Entry
Name
phosphoribosylglycinamide formyltransferase 2;
purT (gene name);
GAR transformylase 2;
GART2;
glycinamide ribonucleotide transformylase 2;
5'-phosphoribosylglycinamide transformylase 2;
GAR transformylase T
Class
Ligases;
Forming carbon-nitrogen bonds;
Acid-D-ammonia (or amine) ligases (amide synthases)
BRITE hierarchy
Sysname
formate:N1-(5-phospho-beta-D-ribosyl)glycinamide ligase (ADP-forming)
Reaction(IUBMB)
ATP + formate + N1-(5-phospho-beta-D-ribosyl)glycinamide = ADP + phosphate + N2-formyl-N1-(5-phospho-beta-D-ribosyl)glycinamide [RN:
R06974 ]
Reaction(KEGG)
Substrate
ATP [CPD:
C00002 ];
formate [CPD:
C00058 ];
N1-(5-phospho-beta-D-ribosyl)glycinamide [CPD:
C03838 ]
Product
ADP [CPD:
C00008 ];
phosphate [CPD:
C00009 ];
N2-formyl-N1-(5-phospho-beta-D-ribosyl)glycinamide [CPD:
C04376 ]
Comment
Two enzymes are known to catalyse the third step in de novo purine biosynthesis. This enzyme requires ATP and utilizes formate, which is provided by the hydrolysis of 10-formyltetrahydrofolate by EC
3.5.1.10 , formyltetrahydrofolate deformylase. The other enzyme, EC
2.1.2.2 , phosphoribosylglycinamide formyltransferase 1, utilizes 10-formyltetrahydrofolate directly. Formyl phosphate is formed during catalysis as an intermediate. The enzyme from the bacterium Escherichia coli can also catalyse the activity of EC
2.7.2.1 , acetate kinase.
History
EC 6.3.1.21 created 2021
Pathway
ec01110 Biosynthesis of secondary metabolites
Orthology
K08289 phosphoribosylglycinamide formyltransferase 2
Genes
ECOO : ECRM13514_2357(purT)
ECOH : ECRM13516_2260(purT)
ELR : ECO55CA74_11070(purT)
ECW : EcE24377A_2079(purT)
EDJ : ECDH1ME8569_1795(purT)
ECOI : ECOPMV1_01942(purT)
SEM : STMDT12_C19070(purT)
SEEH : SEEH1578_18720(purT)
SENJ : CFSAN001992_02020(purT)
REE : electrica_01877(purT)
RTG : NCTC13098_02741(purT)
CLAP : NCTC11466_01778(purT)
KIE : NCTC12125_00948(purT_2)
AHN : NCTC12129_01994(purT)
METY : MRY16398_35560(purT)
PSHI : SAMEA2665130_1163(purT)
MPHG : MPHASIOC01_001534(purT)
YPG : YpAngola_A1634(purT)
YPI : YpsIP31758_2351(purT)
SMW : SMWW4_v1c28230(purT)
SERS : SERRSCBI_13290(purT)
SFJ : SAMEA4384070_2850(purT)
SOF : NCTC11214_03979(purT)
SSAR : SSARUM_002735(purT)
PAQU : DMB82_0011770(purT)
PARL : PEC302110_18340(purT)
DIC : Dpoa569_0002041(purT)
PANS : FCN45_00090 FCN45_10980(purT)
TPTY : NCTC11468_02111(purT)
PHEI : NCTC12003_00998(purT)
PRJ : NCTC6933_03041(purT_2)
HPIT : NCTC13334_00685(purT)
HHZ : NCTC10839_00369(purT)
PDAG : 4362423_00042(purT)
ALIG : NCTC10568_01387(purT)
ASEG : NCTC10977_00503(purT)
AVT : NCTC3438_00610(purT)
PAET : NCTC13378_00383(purT)
