Entry |
|
Name |
7-dehydrocholesterol reductase;
DHCR7 (gene name);
7-DHC reductase;
7-dehydrocholesterol dehydrogenase/cholesterol oxidase;
Delta7-sterol reductase
|
Class |
Oxidoreductases;
Acting on the CH-CH group of donors;
With NAD+ or NADP+ as acceptor
|
Sysname |
cholesterol:NADP+ Delta7-oxidoreductase
|
Reaction(IUBMB) |
cholesterol + NADP+ = cholesta-5,7-dien-3beta-ol + NADPH + H+ [RN: R01456]
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Reaction(KEGG) |
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Substrate |
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Product |
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Comment |
The enzyme is part of the cholesterol biosynthesis pathway.
|
History |
EC 1.3.1.21 created 1972, modified 2013
|
Pathway |
ec01110 | Biosynthesis of secondary metabolites |
|
Orthology |
K00213 | 7-dehydrocholesterol reductase |
|
Genes |
PMUR: | 107294554 107294556 107294557 |
CTIG: | 120316163 120316165 |
PMUA: | 114596913 114596955 |
XLA: | 379273(dhcr7.S) 380248(dhcr7.L) |
SRX: | 107727115(dhcr7) 107730061 |
SANH: | 107679738 107686818 |
CCAR: | 109103437 109103439 |
CAUA: | 113052398 113106502(dhcr7) |
MASI: | 127414967 127440584 |
TNG: | GSTEN00019198G001 GSTEN00019199G001 |
SASA: | 106562054(dhcr7) 106587139 |
STRU: | 115167486 115202959 |
ONE: | 115112100 115113560(dhcr7) |
OCLA: | 139385094 139411339 |
SALP: | 111969284 111974247 |
CCLU: | 121573333 121582316 |
PSPA: | 121294271 121330286 |
ARUT: | 117432415 117435021 |
AFIL: | 140146488 140157287 140168680 |
PFLL: | 139151070 139151071 |
BTAB: | 109033727 109040108 |
PPOI: | 119093227 119093228 119093748 |
DSV: | 119461006 119461010 119462124 119462125 119465009 119465134 |
RSAN: | 119378567 119396498 119396499 119397514 |
RMP: | 119174557 119174682 119174683 |
CSCU: | 111636841 111636843 |
PCAN: | 112574082 112574092 |
LSAX: | 138966598 138966601 |
BGT: | 106053689 106067257 106067259 106068985 106071865 |
PMAX: | 117326295 117328004 |
MMER: | 123525122 123533770 |
RPHI: | 132725325 132737374 132737377 132752645 |
DPOL: | 127853110 127861466 127862103 127862104 127862105 127862107 |
MAEA: | 128213071 128215561 128230743 |
CSAT: | 104742576 104758352 104777974 |
RSZ: | 108848514 108848528 108859250 |
MSYL: | 126612363 126634227 |
PCOX: | 137708042 137739096 |
PALZ: | 118045106 118060206 |
SLY: | 101248602 101256596(DWF5-2) |
SPEN: | 107008408 107023649 |
SOT: | 102589505 102604909(StDWF5) |
SSTN: | 125872987 125873602 |
SDUL: | 129887626 129898764 |
CANN: | 107845860 107875679 |
SSPL: | 121797430 121801269 |
PSOM: | 113298913 113298926 113358687 |
TAES: | 123063456 123072467 123080701 |
MFLO: | 136463303 136473573 136473592 |
PVIR: | 120655686 120700873 |
PAUA: | 133918910 133922165 |
ZOF: | 122027064 122029360 122031900 122034394 |
SMO: | SELMODRAFT_135440(DWF5-2) SELMODRAFT_185064(DWF5-1) |
FOX: | FOXG_12967 FOXG_16578 |
CDET: | 87949448(CDEST_12948) |
PSCO: | LY89DRAFT_698617 LY89DRAFT_746866 |
AOR: | AO090001000167 AO090003000792 AO090010000319 AO090010000690 |
AFV: | AFLA_000891 AFLA_008510 AFLA_013802 AFLA_014184 |
APUU: | APUU_22197A APUU_40100A |
FFU: | CLAFUR5_03217 CLAFUR5_09494 |
LJR: | NCTC11533_02823(DWF) |
LCJ: | NCTC11976_02540(DWF) |
» show all
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Reference |
|
Authors |
DEMPSEY ME, SEATON JD, SCHROEPFER GJ Jr, TROCKMAN RW. |
Title |
THE INTERMEDIARY ROLE OF DELTA-5,7-CHOLESTADIEN-3-BETA-OL IN CHOLESTEROL BIOSYNTHESIS. |
Journal |
J Biol Chem 239:1381-7 (1964) |
Reference |
|
Authors |
Moebius FF, Fitzky BU, Lee JN, Paik YK, Glossmann H |
Title |
Molecular cloning and expression of the human delta7-sterol reductase. |
Journal |
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Sequence |
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Other DBs |
ExplorEnz - The Enzyme Database: | 1.3.1.21 |
ExPASy - ENZYME nomenclature database: | 1.3.1.21 |
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LinkDB |
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