KEGG ENZYME: 1.5.5.3

ENZYME: 1.5.5.3

Entry

EC 1.5.5.3                  Enzyme

Name

hydroxyproline dehydrogenase;
HYPDH;
OH-POX;
hydroxyproline oxidase;
PRODH2 (gene name)

Class

Oxidoreductases;
Acting on the CH-NH group of donors;
With a quinone or similar compound as acceptor

Sysname

trans-4-hydroxy-L-proline:quinone oxidoreductase

Reaction(IUBMB)

trans-4-hydroxy-L-proline + a quinone = (3R,5S)-3-hydroxy-1-pyrroline-5-carboxylate + a quinol [RN:R03295]

Reaction(KEGG)

R03295

Substrate

trans-4-hydroxy-L-proline [CPD:C01157];
quinone [CPD:C00472]

Product

(3R,5S)-3-hydroxy-1-pyrroline-5-carboxylate [CPD:C04281];
quinol [CPD:C00530]

Comment

A flavoprotein (FAD). The enzyme from human also has low activity with L-proline (cf. EC 1.5.5.2, proline dehydrogenase).

History

EC 1.5.5.3 created 2017

Pathway

ec00330

Arginine and proline metabolism

ec01100

Metabolic pathways

Orthology

K11394

hydroxyproline dehydrogenase

Genes

HSA:	58510(PRODH2)

PTR:	469076(PRODH2)

PPS:	100988900(PRODH2)

GGO:	101154315(PRODH2)

PON:	100441645(PRODH2)

PPYG:

129019526(PRODH2)

NLE:	100582687(PRODH2)

HMH:	116479635(PRODH2)

SSYN:

129460140(PRODH2)

MCC:	718914(PRODH2)

MCF:	102119447(PRODH2)

MTHB:

126941910

MNI:	105495496(PRODH2)

CSAB:

103235488(PRODH2)

CATY:

105578193(PRODH2)

PANU:

101016659(PRODH2)

TGE:	112611985(PRODH2)

MLEU:

105543103(PRODH2)

RRO:	104667131(PRODH2)

TFN:

117092378

PTEH:

111529920(PRODH2)

CANG:

105516704(PRODH2)

CJC:	100409353(PRODH2)

SBQ:	101051757(PRODH2)

CIMI:

108298522(PRODH2)

ANAN:

105707000(PRODH2)

CSYR:

103249678(PRODH2)

MMUR:

105876908(PRODH2)

LCAT:

123624454(PRODH2)

PCOQ:

105816146(PRODH2)

OGA:	105887642(PRODH2)

MMU:	56189(Prodh2)

MCAL:

110297695(Prodh2)

MPAH:

110335390(Prodh2)

RNO:	361538(Prodh2)

MCOC:

116100441(Prodh2)

ANU:	117721570(Prodh2)

ASYL:

127682861(Prodh2)

MUN:	110550901(Prodh2)

CGE:	100773901(Prodh2)

MAUA:

106022088(Prodh2)

PROB:

127238421(Prodh2)

PLEU:

114681696(Prodh2)

MORG:

121449990(Prodh2)

MFOT:

126486731

AAMP:

119820680(Prodh2)

NGI:	103729941(Prodh2)

HGL:	101703531(Prodh2)

CPOC:

100736006(Prodh2)

CCAN:

109689445(Prodh2)

DORD:

105993097(Prodh2)

DSP:	122097495(Prodh2)

PLOP:

125368012(Prodh2)

NCAR:

124966378

MMMA:

107151783(Prodh2)

ITI:	101964478(Prodh2)

OCU:

100354740

OPI:	101536287(PRODH2)

TUP:	102492745(PRODH2)

GVR:	103592829(PRODH2)

CFA:	484572(PRODH2)

CLUD:

112643571(PRODH2)

VVP:	112928512(PRODH2)

VLG:	121484394(PRODH2)

NPO:	129500989(PRODH2)

AML:	100474293(PRODH2)

UMR:	103682563(PRODH2)

UAH:	113244764(PRODH2)

UAR:	123793900(PRODH2)

ELK:

111161589

LLV:

125088416

MPUF:

101671462(PRODH2)

MNP:	132006160(PRODH2)

MLK:	131818468(PRODH2)

NVS:	122911569(PRODH2)

ORO:	101380565(PRODH2)

EJU:	114224383(PRODH2)

ZCA:	113935606(PRODH2)

MLX:	118022832(PRODH2)

NSU:	110590134(PRODH2)

