| Entry |
|
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| Name |
dimethylmaleate hydratase;
(2R,3S)-2,3-dimethylmalate hydro-lyase
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| Class |
Lyases;
Carbon-oxygen lyases;
Hydro-lyases
|
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| Sysname |
(2R,3S)-2,3-dimethylmalate hydro-lyase (dimethylmaleate-forming)
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| Reaction(IUBMB) |
(2R,3S)-2,3-dimethylmalate = dimethylmaleate + H2O [RN: R03069]
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| Reaction(KEGG) |
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| Substrate |
(2R,3S)-2,3-dimethylmalate [CPD: C03652]
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| Product |
dimethylmaleate;
H2O [CPD: C00001]
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| Comment |
Requires Fe2+. Inhibited by oxygen.
|
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| History |
EC 4.2.1.85 created 1989
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| Pathway |
| ec00760 | Nicotinate and nicotinamide metabolism |
| ec01120 | Microbial metabolism in diverse environments |
|
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| Orthology |
| K20452 | dimethylmaleate hydratase large subunit |
| K20453 | dimethylmaleate hydratase small subunit |
|
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| Genes |
| EMT: | CPZ25_006030(leuD) CPZ25_006035(leuC) |
| ELIM: | B2M23_20185 B2M23_20190 |
| SCAZ: | ACI3DN_18680(leuD) ACI3DN_18685(leuC) |
| ETM: | CE91St48_22370(leuC) CE91St48_22380(leuD) |
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| Reference |
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| Authors |
Kollmann-Koch A, Eggerer H |
|---|
| Title |
Nicotinic acid metabolism. Dimethylmaleate hydratase. |
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| Journal |
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| Sequence |
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| Other DBs |
| ExplorEnz - The Enzyme Database: | 4.2.1.85 |
| ExPASy - ENZYME nomenclature database: | 4.2.1.85 |
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| LinkDB |
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