KEGG   DRUG: Mephenytoin
Entry
D00375                      Drug                                   
Name
Mephenytoin (USP/INN);
Mesantoin (TN)
Formula
C12H14N2O2
Exact mass
218.1055
Mol weight
218.25
Structure
Simcomp
Class
Neuropsychiatric agent
 DG03199  Antiepileptic agent
  DG02031  Hydantoin antiepileptic
Metabolizing enzyme substrate
 DG01639  CYP2C19 substrate
Remark
ATC code: N03AB04
Efficacy
Anticonvulsant
Comment
Hydantoin derivative
Target
SCN1A [HSA:6323] [KO:K04833]
SCN2A [HSA:6326] [KO:K04834]
SCN3A [HSA:6328] [KO:K04836]
SCN4A [HSA:6329] [KO:K04837]
SCN5A [HSA:6331] [KO:K04838]
SCN8A [HSA:6334] [KO:K04840]
SCN9A [HSA:6335] [KO:K04841]
SCN10A [HSA:6336] [KO:K04842]
SCN11A [HSA:11280] [KO:K04843]
  Pathway
hsa04728  Dopaminergic synapse
Metabolism
Enzyme: CYP2C19 [HSA:1557]
Interaction
Structure map
map07033  Anticonvulsants
Brite
Anatomical Therapeutic Chemical (ATC) classification [BR:br08303]
 N NERVOUS SYSTEM
  N03 ANTIEPILEPTICS
   N03A ANTIEPILEPTICS
    N03AB Hydantoin derivatives
     N03AB04 Mephenytoin
      D00375  Mephenytoin (USP/INN)
Drug groups [BR:br08330]
 Neuropsychiatric agent
  DG03199  Antiepileptic agent
   DG02031  Hydantoin antiepileptic
    D00375  Mephenytoin
 Metabolizing enzyme substrate
  DG01639  CYP2C19 substrate
   D00375  Mephenytoin
Target-based classification of drugs [BR:br08310]
 Ion channels
  Voltage-gated ion channels
   Sodium channels
    SCN1A
     D00375  Mephenytoin (USP/INN)
    SCN2A
     D00375  Mephenytoin (USP/INN)
    SCN3A
     D00375  Mephenytoin (USP/INN)
    SCN4A
     D00375  Mephenytoin (USP/INN)
    SCN5A
     D00375  Mephenytoin (USP/INN)
    SCN8A
     D00375  Mephenytoin (USP/INN)
    SCN9A
     D00375  Mephenytoin (USP/INN)
    SCN10A
     D00375  Mephenytoin (USP/INN)
    SCN11A
     D00375  Mephenytoin (USP/INN)
Drug metabolizing enzymes and transporters [br08309.html]
 Drug metabolizing enzymes
  D00375
Other DBs
CAS: 50-12-4
PubChem: 7847441
ChEBI: 6757
LigandBox: D00375
NIKKAJI: J4.097E
LinkDB
KCF data

ATOM        16
            1   C1z C    20.8941  -17.2706
            2   C5x C    19.4767  -17.2762
            3   N1x N    21.3729  -15.9550
            4   N1y N    19.1015  -15.9329
            5   O5x O    18.6308  -18.4135
            6   C5x C    20.2356  -15.1090
            7   C1a C    17.7859  -15.4541
            8   O5x O    20.2300  -13.6917
            9   C8y C    22.2941  -17.2706
            10  C8x C    22.9937  -18.4823
            11  C8x C    24.3937  -18.4824
            12  C8x C    25.0937  -17.2699
            13  C8x C    24.3941  -16.0582
            14  C8x C    22.9941  -16.0581
            15  C1b C    20.8941  -18.6706
            16  C1a C    19.6477  -19.3902
BOND        17
            1     1   2 1
            2     1   3 1
            3     2   4 1
            4     2   5 2
            5     3   6 1
            6     4   7 1
            7     6   8 2
            8     4   6 1
            9     1   9 1
            10    9  10 2
            11   10  11 1
            12   11  12 2
            13   12  13 1
            14   13  14 2
            15    9  14 1
            16    1  15 1
            17   15  16 1

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