KEGG ENZYME: 2.7.11.15

ENZYME: 2.7.11.15

Entry

EC 2.7.11.15                Enzyme

Name

beta-adrenergic-receptor kinase;
ATP:beta-adrenergic-receptor phosphotransferase;
[beta-adrenergic-receptor] kinase;
beta-adrenergic receptor-specific kinase;
beta-AR kinase;
beta-ARK;
beta-ARK 1;
beta-ARK 2;
beta-receptor kinase;
GRK2;
GRK3;
beta-adrenergic-receptor kinase (phosphorylating);
beta2ARK;
betaARK1;
beta-adrenoceptor kinase;
beta-adrenoceptor kinase 1;
beta-adrenoceptor kinase 2;
ADRBK1;
BARK1;
adrenergic receptor kinase;
STK15

Class

Transferases;
Transferring phosphorus-containing groups;
Protein-serine/threonine kinases

Sysname

ATP:[beta-adrenergic receptor] phosphotransferase

Reaction(IUBMB)

ATP + [beta-adrenergic receptor] = ADP + phospho-[beta-adrenergic receptor] [RN:R03274]

Reaction(KEGG)

R03274

Substrate

ATP [CPD:C00002];
[beta-adrenergic receptor] [CPD:C01141]

Product

ADP [CPD:C00008];
phospho-beta-adrenergic receptor [CPD:C04141]

Comment

Requires G-protein for activation and therefore belongs to the family of G-protein-dependent receptor kinases (GRKs). Acts on the agonist-occupied form of the receptor; also phosphorylates rhodopsin, but more slowly. Does not act on casein or histones. The enzyme is inhibited by Zn2+ and digitonin but is unaffected by cyclic-AMP (cf. EC 2.7.11.14, rhodopsin kinase and EC 2.7.11.16, G-protein-coupled receptor kinase).

History

EC 2.7.11.15 created 1989 as EC 2.7.1.126, transferred 2005 to EC 2.7.11.15

Orthology

K00910

beta-adrenergic-receptor kinase

Genes

HSA:	156(GRK2) 157(GRK3)

PTR:	100614029(GRK3) 451363(GRK2)

PPS:	100984800(GRK3) 100991802(GRK2)

GGO:	101140574(GRK2) 101148325(GRK3)

PON:	100454669(GRK3) 100461893(GRK2)

PPYG:

129007336(GRK2) 129023109(GRK3)

NLE:	100582671(GRK3) 100604826(GRK2)

HMH:	116459253(GRK3) 116469070(GRK2)

SSYN:

129468548(GRK3) 129475997(GRK2)

MCC:	714510(GRK3) 721754(GRK2)

MCF:	102141861(GRK2) 102141926(GRK3)

MTHB:

126929499 126935345

MNI:	105469669(GRK2) 105495703(GRK3)

CSAB:

103219132(GRK2) 103223079(GRK3)

CATY:

105575649(ADRBK2) 105577363(ADRBK1)

PANU:

101003424(GRK3) 101017434(GRK2)

TGE:	112606411(GRK2) 112633452(GRK3)

MLEU:

105536092(ADRBK2) 105544458(ADRBK1)

RRO:	104664749(GRK2) 104671949(GRK3)

RBB:	108515962(GRK3) 108518610(GRK2)

TFN:	117080248(GRK2) 117096104(GRK3)

PTEH:

111522233(GRK2) 111525328(GRK3)

CANG:

105506642(ADRBK2) 105512098(ADRBK1)

CJC:	100396838(GRK3) 118145540(GRK2)

SBQ:	101027803(ADRBK2) 101049133(ADRBK1)

CIMI:

108282277(GRK3) 108310356(GRK2)

ANAN:

105717604(GRK2) 105725760(GRK3)

CSYR:

103258733(GRK2) 103265957(GRK3)

MMUR:

105866915(GRK3) 105867521(GRK2)

LCAT:

123625781(GRK3) 123642864(GRK2)

PCOQ:

105810179(ADRBK2) 105827405(ADRBK1)

OGA:	100943694(GRK2) 100966357(GRK3)

MMU:	110355(Grk2) 320129(Grk3)

MCAL:

110285277(Grk2) 110295078(Grk3)

MPAH:

