Entry
Name
2,3-bis-O-geranylgeranyl-sn-glycerol 1-phosphate reductase [NAD(P)H];
digeranylgeranylglycerophospholipid reductase;
Ta0516m (gene name);
DGGGPL reductase;
2,3-digeranylgeranylglycerophospholipid reductase
Class
Oxidoreductases;
Acting on the CH-CH group of donors;
With NAD+ or NADP+ as acceptor
BRITE hierarchy
Sysname
2,3-bis-(O-phytany)l-sn-glycerol 1-phosphate:NAD(P)+ oxidoreductase
Reaction(IUBMB)
2,3-bis-(O-phytanyl)-sn-glycerol 1-phosphate + 8 NAD(P)+ = 2,3-bis-(O-geranylgeranyl)-sn-glycerol 1-phosphate + 8 NAD(P)H + 8 H+ [RN:
R10325 R10326 ]
Reaction(KEGG)
Substrate
2,3-bis-(O-phytanyl)-sn-glycerol 1-phosphate [CPD:
C20518 ];
NAD+ [CPD:
C00003 ];
NADP+ [CPD:
C00006 ]
Product
Comment
A flavoprotein (FAD). The enzyme from the archaeon Thermoplasma acidophilum is involved in the biosynthesis of membrane lipids. In vivo the reaction occurs in the reverse direction with the formation of 2,3-bis-O-phytanyl-sn-glycerol 1-phosphate. cf. EC
1.3.7.11 , 2,3-bis-O-geranylgeranyl-sn-glycero-phospholipid reductase.
History
EC 1.3.1.101 created 2013
Pathway
ec00564 Glycerophospholipid metabolism
ec01110 Biosynthesis of secondary metabolites
Orthology
K17830 digeranylgeranylglycerophospholipid reductase
Genes
FSU : Fisuc_0330 Fisuc_2122
POB : LPB03_12595 LPB03_16045
CLB : Clo1100_3094 Clo1100_3095
CLT : CM240_1758 CM240_1759
RHER : EHE19_004620 EHE19_004625
TEX : Teth514_0218 Teth514_0219
TMT : Tmath_0322 Tmath_0323
MFE : Mefer_0023 Mefer_0586
MVU : Metvu_0248 Metvu_0470
MFS : MFS40622_0302 MFS40622_0533
MMG : MTBMA_c02950 MTBMA_c07260 MTBMA_c11210
MWO : MWSIV6_0259 MWSIV6_0692 MWSIV6_1100
MTEE : MTTB_09190 MTTB_14720
METC : MTCT_0239 MTCT_1570
METE : tca_00257(menJ_1) tca_01663(menJ_2)
METZ : METMT2_0572 METMT2_0721 METMT2_1561
METK : FVF72_00920 FVF72_03085
MTHM : FZP57_01175 FZP57_03320 FZP57_05215
METJ : FZP68_06180 FZP68_08325
MST : Msp_0758 Msp_0874 Msp_1062 Msp_1307 Msp_1320
METB : AW729_08940 AW729_09050 AW729_10575 AW729_10930
MEIS : PXD04_00860 PXD04_02310 PXD04_02685
MRU : mru_1341 mru_1441 mru_1471
MEL : Metbo_0471 Metbo_2033 Metbo_2366
MEW : MSWAN_0290 MSWAN_0605 MSWAN_1925
METH : MBMB1_0335 MBMB1_0639 MBMB1_1556 MBMB1_1827
MFC : BRM9_0792 BRM9_1599 BRM9_1933 BRM9_2158
MFI : DSM1535_0120 DSM1535_0754 DSM1535_1097 DSM1535_2293
MCUB : MCBB_0308 MCBB_0619 MCBB_1812
MSUB : BK009_01280 BK009_06770 BK009_11855
METN : BK008_02415 BK008_07495 BK008_09685
METT : CIT01_01350 CIT01_04015 CIT01_04025 CIT01_07320 CIT01_10150
METO : CIT02_03745 CIT02_05170 CIT02_08440 CIT02_10165
