| Entry |
|
|---|
| Name |
vetispiradiene synthase;
vetispiradiene-forming farnesyl pyrophosphate cyclase;
pemnaspirodiene synthase;
HVS;
vetispiradiene cyclase
|
|---|
| Class |
Lyases;
Carbon-oxygen lyases;
Acting on phosphates
|
|---|
| Sysname |
(2E,6E)-farnesyl-diphosphate diphosphate-lyase (cyclizing, vetispiradiene-forming)
|
|---|
| Reaction(IUBMB) |
(2E,6E)-farnesyl diphosphate = vetispiradiene + diphosphate [RN: R06523]
|
|---|
| Reaction(KEGG) |
|
|---|
| Substrate |
(2E,6E)-farnesyl diphosphate [CPD: C00448]
|
|---|
| Product |
|
|---|
| Comment |
The initial internal cyclization produces the monocyclic intermediate germacrene A.
|
|---|
| History |
EC 4.2.3.21 created 2004, modified 2011
|
|---|
| Pathway |
| ec00909 | Sesquiterpenoid and triterpenoid biosynthesis |
| ec01110 | Biosynthesis of secondary metabolites |
|
|---|
| Orthology |
| K14182 | vetispiradiene synthase |
|
|---|
| Genes |
| MINC: | 123218109 123218110 |
| SLY: | 101264374(TPS33) 101264676(TPS35) |
| SOT: | 102577472(PVS2) 102580114 102595695(PVS4) |
| SSTN: | 125853677 125868239 125868250 |
| SDUL: | 129886022 129886023 129886026 129886027 129886029 129886031 129886033 129886037 |
| ITR: | 116007323 116023016 116023036 116023069 116023259 116032609 |
| EGT: | 105964611 105964660 105964663 105975162 105975175 |
| SSPL: | 121757465 121768525 121773636 121774028 121777090 121778732 121781655 121793662 121803528 121803673 121807564 121807658 121807662 |
| SMIL: | 130986771 131015157 |
| SHIS: | 125185210 125185496 125185544 125197401 125199919 125214593 125215587 125217922 125218276 125223786 |
| APAN: | 127240970 127242652 127242667 127242698 127242751 127247280 127247308 127249380 127258815 127258816 127262648 127262649 127262650 127265677 |
| RVL: | 131309582 131311084 131312077 |
|
|---|
| Reference |
|
|---|
| Authors |
Back K, Chappell J |
|---|
| Title |
Cloning and bacterial expression of a sesquiterpene cyclase from Hyoscyamus muticus and its molecular comparison to related terpene cyclases. |
|---|
| Journal |
|
|---|
| Sequence |
|
|---|
| Reference |
2 |
|---|
| Authors |
Keller H, Czernic P, Ponchet M, Ducrot PH, Back K, Chappell J, Ricci P, Marco Y. |
|---|
| Title |
Sesquiterpene cyclase is not a determining factor for elicitor- and pathogen-induced capsidiol accumulation in tobacco. |
|---|
| Journal |
Planta 205:467-476 (1998) |
|---|
| Reference |
|
|---|
| Authors |
Mathis JR, Back K, Starks C, Noel J, Poulter CD, Chappell J. |
|---|
| Title |
Pre-steady-state study of recombinant sesquiterpene cyclases. |
|---|
| Journal |
|
|---|
| Reference |
|
|---|
| Authors |
Yoshioka H, Yamada N, Doke N. |
|---|
| Title |
cDNA cloning of sesquiterpene cyclase and squalene synthase, and expression of the genes in potato tuber infected with Phytophthora infestans. |
|---|
| Journal |
|
|---|
| Sequence |
|
|---|
| Reference |
|
|---|
| Authors |
Martin VJ, Yoshikuni Y, Keasling JD. |
|---|
| Title |
The in vivo synthesis of plant sesquiterpenes by Escherichia coli. |
|---|
| Journal |
|
|---|
| Other DBs |
| ExplorEnz - The Enzyme Database: | 4.2.3.21 |
| ExPASy - ENZYME nomenclature database: | 4.2.3.21 |
|
|---|
| LinkDB |
|
|---|