110312827(Grk2) 110312920(Grk3)

RNO:	25238(Grk2) 25372(Grk3)

MCOC:

116068187(Grk3) 116103332(Grk2)

ANU:	117698386(Grk3) 117715177(Grk2)

ASYL:

127673324(Grk3) 127692842(Grk2)

MUN:	110554001(Grk3) 110560356(Grk2)

CGE:	100761290 100762552(Grk2)

MAUA:

101825875(Grk2) 101842273(Grk3)

PROB:

127215942(Grk3) 127228646(Grk2)

PLEU:

114684308(Grk3) 114685988(Grk2)

MORG:

121446010(Grk3) 121454366(Grk2)

MFOT:

126488006 126498509

AAMP:

119824874(Grk2) 119825427(Grk3)

NGI:	103725575(Grk2) 103746714(Grk3)

HGL:	101708742(Grk3) 101708906(Grk2)

CPOC:

100730505(Grk3) 100732560(Grk2)

CCAN:

109684472 109690706(Grk2) 109701375(Grk3)

DORD:

105984177(Adrbk2) 105989215(Adrbk1)

DSP:	122097920(Grk3) 122104916(Grk2)

PLOP:

125349001(Grk3) 125361351(Grk2)

NCAR:

124960255 124990808

MMMA:

107156995(Grk2)

ITI:	101970775(Grk3) 101973456(Grk2)

OCU:	100349708 103345045

OPI:	101524133(GRK2) 101526829(GRK3)

TUP:	102482004(GRK2) 102499442(GRK3)

GVR:	103589973(ADRBK1) 103599704(ADRBK2)

CFA:	483701(GRK2) 486327(GRK3)

CLUD:

112659363(GRK2) 112676744(GRK3)

VVP:	112923199(GRK3) 112924194(GRK2)

VLG:	121471974(GRK2) 121475364(GRK3)

NPO:	129502957(GRK2) 129507881(GRK3)

AML:	100469854(GRK2) 100475417(GRK3)

UMR:	103659256(GRK3) 103679607(GRK2)

UAH:	113244040(GRK2) 113244983(GRK3)

UAR:	123778398(GRK2) 123788122(GRK3)

ELK:	111149447 111160050

LLV:	125078662 125081722

MPUF:

101676854(ADRBK2) 101690956(ADRBK1)

MNP:	132018006(GRK2) 132023279(GRK3)

MLK:	131811921(GRK3) 131816253(GRK2)

NVS:	122903308(GRK3) 122913175(GRK2)

ORO:	101384757(ADRBK1) 101385645(ADRBK2)

EJU:	114220504(GRK2) 114225191

ZCA:	113912434(GRK3) 113914853(GRK2)

MLX:	118016116(GRK2) 118018603(GRK3)

NSU:	110576028(GRK2) 110592467(GRK3)

LWW:	102734997(GRK2)

FCA:	101090393(GRK3) 101101082(GRK2)

PYU:	121022621(GRK3) 121023660(GRK2)

PCOO:

112851961(GRK2) 112870399(GRK3)

PBG:	122470448(GRK3) 122484042(GRK2)

PVIV:

125146718(GRK2) 125148744(GRK3)

LRUF:

124504590 124518213

LGF:	123588396(GRK3) 123601983(GRK2)

AJU:	106971185 106982294

PTG:	102957039(GRK3) 102970752(GRK2)

PPAD:

109246837(GRK2) 109253514(GRK3)

PUC:	125914928 125930681

PLEZ:

122199448(GRK2) 122204242(GRK3)

HHV:	120227230(GRK3) 120233906(GRK2)

BTA:	282136(GRK3) 282682(GRK2)

BOM:	102286310(GRK2) 102288247(GRK3)

BIU:	109554452(GRK2) 109571286(GRK3)

BBUB:

102408612(GRK2) 102414435(GRK3)

BBIS:

104980103(ADRBK2) 104987070(ADRBK1)

CHX:	102180735(GRK2) 102185296(GRK3)

OAS:	101108265(GRK2) 101117366(GRK3)

BTAX:

128062244(GRK3) 128068499(GRK2)

CSUM:

138082663(GRK2) 138093653(GRK3)

ODA:	120871211(GRK3) 120874764(GRK2)

