KEGG ENZYME: 2.5.1.82

ENZYME: 2.5.1.82

Entry

EC 2.5.1.82                 Enzyme

Name

hexaprenyl diphosphate synthase [geranylgeranyl-diphosphate specific];
HexPS(ambiguous);
(all-E) hexaprenyl diphosphate synthase;
(all-trans) hexaprenyl diphosphate synthase;
hexaprenyl pyrophosphate synthase (ambiguous);
HexPPs (ambiguous);
hexaprenyl diphosphate synthase (ambiguous);
geranylgeranyl-diphosphate:isopentenyl-diphosphate transferase (adding 2 isopentenyl units)

Class

Transferases;
Transferring alkyl or aryl groups, other than methyl groups;
Transferring alkyl or aryl groups, other than methyl groups (only sub-subclass identified to date)

Sysname

geranylgeranyl-diphosphate:3-methylbut-3-en-1-yl-diphosphate transferase (adding 2 units of 3-methylbut-3-en-1-yl)

Reaction(IUBMB)

geranylgeranyl diphosphate + 2 (3-methylbut-3-en-1-yl diphosphate) = 2 diphosphate + all-trans-hexaprenyl diphosphate [RN:R09246]

Reaction(KEGG)

R09246

Substrate

geranylgeranyl diphosphate [CPD:C00353];
3-methylbut-3-en-1-yl diphosphate [CPD:C00129]

Product

diphosphate [CPD:C00013];
all-trans-hexaprenyl diphosphate [CPD:C01230]

Comment

The enzyme prefers geranylgeranyl diphosphate to farnesyl diphosphate as an allylic substrate and does not show activity for geranyl diphosphate and prenyl diphosphate. Requires Mg2+ [1].

History

EC 2.5.1.82 created 1984 as EC 2.5.1.33, part transferred 2010 to EC 2.5.1.82

Pathway

ec00900

Terpenoid backbone biosynthesis

ec01110

Biosynthesis of secondary metabolites

Orthology

K05355

hexaprenyl diphosphate synthase

K21268

hexaprenyl diphosphate synthase

Genes

CME:	CYME_CMJ246C

SCE:	YBR003W(COQ1)

SEUB:

DI49_0184

SPAO:

SPAR_B01070

AGO:	AGOS_AER004W

ERC:

Ecym_5300

KLA:	KLLA0_E17183g

KMX:	KLMA_60114(COQ1)

LTH:	KLTH0G16368g

VPO:	Kpol_1036p41

ZRO:	ZYRO0A04620g

CGR:	2886824(GVI51_C04037)

NCS:	NCAS_0I01970(NCAS0I01970)

NDI:	NDAI_0A06570(NDAI0A06570)

TPF:	TPHA_0A04460(TPHA0A04460)

TBL:	TBLA_0F00560(TBLA0F00560)

TGB:	HG536_0G03050

TDL:	TDEL_0D04200(TDEL0D04200)

KAF:	KAFR_0F02550(KAFR0F02550)

KNG:	KNAG_0J01180(KNAG0J01180)

ZMK:	HG535_0C02340

SLUD:

SCDLUD_002533

DHA:	DEHA2B02640g

PIC:	PICST_86778(COQ1)

PGU:	PGUG_02562

SPAA:

SPAPADRAFT_59987

LEL:	PVL30_000484(COQ1)

LBG:	92205789(LODBEIA_P05930)

CAL:	CAALFM_CR00570WA(CaO19.7478)

CTP:	CTRG_01016

COT:	CORT_0A03790

CDU:	CD36_25670

CTEN:

18246326(COQ1)

CLU:	CLUG_04350

CLUS:

A9F13_04g01595

CAUR:

CJI96_0003402

ASAU:

88172993(PUMCH_001928)

PPA:	PAS_chr4_0819

PKZ:	C5L36_0D01990

BNN:	FOA43_001379

BBRX:

BRETT_002538

OPA:	HPODL_03901

YLI:	2909963(YALI2_B00439g)

SLB:	AWJ20_394(COQ1)

NCR:

NCU02305

NTE:	NEUTE1DRAFT124027(NEUTE1DRAFT_124027)

SMP:	10801768(SMAC4_08723)

PAN:	PODANSg1807

PBEL:

QC761_509670(COQ1)

PPSD:

QC762_509670(COQ1)

PPSP:

QC763_509670(COQ1)

PPSA:

QC764_509670(COQ1)

TTT:	THITE_2117141

MTM:	MYCTH_2308814

CTHR:

CTHT_0016730

RTHE:

98124138(VTJ83DRAFT_3148)

MGR:

MGG_03343

PPEI:

PpBr36_06486

PGRI:

PgNI_00709

SSCK:

SPSK_04068

FGR:	FGSG_10933

FPU:	FPSE_06046

FPOA:

FPOAC1_009679

FVN:	FVRRES_10316

FVR:	FVEG_11617

FOX:	FOXG_12870

NHE:	NECHADRAFT_93238

FFC:	NCS54_00645700

FKR:	NCS57_00686000

FMU:	J7337_010022

TRE:	TRIREDRAFT_68728

TRR:	M419DRAFT_38563

TATV:

25779678(TrAtP1_008741)

TASP:

36617842(TrAFT101_002694)

MAJ:

MAA_03330

MBRN:

26246070(G6M90_00g085240)

PCHM:

VFPPC_04198

CMT:

CCM_00496

AMUS:

LMH87_000769

PLJ:	28884193(PLICBS_005461)

PTKZ:

JDV02_003904(COQ1)

VAL:	VDBG_03289

VDA:	VDAG_02194

CFJ:	CFIO01_07326

CLUP:

CLUP02_12999

CHIG:

CH63R_12248

CDET:

87947006(CDEST_10504)

SAPO:

SAPIO_CDS3842

ELA:	UCREL1_11765

PFY:	PFICI_14449

SSL:	SS1G_11088

BFU:	BCIN_02g05540(Bccoq1)

MBE:

MBM_07123

PSCO:

LY89DRAFT_649566

GLZ:	GLAREA_07665

ANI:	ANIA_10340

AFM:	AFUA_3G06120

ACT:	ACLA_034080

NFI:	NFIA_071130

AOR:	AO090020000085

ANG:	An11g10370

AFV:	AFLA_010570

ALUC:

AKAW2_80893A(COQ1)

ACHE:

ACHE_70473A(COQ1)

APUU:

APUU_31174S(COQ1)

PCS:	N7525_009212

PDP:	PDIP_00870

POU:	POX_g09019

TMF:	EYB26_009001

TRG:	TRUGW13939_11219

CIM:	CIMG_00484

CPW:	9691985(COQ1)

URE:	UREG_00522

ABE:

ARB_07252

TVE:

TRV_03960

PBL:	PAAG_05961

AJE:	HCAG_01245

BGH:	BDBG_06739

PNO:	SNOG_03045

PTE:

PTT_13690

PTRR:

6338962(PtrM4_028830)

BZE:	COCCADRAFT_107085

BSC:	COCSADRAFT_169302

BOR:	COCMIDRAFT_22591

AALT:

CC77DRAFT_951220

ADAC:

96087831(ACET3X_007509)

ARAB:

EKO05_0000542

ZTR:	MYCGRDRAFT_73426(COQ1)

PFJ:	MYCFIDRAFT_72669

FFU:	CLAFUR5_09538

CBET:

CB0940_10267

BCOM:

BAUCODRAFT_34812

NPA:	UCRNP2_7312

TML:	GSTUM_00003780001

SPO:	2541402(dps1)

SOM:	SOMG_02290(dps1)

CNE:

CNI01740

CNB:

CNBH1650

CNG:	CNAG_04375

CGI:	CGB_H2490W

CDEU:

CNBG_2676

CDEP:

91090354(L203_106146)

KMG:	30163645(I203_102858)

KNE:	92182342(IAR55_005084)

TMS:	TREMEDRAFT_15595

CCAC:

CcaHIS019_0305350(COQ1)

PPL:	POSPLDRAFT_90841

TVS:	TRAVEDRAFT_157916

DSQ:	DICSQDRAFT_173926 DICSQDRAFT_176811

PCO:	PHACADRAFT_168921

SHS:	STEHIDRAFT_71092

HIR:	HETIRDRAFT_308186

PSQ:	PUNSTDRAFT_25993

ADL:	AURDEDRAFT_110102

FME:	FOMMEDRAFT_136957

GTR:	GLOTRDRAFT_67486

LBC:	LACBIDRAFT_251291 LACBIDRAFT_335947

CCI:	CC1G_00492 CC1G_05865

ABP:	AGABI1DRAFT117445(AGABI1DRAFT_117445) AGABI1DRAFT121951(AGABI1DRAFT_121951)

ABV:	AGABI2DRAFT123328(AGABI2DRAFT_123328) AGABI2DRAFT214023(AGABI2DRAFT_214023)

PCUB:

