Entry
Name
all-trans-octaprenyl-diphosphate synthase;
octaprenyl-diphosphate synthase;
octaprenyl pyrophosphate synthetase;
polyprenylpyrophosphate synthetase;
terpenoidallyltransferase;
terpenyl pyrophosphate synthetase;
trans-heptaprenyltranstransferase;
trans-prenyltransferase
Class
Transferases;
Transferring alkyl or aryl groups, other than methyl groups;
Transferring alkyl or aryl groups, other than methyl groups (only sub-subclass identified to date)
BRITE hierarchy
Sysname
(2E,6E)-farnesyl-diphosphate:isopentenyl-diphosphate farnesyltranstransferase (adding 5 isopentenyl units)
Reaction(IUBMB)
(2E,6E)-farnesyl diphosphate + 5 isopentenyl diphosphate = 5 diphosphate + all-trans-octaprenyl diphosphate [RN:
R09248 ]
Reaction(KEGG)
Substrate
(2E,6E)-farnesyl diphosphate [CPD:
C00448 ];
isopentenyl diphosphate [CPD:
C00129 ]
Product
diphosphate [CPD:
C00013 ];
all-trans-octaprenyl diphosphate [CPD:
C04146 ]
Comment
This enzyme catalyses the condensation reactions resulting in the formation of all-trans-octaprenyl diphosphate, the isoprenoid side chain of ubiquinone-8 and menaquinone-8. The enzyme adds five isopentenyl diphosphate molecules sequentially to farnesyl diphosphate with trans stereochemistry
History
EC 2.5.1.90 created 2010
Pathway
ec00900 Terpenoid backbone biosynthesis
ec01110 Biosynthesis of secondary metabolites
Orthology
K02523 octaprenyl-diphosphate synthase
Genes
ECOO : ECRM13514_4146(ispB)
ECOH : ECRM13516_3950(ispB)
ECW : EcE24377A_3673(ispB)
EDJ : ECDH1ME8569_3076(ispB)
ECOI : ECOPMV1_03498(ispB)
REE : electrica_00496(ispB)
RTG : NCTC13098_00684(ispB)
CLAP : NCTC11466_00346(ispB)
KIE : NCTC12125_04436(ispB)
AHN : NCTC12129_04358(ispB_2)
PTF : PROFFT_A_00410(ispB)
PSHI : SAMEA2665130_2687(ispB)
MPHG : MPHASIOC01_003689(ispB)
YPG : YpAngola_A3973(ispB)
YPI : YpsIP31758_3613(ispB)
SMW : SMWW4_v1c04140(ispB)
SFJ : SAMEA4384070_0491(ispB)
SOF : NCTC11214_01131(ispB)
SSAR : SSARUM_000367(ispB)
PAQU : DMB82_0003460(ispB)
PARL : PEC302110_05960(ispB)
DIC : Dpoa569_0003370(ispB)
EHD : ERCIPSTX3056_156(ispB)
TPTY : NCTC11468_00294(ispB)
PHEI : NCTC12003_03637(ispB)
PRJ : NCTC6933_03648(ispB)
LRI : NCTC12151_03065(ispB)
HIC : NTHIC486_00101(ispB)
HPIT : NCTC13334_00152(ispB)
HHZ : NCTC10839_00799(ispB)
HAEG : NCTC8502_00123(ispB)
PDAG : 4362423_00214(ispB)
ADP : NCTC12871_01015(ispB)
ALIG : NCTC10568_02391(ispB)
ASEG : NCTC10977_01896(ispB)
AVT : NCTC3438_01883(ispB)
RPNE : NCTC8284_00914(ispB)
PAET : NCTC13378_01461(ispB)
XFU : XFF4834R_chr17330(ispB)
XPH : XppCFBP6546_21380(XppCFBP6546P_21380)
LLZ : LYB30171_00862(ispB)
VAU : VANGNB10_cI0310c(ispB)
VPL : SA104470976_02277(ispB)
PAEB : NCGM1900_2407(ispB)
