KEGG   ENZYME: 4.2.3.148
Entry
EC 4.2.3.148                Enzyme                                 
Name
cembrene C synthase;
DtcycA (gene name)
Class
Lyases;
Carbon-oxygen lyases;
Acting on phosphates
Sysname
geranylgeranyl-diphosphate diphosphate-lyase (cembrene-C-forming)
Reaction(IUBMB)
geranylgeranyl diphosphate = cembrene C + diphosphate [RN:R10896]
Reaction(KEGG)
R10896
Substrate
geranylgeranyl diphosphate [CPD:C00353]
Product
cembrene C [CPD:C20922];
diphosphate [CPD:C00013]
Comment
Requires Mg2+. Isolated from the bacterium Streptomyces sp. SANK 60404. This bifunctional enzyme also produces (R)-nephthenol. See EC 4.2.3.149, nephthenol synthase.
History
EC 4.2.3.148 created 2014
Orthology
K20504  cembrene C/nephthenol synthase
Reference
1  [PMID:23386483]
  Authors
Meguro A, Tomita T, Nishiyama M, Kuzuyama T
  Title
Identification and characterization of bacterial diterpene cyclases that synthesize the cembrane skeleton.
  Journal
Chembiochem 14:316-21 (2013)
DOI:10.1002/cbic.201200651
  Sequence
[ag:BAM78697]
Other DBs
ExplorEnz - The Enzyme Database: 4.2.3.148
IUBMB Enzyme Nomenclature: 4.2.3.148
ExPASy - ENZYME nomenclature database: 4.2.3.148
BRENDA, the Enzyme Database: 4.2.3.148
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