XFU : XFF4834R_chr33030(purT)
XPH : XppCFBP6546_05300(purT)
XHD : LMG31886_30970(purT)
LLZ : LYB30171_01861(purT)
VAU : VANGNB10_cI1543(purT)
VSR : Vspart_02020(purT_1)
VPL : SA104470976_00978(purT)
VIB : VspSTUT11_17730(purT)
VIS : VspSTUT16_18530(purT)
PPUD : DW66_1057 DW66_1390
PVD : CFBP1590__4116(purT)
PPRC : PFLCHA0_c11090(purT)
PMUD : NCTC8068_01112(purT)
PFW : PF1751_v1c45050(purT)
PFF : PFLUOLIPICF713520(purT)
PPUU : PputUW4_00977(purT)
PGY : AWU82_18805(purT) AWU82_29295(purT)
PTRT : HU722_0023945(purT)
PTW : TUM18999_49090(purT)
PTAE : NCTC10697_03526(purT)
MSHE : MAALD49_24310(purT)
SCAA : TUM17387_09420(purT)
PLZ : S4054249_00885(purT)
MISZ : MishRS11D_17420(purT)
FTR : NE061598_10290(purT)
TIB : THMIRHAM_21880(purT)
TSE : THMIRHAS_24480(purT)
TZO : THMIRHAT_21830(purT)
ALCA : ASALC70_03625(purT)
AEL : NCTC12917_01987(purT)
CDIZ : CEDIAZO_01837(purT)
BMV : BMASAVP1_A1035(purT)
BML : BMA10229_A0832(purT)
BPM : BURPS1710b_1349(purT)
BPL : BURPS1106A_1196(purT)
PLG : NCTC10937_01396(purT)
BUO : BRPE64_ACDS09180(purT)
BUE : BRPE67_ACDS08160(purT)
BTRM : SAMEA390648700861(purT)
AXX : ERS451415_05888(purT)
ASAH : AVXHC19_43080(purT)
LIM : L103DPR2_01668(purT)
LIH : L63ED372_00689(purT)
SMIO : CATMQ487_35140(purT)
THAG : CKCBHOJB_01818(purT)
FPHO : SHINM1_021220(purT)
RBS : RHODOSMS8_01837(purT)
BVY : NCTC9239_00761(purT)
TSV : DSM104635_02737(purT)
SFLA : SPHFLASMR4Y_00074(purT)
GBN : GEOBRER4_01460(purT)
BTHO : Btheta7330_02325(purT_1)
BCEL : BcellWH2_00095(purT)
BFC : BacF7301_19305(purT)
COPR : Cop2CBH44_19640(purT)
CFAS : Cfast33896_19700(purT)
PMZ : HMPREF0659_A6854(purT)
PDN : HMPREF9137_1299(purT)
PHER : prwr041_02880(purT)
POC : NCTC13071_02193(purT)
ACOU : A5CBH24_23250(purT)
ADA : A5CPEGH6_21680(purT)
FOK : KK2020170_03020(purT)
BAZ : BAMTA208_01085(purT)
BAE : BATR1942_19755(purT)
BACI : B1NLA3E_10225(purT)
PPQ : PPSQR21_028190(purT)
PCHI : PC41400_13340(purT)
PNK : AASFL403_05310(purT)
COHN : KCTCHS21_39380(purT)
MAVM : MAA44156_04217(purT)
MMAE : MMARE11_06350(purT)
MBAI : MB901379_00570(purT)
MHEK : JMUB5695_04313(purT)
MADI : A7U43_09145 A7U43_27165
MWU : PT015_16990(purT) PT015_20335(purT)
MYW : BVC93_16820 BVC93_17700
MSM : MSMEG_0766(purT) MSMEG_5274(purT)
MSG : MSMEI_0750(purT) MSMEI_5135
MSB : LJ00_03805 LJ00_26080
MSN : LI99_03805 LI99_26085
MSH : LI98_03805 LI98_26090
MSP : Mspyr1_05550 Mspyr1_14630
MNE : D174_04660 D174_21590
MYN : MyAD_04560 MyAD_21175
MPHL : MPHLCCUG_04660(purT)
MVQ : MYVA_0522 MYVA_4506(purT)
MTHN : 4412656_00467(purT)
MAUU : NCTC10437_00519(purT_1) NCTC10437_04404(purT_2)
MIJ : MINS_09970(purT_1) MINS_38840(purT_2)
