KEGG   ENZYME: 4.2.3.221
Entry
EC 4.2.3.221                Enzyme                                 
Name
macrophomene synthase;
MpMS
Class
Lyases;
Carbon-oxygen lyases;
Acting on phosphates
Sysname
pentaprenyl-diphosphate diphosphate-lyase [cyclizing, macrophomene-forming]
Reaction(IUBMB)
all-trans-hexaprenyl diphosphate = macrophomene + diphosphate [RN:R13293]
Reaction(KEGG)
R13293
Substrate
all-trans-hexaprenyl diphosphate [CPD:C01230]
Product
macrophomene [CPD:C22895];
diphosphate [CPD:C00013]
Comment
Isolated from Macrophomina phaseolina, a pathogenic fungus that causes damping off, seedling blight, collar rot, stem rot, charcoal rot, basal stem rot, and root rot on many plant species. The 22-membered ring in macrophomene represents the largest macrocycle discovered in terpenes so far.
History
EC 4.2.3.221 created 2024
Orthology
K27607  hexaprenyl diphosphate synthase / macrophomene synthase
Reference
1  [PMID:35650436]
  Authors
Tao H, Lauterbach L, Bian G, Chen R, Hou A, Mori T, Cheng S, Hu B, Lu L, Mu X, Li M, Adachi N, Kawasaki M, Moriya T, Senda T, Wang X, Deng Z, Abe I, Dickschat JS, Liu T.
  Title
Discovery of non-squalene triterpenes.
  Journal
Nature 606:414-419 (2022)
DOI:10.1038/s41586-022-04773-3
  Sequence
Other DBs
ExplorEnz - The Enzyme Database: 4.2.3.221
IUBMB Enzyme Nomenclature: 4.2.3.221
ExPASy - ENZYME nomenclature database: 4.2.3.221
BRENDA, the Enzyme Database: 4.2.3.221
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