Entry
Name
alpha-tubulin N-acetyltransferase;
ATAT1 (gene name);
MEC17 (gene name);
alpha-tubulin acetylase;
TAT;
alpha-tubulin acetyltransferase;
tubulin N-acetyltransferase (ambiguous);
acetyl-CoA:alpha-tubulin-L-lysine N-acetyltransferase;
acetyl-CoA:[alpha-tubulin]-L-lysine 6-N-acetyltransferase
Class
Transferases;
Acyltransferases;
Transferring groups other than aminoacyl groups
BRITE hierarchy
Sysname
acetyl-CoA:[alpha-tubulin]-L-lysine N6-acetyltransferase
Reaction(IUBMB)
acetyl-CoA + [alpha-tubulin]-L-lysine = CoA + [alpha-tubulin]-N6-acetyl-L-lysine [RN:
R04192 ]
Reaction(KEGG)
Substrate
acetyl-CoA [CPD:
C00024 ];
[alpha-tubulin]-L-lysine [CPD:
C03318 ]
Product
CoA [CPD:
C00010 ];
[alpha-tubulin]-N6-acetyl-L-lysine [CPD:
C04149 ]
Comment
The enzyme is conserved from protists to mammals and is present in flowering plants. In most organisms it acetylates L-lysine at position 40 of alpha-tubulin.
History
EC 2.3.1.108 created 1989, modified 2021
Orthology
K19573 alpha-tubulin N-acetyltransferase 1
Genes
CFA : 477580(ATAT1) 609464
CLUD : 112641245(ATAT1) 112656233
NSU : 110578840 110586666(ATAT1)
CDK : 105087501(ATAT1) 116147121
STOW : 125427701(ATAT1) 125427707
XLA : 734258(atat1.L) 735057(atat1.S)
SANH : 107677465 107677472 107694337
CCAR : 109063750 109063757
CAUA : 113090768 113119529
CGIB : 127935572 127979007
MASI : 127421051 127425466
TRU : 101074501 115251809(atat1)
ASTR : 137606958 137607123(atat1)
CSEM : 103384383 103394495(atat1)
SSEN : 122783133 122786311(atat1)
SSOE : 131445095 131447393(atat1)
SASA : 106570679 106589060(atat1)
STRU : 115174126 115175310(atat1)
OKE : 118378726 118380316(atat1)
OCLA : 139372391 139392391 139403950
SNH : 120021996(atat1) 120027367
CCLU : 121572234 121586834
ARUT : 117433594 117964778
DME : Dmel_CG17003(lky) Dmel_CG3967(Atat)
DSI : Dsimw501_GD12926(Dsim_GD12926) Dsimw501_GD15558(Dsim_GD15558)
DYA : Dyak_GE17347 Dyak_GE21245
DPO : 6900997 6900998 6901295
DPE : 113566753 6598554 6599632
DMN : 108151967 108151969 108156830
DMO : Dmoj_GI13265 Dmoj_GI14817
CCAT : 101451142 101452477
AMER : 121591919 121602792
AALB : 109409698 109411441
BCOO : 119082181 119082516
ATD : 109602224 109608541 109608563 109608617
PMAC : 106719746 106719891
PPOT : 106102600 106102989
CFEL : 113369258 113377702 113385498
API : 100162553 100168047 100169461 100570380 100570471 100570672 100575498
DNX : 107164488 107173589 107173592 107174168 107174192
AGS : 114123315 114123904 114132529 114132549 126551307
RMD : 113548079 113549333 113556182 113556835 113557143 113557201
ACOO : 126842722 126842723 126846216 126846402 126846710
DVT : 126894176 126903274 126903275
CLEC : 106668236 106668237
MQU : 128994330 128994388 128995325 128995724 128995734 128995878
TPAL : 117653839 117654003
RSAN : 119378785 119406384
CEL : CELE_F57H12.7(mec-17) CELE_W06B11.1(atat-2)
CBR : CBG_14763(Cbr-atat-2) CBG_17726(Cbr-mec-17)
CRQ : GCK72_014792 GCK72_024480
LGI : LOTGIDRAFT_109299 LOTGIDRAFT_148609
TAD : TRIADDRAFT_35009 TRIADDRAFT_53139
AQU : 100640763 105315491 109587786
PTM : GSPATT00035333001 GSPATT00035468001 GSPATT00036506001 GSPATT00037844001 GSPATT00038558001
TCR : 467287.10 509233.160
LMAT : 92515302(LSCM1_05319)
LOI : 92360386(LSCM4_04468)
LEIS : 94179773(GH5_04332)
LENR : 94172425(CUR178_05221)
LEIN : 94188182(JIQ42_04524)
TVA : TVAG_2v0166300 TVAG_2v0307470
SSAO : 94294444(SS50377_20421)
» show all
Taxonomy
Reference
Authors
Greer K, Maruta H, L'Hernault SW, Rosenbaum JL.
Title
Alpha-tubulin acetylase activity in isolated Chlamydomonas flagella.
Journal
Reference
Authors
Akella JS, Wloga D, Kim J, Starostina NG, Lyons-Abbott S, Morrissette NS, Dougan ST, Kipreos ET, Gaertig J
Title
MEC-17 is an alpha-tubulin acetyltransferase.
Journal
Reference
Authors
Shida T, Cueva JG, Xu Z, Goodman MB, Nachury MV
Title
The major alpha-tubulin K40 acetyltransferase alphaTAT1 promotes rapid ciliogenesis and efficient mechanosensation.
Journal
Reference
Authors
Taschner M, Vetter M, Lorentzen E.
Title
Atomic resolution structure of human alpha-tubulin acetyltransferase bound to acetyl-CoA.
Journal
Reference
Authors
Friedmann DR, Aguilar A, Fan J, Nachury MV, Marmorstein R.
Title
Structure of the alpha-tubulin acetyltransferase, alphaTAT1, and implications for tubulin-specific acetylation.
Journal
Reference
Authors
Kalebic N, Sorrentino S, Perlas E, Bolasco G, Martinez C, Heppenstall PA.
Title
alphaTAT1 is the major alpha-tubulin acetyltransferase in mice.
Journal
Other DBs
ExPASy - ENZYME nomenclature database: 2.3.1.108
LinkDB
All DBs