MEME : HYG87_07945 HYG87_10880
MFEG : GCM10025860_04480 GCM10025860_12360 GCM10025860_16550
MEER : NKF70_04595 NKF70_08080 NKF70_09965
MRID : FGU46_01900 FGU46_07110
AST : Asulf_00147 Asulf_01626
GAH : GAH_00300 GAH_00353 GAH_01689
MBY : MSBRM_1245 MSBRM_2785
MBAR : MSBR2_1164 MSBR2_2742
MBAK : MSBR3_1297 MSBR3_2679
MAC : MA_1484 MA_2893 MA_3894 MA_4421
MMA : MM_0718 MM_2499 MM_3299
MMAZ : MmTuc01_0739 MmTuc01_2550 MmTuc01_3399
MMJ : MSMAS_0599 MSMAS_1387 MSMAS_2202
MMAC : MSMAC_0600 MSMAC_2252 MSMAC_2749
MVC : MSVAZ_0959 MSVAZ_1325 MSVAZ_1805
MEK : MSKOL_0928 MSKOL_1264 MSKOL_1782
MLS : MSLAZ_1440 MSLAZ_1542 MSLAZ_2928
METM : MSMTP_0646 MSMTP_0954 MSMTP_1509
MEF : MSWH1_1330 MSWH1_1478 MSWH1_1898
MEQ : MSWHS_1414 MSWHS_1853 MSWHS_3173
MSJ : MSSAC_1463 MSSAC_2883 MSSAC_4107
MSZ : MSSIH_1494 MSSIH_2538 MSSIH_3643
MSW : MSSIT_1552 MSSIT_2581 MSSIT_3698
MTHR : MSTHT_0217 MSTHT_0358 MSTHT_1727 MSTHT_2311
MTHE : MSTHC_0364 MSTHC_0514 MSTHC_0969 MSTHC_1561
MHOR : MSHOH_0251 MSHOH_1697 MSHOH_2811
MFZ : AOB57_000445 AOB57_001340 AOB57_003910 AOB57_007820
MHAB : RSJ42_05730 RSJ42_09895
MBU : Mbur_0303 Mbur_0369 Mbur_0939 Mbur_1077 Mbur_1308
MMET : MCMEM_0833 MCMEM_0997 MCMEM_1441 MCMEM_1598 MCMEM_1755
MELO : J7W08_02385 J7W08_03355 J7W08_05920 J7W08_06945 J7W08_07805
MMH : Mmah_0579 Mmah_0675 Mmah_1258 Mmah_1613
MHAZ : BHR79_00515 BHR79_05660 BHR79_07245 BHR79_10225
MPOT : BKM01_01750 BKM01_07890 BKM01_09925
MEV : Metev_0262 Metev_0801 Metev_1607 Metev_1731
MZH : Mzhil_0235 Mzhil_0513 Mzhil_0683 Mzhil_1608
MPY : Mpsy_0099 Mpsy_1026 Mpsy_1467 Mpsy_2554
MZI : HWN40_01470 HWN40_03330 HWN40_05930 HWN40_09670
MHZ : Metho_0239 Metho_0947 Metho_1579 Metho_1933
MEES : MmiEs2_09160(thi4_2) MmiEs2_09170(thi4_3)
MTP : Mthe_0044 Mthe_0513 Mthe_0671 Mthe_0714
MCJ : MCON_1147 MCON_3250 MCON_3296
MHI : Mhar_0556 Mhar_1078 Mhar_1156 Mhar_2172
MEM : Memar_0506 Memar_1711
MPD : MCP_0504 MCP_1168 MCP_1480
MEZ : Mtc_0895(bchP) Mtc_1643 Mtc_1724
RCI : RCIX2051(bchP) RCIX2708
MJK : N2V74_06940 N2V74_07005
HALR : EFA46_006370 EFA46_006470
HALJ : G9465_08440 G9465_08805 G9465_20450
HUT : Huta_0881 Huta_1007 Huta_2954
HALA : Hrd1104_04765 Hrd1104_09045
HMU : Hmuk_1955 Hmuk_2206 Hmuk_3091 Hmuk_3127
HALZ : E5139_02700 E5139_02875 E5139_12890 E5139_14170
HALL : LC1Hm_1280 LC1Hm_1619(fixC) LC1Hm_2428(fixC3) LC1Hm_2469(fixC4)
HAZP : GBQ70_02700 GBQ70_12905 GBQ70_14185
HRR : HZS55_18830 HZS55_20705
HPEL : HZS54_21655 HZS54_22270 HZS54_24195
HLT : I7X12_15485 I7X12_16545 I7X12_17600
HAQ : DU484_09565 DU484_17775
HAJ : DU500_00815 DU500_09815
