KEGG ENZYME: 2.1.3.1

ENZYME: 2.1.3.1

Entry

EC 2.1.3.1                  Enzyme

Name

methylmalonyl-CoA carboxytransferase;
transcarboxylase;
methylmalonyl coenzyme A carboxyltransferase;
methylmalonyl-CoA transcarboxylase;
oxalacetic transcarboxylase;
methylmalonyl-CoA carboxyltransferase;
(S)-2-methyl-3-oxopropanoyl-CoA:pyruvate carboxyltransferase;
(S)-2-methyl-3-oxopropanoyl-CoA:pyruvate carboxytransferase carboxytransferase [incorrect]

Class

Transferases;
Transferring one-carbon groups;
Carboxy- and carbamoyltransferases

Sysname

(S)-methylmalonyl-CoA:pyruvate carboxytransferase

Reaction(IUBMB)

(S)-methylmalonyl-CoA + pyruvate = propanoyl-CoA + oxaloacetate [RN:R00930]

Reaction(KEGG)

R00930;
(other) R00353

Substrate

(S)-methylmalonyl-CoA [CPD:C00683];
pyruvate [CPD:C00022]

Product

propanoyl-CoA [CPD:C00100];
oxaloacetate [CPD:C00036]

Comment

A biotinyl-protein, containing cobalt and zinc. The enzyme, described from the bacterium Propionibacterium shermanii, is unique among the biotin-dependent enzymes in that it catalyses carboxyl transfer between two organic molecules, utilizing two separate carboxyltransferase domains. The enzyme is a very large complex, consisting of a hexameric central core of 12S subunits surrounded by six 5S subunit dimers, each connected to the central core by twelve 1.3S biotin carrier subunits.

History

EC 2.1.3.1 created 1961

Pathway

ec00640

Propanoate metabolism

ec01100

Metabolic pathways

Orthology

K03416

methylmalonyl-CoA carboxyltransferase 5S subunit

K17489

methylmalonyl-CoA carboxyltransferase 12S subunit

K17490

methylmalonyl-CoA carboxyltransferase 1.3S subunit

Genes

DDEN:

KI615_02180 KI615_02185 KI615_08785 KI615_08795 KI615_08800

THAG:

CKCBHOJB_01243 CKCBHOJB_01244 CKCBHOJB_01245

GEM:	GM21_0316 GM21_0317 GM21_0318 GM21_0319

GBM:	Gbem_0334 Gbem_0335 Gbem_0336 Gbem_0337

GER:	KP004_00725 KP004_00730

GSUB:

KP001_14770

GNT:	KP003_00415

GPL:	M1B72_20165

PPD:	Ppro_0033 Ppro_0034 Ppro_0035 Ppro_3082 Ppro_3083 Ppro_3084

LLH:	I41_49080 I41_49090

AMUC:

Pan181_03350 Pan181_03360 Pan181_03370 Pan181_03380

PLH:	VT85_16875 VT85_16880 VT85_16885 VT85_16890

CCOP:

Mal65_44080 Mal65_44090 Mal65_44100

PBOR:

BSF38_02050 BSF38_02051 BSF38_02052 BSF38_02053

AGV:	OJF2_03070 OJF2_03080 OJF2_03100

TPLA:

ElP_40030 ElP_40040 ElP_40050

PCOR:

KS4_34690

ABA:	Acid345_3023 Acid345_3024 Acid345_3025 Acid345_3026

SUS:	Acid_2261 Acid_6958 Acid_6959 Acid_6960 Acid_6961

PFER:

IRI77_05250 IRI77_05255 IRI77_05260 IRI77_05265

LUB:	TBR22_A32260 TBR22_A41020 TBR22_A41030(oadA)

CLZ:	BIU88_04850 BIU88_04855 BIU88_04860 BIU88_04865

CPH:	Cpha266_1591 Cpha266_1592 Cpha266_1593 Cpha266_1594

BCHS:

JNE38_23625

BREH:

HP435_22345

SSG:	Selsp_0507

SRI:	SELR_10340

MHG:

MHY_07420

SGBI:

P3F81_03505

MYV:	G155_29450

MFT:	XA26_59530

MALV:

MALV_37140

MAUB:

MAUB_31710

MMUC:

C1S78_028595

CEF:	CE0804 CE0805 CE0806 CE0807

CDI:	DIP0739(pycB) DIP0740(mmdA) DIP0741 DIP0742

CDP:	CD241_0674(pycB) CD241_0675(accD2) CD241_0676 CD241_0677

CDH:	CDB402_0651(pycB) CDB402_0652(accD2) CDB402_0653 CDB402_0654

CDT:	CDHC01_0674(pycB) CDHC01_0675(accD2) CDHC01_0676 CDHC01_0677

CDE:	CDHC02_0677(pycB) CDHC02_0678(accD2) CDHC02_0679 CDHC02_0680

CDR:	CDHC03_0660(pycB) CDHC03_0661(accD2) CDHC03_0662 CDHC03_0663

CDA:	CDHC04_0666(pycB) CDHC04_0667(accD2) CDHC04_0668 CDHC04_0669

CDZ:	CD31A_0770(pycB) CD31A_0771(accD2) CD31A_0772 CD31A_0773

CDB:	CDBH8_0728(pycB) CDBH8_0729(accD2) CDBH8_0730 CDBH8_0731

CDS:	CDC7B_0689(pycB) CDC7B_0690(accD2) CDC7B_0691 CDC7B_0692

CDD:	CDCE8392_0687(pycB) CDCE8392_0688(accD2) CDCE8392_0689 CDCE8392_0690

CDW:	CDPW8_0743(pycB) CDPW8_0744(accD2) CDPW8_0745 CDPW8_0746

CDV:	CDVA01_0621(pycB) CDVA01_0622(accD2) CDVA01_0623 CDVA01_0624

CDIP:

ERS451417_00670(pycB) ERS451417_00671(accD2) ERS451417_00672 ERS451417_00673

CKP:	ckrop_0042(oadA) ckrop_0043 ckrop_0044 ckrop_0045

CPU:	CPFRC_02860 CPFRC_02865 CPFRC_02870 CPFRC_02875

CPL:	Cp3995_0577 Cp3995_0578 Cp3995_0579 Cp3995_0580

CPG:	CP316_02970 CP316_02975 CP316_02980 CP316_02985

CPP:	CpP54B96_0578 CpP54B96_0579 CpP54B96_0580 CpP54B96_0581

CPK:	CP1002_02860 CP1002_02865 CP1002_02870 CP1002_02875

CPQ:	CPC231_02860 CPC231_02865 CPC231_02870 CPC231_02875

CPX:	CPI19_02860 CPI19_02865 CPI19_02870 CPI19_02875

CPZ:	CpPAT10_0570 CpPAT10_0571 CpPAT10_0572 CpPAT10_0573

COR:	Cp267_0594 Cp267_0595 Cp267_0596 Cp267_0597

COP:	CP31_03200 CP31_03205 CP31_03210 CP31_03215

COD:	Cp106_0552 Cp106_0553 Cp106_0554 Cp106_0555

COS:	Cp4202_0563 Cp4202_0564 Cp4202_0565 Cp4202_0566

COI:	CPCIP5297_02985 CPCIP5297_02990 CPCIP5297_02995 CPCIP5297_03000

COE:	CP258_02985 CP258_02990 CP258_02995 CP258_03000

COU:	CP162_07510 CP162_07515 CP162_07520 CP162_07525

CPSE:

CPTA_01118 CPTA_01119 CPTA_01120 CPTA_01121

CPSU:

CPTB_00411 CPTB_00412 CPTB_00413 CPTB_00414

CPSF:

CPTC_00070 CPTC_00071 CPTC_00072 CPTC_00073

CUL:	CULC22_00619(oadA) CULC22_00620(mmdA) CULC22_00621 CULC22_00622

CUC:	CULC809_00611(oadA) CULC809_00612(mmdA) CULC809_00613 CULC809_00614

CUE:	CULC0102_0722(oadA) CULC0102_0723(mmdA) CULC0102_0724 CULC0102_0725

CUN:	Cul210932_0641 Cul210932_0642(mmdA) Cul210932_0643 Cul210932_0644

CUQ:	Cul210931_0615 Cul210931_0616(mmdA) Cul210931_0617 Cul210931_0618

CUZ:	Cul05146_0657 Cul05146_0658(mmdA) Cul05146_0659 Cul05146_0660

CUJ:	CUL131002_0619 CUL131002_0620(mmdA) CUL131002_0621 CUL131002_0622

CUS:	CulFRC11_0614 CulFRC11_0615(mmdA) CulFRC11_0616 CulFRC11_0617

CAZ:	CARG_02100 CARG_02105 CARG_02110 CARG_02115

CVT:	B843_03830 B843_03835 B843_03840 B843_03845

COA:	DR71_253 DR71_254 DR71_255 DR71_256

CKU:	UL82_08890 UL82_08895 UL82_08900 UL82_08905

CMV:	CMUST_04215 CMUST_04220 CMUST_04225 CMUST_04230

CEI:	CEPID_03475 CEPID_03480 CEPID_03485 CEPID_03490

CLW:	CLAC_07680 CLAC_07685 CLAC_07690 CLAC_07695

CAQU:

CAQU_03350 CAQU_03355 CAQU_03360 CAQU_03365

CPEG:

CPELA_08135 CPELA_08140 CPELA_08145 CPELA_08150

CGK:	CGERO_02945 CGERO_02950 CGERO_02955 CGERO_02960

CRF:	FRC0190_00731 FRC0190_00732 FRC0190_00733 FRC0190_00734

CCHO:

CCHOA_02710 CCHOA_02715 CCHOA_02720 CCHOA_02725

CPSO:

CPPEL_08365 CPPEL_08370 CPPEL_08375 CPPEL_08380

CMAT:

HBA49_10305 HBA49_10310 HBA49_10315 HBA49_10320

CAMC:

I6I65_03615 I6I65_03620 I6I65_03625 I6I65_03630

CGLU:

I6J20_06300 I6J20_06305 I6J20_06310 I6J20_06315

CSIL:

CBE74_03325 CBE74_03330 CBE74_03335 CBE74_03340

CKW:	CKALI_08895 CKALI_08900 CKALI_08905 CKALI_08910

CHIN:

J5O04_04870 J5O04_04875 J5O04_04880 J5O04_04885

CFG:	CFREI_03385 CFREI_03390 CFREI_03395 CFREI_03400

CCAW:

CCANI_03535 CCANI_03540 CCANI_03545 CCANI_03550

CFAC:

CFAEC_03460 CFAEC_03465 CFAEC_03470 CFAEC_03475

CFEU:

CFELI_03425 CFELI_03430 CFELI_03435 CFELI_03440

CDUR:

CDUR_03270 CDUR_03275 CDUR_03280 CDUR_03285

CPYR:

CYJ47_08920 CYJ47_08925 CYJ47_08930 CYJ47_08935

CPSK:

Q0N40_00220 Q0N40_00225 Q0N40_00230 Q0N40_00235

CBEL:

ABMV07_04005 ABMV07_04010 ABMV07_04015 ABMV07_04020

RHOD:

AOT96_33450

ASUF:

MNQ99_17180

ARS:	ADJ73_02365 ADJ73_02370 ADJ73_02375 ADJ73_02380

DCO:	SAMEA4475696_1332 SAMEA4475696_1333 SAMEA4475696_1334 SAMEA4475696_1335

AUS:	IPK37_14725 IPK37_14730 IPK37_14735 IPK37_14740

PAC:	PPA2005 PPA2006 PPA2007 PPA2008

PAK:	HMPREF0675_5070 HMPREF0675_5071 HMPREF0675_5072 HMPREF0675_5073

PAV:	TIA2EST22_09810 TIA2EST22_09815 TIA2EST22_09820 TIA2EST22_09825

PAX:	TIA2EST36_09790 TIA2EST36_09795 TIA2EST36_09800 TIA2EST36_09805

PAZ:	TIA2EST2_09750 TIA2EST2_09755 TIA2EST2_09760 TIA2EST2_09765

PAW:	PAZ_c20940(mmdC) PAZ_c20950 PAZ_c20960 PAZ_c20970

PAD:	TIIST44_02805 TIIST44_02810 TIIST44_02815 TIIST44_02820

PCN:	TIB1ST10_10205 TIB1ST10_10210 TIB1ST10_10215 TIB1ST10_10220

PACC:

PAC1_10235 PAC1_10240 PAC1_10245 PAC1_10250

PACH:

PAGK_1918 PAGK_1919 PAGK_1920 PAGK_1921

PACN:

TIA1EST1_09895 TIA1EST1_09900 TIA1EST1_09905 TIA1EST1_09910

CACN:

RN83_10340 RN83_10345 RN83_10350 RN83_10355

PRA:	PALO_00960 PALO_00965 PALO_00970 PALO_00975

PRL:	BCB70_08380 BCB70_08385 BCB70_08390 BCB70_08395

CGRN:

4412665_00693 4412665_00694 4412665_00695 4412665_00696

CEQU:

