY:	YG5714_2976

SIN:	YN1551_3167

SII:

LD85_3126

SIH:

SiH_2755

SIR:

SiRe_2691

SIC:

SiL_2637

SULA:

BFU36_10310

SULE:

GFS03_01510(asd)

SAI:	Saci_2147 Saci_2370

SACN:

SacN8_10450 SacN8_11535

SACR:

SacRon12I_10705 SacRon12I_11780

SACS:

SUSAZ_09800 SUSAZ_11160

SULO:

GFS33_06710(asd)

SULL:

EWF20_13035(asd)

MSE:

Msed_0709

MEMJ:

MJ1HA_0819

MCN:

Mcup_1427

MHK:	DFR87_03300(asd)

MPRU:

DFR88_03035(asd)

MTEN:

GWK48_08305(asd)

MJN:	MjAS7_1475

AHO:

Ahos_2348

AMAN:

B6F84_02355

ABRI:

DFR85_01565(asd)

ASUL:

DFR86_02340(asd)

AAMB:

D1866_06835(asd)

ACIH:

HS5_12500

SAZO:

D1868_09095(asd)

CSTY:

KN1_05910

STEP:

IC006_0038

SMET:

RQ359_001521(asd)

» show all

Reference

1 [PMID:8354269]

Authors

Strauss G, Fuchs G

Title

Enzymes of a novel autotrophic CO2 fixation pathway in the phototrophic bacterium Chloroflexus aurantiacus, the 3-hydroxypropionate cycle.

Journal

Eur J Biochem 215:633-43 (1993)
DOI:10.1111/j.1432-1033.1993.tb18074.x

Reference

2 [PMID:18079405]

Authors

Berg IA, Kockelkorn D, Buckel W, Fuchs G

Title

A 3-hydroxypropionate/4-hydroxybutyrate autotrophic carbon dioxide assimilation pathway in Archaea.

Journal

Science 318:1782-6 (2007)
DOI:10.1126/science.1149976

Sequence

[mse:Msed_0709]

Reference

3 [PMID:17041055]

Authors

Alber B, Olinger M, Rieder A, Kockelkorn D, Jobst B, Hugler M, Fuchs G

Title

Malonyl-coenzyme A reductase in the modified 3-hydroxypropionate cycle for autotrophic carbon fixation in archaeal Metallosphaera and Sulfolobus spp.

Journal

J Bacteriol 188:8551-9 (2006)
DOI:10.1128/JB.00987-06

Sequence

[mse:Msed_0709] [sto:STK_21710]

Reference

4 [PMID:11948153]

Authors

Hugler M, Menendez C, Schagger H, Fuchs G

Title

Malonyl-coenzyme A reductase from Chloroflexus aurantiacus, a key enzyme of the 3-hydroxypropionate cycle for autotrophic CO(2) fixation.

Journal

J Bacteriol 184:2404-10 (2002)
DOI:10.1128/JB.184.9.2404-2410.2002

Sequence

[cau:Caur_2614]

Other DBs

ExplorEnz - The Enzyme Database:

1.2.1.75

IUBMB Enzyme Nomenclature:

1.2.1.75

ExPASy - ENZYME nomenclature database:

1.2.1.75

BRENDA, the Enzyme Database:

1.2.1.75

LinkDB

DBGET integrated database retrieval system