LWW:	102738808(PRODH2)

FCA:	101087368(PRODH2)

PYU:	121011544(PRODH2)

PCOO:

112851027(PRODH2)

PBG:	122495009(PRODH2)

PVIV:

125153574(PRODH2)

LRUF:

124511931

LGF:	123578255(PRODH2)

AJU:

106974672

PTG:	102963452(PRODH2)

PPAD:

109251455(PRODH2)

PUC:

125915107

PLEZ:

122208222(PRODH2)

HHV:	120243503(PRODH2)

BTA:	508542(PRODH2)

BOM:	102278759(PRODH2)

BIU:	109572365(PRODH2)

BBUB:

102409119(PRODH2)

BBIS:

104995257(PRODH2)

CHX:	102176816(PRODH2)

OAS:	101105181(PRODH2)

BTAX:

128063762(PRODH2)

CSUM:

138095806(PRODH2)

ODA:	120872535(PRODH2)

CCAD:

122421420(PRODH2)

MREE:

136161228(PRODH2)

OVR:	110123691(PRODH2)

MBEZ:

129546106(PRODH2)

CFR:	102508280(PRODH2)

CBAI:

105065057(PRODH2)

CDK:	105088061(PRODH2)

VPC:	102527118(PRODH2)

BACU:

103020530(PRODH2)

BMUS:

118884847(PRODH2)

LVE:	103075818(PRODH2)

OOR:	101279871(PRODH2)

LALB:

132509878(PRODH2)

DLE:	111181175(PRODH2)

PCAD:

102988845(PRODH2)

PSIU:

116744597(PRODH2)

NASI:

112392264(PRODH2)

ECB:	100630262(PRODH2)

EPZ:	103566804(PRODH2)

EAI:	106829258(PRODH2)

MYB:	102243035(PRODH2)

MYD:	102760255(PRODH2)

MMYO:

118674658(PRODH2)

MLF:	102420802(PRODH2)

MDT:	132216976(PRODH2)

MYUM:

138996877(PRODH2)

PKL:	118720660(PRODH2)

EFUS:

103284519(PRODH2)

MNA:	107543420(PRODH2)

DRO:	112320057(PRODH2)

SHON:

118982564(PRODH2)

AJM:	119044201(PRODH2)

PDIC:

114511204(PRODH2)

PHAS:

123823819(PRODH2)

MMF:	118638631(PRODH2)

PPAM:

129083102(PRODH2)

HAI:	109372033(PRODH2)

RFQ:	117034953(PRODH2)

PALE:

102881173(PRODH2)

PGIG:

120592449(PRODH2)

PVP:	105306655(PRODH2)

RAY:	107497651(PRODH2)

MJV:	108401524(PRODH2)

TOD:	119250206(PRODH2)

SARA:

101538488(PRODH2)

SFUM:

130043974(PRODH2)

SETR:

126027622(PRODH2)

LAV:	100665466(PRODH2)

TMU:

101347296

ETF:	101657990(PRODH2)

DNM:	101424361(PRODH2)

MDO:	100016428(PRODH2)

GAS:	123243033(PRODH2)

SHR:	111719924(PRODH2)

AFZ:

127556084

PCW:	110201606(PRODH2)

TVP:	118839038(PRODH2)

PBRV:

138154098(PRODH2)

OAA:	114812117(PRODH2)

TACU:

119945734(PRODH2)

GGA:	107050361(PRODH2)

CATA:

118261618

LSR:

116184746

PRUF:

121364410

ATRC:

139586210

PHI:	102108371(PRODH2)

ACOE:

138100994(PRODH2)

CCIC:

134055878

SHAB:

115602951

AGEN:

126036653

ASN:	102378835(PRODH2)

AMJ:	102567357(PRODH2)

CMY:	119566296(PRODH2)

CCAY:

125637978(PRODH2)

DCC:	119856739(PRODH2)

CPIC:

103306964(PRODH2)

CABI:

116826185(PRODH2)

MRV:	120404560(PRODH2)

ACS:	100555092(prodh2)

ASAO:

132779394(PRODH2)

PVT:	110078478(PRODH2)

SUND:

121932668(PRODH2)

PBI:	103056447(PRODH2)

PMUR:

107282463

CTIG:

120304571(PRODH2)

TSR:

106555418

PGUT:

117669155(PRODH2)

APRI:

131198602(PRODH2)

PTEX:

113443488(PRODH2)

NSS:	113418577(PRODH2)

VKO:	123032097(PRODH2)

