| Entry |
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| Name |
saccharopine dehydrogenase (NADP+, L-glutamate-forming);
saccharopine (nicotinamide adenine dinucleotide phosphate, glutamate-forming) dehydrogenase;
aminoadipic semialdehyde-glutamic reductase;
aminoadipate semialdehyde-glutamate reductase;
aminoadipic semialdehyde-glutamate reductase;
epsilon-N-(L-glutaryl-2)-L-lysine:NAD+(P) oxidoreductase (L-2-aminoadipate-semialdehyde forming);
saccharopine reductase;
6-N-(L-1,3-dicarboxypropyl)-L-lysine:NADP+ oxidoreductase (L-glutamate-forming)
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| Class |
Oxidoreductases;
Acting on the CH-NH group of donors;
With NAD+ or NADP+ as acceptor
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| Sysname |
N6-(L-1,3-dicarboxypropyl)-L-lysine:NADP+ oxidoreductase (L-glutamate-forming)
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| Reaction(IUBMB) |
N6-(L-1,3-dicarboxypropyl)-L-lysine + NADP+ + H2O = L-glutamate + (S)-2-amino-6-oxohexanoate + NADPH + H+ [RN: R02315]
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| Reaction(KEGG) |
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| Substrate |
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| Product |
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| History |
EC 1.5.1.10 created 1972, modified 2011
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| Pathway |
| ec01110 | Biosynthesis of secondary metabolites |
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| Orthology |
| K00293 | saccharopine dehydrogenase (NADP+, L-glutamate forming) |
| K24034 | spermidine synthase / saccharopine dehydrogenase (NADP+, L-glutamate-forming) |
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| Genes |
| NCS: | NCAS_0A05670(NCAS0A05670) |
| NDI: | NDAI_0K02690(NDAI0K02690) |
| TPF: | TPHA_0M02120(TPHA0M02120) |
| TBL: | TBLA_0F00190(TBLA0F00190) |
| TDL: | TDEL_0A07910(TDEL0A07910) |
| KAF: | KAFR_0C04810(KAFR0C04810) |
| KNG: | KNAG_0D00180(KNAG0D00180) |
| LBG: | 92208409(LODBEIA_P32130) |
| CAL: | CAALFM_C306590WA(LYS9) |
| ASAU: | 88173721(PUMCH_002657) |
| YLI: | 2910249(YALI2_D00480g) |
| NTE: | NEUTE1DRAFT58317(NEUTE1DRAFT_58317) |
| SMP: | 10809790(SMAC4_02595) |
| TTT: | THITE_2050253 THITE_2107047 |
| RTHE: | 98127011(VTJ83DRAFT_5734) |
| FPU: | FPSE_00004 FPSE_09212 |
| FPOA: | FPOAC1_000362(LYS3) FPOAC1_003319 |
| NHE: | NECHADRAFT_101578 NECHADRAFT_92326 |
| FFC: | NCS54_00466900 NCS54_01134500 |
| FKR: | NCS57_00474100 NCS57_01125000 |
| TATV: | 25782360(TrAtP1_006292) |
| PLJ: | 28889964(PLICBS_008631) |
| CFJ: | CFIO01_01988 CFIO01_06768 |
| CHIG: | CH63R_03270 CH63R_08861 |
| CDET: | 87938109(CDEST_01606) 87950038(CDEST_13538) |
| ELA: | UCREL1_7945 UCREL1_8042 |
| BFU: | BCIN_03g09280(Bclys9) |
| GLZ: | GLAREA_00865 GLAREA_05240 |
| ACT: | ACLA_003400 ACLA_050430 |
| AOR: | AO090001000233 AO090003001086 |
| ANG: | An01g13590 An04g05260 |
| AFV: | AFLA_000585 AFLA_008579 |
| ALUC: | AKAW2_10277A AKAW2_51500S(LYS3) |
| PCS: | N7525_000842 N7525_005645 |
| PTRR: | 6339704(PtrM4_014470) 6344550(PtrM4_047610) |
| ADAC: | 96089000(ACET3X_008678) |
| ZTR: | MYCGRDRAFT_110462(LYS9) |
| PFJ: | MYCFIDRAFT_49608 MYCFIDRAFT_54301 |
| CDEP: | 91085546(L203_101333) |
| KMG: | 30159916(I203_104953) |
| KNE: | 92180591(IAR55_003333) |
| CCAC: | CcaHIS019_0502360(LYS9) |
| PCO: | PHACADRAFT_187523 PHACADRAFT_262714 |
| SHS: | STEHIDRAFT_129850 STEHIDRAFT_76391 |
| ABP: | AGABI1DRAFT64147(AGABI1DRAFT_64147) |
| ABV: | AGABI2DRAFT184364(AGABI2DRAFT_184364) |
| SCM: | SCHCO_02542524(SCHCODRAFT_02542524) SCHCO_02628453(SCHCODRAFT_02628453) |
| CPUT: | CONPUDRAFT_168017 CONPUDRAFT_84267 |
| MLR: | MELLADRAFT_73077 MELLADRAFT_91581 |
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| Reference |
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| Authors |
Jones EE, Broquist HP. |
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| Title |
Saccharopine, an intermediate of the aminoadipic acid pathway of lysine biosynthesis. 3. Aminoadipic semialdehyde-glutamate reductase. |
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| Journal |
J Biol Chem 241:3430-4 (1966) |
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| Other DBs |
| ExplorEnz - The Enzyme Database: | 1.5.1.10 |
| ExPASy - ENZYME nomenclature database: | 1.5.1.10 |
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| LinkDB |
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