JR316_0011391

MPR:	MPER_08383

MRR:	Moror_7207 Moror_8053

E1B28_001638 E1B28_004206

SCM:	SCHCO_02488796(SCHCODRAFT_02488796) SCHCO_02492233(SCHCODRAFT_02492233) SCHCO_02641733(SCHCODRAFT_02641733) SCHCO_02697952(SCHCODRAFT_02697952)

CPUT:

CONPUDRAFT_116134

SLA:	SERLADRAFT_444711

WSE:	WALSEDRAFT_59360

WIC:	J056_004047

UMA:	UMAG_11674

PFP:	PFL1_02050

SGRA:

EX895_004282

MGL:

MGL_1241

MRT:

MRET_2902

MSYM:

MSY001_0654

PGR:	PGTG_00683

PTRC:

PtA15_13A363 PtA15_1A555 PtA15_1A569

PSTR:

Pst134EA_000298 Pst134EA_000303

MLR:	MELLADRAFT_102532

RIE:	OCT59_000539

DFA:	DFA_03641(coq1)

PYO:	PY17X_0301300

PCB:	PCHAS_0303000

PBE:	PBANKA_0300800

PKN:	PKNH_0418400

PVX:	PVX_003575

PCY:	PCYB_042740

FCY:	FRACYDRAFT_275453

PSOJ:

PHYSODRAFT_336262

STO:

STK_04870

SOH:	D1869_02255

SJV:	SJAV_14940(gdS-2)

SSO:	SSO2345(gdS-2)

SOL:

Ssol_0157

SSOA:

SULA_0149

SSOL:

SULB_0150

SSOF:

SULC_0149

SSHI:

J5U23_01140

SCAS:

SACC_19450

SIS:	LS215_0173

SIA:	M1425_0142

SIM:	M1627_0142

SID:

M164_0161

SIY:	YG5714_0146

SIN:	YN1551_2745

SII:

LD85_0146

SIH:

SiH_0146

SIR:

SiRe_0142

SIC:

SiL_0133

SULA:

BFU36_10510

SULE:

GFS03_02260

SAI:

Saci_0995

SACN:

SacN8_04825

SACR:

SacRon12I_04815

SACS:

SUSAZ_04575

SULO:

GFS33_08965

SULL:

EWF20_03780

MSE:

Msed_0691

MEMJ:

MJ1HA_0801

MCN:

Mcup_1409

MHK:	DFR87_03200

MPRU:

DFR88_03125

MTEN:

GWK48_08915

MJN:	MjAS7_1457

AHO:

Ahos_2145

AMAN:

B6F84_03375

ABRI:

DFR85_06020

ASUL:

DFR86_03380

AAMB:

D1866_05705

ACIH:

HS5_09560

SAZO:

D1868_10440

CSTY:

KN1_02790

STEP:

IC006_2729

SMET:

RQ359_001711(gdS-2)

SAHS:

HS7_16810

» show all

Reference

1 [PMID:11790729]

Authors

Hemmi H, Ikejiri S, Yamashita S, Nishino T

Title

Novel medium-chain prenyl diphosphate synthase from the thermoacidophilic archaeon Sulfolobus solfataricus.

Journal

J Bacteriol 184:615-20 (2002)
DOI:10.1128/JB.184.3.615-620.2002

Sequence

[sso:SSO2345]

Reference

2 [PMID:12372398]

Authors

Hemmi H, Noike M, Nakayama T, Nishino T

Title

Change of product specificity of hexaprenyl diphosphate synthase from Sulfolobus solfataricus by introducing mimetic mutations.

Journal

Biochem Biophys Res Commun 297:1096-101 (2002)
DOI:10.1016/S0006-291X(02)02348-3

Reference

3 [PMID:16291686]

Authors

Sun HY, Ko TP, Kuo CJ, Guo RT, Chou CC, Liang PH, Wang AH

Title

Homodimeric hexaprenyl pyrophosphate synthase from the thermoacidophilic crenarchaeon Sulfolobus solfataricus displays asymmetric subunit structures.

Journal

J Bacteriol 187:8137-48 (2005)
DOI:10.1128/JB.187.23.8137-8148.2005

Sequence

[sso:SSO2345]

Other DBs

ExplorEnz - The Enzyme Database:

2.5.1.82

IUBMB Enzyme Nomenclature:

2.5.1.82

ExPASy - ENZYME nomenclature database:

2.5.1.82

BRENDA, the Enzyme Database:

2.5.1.82

LinkDB

DBGET integrated database retrieval system