PMUA:

114582127(PRODH2)

PRAF:

128401066(PRODH2)

ZVI:	118095866(PRODH2)

HCG:	128330949(PRODH2)

GJA:	107116343(PRODH2)

EMC:	129338259(PRODH2)

XLA:	398760(prodh2.L)

XTR:	101734436(prodh2)

NPR:	108789185(PRODH2)

RTEM:

120943083(PRODH2)

BBUF:

121007568(PRODH2)

BGAR:

122945283(PRODH2)

PWL:	138304165(PRODH2)

MUO:	115474312(PRODH2)

GSH:	117361299(PRODH2)

DRE:	436664(zgc:92040)

SRX:	107708971(prodh2)

SANH:

107693688(prodh2)

SGH:

107562014

CCAR:

109052804

CAUA:

113112084(prodh2)

CGIB:

127968710

PTET:

122333364(prodh2)

LROH:

127174616(prodh2)

OMC:	131551143(prodh2)

PPRM:

120469022(prodh2)

RKG:	130080601(prodh2)

MAMB:

125255611(prodh2)

CIDE:

127523442

CERY:

137007768(prodh2)

MASI:

127422819 127427392

TROS:

130568787(prodh2)

TDW:	130438579(prodh2)

MANU:

129420497(prodh2)

PDAB:

135734580 135739322

IPU:

108273642

IFU:	128617398(prodh2)

PHYP:

113527045(prodh2)

SMEO:

124388555(prodh2)

TFD:	113653517(prodh2)

TVC:	132841530(prodh2)

CGAR:

128541556(prodh2)

NGRA:

132898058(prodh2)

TRN:	134321739(prodh2)

AMEX:

103022862(prodh2)

CMAO:

118809756(prodh2)

EEE:	113587524(prodh2)

CHAR:

105909097(prodh2)

SPIL:

134077139(prodh2)

TRU:	101078218(prodh2)

TFS:	130522305(prodh2)

TNG:	GSTEN00028317G001

LCO:	104926870(prodh2)

NCC:	104953237(prodh2)

TBEN:

117473940(prodh2)

CGOB:

115024870(prodh2)

PGEO:

117464422(prodh2)

GACU:

117545004(prodh2)

EMAC:

134870598(prodh2)

ELY:	117246798(prodh2)

EFO:	125880413(prodh2)

PLEP:

121958569(prodh2)

SLUC:

116061559(prodh2)

ECRA:

117937303(prodh2)

ESP:	116671297(prodh2)

PFLV:

114548408(prodh2)

GAT:	120819101(prodh2)

PPUG:

119212632(prodh2)

AFB:	129091288(prodh2)

PSWI:

130203323(prodh2)

CANA:

137789529(prodh2)

MSAM:

119916307(prodh2)

SCHU:

122868155(prodh2)

CUD:	121528303(prodh2)

SPUL:

138593992(prodh2)

LMIX:

132955558(prodh2)

ALAT:

119009899(prodh2)

ASTR:

137588586(prodh2)

MZE:	101487644(prodh2)

ONL:	100703669(prodh2)

OAU:	116327639(prodh2)

OLA:	101155724(prodh2)

OML:	112154696(prodh2)

CSAI:

133419346(prodh2)

XMA:	102226277(prodh2)

XCO:	114151741(prodh2)

XHE:	116726804(prodh2)

PRET:

103481397(prodh2)

PFOR:

103152334(prodh2)

PLAI:

106956243(prodh2)

PMEI:

106904144

GAF:	122823377(prodh2)

PPRL:

129377768(prodh2)

CVG:	107097212(prodh2)

CTUL:

119796745(prodh2)

GMU:	124874790(prodh2)

NFU:	107387966(prodh2)

KMR:	108247131(prodh2)

ALIM:

106521389(prodh2)

NWH:	119423598(prodh2)

AOCE:

111581595(prodh2)

EJA:	138202014(prodh2)

BFRE:

138616984(prodh2)

MCEP:

125022425(prodh2)

CSEM:

103381976(prodh2)

POV:	109642723(prodh2)

SSEN:

122759684(prodh2)

SSOE:

131448599(prodh2)

HHIP:

117752768(prodh2)

HSP:	118100647(prodh2)

PPLT:

128426661(prodh2)

SMAU:

118287419(prodh2)

LCF:

108884464

SDU:	111219983(prodh2)

SLAL:

111658668(prodh2)

XGL:	120794641(prodh2)

HCQ:	109523978(prodh2)