PVD : CFBP1590__1008(ispB)
PPRC : PFLCHA0_c53040(ispB)
PMUD : NCTC8068_04542(ispB)
PPUU : PputUW4_04677(ispB)
PTW : TUM18999_11660(ispB)
PTAE : NCTC10697_00743(ispB)
PSIV : LZ023_08775 LZ023_08795
MSHE : MAALD49_08380(ispB)
PSYC : DABAL43B_2061(ispB)
ACUM : C9E88_015910 C9E88_17075
MCAT : MC25239_01134(ispB)
MCUN : NCTC10297_01597(ispB)
SCAA : TUM17387_09150(ispB)
SALH : HMF8227_00439(ispB)
AFUS : EYZ66_02070 EYZ66_11065
LLO : LLO_2666(ispB) LLO_3345(ispB-2)
LHA : LHA_0618(ispB) LHA_1132
LSH : CAB17_00060 CAB17_03540
LLG : 44548918_00501(ispB)
LJR : NCTC11533_00558(ispB)
LCJ : NCTC11976_03222(ispB)
LWA : SAMEA4504053_3153(ispB)
LSS : NCTC12082_02702(ispB)
LADL : NCTC12735_00822(ispB-2)
TIB : THMIRHAM_03990(ispB)
TSE : THMIRHAS_21930(ispB)
TZO : THMIRHAT_03780(ispB)
RHEI : ATY27_06600 ATY27_18260
TFRI : Thiofri_01180(ispB)
TNI : TVNIR_0159(ispB_[H])
SHAI : LMH63_04410 LMH63_11075
GAI : IMCC3135_01695(ispB)
HAAH : HALA3H3_320031(ispB)
HAA : A5892_12640 A5892_19190
KUY : FY550_10195 FY550_13775(ispB)
ALCA : ASALC70_01418(ispB)
AEL : NCTC12917_03428(ispB)
CHJ : NCTC10426_00357(ispB)
CDIZ : CEDIAZO_00742(ispB)
NMQ : NMBM04240196_0334(ispB)
NMZ : NMBNZ0533_1919(ispB)
NMX : NMA510612_2451(ispB)
NWE : SAMEA3174300_2003(ispB)
NZO : SAMEA4504057_2266(ispB)
NCI : NCTC10296_00224(ispB)
NCZ : NCTC10294_00039(ispB)
NANI : NCTC12227_00302(ispB)
ECOR : SAMEA4412678_0171(ispB)
BMV : BMASAVP1_A0447(ispB)
BML : BMA10229_A1306(ispB)
BPM : BURPS1710b_3524(ispB)
BPL : BURPS1106A_3527(ispB)
PARB : CJU94_07720 CJU94_40095
POLT : TUM22923_01890(ispB)
PLG : NCTC10937_00934(ispB)
LMIR : NCTC12852_00875(ispB)
BUO : BRPE64_ACDS23970(ispB)
BTRM : SAMEA390648701498(cel)
AXX : ERS451415_05825(ispB)
LIM : L103DPR2_00779(ispB)
LIH : L63ED372_02553(ispB)
HPSE : HPF_12290(ispB1) HPF_19515(ispB2)
KIA : G8A07_06220(ispB) G8A07_25480
SMIO : CATMQ487_47840(ispB)
URU : DSM104443_03227(ispB)
UPL : DSM104440_02777(ispB)
DDEN : KI615_18915(ispB) KI615_20125
AZI : AzCIB_3320 AzCIB_4440
AZD : CDA09_03075 CDA09_21570
TMZ : Tmz1t_0074 Tmz1t_1651
THAG : CKCBHOJB_00016(ispB_1) CKCBHOJB_02648(ispB_2)
FPHO : SHINM1_016850(ispB)
WELO : NMD99_00095 NMD99_07890
ERW : ERWE_CDS_00510(ispB)
ERG : ERGA_CDS_00500(ispB)
RBS : RHODOSMS8_00263(ispB)
SMEL : SM2011_c00860(ispB)
SFD : USDA257_c05560(ispB)
SAME : SAMCFNEI73_Ch0883(ispB)
AGR : AGROH133_04119(ispB)
AVV : RvVAT039_23090(ispB)
AVF : RvVAR031_10390(ispB)
REC : RHECIAT_CH0000965(ispB)
REL : REMIM1_CH00889(ispB)
REP : IE4803_CH00887(ispB)
REI : IE4771_CH00915(ispB)
RGA : RGR602_CH00936(ispB)
RPHA : AMC79_CH00903(ispB)
NEN : NCHU2750_04360(ispB)
LAS : CLIBASIA_03210(ispB)
VGO : GJW-30_1_01585(ispB)
BHS : BM1374165_00397(ispB)