CCAD:

122421867(GRK3) 122430520(GRK2)

MREE:

136145723(GRK3) 136169787(GRK2)

OVR:	110133664(GRK2) 110137672(GRK3)

MBEZ:

129542379(GRK3) 129548707(GRK2)

SSC:	100156449(GRK3) 100513842(GRK2)

CFR:	102505202(GRK3) 102523137(GRK2)

CBAI:

105066103(ADRBK2) 105070324(ADRBK1)

CDK:	105099520(GRK3) 105104436(GRK2)

VPC:	102536025(GRK3) 102543317(GRK2)

BACU:

103005732(GRK3) 103019615(GRK2)

BMUS:

118880046 118899749(GRK2) 118906941(GRK3)

LVE:	103073421(ADRBK2) 103076247(ADRBK1)

OOR:	101270842(GRK3) 101283682(GRK2)

LALB:

132503926(GRK3) 132525579(GRK2)

DLE:	111162697(GRK3) 111183685(GRK2)

PCAD:

102978788(GRK3) 102996848(GRK2) 114485015

PSIU:

116738732(GRK3) 116757833(GRK2)

NASI:

112397265(GRK3) 112402130(GRK2)

ECB:	100059001(GRK2) 100065495(GRK3) 111767400(GRK3)

EPZ:	103550032(GRK3) 103559830(GRK2)

EAI:	106833505(GRK2) 106841709(GRK3)

MYB:	102243341(GRK2) 102248143(GRK3)

MYD:	102761774(GRK3) 102764962(GRK2)

MMYO:

118665230(GRK2) 118678342(GRK3)

MLF:	102419138 102432583(GRK2) 102441969

MDT:	132222116(GRK3) 132241342(GRK2)

MYUM:

138998032(GRK3) 139018806(GRK2)

PKL:	118706968(GRK2) 118725511(GRK3)

EFUS:

103286887(GRK3) 103290933(GRK2)

MNA:	107533587(ADRBK1) 107533866(ADRBK2)

DRO:	112310529(GRK3) 112317213(GRK2)

SHON:

118991232(GRK3) 118991804(GRK2)

AJM:	119041860(GRK2) 119057439(GRK3)

PDIC:

114499827(GRK2) 114509548(GRK3)

PHAS:

123820806(GRK3) 123829489(GRK2)

MMF:	118627698(GRK2) 118639875(GRK3)

PPAM:

129068539(GRK2) 129087247(GRK3)

HAI:	109384296(GRK2) 109394134(GRK3)

RFQ:	117017286(GRK3) 117030570(GRK2)

PALE:

102881239(GRK3) 102893733(GRK2)

PGIG:

120584771(GRK2) 120601990(GRK3)

PVP:	105301826(GRK3) 105309917(GRK2)

RAY:	107499745(ADRBK2) 107503771(ADRBK1)

MJV:	108387037(GRK3) 108393151(GRK2)

TOD:	119244788(GRK3) 119249919(GRK2)

SARA:

101548616(ADRBK1) 101549489(ADRBK2)

SFUM:

130023892(GRK3) 130039753(GRK2)

SETR:

126018096(GRK2) 126030572(GRK3)

LAV:	100666578(GRK3) 100671884(GRK2)

TMU:	101346329 101357163

ETF:	101645252(GRK2) 101650611(GRK3)

DNM:	101428937(GRK2) 101433169(GRK3)

MDO:	100009844(GRK3)

GAS:	123245282(GRK3) 123254338

SHR:	100913578(GRK3) 116420004(GRK2)

AFZ:	127541284 127545614

PCW:	110195409(GRK2) 110215258(GRK3)

TVP:	118846619(GRK3) 118853446(GRK2)

PBRV:

138144911(GRK2) 138156461(GRK3)

OAA:	100078284(GRK3) 100090102(GRK2)

TACU:

119942378(GRK3) 119943801(GRK2)

GGA:	416904(GRK3) 426000(GRK2)

PCOC:

116228526(GRK3) 116243006(GRK2)

MGP:	100541374(GRK3) 100545380(GRK2)

CJO:	107314190(GRK2) 107321443(GRK3)

TPAI:

128084682(GRK3) 128086779(GRK2)