SSCV:

125990918(prodh2)

SBIA:

133496028(prodh2)

PEE:	133395254(prodh2)

PTAO:

133469695(prodh2)

BPEC:

110159594(prodh2)

MALB:

109973598(prodh2)

BSPL:

114845927(prodh2)

SJO:	128381410(prodh2)

SSCO:

134002938(prodh2)

GMH:	115531066(prodh2)

SASA:

106578328(prodh2)

STRU:

115200976(prodh2)

OTW:	112232855(prodh2)

OMY:	110498805(prodh2)

OGO:	124039926(prodh2)

ONE:	115143935(prodh2)

OKI:	109881735(prodh2)

OKE:	118357763(prodh2)

OMM:	135523941(prodh2)

OCLA:

139376461

SALP:

111976348(prodh2)

SNH:	120060911(prodh2)

CCLU:

121547167(prodh2)

ELS:	105024364(prodh2)

SFM:	108933021(prodh2)

PKI:	111835827(prodh2)

AANG:

118220234(prodh2)

AROT:

135249204(prodh2)

CCOG:

133122507(prodh2)

PSPA:

121306794(prodh2)

ARUT:

117398777(prodh2)

PSEX:

120536561(prodh2)

LCM:	102354203(PRODH2)

BFO:	118417335 118426280

BBEL:

109467218 109482107

CIN:

100180610

SCLV:

120330165

SPU:

576696

APLC:

110986277

ARUN:

117290549

AAMU:

139938842

AFIL:

140168531 140168727

SKO:	100377930 102805849 102805974

PFLL:

139145470

CSEC:

111870040

BROR:

134529400

IEL:

124155633

HAMR:

139693827

DPX:	DAPPUDRAFT_204241

DMK:

116931073

DPZ:

124349686

PVM:

113809427

PJA:

122250188

PCHN:

125030369

HAME:

121871864

PCLA:

123756392

CQD:

128694649

PTRU:

123520676

ESN:

126998472

MNZ:

135202330

MRJ:

136847129

PORN:

139753767

HAZT:

108677818

EAF:	111711121 111717152

TCF:	131883838 131886973

PPOI:

119094904 119094914 119095844 119110169

DSV:

119440384

RSAN:

119386917

RMP:

119178297

CSCU:

111619182

CVS:

136980139

PTEP:

107456183

ABRU:

129980899

UDV:

129227683

SDM:

118192813

LPOL:

106459347 106464159

PVUL:

126824415

PCAN:

112562444

LSAX:

138955696

BGT:

106070289

HRF:

124141689

HRJ:

124278048

HCRA:

139455230

CRG:	105335584 117680326

CANU:

128190697

CVN:	111132312 111136064

OED:

125664753

MYI:	110443255 110443384

PMAX:

117332253 117333133 117333135

AIRR:

138331668 138331669

MMER:

123530308

DPOL:

127877427

MAEA:

128216660

OBI:

106869190

OSN:	115221635 115221636 115229811 115231961

LJP:

135476916

LAK:

106181047

LLON:

135482803

NVE:

5511574

EPA:

110253348

ATEN:

116290773

ADF:	107336175 107352366

AMIL:

114959075

PDAM:

113673699

SPIS:

111329332

DGT:

114523876

XEN:

124434978

HMG:

100204778

HSY:

130656712

RES:

135683123

» show all

Reference

1 [PMID:18287100]

Authors

Cooper SK, Pandhare J, Donald SP, Phang JM

Title

A novel function for hydroxyproline oxidase in apoptosis through generation of reactive oxygen species.

Journal

J Biol Chem 283:10485-92 (2008)
DOI:10.1074/jbc.M702181200

Sequence

[hsa:58510]

Reference

2 [PMID:25697095]

Authors

Summitt CB, Johnson LC, Jonsson TJ, Parsonage D, Holmes RP, Lowther WT

Title

Proline dehydrogenase 2 (PRODH2) is a hydroxyproline dehydrogenase (HYPDH) and molecular target for treating primary hyperoxaluria.

Journal

Biochem J 466:273-81 (2015)
DOI:10.1042/BJ20141159

Sequence

[hsa:58510]

Other DBs

ExplorEnz - The Enzyme Database:

1.5.5.3

IUBMB Enzyme Nomenclature:

1.5.5.3

ExPASy - ENZYME nomenclature database:

1.5.5.3

BRENDA, the Enzyme Database:

1.5.5.3

LinkDB

DBGET integrated database retrieval system