BTX : BM1374166_00590(ispB)
BEZ : NCTC12898_00271(ispB)
MAQU : Maq22A_1p34300(ispA)
MTUN : MTUNDRAET4_0705(ispB)
FIL : BN1229_v1_3915(ispB)
FIY : BN1229_v1_3903(ispB)
BVY : NCTC9239_01820(ispB)
TSV : DSM104635_02653(ispB)
RLI : RLO149_c027570(ispB)
PHP : PhaeoP97_03024(ispB)
PPIC : PhaeoP14_00253(ispB)
SINL : DSM14862_00644(ispB)
SPSE : SULPSESMR1_02445(ispB)
RMM : ROSMUCSMR3_01867(ispB)
AHT : ANTHELSMS3_00460(ispB)
LALG : LentiSH36_01919(ispB)
LVS : LOKVESSMR4R_02960(ispB)
SPHK : SKP52_01130 SKP52_07140(ispB)
SBD : ATN00_07540 ATN00_09560
SPAG : sphantq_01034(ispB)
SFLA : SPHFLASMR4Y_01358(ispB)
PMAS : NCF86_06440 NCF86_15445(ispB)
APB : SAR116_2127 SAR116_2270
SNEA : NBZ79_07225 NBZ79_07265
HCL : NCTC13205_00193(ispB)
HSH : NHP194022_13340(ispB)
HPUL : NCTC13154_01418(ispB)
HFI : NHP21005_02060(ispB)
HGA : NHP190012_03540(ispB)
HGS : NHP190003_10220(ispB)
CJV : MTVDSCj20_0558(ispB)
CFV : CFVI03293_0655(ispB)
CAMP : CFT03427_0678(ispB)
CCOC : CCON33237_0795(ispB)
CLR : UPTC16701_0785(ispB)
CLM : UPTC16712_0789(ispB)
CAMR : CAQ16704_0769(ispB)
CHV : CHELV3228_1462(ispB)
CPIN : CPIN18020_0469(ispB)
CAMZ : CVIC12175_0977(ispB)
GBN : GEOBRER4_33460(ispB)
PPOR : JCM14722_13690(ispB)
SAQI : AXG55_09140 AXG55_14330
OBG : Verru16b_01691(hepT)
RML : FF011L_15200(sdsA_1)
MFF : MFFC18_14240(ispB_1)
RCF : Poly24_46770(ispB_1)
LCRE : Pla8534_42610(ispB)
HBS : IPV69_20700 IPV69_20720
BAFH : BafHLJ01_0342(ispB)
LKB : LPTSP3_g29300(ispA_2)
BTHO : Btheta7330_05041(sdsA)
BCEL : BcellWH2_02681(sdsA)
PCRE : NCTC12858_00438(ispB)
PCAG : NCTC12856_01403(ispB)
POC : NCTC13071_00515(ispB)
CSAC : SIO70_13890 SIO70_31795
SMIZ : 4412673_00446(ispB)
SDJ : NCTC13534_00452(hepT)
STHA : NCTC11429_00906(hepT_1)
PSEZ : HME7025_02009(ispB)
PHG : KCTC32516_01148(sdsA)
AALG : AREALGSMS7_02484(sdsA)
AANR : KCTC52924_00454(sdsA)
KOS : KORDIASMS9_02005(sdsA)
KAN : IMCC3317_37770(sdsA)
SPON : HME9304_02282(ispB)
CGLE : NCTC11432_01790(hepT)
CTAI : NCTC12078_00837(ispB)
CTAK : 4412677_00206(hepT)
CJG : NCTC13459_00564(hepT)
CANT : NCTC13489_00659(ispB_1)
PROC : Ptc2401_01219(ispB_2)
TVO : TVG1113858(TVG1113858)
» show all
Taxonomy
Reference
Authors
Fujisaki S, Nishino T, Katsuki H
Title
Isoprenoid synthesis in Escherichia coli. Separation and partial purification of four enzymes involved in the synthesis.
Journal
Reference
Authors
Asai K, Fujisaki S, Nishimura Y, Nishino T, Okada K, Nakagawa T, Kawamukai M, Matsuda H
Title
The identification of Escherichia coli ispB (cel) gene encoding the octaprenyl diphosphate synthase.
Journal
Sequence
Other DBs
ExplorEnz - The Enzyme Database: 2.5.1.90
ExPASy - ENZYME nomenclature database: 2.5.1.90
LinkDB
All DBs