LMUT:

125694632(GRK2) 125701633(GRK3)

NMEL:

110400830(GRK2) 110406207(GRK3)

APLA:

101801089(GRK2) 119718575(GRK3)

ACYG:

106029321(GRK2) 106031075(GRK3)

CATA:

118244738(GRK2) 118257635(GRK3)

AFUL:

116489819(GRK2) 116495958(GRK3)

TGU:	100217970(GRK3) 100227701(GRK2)

LSR:	110478203(GRK3) 110484938(GRK2)

SCAN:

103818288(GRK3) 103822132(GRK2)

PMOA:

120499554(GRK2) 120509589(GRK3)

OTC:	121338834(GRK3) 121339908(GRK2)

PRUF:

121355192(GRK2) 121364845(GRK3)

ATRC:

139590552(GRK2) 139598631(GRK3)

GFR:	102032477(GRK2) 102036360(GRK3)

FAB:	101810197(GRK3) 101811193(GRK2)

OMA:	130254262(GRK2) 130259545(GRK3)

PHI:	102108753(ADRBK2) 102114443(ADRBK1)

PMAJ:

107205270(GRK2) 107211779(GRK3)

CCAE:

111936727(GRK3) 111945589

CCW:	104688799(GRK3) 120410071(GRK2)

CBRC:

103611864 103616077(GRK3)

ACOE:

138111106(GRK2) 138119187(GRK3)

ETL:	114066071(GRK3) 114067868(GRK2)

ZAB:	102062501 102065350(GRK3)

ZLE:	135448991(GRK2) 135454441(GRK3)

ACHL:

103807700 103809116

SVG:	106852347(ADRBK2) 106854669(ADRBK1)

MMEA:

130580087(GRK2) 130584877(GRK3)

HRT:	120753709(GRK2) 120760443(GRK3)

SATI:

136362096(GRK2) 136368977(GRK3)

CCIC:

134044775(GRK2) 134050854(GRK3)

FPG:	101911656(GRK2) 101916842(GRK3)

FCH:	102048951(GRK3) 102058946(GRK2)

CCRI:

104161504

NNT:

104410824

SHAB:

115614400(GRK3)

ACUN:

113485979(GRK3)

TALA:

104367315(GRK3) 116965084(GRK2)

ACHC:

115345756(GRK3) 115351926(GRK2)

HALD:

104316012

HLE:	104833294(ADRBK1) 104840822(ADRBK2)

AGEN:

126040702 126046880

HHAR:

128145694(GRK3) 128152805(GRK2)

GCL:

127023074

CSTI:

104562578

LDI:

104346010

MNB:

103769385

DPUB:

104304459(ADRBK1) 104308433(ADRBK2)

PPUS:

135186057(GRK2) 135189003(GRK3)

AVIT:

104276925

BRHI:

104501584

EGZ:	104128318(GRK3) 104129654

NNI:	104009467(ADRBK1) 104020459(ADRBK2)

PCRI:

104034939

PCAO:

104052698

PADL:

103925680(ADRBK2)

AFOR:

103901875(GRK3) 103906022

FGA:

104079233

GSTE:

104255524

CLV:	102092240(GRK2) 102096658(GRK3)

MUI:

104545003

PGUU:

104461559

EHS:

104509028

CMAC:

104479558

CUCA:

104058918(GRK3) 104063353(GRK2)

TEO:	104376114 104383547

BREG:

104632266 104638956

OHA:

104328558

ACAR:

104524416

CPEA:

104386421 104388049(ADRBK2)

CVF:	104287546 104290107(ADRBK2)

RTD:	128909217(GRK2) 128917037(GRK3)

CRID:

134514886(GRK2) 134523068(GRK3)

AAM:	106492546(GRK3) 106493396

AROW:

112963364(GRK3) 112967069(GRK2)

NPD:	112945167(GRK3) 112954249(GRK2)

TGT:	104576473 104579944

DNE:	112988615(GRK2) 112991748(GRK3)

SCAM:

104140378 104150507(ADRBK2)

ASN:	102367979(GRK2) 102378654(GRK3)

AMJ:	102563874(GRK2) 106737118(GRK3)

CPOO:

109312973(GRK3) 109324606(GRK2)

