KEGG   DRUG: Dactinomycin
Entry
D00214                      Drug                                   
Name
Dactinomycin (USP);
Actinomycin D (JP18);
Cosmegen (TN)
Product
  Generic
DACTINOMYCIN (Eugia US LLC), DACTINOMYCIN (Eugia US LLC), DACTINOMYCIN (Hisun Pharmaceuticals USA), DACTINOMYCIN (Meitheal Pharmaceuticals), DACTINOMYCIN (XGen Pharmaceuticals DJB)
Formula
C62H86N12O16
Exact mass
1254.6285
Mol weight
1255.42
Structure
Simcomp
Sequence
0 4MHA  1 Thr  2 D-Val  3 Pro  4 Sar  5 Val
(Cyclization: 1-5, Dimer)
  Type
NRP
Source
Streptomyces parvullus [TAX:146923]
Remark
Same as: C06770
Therapeutic category: 4233
ATC code: L01DA01
Product: D00214<JP/US>
Efficacy
Antineoplastic
  Disease
Wilms tumor [DS:H02301]
Rhabdomyosarcoma [DS:H00037]
Ewings sarcoma [DS:H00035]
Testicular cancer [DS:H00023]
Solid malignancies [DS:H02421]
Target
RNA polymerase
Interaction
Structure map
map07042  Antineoplastics - agents from natural products
map07046  Immunosuppressive agents
Other map
map04976  Bile secretion
Brite
Anatomical Therapeutic Chemical (ATC) classification [BR:br08303]
 L ANTINEOPLASTIC AND IMMUNOMODULATING AGENTS
  L01 ANTINEOPLASTIC AGENTS
   L01D CYTOTOXIC ANTIBIOTICS AND RELATED SUBSTANCES
    L01DA Actinomycines
     L01DA01 Dactinomycin
      D00214  Dactinomycin (USP) <JP/US>
USP drug classification [BR:br08302]
 Antineoplastics
  Antineoplastics, Other
   Antineoplastics, Miscellaneous
    Dactinomycin
     D00214  Dactinomycin (USP)
Therapeutic category of drugs in Japan [BR:br08301]
 4  Agents affecting cellular function
  42  Antineoplastics
   423  Antibiotics
    4233  Actinomycin D
     D00214  Dactinomycin (USP); Actinomycin D (JP18)
Drugs listed in the Japanese Pharmacopoeia [BR:br08311]
 Chemicals
  D00214  Actinomycin D
Other DBs
CAS: 50-76-0
PubChem: 7847281
ChEBI: 27666
LigandBox: D00214
NIKKAJI: J3.209C
LinkDB
KCF data

ATOM        90
            1   C8y C    25.6418  -18.7249
            2   C8y C    25.6541  -17.4511
            3   N5x N    24.5349  -19.3619
            4   C8y C    26.7301  -19.3682
            5   O2x O    24.5473  -16.8017
            6   C8y C    26.7612  -16.8265
            7   C8y C    23.4279  -18.7188
            8   C8y C    27.8433  -18.7373
            9   C5a C    26.7240  -20.6481
            10  C8y C    23.4403  -17.4324
            11  C8y C    27.8619  -17.4696
            12  C1a C    26.7673  -15.5587
            13  C8y C    22.3395  -19.3558
            14  N1a N    28.9440  -19.3927
            15  N1b N    27.8248  -21.2974
            16  O5a O    25.6109  -21.2727
            17  C8y C    22.3395  -16.7956
            18  O5x O    28.9625  -16.8388
            19  C8x C    21.2326  -18.7188
            20  C5a C    22.3395  -20.6357
            21  C1y C    27.8124  -22.5714
            22  C8x C    21.2326  -17.4324
            23  C1a C    22.3395  -15.5216
            24  N1b N    21.2326  -21.2727
            25  O5a O    23.4403  -21.2666
            26  C5x C    26.6993  -23.2022
            27  C1y C    28.9132  -23.2206
            28  C1y C    21.2326  -22.5528
            29  N1x N    26.6540  -28.2854
            30  O5x O    25.6046  -22.5528
            31  O7x O    30.0263  -22.5899
            32  C1a C    28.9069  -24.4946
            33  C5x C    22.3395  -23.1835
            34  C1y C    20.1258  -23.1898
            35  C1y C    28.3999  -28.9841
            36  C7x C    31.1208  -23.2393
            37  N1x N    22.3334  -28.2235
            38  O5x O    23.4465  -22.5467
            39  O7x O    19.0311  -22.5591
            40  C1a C    20.1258  -24.4699
            41  C5x C    30.3416  -28.2667
            42  C1c C    28.3999  -30.2209
            43  C1y C    32.2339  -22.6147
            44  O6a O    31.1784  -24.5194
            45  C1y C    21.0286  -28.9285
            46  C7x C    17.9180  -23.1959
            47  N1y N    32.2524  -29.1139
            48  O5x O    30.3416  -26.9867
            49  C1a C    27.2868  -30.8579
            50  C1a C    29.5005  -30.8579
            51  N1y N    33.3347  -23.2578
            52  C1c C    32.1763  -21.3346
            53  C5x C    18.7715  -28.2854
