Entry Name 3'-hydroxy-N-methyl-(S)-coclaurine 4'-O-methyltransferase
Class Transferases;BRITE hierarchy
Sysname S-adenosyl-L-methionine:3'-hydroxy-N-methyl-(S)-coclaurine 4'-O-methyltransferase
Reaction(IUBMB) S-adenosyl-L-methionine + 3'-hydroxy-N-methyl-(S)-coclaurine = S-adenosyl-L-homocysteine + (S)-reticuline [RN:
R03832 ]
Reaction(KEGG) Substrate S-adenosyl-L-methionine [CPD:
C00019 ];
3'-hydroxy-N-methyl-(S)-coclaurine [CPD:
C05202 ]
Product S-adenosyl-L-homocysteine [CPD:
C00021 ];
(S)-reticuline [CPD:
C02105 ]
Comment Involved in isoquinoline alkaloid metabolism in plants. The enzyme has also been shown to catalyse the methylation of (RS)-laudanosoline, (S)-3'-hydroxycoclaurine and (RS)-7-O-methylnorlaudanosoline.
History EC 2.1.1.116 created 1999
Pathway ec00950 Isoquinoline alkaloid biosynthesis
ec01110 Biosynthesis of secondary metabolites
Orthology K13386 3'-hydroxy-N-methyl-(S)-coclaurine 4'-O-methyltransferase
Genes MING : 122065299 122065307
PSOM : 113294323 113326743 113326977 113327792 113328438 113339850 113339870 113353561
Taxonomy Reference 1
Authors Frenzel T, Zenk MH.
Title S-Adenosyl-L-methionine: 3'-hydroxy-N-methyl-(S)-coclaurine 4'-O-methyltransferase, a regio- and stereoselective enzyme of the (S)-reticuline pathway.
Journal Phytochemistry 29:3505-3511 (1990)
Other DBs ExPASy - ENZYME nomenclature database: 2.1.1.116
LinkDB All DBs
