KEGG   ENZYME: 2.6.1.89
Entry
EC 2.6.1.89                 Enzyme                                 
Name
dTDP-3-amino-3,6-dideoxy-alpha-D-glucopyranose transaminase;
TylB;
TDP-3-keto-6-deoxy-D-glucose 3-aminotransferase;
TDP-3-dehydro-6-deoxy-D-glucose 3-aminotransferase;
dTDP-3-keto-6-deoxy-D-glucose 3-aminotransferase;
dTDP-3-dehydro-6-deoxy-D-glucose 3-aminotransferase
Class
Transferases;
Transferring nitrogenous groups;
Transaminases
Sysname
dTDP-3-amino-3,6-dideoxy-alpha-D-glucopyranose:2-oxoglutarate aminotransferase
Reaction(IUBMB)
dTDP-3-amino-3,6-dideoxy-alpha-D-glucopyranose + 2-oxoglutarate = dTDP-3-dehydro-6-deoxy-alpha-D-glucopyranose + L-glutamate [RN:R06423]
Reaction(KEGG)
R06423
Substrate
dTDP-3-amino-3,6-dideoxy-alpha-D-glucopyranose;
2-oxoglutarate [CPD:C00026]
Product
dTDP-3-dehydro-6-deoxy-alpha-D-glucopyranose [CPD:C11908];
L-glutamate [CPD:C00025]
Comment
A pyridoxal-phosphate protein. The reaction occurs in the reverse direction. The enzyme is involved in biosynthesis of D-mycaminose.
History
EC 2.6.1.89 created 2011
Pathway
ec00523  Polyketide sugar unit biosynthesis
ec00541  Biosynthesis of various nucleotide sugars
ec01100  Metabolic pathways
ec01110  Biosynthesis of secondary metabolites
Orthology
K19854  dTDP-3-amino-3,6-dideoxy-alpha-D-glucopyranose transaminase
K24250  dTDP-3-amino-3,6-dideoxy-alpha-D-glucopyranose transaminase
Genes
SAMB: SAM23877_5622(srm15)
SALJ: SMD11_1659
SCAE: IHE65_08875
SCAT: P8A18_33710
Reference
1  [PMID:17209568]
  Authors
Melancon CE 3rd, Hong L, White JA, Liu YN, Liu HW
  Title
Characterization of TDP-4-keto-6-deoxy-D-glucose-3,4-ketoisomerase from the D-mycaminose biosynthetic pathway of Streptomyces fradiae: in vitro activity and substrate specificity studies.
  Journal
Biochemistry 46:577-90 (2007)
DOI:10.1021/bi061907y
Other DBs
ExplorEnz - The Enzyme Database: 2.6.1.89
IUBMB Enzyme Nomenclature: 2.6.1.89
ExPASy - ENZYME nomenclature database: 2.6.1.89
BRENDA, the Enzyme Database: 2.6.1.89
LinkDB

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