GGN:	109290257(GRK3)

PSS:	102443539(GRK2) 102454375

CMY:	102946005(GRK3) 102947181(GRK2)

CCAY:

125623001(GRK3) 125638318(GRK2)

DCC:	119843814(GRK3) 119857403(GRK2)

CPIC:

101944586(GRK2) 101953922(GRK3)

TST:	117876033(GRK2) 117888032(GRK3)

CABI:

116818695(GRK3) 116833414(GRK2)

MRV:	120386194(GRK3) 120393445(GRK2)

ACS:	100555775(grk2) 103282961

ASAO:

132773153(GRK2) 132780912(GRK3)

PVT:	110083438(GRK3) 110085629(GRK2)

SUND:

121923548(GRK2)

PBI:	103064129(GRK2) 103066055(GRK3)

PMUR:

107287274(GRK3) 107296663(GRK2)

CTIG:

120306957(GRK2) 120316784(GRK3)

TSR:	106547124(ADRBK1) 106556848(ADRBK2)

PGUT:

117667175(GRK2) 117672298 132711943

APRI:

131185833(GRK3)

PTEX:

113448648(GRK3) 113448820(GRK2)

NSS:	113423936(GRK3) 113424756(GRK2)

VKO:	123027372(GRK2) 123028537(GRK3)

PMUA:

114582570 114601867(GRK2)

PRAF:

128400774 128419072(GRK2)

ZVI:	118090157(GRK2) 118094381(GRK3)

HCG:	128337965(GRK3) 128341001(GRK2)

GJA:	107116822(GRK2) 107123215(GRK3)

STOW:

125426065(GRK2) 125442586(GRK3)

EMC:	129324161(GRK2) 129341642(GRK3)

XLA:	108707086 108715724

XTR:	100379889(grk3)

NPR:

108790542

RTEM:

120937831(GRK3)

BBUF:

120988837(GRK3)

BGAR:

122924360(GRK3)

PWL:	138266206(GRK3) 138293651(GRK2)

MUO:	115456598(GRK2) 115480598(GRK3)

GSH:	117348236(GRK2) 117365268(GRK3)

DRE:	569403(grk3)

SRX:	107741659 107758628

SANH:

107658541 107689528

SGH:	107567741 107588964

CCAR:

109093673 109097714(grk3)

CAUA:

113054629 113110283

CGIB:

127966062 128020761

PTET:

122333737(grk3)

LROH:

127171804(grk3)

OMC:	131547961(grk3)

PPRM:

120482724(grk3)

RKG:	130094907(grk3)

MAMB:

125262386(grk3)

CIDE:

127519710

CERY:

137028561(grk3)

MASI:

127432575 127433297

TROS:

130545679(grk3)

TDW:	130412265(grk3)

MANU:

129446520(grk3)

PDAB:

135744380(grk3)

IPU:	108276813(grk3)

IFU:	128620582(grk3)

PHYP:

113544847(grk3)

SMEO:

124393295(grk3)

TFD:	113638351(grk3)

TVC:	132863492(grk3)

CGAR:

128545642(grk3)

NGRA:

132873344(grk3)

TRN:	134332148(grk3)

AMEX:

103046030(grk3)

CMAO:

118824976(grk3)

EEE:	113568347 113583216

CHAR:

105890237(grk3)

SPIL:

134100479(grk3)

TRU:	101073064(grk3)

TFS:	130517213(grk3)

TNG:	GSTEN00025383G001

LCO:	104934568(grk3)

TBEN:

117474950 117497082(grk3)

EMAC:

134868582(grk3)

ELY:	117269522(grk3)

EFO:	125905650(grk3)

SLUC:

116041782(grk3)

ESP:

116678823

PFLV:

114570869(grk3)

PPUG:

119226472(grk3)

AFB:	129102105(grk3)

CLUM:

117740105(grk3)

PSWI:

130205726

CANA:

137783493(grk3)

CVE:	137869149(grk3)

MSAM:

119914686(grk3)

SCHU:

122865964(grk3)

CUD:	121524869(grk3)

SPUL:

138602358(grk3)

LMIX:

132992598(grk3)

ALAT:

119029510(grk3)

ASTR:

137608237(grk3)

MZE:	101476711(grk3)

