| Entry |
|
|---|
| Name |
Halothane (JP18/USP/INN);
Fluothane (TN) |
|---|
| Formula |
C2HBrClF3
|
|---|
| Exact mass |
195.8902
|
|---|
| Mol weight |
197.38
|
|---|
| Structure |
|
|---|
| Simcomp |
|
|---|
| Class |
Neuropsychiatric agent
DG02030 Anesthetics
DG02027 General anesthetics
DG02028 Inhalational anaesthetics
DG01994 Halogenated hydrocarbons
Metabolizing enzyme substrate
DG02855 CYP2E1 substrate
DG01633 CYP3A/CYP3A4 substrate
DG02913 CYP3A4 substrate
|
|---|
| Remark |
|
|---|
| Efficacy |
Anesthetic (inhalation) |
|---|
| Comment |
Halogenated alkane derivative
|
|---|
| Metabolism |
Enzyme: CYP2E1 [HSA: 1571], CYP3A4 [HSA: 1576]
|
|---|
| Interaction |
|
|---|
| Brite |
Anatomical Therapeutic Chemical (ATC) classification [BR:br08303]
N NERVOUS SYSTEM
N01 ANESTHETICS
N01A ANESTHETICS, GENERAL
N01AB Halogenated hydrocarbons
N01AB01 Halothane
D00542 Halothane (JP18/USP/INN)
Drug groups [BR:br08330]
Neuropsychiatric agent
DG02030 Anesthetics
DG02027 General anesthetics
DG02028 Inhalational anaesthetics
DG01994 Halogenated hydrocarbons
D00542 Halothane
Metabolizing enzyme substrate
DG02855 CYP2E1 substrate
D00542 Halothane
DG01633 CYP3A/CYP3A4 substrate
DG02913 CYP3A4 substrate
D00542 Halothane
Drugs listed in the Japanese Pharmacopoeia [BR:br08311]
Chemicals
D00542 Halothane
Drug metabolizing enzymes and transporters [br08309.html]
Drug metabolizing enzymes
D00542
|
|---|
| Other DBs |
|
|---|
| LinkDB |
|
|---|
| KCF data |
ATOM 7
1 C1d C 23.0008 -15.7383
2 C1c C 24.2141 -16.4383
3 X F 21.7934 -16.4383
4 X F 23.0008 -14.3384
5 X F 22.9951 -17.1442
6 X Cl 24.2083 -17.8382
7 X Br 25.4275 -15.7442
BOND 6
1 1 2 1
2 1 3 1
3 1 4 1
4 1 5 1
5 2 6 1
6 2 7 1
|
|---|
