Entry
Name
dihydroneopterin triphosphate diphosphatase;
folQ (gene name);
nudB (gene name);
NUDT1 (gene name);
dihydroneopterin triphosphate pyrophosphohydrolase
Class
Hydrolases;
Acting on acid anhydrides;
In phosphorus-containing anhydrides
BRITE hierarchy
Sysname
7,8-dihydroneopterin 3'-triphosphate diphosphohydrolase
Reaction(IUBMB)
7,8-dihydroneopterin 3'-triphosphate + H2O = 7,8-dihydroneopterin 3'-phosphate + diphosphate [RN:
R04638 ]
Reaction(KEGG)
Substrate
7,8-dihydroneopterin 3'-triphosphate [CPD:
C04895 ];
H2O [CPD:
C00001 ]
Product
7,8-dihydroneopterin 3'-phosphate [CPD:
C05925 ];
diphosphate [CPD:
C00013 ]
Comment
The enzyme participates in a folate biosynthesis pathway, which is found in bacteria, fungi, and plants. Requires Mg2+.
History
EC 3.6.1.67 created 2014
Pathway
Orthology
K08310 dihydroneopterin triphosphate diphosphatase
K19965 dihydroneopterin triphosphate pyrophosphohydrolase
Genes
ECOO : ECRM13514_2374(ntpA)
ECOH : ECRM13516_2277(ntpA)
ELR : ECO55CA74_11155(nudB)
ECW : EcE24377A_2095(nudB)
ECOA : APECO78_13140(nudB)
EDJ : ECDH1ME8569_1811(nudB)
ECOI : ECOPMV1_01958(nudB)
SEM : STMDT12_C19250(ntpA)
SETC : CFSAN001921_07565(nudB)
SEEN : SE451236_15445(nudB)
SENH : CFSAN002069_22325(nudB)
SEEH : SEEH1578_18805(nudB)
SENJ : CFSAN001992_01930(nudB)
SEEC : CFSAN002050_15970(nudB)
SEEB : SEEB0189_009975(nudB)
SENC : SEET0819_16210(nudB)
ENR : H650_05060(nudB) H650_07820
REE : electrica_01858(nudB)
RTG : NCTC13098_02705(nudB)
CLAP : NCTC11466_01749(nudB)
KSA : C813_00980 C813_22635
KPSE : IP581_13620(nudB) IP581_16075
KIE : NCTC12125_00931(nudB)
SYM : K6K13_11570(nudB) K6K13_16485 K6K13_18595
AHN : NCTC12129_01976(ntpA)
METY : MRY16398_35750(nudB)
PSHI : SAMEA2665130_1125(nudB)
MPHG : MPHASIOC01_001549(nudB)
SMW : SMWW4_v1c27940(nudB)
SFJ : SAMEA4384070_2823(nudB)
SOF : NCTC11214_04085(nudB)
SSAR : SSARUM_002707(nudB)
PPUJ : E2566_09740(nudB) E2566_13890
PAQU : DMB82_0011845(nudB)
PARL : PEC302110_18160(nudB)
DIC : Dpoa569_0002057(nudB)
DDA : Dd703_0969 Dd703_2159
TPTY : NCTC11468_02124(nudB)
PHEI : NCTC12003_02180(nudB)
PRJ : NCTC6933_01795(nudB)
LRI : NCTC12151_02007(nudB)
HIC : NTHIC486_00672(nudB)
HPIT : NCTC13334_01068(nudB)
HHZ : NCTC10839_00930(nudB)
HAEG : NCTC8502_00907(nudB)
PDAG : 4362423_00133(nudB)
ADP : NCTC12871_00632(ntpA)
ALIG : NCTC10568_01439(ntpA)
ASEG : NCTC10977_01882(nudB)
AVT : NCTC3438_01045(nudB)
RPNE : NCTC8284_01297(nudB)
PAET : NCTC13378_01269(nudB)
VDB : AL552_06525 AL552_17010
VSL : LTQ54_01040 LTQ54_23025
VIS : VspSTUT16_14180 VspSTUT16_32900
PGB : H744_1c0788 H744_1c1167
PGH : FH974_16300 FH974_20445
SALH : HMF8227_01858(nudB)
TFRI : Thiofri_01087(nudB)
GAI : IMCC3135_27615(nudB)
THIC : TspCOW1_15740(ntpA)
NMQ : NMBM04240196_1525(nudB)
NMZ : NMBNZ0533_0684(nudB)
NMX : NMA510612_0953(ntpA)
NWE : SAMEA3174300_0582(ntpA)
NZO : SAMEA4504057_1119(ntpA)
NCI : NCTC10296_01999(ntpA)
NCZ : NCTC10294_00289(ntpA)
NANI : NCTC12227_00763(ntpA)
ECOR : SAMEA4412678_1237(nudB)
REH : H16_A0455(h16_A0455)
BMV : BMASAVP1_A2751(ntpA)
BML : BMA10229_A2327(ntpA)
BPM : BURPS1710b_0853(ntpA)
BPL : BURPS1106A_0692(ntpA)
BPLA : bpln_1g31390 bpln_2g14510
POLT : TUM22923_16310(ntpA)
LMIR : NCTC12852_00802(nudB)
VTR : MYVALT_G_01280(nudB)
ASAH : AVXHC19_37110(nudB)
LIM : L103DPR2_00808(nudB)
LIH : L63ED372_02517(nudB)
SMIO : CATMQ487_51260(ntpA)
URU : DSM104443_03602(nudB)
UPL : DSM104440_03137(nudB)
FPHO : SHINM1_001610(ntpA)
ARUI : G6M88_04045 G6M88_24905
ASAL : CFBP5507_24605 CFBP5507_26895
REI : IE4771_CH03004 IE4771_PE00023
ARA : Arad_15010 Arad_8648(ialA)
BWE : BcerKBAB4_0885 BcerKBAB4_3131
BMYO : BG05_2587 BG05_4902
SMIE : NCTC11169_01046(ntpA_2)
PROM : QO263_03170 QO263_08025
LOKI : Lokiarch_13460(rppH) Lokiarch_31290(mutX)
» show all
Taxonomy
Reference
Authors
Suzuki Y, Brown GM
Title
The biosynthesis of folic acid. XII. Purification and properties of dihydroneopterin triphosphate pyrophosphohydrolase.
Journal
J Biol Chem 249:2405-10 (1974)
Reference
Authors
O'Handley SF, Frick DN, Bullions LC, Mildvan AS, Bessman MJ
Title
Escherichia coli orf17 codes for a nucleoside triphosphate pyrophosphohydrolase member of the MutT family of proteins. Cloning, purification, and characterization of the enzyme.
Journal
Sequence
Reference
Authors
Klaus SM, Wegkamp A, Sybesma W, Hugenholtz J, Gregory JF 3rd, Hanson AD
Title
A nudix enzyme removes pyrophosphate from dihydroneopterin triphosphate in the folate synthesis pathway of bacteria and plants.
Journal
Sequence
Reference
Authors
Gabelli SB, Bianchet MA, Xu W, Dunn CA, Niu ZD, Amzel LM, Bessman MJ
Title
Structure and function of the E. coli dihydroneopterin triphosphate pyrophosphatase: a Nudix enzyme involved in folate biosynthesis.
Journal
Sequence
Other DBs
ExplorEnz - The Enzyme Database: 3.6.1.67
ExPASy - ENZYME nomenclature database: 3.6.1.67
LinkDB
All DBs