KEGG   ENZYME: 2.6.1.58
Entry
EC 2.6.1.58                 Enzyme                                 
Name
phenylalanine(histidine) transaminase;
phenylalanine (histidine) aminotransferase;
phenylalanine(histidine):pyruvate aminotransferase;
histidine:pyruvate aminotransferase;
L-phenylalanine(L-histidine):pyruvate aminotransferase
Class
Transferases;
Transferring nitrogenous groups;
Transaminases
Sysname
L-phenylalanine:pyruvate aminotransferase
Reaction(IUBMB)
L-phenylalanine + pyruvate = phenylpyruvate + L-alanine [RN:R00692]
Reaction(KEGG)
R00692;
(other) R09254
Substrate
L-phenylalanine [CPD:C00079];
pyruvate [CPD:C00022]
Product
phenylpyruvate [CPD:C00166];
L-alanine [CPD:C00041]
Comment
L-Histidine and L-tyrosine can act instead of L-phenylalanine; in the reverse reaction, L-methionine, L-serine and L-glutamine can replace L-alanine.
History
EC 2.6.1.58 created 1978
Pathway
ec00350  Tyrosine metabolism
ec00360  Phenylalanine metabolism
ec00400  Phenylalanine, tyrosine and tryptophan biosynthesis
ec00960  Tropane, piperidine and pyridine alkaloid biosynthesis
ec01100  Metabolic pathways
ec01110  Biosynthesis of secondary metabolites
Orthology
K05821  aromatic amino acid aminotransferase II
Genes
SCE: YHR137W(ARO9)
SPAO: SPAR_H01780
KLA: KLLA0_D11110g
KMX: KLMA_60423(ARO9)
LTH: KLTH0B06270g
VPO: Kpol_1035p30
ZRO: ZYRO0G05346g
CGR: 2888295(ARO9)
NCS: NCAS_0B07220(NCAS0B07220)
NDI: NDAI_0B04550(NDAI0B04550)
TPF: TPHA_0O01520(TPHA0O01520)
TBL: TBLA_0B00990(TBLA0B00990)
TGB: HG536_0G04140
TDL: TDEL_0F00900(TDEL0F00900)
KNG: KNAG_0H03730(KNAG0H03730)
ZMK: HG535_0G00510
PIC: PICST_34099(ARO9.1)
PGU: PGUG_05380
LEL: PVL30_004402(ARO9)
LBG: 92209203(LODBEIA_P40070)
CAL: CAALFM_C405560CA(ARO9)
CTP: CTRG_03861
COT: CORT_0B00660
CDU: CD36_45160
CTEN: 90982291(ARO9)
CLU: CLUG_04493
CLUS: A9F13_25g00781
CAUR: CJI96_0001756
PPA: PAS_chr1-3_0154 PAS_chr4_0147
PKZ: C5L36_0E05810 C5L36_0E05820
BNN: FOA43_004514
BBRX: BRETT_003466
OPA: HPODL_02093
YLI: 2909373(YALI2_C01099g)
 » show all
Reference
1  [PMID:14070]
  Authors
Minatogawa Y, Noguchi T, Kido R.
  Title
Species distribution and properties of hepatic phenylalanine (histidine):pyruvate aminotransferase.
  Journal
Hoppe Seylers Z Physiol Chem 358:59-67 (1977)
DOI:10.1515/bchm2.1977.358.1.59
Other DBs
ExplorEnz - The Enzyme Database: 2.6.1.58
IUBMB Enzyme Nomenclature: 2.6.1.58
ExPASy - ENZYME nomenclature database: 2.6.1.58
BRENDA, the Enzyme Database: 2.6.1.58
CAS: 72560-98-6
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