MAUB : MAUB_25570(purT_1) MAUB_43050(purT_2)
MPHU : MPHO_26410(purT_1) MPHO_44820(purT_2)
MMUC : C1S78_005140(purT) C1S78_024875
MFLV : NCTC10271_04626(purT)
MBRM : L2Z93_000783(purT) L2Z93_003494(purT)
MGO : AFA91_01585 AFA91_14260
MDF : K0O62_03605(purT) K0O62_22790(purT)
MAUS : JN090_02270(purT) JN090_22725(purT)
MFRE : EXE63_11510(purT) EXE63_22225(purT)
MBUG : MU0053_004137(purT)
MMV : MYCMA_0633 MYCMA_2364
MABB : MASS_1189(purT) MASS_4281
MABL : MMASJCM_1217 MMASJCM_4332
MCHE : BB28_05915 BB28_21875
MIZ : BAB75_06500 BAB75_24305
MSTE : MSTE_01159(purT) MSTE_04425
MSAO : MYCSP_05250 MYCSP_19915
MSAL : DSM43276_01059(purT_1) DSM43276_04133(purT_2)
MTER : 4434518_00358(purT)
CDIP : ERS451417_02061(purT)
CUN : Cul210932_2040(purT)
CUQ : Cul210931_1988(purT)
CUJ : CUL131002_1950c(purT)
CMIN : NCTC10288_00273(purT)
CRL : NCTC7448_00495(purT)
CCYS : SAMEA4530656_0113(purT)
RCR : NCTC10994_03389(purT)
RANT : RHODO2019_13095(purT)
DSS : GCM25873_20270(purT)
ANE : ATCC27039_08920(purT)
AVC : NCTC10951_00850(purT)
BBV : HMPREF9228_1290(purT)
PARQ : DSM112329_00604(purT)
SYR : SynRCC307_2528(purT)
SYX : SynWH7803_2526(purT)
SYH : Syncc8109_2756(purT)
SYNW : SynWH8103_02909(purT)
SYP : SYNPCC7002_A2030(purT)
SYNN : NIES970_22810(purT)
NSPH : BDGGKGIB_01211(purT)
STAN : STA3757_29820(purT)
MPD : MCP_2477(purT-1) MCP_2878(purT-2)
SACR : SacRon12I_01030(purT)
» show all
Taxonomy
Reference
Authors
Nagy PL, McCorkle GM, Zalkin H.
Title
purU, a source of formate for purT-dependent phosphoribosyl-N-formylglycinamide synthesis.
Journal
Reference
Authors
Nygaard P, Smith JM.
Title
Evidence for a novel glycinamide ribonucleotide transformylase in Escherichia coli.
Journal
Reference
Authors
Marolewski A, Smith JM, Benkovic SJ
Title
Cloning and characterization of a new purine biosynthetic enzyme: a non-folate glycinamide ribonucleotide transformylase from E. coli.
Journal
Reference
Authors
Marolewski AE, Mattia KM, Warren MS, Benkovic SJ.
Title
Formyl phosphate: a proposed intermediate in the reaction catalyzed by Escherichia coli PurT GAR transformylase.
Journal
Reference
Authors
Thoden JB, Firestine S, Nixon A, Benkovic SJ, Holden HM.
Title
Molecular structure of Escherichia coli PurT-encoded glycinamide ribonucleotide transformylase.
Journal
Sequence
Reference
Authors
Jelsbak L, Mortensen MIB, Kilstrup M, Olsen JE.
Title
The In Vitro Redundant Enzymes PurN and PurT Are Both Essential for Systemic Infection of Mice in Salmonella enterica Serovar Typhimurium.
Journal
Other DBs
ExplorEnz - The Enzyme Database: 6.3.1.21
ExPASy - ENZYME nomenclature database: 6.3.1.21
LinkDB
All DBs