| Entry |
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| Name |
olivetolic acid cyclase;
OAC
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| Class |
Lyases;
Carbon-sulfur lyases;
Carbon-sulfur lyases (only sub-subclass identified to date)
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| Sysname |
3,5,7-trioxododecanoyl-CoA CoA-lyase (2,4-dihydroxy-6-pentylbenzoate-forming)
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| Reaction(IUBMB) |
3,5,7-trioxododecanoyl-CoA = CoA + 2,4-dihydroxy-6-pentylbenzoate [RN: R10278]
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| Reaction(KEGG) |
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| Substrate |
3,5,7-trioxododecanoyl-CoA [CPD: C20413]
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| Product |
CoA [CPD: C00010];
2,4-dihydroxy-6-pentylbenzoate [CPD: C20417]
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| Comment |
Part of the cannabinoids biosynthetic pathway in the plant Cannabis sativa.
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| History |
EC 4.4.1.26 created 2012
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| Pathway |
| ec00999 | Biosynthesis of various plant secondary metabolites |
| ec01110 | Biosynthesis of secondary metabolites |
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| Orthology |
| K20508 | olivetolic acid cyclase |
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| Genes |
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| Reference |
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| Authors |
Gagne SJ, Stout JM, Liu E, Boubakir Z, Clark SM, Page JE |
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| Title |
Identification of olivetolic acid cyclase from Cannabis sativa reveals a unique catalytic route to plant polyketides. |
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| Journal |
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| Sequence |
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| Other DBs |
| ExplorEnz - The Enzyme Database: | 4.4.1.26 |
| ExPASy - ENZYME nomenclature database: | 4.4.1.26 |
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| LinkDB |
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