HAER : DU502_06905 DU502_07185 DU502_16565
HRA : EI982_07520 EI982_14380
HDF : AArcSl_1381 AArcSl_1813
HSAL : JMJ58_01855 JMJ58_05545 JMJ58_12995 JMJ58_22355
HAKZ : J0X25_02870 J0X25_13780
NMG : Nmag_0668 Nmag_1523 Nmag_2507 Nmag_2778
HXA : Halxa_3925 Halxa_3960
NPE : Natpe_0646 Natpe_1962 Natpe_3244
NPL : FGF80_01135 FGF80_07435
HALY : HYG82_09140 HYG82_16990
NGE : Natgr_0786 Natgr_1266 Natgr_3103
HLC : CHINAEXTREME15935 CHINAEXTREME19570
HRU : Halru_1246 Halru_2474
NOU : Natoc_0699 Natoc_2139 Natoc_4277
HLR : HALLA_08655 HALLA_13160 HALLA_17630
NAJ : B1756_02305 B1756_04290 B1756_12495
NAG : AArcMg_1023 AArcMg_2971 AArcMg_3119
NAN : AArc1_0731 AArc1_2601 AArc1_3025
NBG : DV706_00945 DV706_09380 DV706_16325 DV706_19090
NAS : GCU68_02695 GCU68_12755
HDA : BB347_05735 BB347_10350 BB347_10530
MELU : MTLP_05820 MTLP_05840 MTLP_09940
TVO : TVG1046096(TVG1046096) TVG1579590(TVG1579590)
CDIV : CPM_0295 CPM_0485 CPM_0894
TAR : TALC_00223 TALC_00435 TALC_00774
MAX : MMALV_02090 MMALV_03590 MMALV_08730
MER : MMINT_02130 MMINT_12590 MMINT_13170 MMINT_17750
MEAR : Mpt1_c01650 Mpt1_c12530
MARC : AR505_0892 AR505_1433 AR505_1618
ACF : AciM339_0374 AciM339_0468
THB : N186_01490 N186_04950
TCB : TCARB_0050 TCARB_1382
THF : MA03_00905 MA03_06135
THEL : IG193_04155 IG193_06980
NIN : NADRNF5_0722 NADRNF5_1519
NOX : C5F49_05755 C5F49_06640
NGA : Ngar_c10460 Ngar_c11500 Ngar_c18750
NVN : NVIE_003360 NVIE_011700
TAA : NMY3_01977 NMY3_02141 NMY3_02989
NFN : NFRAN_0449 NFRAN_2927
CSY : CENSYa_0520 CENSYa_1317
CSU : CSUB_C1349 CSUB_C1610
TAH : SU86_000125 SU86_003010
» show all
Taxonomy
Reference
Authors
Nishimura Y, Eguchi T
Title
Biosynthesis of archaeal membrane lipids: digeranylgeranylglycerophospholipid reductase of the thermoacidophilic archaeon Thermoplasma acidophilum.
Journal
Sequence
Reference
Authors
Nishimura Y, Eguchi T
Title
Stereochemistry of reduction in digeranylgeranylglycerophospholipid reductase involved in the biosynthesis of archaeal membrane lipids from Thermoplasma acidophilum.
Journal
Sequence
Reference
Authors
Xu Q, Eguchi T, Mathews II, Rife CL, Chiu HJ, Farr CL, Feuerhelm J, Jaroszewski L, Klock HE, Knuth MW, Miller MD, Weekes D, Elsliger MA, Deacon AM, Godzik A, Lesley SA, Wilson IA
Title
Insights into substrate specificity of geranylgeranyl reductases revealed by the structure of digeranylgeranylglycerophospholipid reductase, an essential enzyme in the biosynthesis of archaeal membrane lipids.
Journal
Sequence
Other DBs
ExPASy - ENZYME nomenclature database: 1.3.1.101
LinkDB
All DBs