ONL:	100707869(grk3)

OAU:	116329300(grk3)

OLA:	111948284(grk3)

OML:	112163042(grk3)

CSAI:

133455154(grk3)

XMA:	102224709(grk3)

XCO:	114150251(grk3)

XHE:	116724737(grk3)

PRET:

103473184

PFOR:

103151765(adrbk2) 103156162

PLAI:

106955254(adrbk2) 106958266

PMEI:

106911922 106923393(adrbk2)

GAF:	122846969(grk3)

PPRL:

129379853(grk3)

CVG:

107101402

CTUL:

119795954(grk3)

GMU:	124872423(grk3)

NFU:

107396329

KMR:	108245400(grk3)

ALIM:

106526089

NWH:	119424810(grk3)

AOCE:

111566117(grk3)

EJA:	138208604(grk3)

BFRE:

138622329(grk3)

MCEP:

124996697(grk3)

CSEM:

103389928(grk3)

POV:	109626032(grk3)

SSEN:

122758514(grk3)

SSOE:

131446083(grk3)

HHIP:

117771896(grk3)

HSP:	118125561(grk3)

PPLT:

128424728(grk3)

SMAU:

118301627(grk3)

LCF:

108895613

SDU:	111224273(grk3)

SLAL:

111664712(grk3)

XGL:	120806051(grk3)

HCQ:	109527953(grk3)

SSCV:

125979379(grk3)

SBIA:

133515313(grk3)

PEE:	133413336(grk3)

PTAO:

133490320(grk3)

BPEC:

110166677(grk3)

MALB:

109974750(grk3)

BSPL:

114866467(grk3)

SJO:	128379915(grk3)

SSCO:

133995197

GMH:	115531947(grk3)

SASA:

106563006 106563091 106568375

STRU:

115160295 115203881

OTW:	112230856 112237178(grk3)

OMY:	110512753 110523401(grk3)

OGO:	124006666 124049121

ONE:	115117262 115146893

OKI:

109881237

OKE:	118379134 118385686

OMM:	135518136 135544586

OCLA:

139388107 139408508

SALP:

112070845

SNH:	120020946 120026183

CCLU:

121541513 121582681

ELS:	105015221(grk3)

SFM:

108930044

PKI:	111851486(grk3)

AANG:

118212322(grk3)

AROT:

135239817(grk3)

CCOG:

133141842(grk3)

LOC:

102695299

PSPA:

121307722 121307723

ARUT:

117426618 117963071

PSEX:

120540723(grk3)

LCM:	102362780(GRK2) 102365333(ADRBK2)

CMK:	103184070(grk3)

RTP:	109914938(grk3)

CPLA:

122562610(grk3)

HOC:	132812803 132827089(grk3)

LERI:

129709472(grk3)

PMRN:

116938077

BFO:

118425552

BBEL:

109467794

CIN:

100184862

SCLV:

120343533

SPU:

100888242

LPIC:

129253614

AJJ:

139980865

APLC:

110987558

ARUN:

117290782

AAMU:

139938004

AFIL:

140135517

AJC:

117116954

SKO:

100366720

PFLL:

139144908 139144929

DME:	Dmel_CG40129(Gprk1)

DER:

6541861

DSE:

6620153

DSI:	Dsimw501_GD17695(Dsim_GD17695)

DYA:	Dyak_GE25059

DAN:

6497632

DSR:

110185369

DPO:

26533805

DPE:

6602044

DMN:

117188156

DWI:

6640045

DGR:

6559369

DMO:	Dmoj_GI18854

DAZ:

108616079

DNV:

115564429

DHE:

111600089

DVI:	6635312(Gprk1)

CCAT:

101454248

BOD:

118683218

BDR:

105226853

RZE:	108359276 108377199

AOQ:

129244003

ALUD:

128865951

TDA:

119679904

MDE:

101896222

SCAC:

106083442

LCQ:

111677046

LSQ:

119600608

CVJ:

135959626

GFS:

119641238

ECOE:

129951176

CLON:

129607215

HIS:

119656249

AGA:

1280643

ACOZ:

120954673

AARA:

120902452

AMER:

121600591

ASTE:

118503899

AMAP:

126567934

AFUN:

125768362

AMOU:

128298808

AALI:

118464983

ACOS:

131260673

AAG:	110681207 5568458

AALB:

109426380

ASUA:

134226492

CQU:	CpipJ_CPIJ004658

CPII:

120415167

BCOO:

119071163

LLL:

129795394

PPAP:

129802966

AME:

413197

ACER:

107992508 108000044

ALAB:

122716961

ADR:

102678223

AFLR:

100867211

BIM:

100748232

BBIF:

117207879

BVK:

117238306

BVAN:

117158816

BHUN:

126865553

BTER:

100651375

BAFF:

126920485

BPYO:

122570540

BPAS:

132906384

FVI:

122535994

CCAL:

108621983

OBB:

114883156

OLG:

117608244

MGEN:

117220029

NMEA:

116431916

CGIG:

122396225

SOC:

105194556

MPHA:

105832639

AEC:

105153411

ACEP:

105619512

PBAR:

105422796

VEM:

105564800

COBS:

139104231(Gprk1)

TLN:	139808038(Gprk1)

HST:

105181552

DQU:

106746819

CFO:

105258109

FEX:

115238912

PMEC:

138943902(Gprk1)

LHU:	105678424(Gprk1)

PGC:

109856349

OBO:

105276693

PCF:

106783861

PFUC:

122525965

VPS:

122632866

VCRB:

124428115

VVE:

124953055

NVI:

100121113

CSOL:

105363982

TPRE:

106648977

LHT:

122508878

LBD:

127276894

MDL:

103575167

CGLO:

123265859

FAS:

105269996

DAM:

107040937

AGIF:

122848918

CINS:

118066204

VCAN:

122409008

CCIN:

107271505

DSM:

124410502

NPT:	124220422(Gprk1)

NFB:

124183976

NLO:

107221284

NVG:

124306342

AROA:

105686373

TCA:

654946

TMOL:

138138363(Gprk1)

DPA:

109537817

ESIM:

136419938

EFOR:

136339898

SOY:

115887220

AGRG:

126738030

ATD:

109598675

CSET:

123316262

HAXR:

123681722

AGB:

108903923

LDC:

111505067

DVV:

114335546

NVL:

108568789

DCOR:

135790935

APLN:

108732559

PPYR:

116179800

OTU:

111417188

BMOR:

101741546

BMAN:

114249881

MSEX:

115447635

DPL:	KGM_204545 KGM_212300A

BANY:

112051822

MJU:

123872815

NIQ:

126773558

VCD:

124533975

MCIX:

123656122

PMAC:

106717955

PPOT:

106108436

PXU:

106115946

BPHI:

137933609(Gprk1)

PRAP:

110992337

PBX:

123709399

PNAP:

125053612

ZCE:

119830779

CCRC:

123695982

LSIN:

126977889

AAGE:

121733371

HAW:

110372807

HZE:

124637266

TNL:

113499032

SLIU:

111364977

OFU:

114364577

ONU:

135075183

ATRA:

106137977

GMW:

113520648

PXY:

105389442

PGW:

126372061

LGLY:

125230099

CSTB:

134746124

CFEL:

113376144

CCRN:

123294266

API:

100166085

DNX:

107162156

AGS:

114126939

RMD:

113560481

ACOO:

126838134

DVT:

126901921

BTAB:

109037372

DCI:

103519341

HHAL:

106685857

NLU:

111046871

HVI:

124367311

MQU:

128989212

PHU:	Phum_PHUM014910

FOC:

113204646

TPAL:

117639615

ZNE:

110841237

CSEC:

111871818

SGRE:

126336941

BROR:

134539813

IEL:

124158877

HAMR:

139691986(Gprk1)

FCD:

110856660

DPX:	DAPPUDRAFT_194156(Grk2)

DMK:

116917985

DPZ:

124340930

AFRA:

136026035

PVM:

113809193

PJA:

122251215

PMOO:

119587090

HAME:

121855948

PCLA:

123766420(Gprk1)

CQD:	128695755(Gprk1)

PTRU:

123503990

ESN:

127006428

MNZ:

135221723

MRJ:

136844419

PORN:

139754942(Gprk1)

HAZT:

108664662

EAF:

111703766

LSM:	121131974(Gprk1)