O6R08_09200 O6R08_09205 O6R08_09210 O6R08_09215

PFR:	PFREUD_18840(bccp) PFREUD_18850 PFREUD_18860(mmdA) PFREUD_18870

PFRE:

RM25_1792 RM25_1793 RM25_1794 RM25_1795

PACD:

EGX94_04685 EGX94_04690 EGX94_04695 EGX94_04700

PAUS:

NCTC13651_02414 NCTC13651_02415 NCTC13651_02416 NCTC13651_02417

PPC:	HMPREF9154_0665 HMPREF9154_0667 HMPREF9154_0669

ARUB:

J5A65_11605 J5A65_11610 J5A65_11615 J5A65_11620

PBO:	PACID_07970 PACID_07980 PACID_07990 PACID_08000(bccP)

AACI:

ASQ49_00810 ASQ49_00815 ASQ49_00820 ASQ49_00825

ACIJ:

JS278_02521 JS278_02522 JS278_02523 JS278_02524

AJI:	C0Z10_10440 C0Z10_10445 C0Z10_10450 C0Z10_10455

TFL:	RPIT_00055 RPIT_00060 RPIT_11355 RPIT_11360 RPIT_11365 RPIT_11370

TFA:	BW733_11045 BW733_11050 BW733_11055 BW733_11060

TES:	BW730_11920 BW730_11925 BW730_11930 BW730_11935

TEZ:	BKM78_05350 BKM78_05355 BKM78_05360 BKM78_05365

TDF:	H9L22_11645 H9L22_11650

TLA:	TLA_TLA_01085 TLA_TLA_01086 TLA_TLA_01087 TLA_TLA_01088

TEJ:	KDB89_02260 KDB89_02265 KDB89_02270 KDB89_02275

TLS:	QH948_11840 QH948_11845 QH948_11850 QH948_11855

RAIN:

Rai3103_10160 Rai3103_10165 Rai3103_10170

PRV:	G7070_04830 G7070_04835 G7070_04840 G7070_04845

BRT:	J4N02_13890 J4N02_13895 J4N02_13900 J4N02_13905

PSOI:

PCC79_02570 PCC79_02575 PCC79_02580 PCC79_02585

PROP:

QQ658_12405 QQ658_12410 QQ658_12415 QQ658_12420

BROO:

brsh051_10970 brsh051_10980 brsh051_10990 brsh051_11000(oadA)

NCA:	Noca_1247 Noca_1248 Noca_1249 Noca_1250

NBE:	Back2_17330

MGG:	MPLG2_3743 MPLG2_3744(yqjD) MPLG2_3745 MPLG2_3746

TALX:

FOF52_14945

ACTY:

OG774_14135

PBAJ:

LRS13_06700

SBAE:

DSM104329_02823

DFC:	DFI_07755 DFI_07760 DFI_07765 DFI_07770

» show all

Reference

1 [PMID:16590594]

Authors

Swick RW, Wood HG.

Title

THE ROLE OF TRANSCARBOXYLATION IN PROPIONIC ACID FERMENTATION.

Journal

Proc Natl Acad Sci U S A 46:28-41 (1960)
DOI:10.1073/pnas.46.1.28

Reference

2 [PMID:3893281]

Authors

Wood HG, Kumar GK.

Title

Transcarboxylase: its quaternary structure and the role of the biotinyl subunit in the assembly of the enzyme and in catalysis.

Journal

Ann N Y Acad Sci 447:1-22 (1985)
DOI:10.1111/j.1749-6632.1985.tb18422.x

Reference

3 [PMID:15188046]

Authors

Peikert C, Seeger K, Bhat RK, Berger S.

Title

Determination of the binding specificity of the 12S subunit of the transcarboxylase by saturation transfer difference NMR.

Journal

Org Biomol Chem 2:1777-81 (2004)
DOI:10.1039/b404238g

Reference

4 [PMID:17134979]

Authors

Kumar Bhat R, Berger S.

Title

New and easy strategy for cloning, expression, purification, and characterization of the 5S subunit of transcarboxylase from Propionibacterium f. shermanii.

Journal

Prep Biochem Biotechnol 37:13-26 (2007)
DOI:10.1080/10826060601039394

Reference

5 [PMID:15814455]

Authors

Carey PR, Sonnichsen FD, Yee VC.

Title

Transcarboxylase: one of nature's early nanomachines.

Journal

IUBMB Life 56:575-83 (2004)
DOI:10.1080/15216540400022417

Other DBs

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