KEGG ENZYME: 2.6.1.33

ENZYME: 2.6.1.33

Entry

EC 2.6.1.33                 Enzyme

Name

dTDP-4-amino-4,6-dideoxy-D-glucose transaminase;
thymidine diphospho-4-amino-4,6-dideoxyglucose aminotransferase;
thymidine diphospho-4-amino-6-deoxyglucose aminotransferase;
thymidine diphospho-4-keto-6-deoxy-D-glucose transaminase;
thymidine diphospho-4-keto-6-deoxy-D-glucose-glutamic transaminase;
TDP-4-keto-6-deoxy-D-glucose transaminase;
VioA;
dTDP-4-amino-4,6-dideoxy-D-glucose:2-oxoglutarate aminotransferase

Class

Transferases;
Transferring nitrogenous groups;
Transaminases

Sysname

dTDP-4-amino-4,6-dideoxy-alpha-D-glucose:2-oxoglutarate aminotransferase

Reaction(IUBMB)

dTDP-4-amino-4,6-dideoxy-alpha-D-glucose + 2-oxoglutarate = dTDP-4-dehydro-6-deoxy-alpha-D-glucose + L-glutamate [RN:R02773]

Reaction(KEGG)

R02773;
(other) R02772

Substrate

dTDP-4-amino-4,6-dideoxy-alpha-D-glucose [CPD:C04268];
2-oxoglutarate [CPD:C00026]

Product

dTDP-4-dehydro-6-deoxy-alpha-D-glucose [CPD:C11907];
L-glutamate [CPD:C00025]

Comment

A pyridoxal-phosphate protein.

History

EC 2.6.1.33 created 1972

Pathway

ec00523

Polyketide sugar unit biosynthesis

ec00525

Acarbose and validamycin biosynthesis

ec00541

Biosynthesis of various nucleotide sugars

ec01100

Metabolic pathways

ec01110

Biosynthesis of secondary metabolites

Orthology

K13308

dTDP-4-amino-4,6-dideoxy-D-glucose transaminase

K20428

dTDP-4-amino-4,6-dideoxy-D-glucose transaminase

K20429

dTDP-4-amino-4,6-dideoxy-D-glucose transaminase

K21328

dTDP-4-amino-4,6-dideoxy-D-glucose/dTDP-4-amino-2,4-dideoxy-beta-L-xylose transaminase

Genes

ECT:	ECIAI39_0979(vioA)

EOC:	CE10_2353(vioA)

EBR:	ECB_01942(vioA)

ECOB:

C3029_14350

EBL:	ECD_01942(vioA)

EBE:	B21_01931(ybl97)

EBD:

ECBD_1619

SHQ:	A0259_14015

ESH:	C1N69_14925

PDZ:	HHA33_11055

EBB:

F652_1773

PAY:	PAU_04327(vioA)

HAV:	AT03_13955

SHE:	Shewmr4_1321

SHW:	Sputw3181_1468

SCHK:

GII14_07745

THAT:

H3N35_23260

TVD:	SG34_025420

PAEW:

KIH87_05075

CJA:

CJA_3257

AHI:	VU14_07300

ASAA:

KXJ75_15915(vioA)

SUR:	STAUR_1378(gacV)

SCYE:

R2B67_24620

SGU:	SGLAU_00985(gacV)

STRE:

GZL_03714

SXI:	SXIM_35940

STRM:

M444_29855

SCAD:

DN051_13755

SNR:	SNOUR_10120(eryCIV)

SGF:	HEP81_07915

SGX:	H4W23_25490

SATA:

C5746_38530

SROI:

IAG44_16020

SHK:	J2N69_01045

SGK:	PET44_28275

SYUN:

MOV08_16445

SCAT:

P8A18_33700

STRH:

GXP74_26620

AER:	AERYTH_15840

ACIR:

OG979_40450

SEN:	SACE_0716(eryCIV)

AMOG:

QRX60_49190

KAL:	KALB_4714 KALB_6578(acuN2)

STP:	Strop_2221

SAQ:	Sare_2034 Sare_2945

MCAB:

HXZ27_06180(rosQ)

ASE:	ACPL_3667(acbV)

AEY:	CDG81_13210

MOX:

DAMO_2610

» show all

Reference

1 [PMID:5332731]

Authors

Matsuhashi M, Strominger JL.

Title

Thymidine diphosphate 4-acetamido-2,6-dideoxyhexoses. 3. Purification and properties of thymidine diphosphate 4-keto-6-deoxy-D-glucose transaminase from Escherichia coli strain B.

Journal

J Biol Chem 241:4738-44 (1966)

Reference

2 [PMID:17905981]

Authors

Wang Y, Xu Y, Perepelov AV, Qi Y, Knirel YA, Wang L, Feng L

Title

Biochemical characterization of dTDP-D-Qui4N and dTDP-D-Qui4NAc biosynthetic pathways in Shigella dysenteriae type 7 and Escherichia coli O7.

Journal

J Bacteriol 189:8626-35 (2007)
DOI:10.1128/JB.00777-07

Sequence

[ag:AAD44154 AAR97958]