TCF:

131889333

PPOI:

119111891 119112879

ISC:

8033785

DSV:

119446021

RSAN:

119390439

RMP:

119171976

VDE:

111252280

VJA:

111266831

TUT:

107361145

DPTE:

113793852

DFR:

124500542

CSCU:

111628135

CVS:

136982618

PTEP:

107446386

ABRU:

129972307

UDV:

129221479

SDM:

118181383

LPOL:

106462922 106466098 106468258 106472589

PMEO:

129589233

CEL:	CELE_W02B3.2(grk-2)

CBR:	CBG_15249(Cbr-grk-2)

CRQ:	GCK72_011910

NAI:	NECAME_16586

BMY:	BM_BM7964(Bma-grk-2)

LOA:	LOAG_06661

TSP:

Tsp_00495

HRO:	HELRODRAFT_75424

LGI:	LOTGIDRAFT_144613

PVUL:

126823361

PCAN:

112562704

LSAX:

138977044

BGT:

106069803

GAE:

121369275

HRF:

124134938

HRJ:

124266637

HASI:

137297353

HCRA:

139456346

CRG:

105319304

CANU:

128187079

CVN:

111134242

OED:

125663920

MYI:

110461337

PMAX:

117332490

AIRR:

138332077

MCAF:

127713002

MMER:

123533318

RPHI:

132757839

DPOL:

127836523

MAEA:

128230411

OBI:

106871981

OSN:

115224846

LJP:

135476243

LAK:

106181894

SMM:	Smp_210820

SHX:	MS3_00001743(ADRBK2_1)

OVI:	T265_09192

EGL:	EGR_01776 EGR_04327

LLON:

135483253

NVE:

5506466

EPA:

110243336

ATEN:

116303328

ADF:

107338012

AMIL:

114960143

MCAZ:

138047086

MFOO:

137974851

PDAM:

113665499

SPIS:

111345132

DGT:

114538288

XEN:

124434319

HMG:

100214170

HSY:

130623550

RES:

135683327

TAD:	TRIADDRAFT_59012

AQU:

100638292

MBR:	MONBRDRAFT_38629

SRE:	PTSG_08590

PTI:	PHATRDRAFT_27639

FCY:	FRACYDRAFT_169425

TPS:	THAPSDRAFT_15351

PIF:	PITG_16476

PSOJ:

PHYSODRAFT_297885

EHX:	EMIHUDRAFT_234416 EMIHUDRAFT_428179 EMIHUDRAFT_444936 EMIHUDRAFT_466622

» show all

Reference

1 [PMID:3036840]

Authors

Benovic JL, Mayor F Jr, Staniszewski C, Lefkowitz RJ, Caron MG

Title

Purification and characterization of the beta-adrenergic receptor kinase.

Journal

J Biol Chem 262:9026-32 (1987)

Reference

2 [PMID:8394172]

Authors

Kim CM, Dion SB, Onorato JJ, Benovic JL.

Title

Expression and characterization of two beta-adrenergic receptor kinase isoforms using the baculovirus expression system.

Journal

Receptor 3:39-55 (1993)

Reference

3 [PMID:9349395]

Authors

Laugwitz KL, Kronsbein K, Schmitt M, Hoffmann K, Seyfarth M, Schomig A, Ungerer M.

Title

Characterization and inhibition of beta-adrenergic receptor kinase in intact myocytes.

Journal

Cardiovasc Res 35:324-33 (1997)
DOI:10.1016/s0008-6363(97)00102-8

Reference

4 [PMID:7559596]

Authors

Ferguson SS, Menard L, Barak LS, Koch WJ, Colapietro AM, Caron MG.

Title

Role of phosphorylation in agonist-promoted beta 2-adrenergic receptor sequestration. Rescue of a sequestration-defective mutant receptor by beta ARK1.

Journal

J Biol Chem 270:24782-9 (1995)
DOI:10.1074/jbc.270.42.24782

Reference

5 [PMID:14654303]

Authors

Willets JM, Challiss RA, Nahorski SR.

Title

Non-visual GRKs: are we seeing the whole picture?

Journal

Trends Pharmacol Sci 24:626-33 (2003)
DOI:10.1016/j.tips.2003.10.003

Other DBs

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