            54  C1c C    21.0286  -30.2086
            55  C1y C    16.8112  -22.5652
            56  O6a O    17.9180  -24.4760
            57  C1y C    33.2913  -28.3718
            58  C1x C    32.6358  -30.3321
            59  C5x C    33.3223  -24.5317
            60  C1a C    34.4478  -22.6270
            61  C1a C    33.3655  -20.7099
            62  C1a C    31.1516  -20.6852
            63  N1y N    16.7493  -29.0583
            64  O5x O    18.7715  -26.9929
            65  C1a C    19.9217  -30.8456
            66  C1a C    22.1354  -30.8456
            67  N1y N    15.7104  -23.2022
            68  C1c C    16.8049  -21.2851
            69  C1x C    34.3178  -29.1326
            70  C5x C    33.3036  -27.0856
            71  C1x C    33.9098  -30.3445
            72  C1x C    34.4231  -25.1809
            73  O5x O    32.2153  -25.1625
            74  C1y C    15.7165  -28.3162
            75  C1x C    16.3598  -30.2765
            76  C5x C    15.6465  -24.4822
            77  C1a C    14.6034  -22.5714
            78  C1a C    17.9180  -20.6481
            79  C1a C    15.7041  -20.6481
            80  N1y N    34.4168  -26.4673
            81  O5x O    32.2092  -26.4426
            82  C1x C    14.6776  -29.0583
            83  C5x C    15.7165  -27.0361
            84  C1x C    15.0797  -30.2765
            85  C1x C    14.6034  -25.1192
            86  O5x O    16.8112  -25.1130
            87  C1a C    35.5238  -27.1165
            88  N1y N    14.6096  -26.3992
            89  O5x O    16.8112  -26.3931
            90  C1a C    13.5089  -27.0424
BOND        96
            1     1   2 1
            2     1   3 2
            3     1   4 1
            4     2   5 1
            5     2   6 2
            6     3   7 1
            7     4   8 2
            8     4   9 1
            9     5  10 1
            10    6  11 1
            11    6  12 1
            12    7  13 2
            13    8  14 1
            14    9  15 1
            15    9  16 2
            16   10  17 2
            17   11  18 2
            18   13  19 1
            19   13  20 1
            20   15  21 1
            21   17  22 1
            22   17  23 1
            23   20  24 1
            24   20  25 2
            25   21  26 1
            26   21  27 1
            27   24  28 1
            28   26  29 1
            29   26  30 2
            30   27  31 1
            31   27  32 1
            32   28  33 1
            33   28  34 1
            34   29  35 1
            35   31  36 1
            36   33  37 1
            37   33  38 2
            38   34  39 1
            39   34  40 1
            40   35  41 1
            41   35  42 1
            42   36  43 1
            43   36  44 2
            44   37  45 1
            45   39  46 1
            46   41  47 1
            47   41  48 2
            48   42  49 1
            49   42  50 1
            50   43  51 1
            51   43  52 1
            52   45  53 1
            53   45  54 1
            54   46  55 1
            55   46  56 2
            56   47  57 1
            57   47  58 1
            58   51  59 1
            59   51  60 1
            60   52  61 1
            61   52  62 1
            62   53  63 1
            63   53  64 2
            64   54  65 1
            65   54  66 1
            66   55  67 1
            67   55  68 1
            68   57  69 1
            69   57  70 1
            70   58  71 1
            71   59  72 1
            72   59  73 2
            73   63  74 1
            74   63  75 1
            75   67  76 1
            76   67  77 1
            77   68  78 1
            78   68  79 1
            79   70  80 1
            80   70  81 2
            81   74  82 1
            82   74  83 1
            83   75  84 1
            84   76  85 1
            85   76  86 2
            86   80  87 1
            87   83  88 1
            88   83  89 2
            89   88  90 1
            90    7  10 1
            91    8  11 1
            92   19  22 2
            93   69  71 1
            94   72  80 1
            95   82  84 1
            96   85  88 1

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