| Entry |
|
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| Name |
Mirtazapine (JAN/USP/INN);
Remeron (TN);
Reflex (TN) |
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| Product |
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| Generic |
MIRTAZAPINE (A-S Medication Solutions), MIRTAZAPINE (A-S Medication Solutions), MIRTAZAPINE (Advanced Rx Pharmacy of Tennessee), MIRTAZAPINE (American Health Packaging), MIRTAZAPINE (American Health Packaging), MIRTAZAPINE (Aphena Pharma Solutions - Tennessee), MIRTAZAPINE (Aphena Pharma Solutions - Tennessee), MIRTAZAPINE (Aphena Pharma Solutions - Tennessee), MIRTAZAPINE (Aphena Pharma Solutions - Tennessee), MIRTAZAPINE (Aphena Pharma Solutions - Tennessee), MIRTAZAPINE (Aphena Pharma Solutions - Tennessee), MIRTAZAPINE (Aphena Pharma Solutions - Tennessee), MIRTAZAPINE (Aphena Pharma Solutions - Tennessee), MIRTAZAPINE (Aphena Pharma Solutions - Tennessee), MIRTAZAPINE (Aphena Pharma Solutions - Tennessee), MIRTAZAPINE (Apotex Corp.), MIRTAZAPINE (Aurobindo Pharma Limited), MIRTAZAPINE (Aurobindo Pharma Limited), MIRTAZAPINE (Aurolife Pharma LLC), MIRTAZAPINE (AvKARE), MIRTAZAPINE (Bryant Ranch Prepack), MIRTAZAPINE (Bryant Ranch Prepack), MIRTAZAPINE (Bryant Ranch Prepack), MIRTAZAPINE (Bryant Ranch Prepack), MIRTAZAPINE (Bryant Ranch Prepack), MIRTAZAPINE (Bryant Ranch Prepack), MIRTAZAPINE (Bryant Ranch Prepack), MIRTAZAPINE (Bryant Ranch Prepack), MIRTAZAPINE (Bryant Ranch Prepack), MIRTAZAPINE (Bryant Ranch Prepack), MIRTAZAPINE (Bryant Ranch Prepack), MIRTAZAPINE (Bryant Ranch Prepack), MIRTAZAPINE (Bryant Ranch Prepack), MIRTAZAPINE (Bryant Ranch Prepack), MIRTAZAPINE (Bryant Ranch Prepack), MIRTAZAPINE (Bryant Ranch Prepack), MIRTAZAPINE (Bryant Ranch Prepack), MIRTAZAPINE (Cardinal Health 107), MIRTAZAPINE (Cardinal Health 107), MIRTAZAPINE (Cardinal Health 107), MIRTAZAPINE (Coupler LLC), MIRTAZAPINE (Coupler LLC), MIRTAZAPINE (Coupler LLC), MIRTAZAPINE (Direct_Rx), MIRTAZAPINE (Golden State Medical Supply), MIRTAZAPINE (Major Pharmaceuticals), MIRTAZAPINE (McKesson Corporation dba SKY Packaging), MIRTAZAPINE (Mylan Institutional), MIRTAZAPINE (Mylan Pharmaceuticals), MIRTAZAPINE (NCS HealthCare of KY), MIRTAZAPINE (NCS HealthCare of KY), MIRTAZAPINE (NuCare Pharmaceuticals), MIRTAZAPINE (Prasco Laboratories), MIRTAZAPINE (Preferred Pharmaceuticals), MIRTAZAPINE (Preferred Pharmaceuticals), MIRTAZAPINE (Preferred Pharmaceuticals), MIRTAZAPINE (Preferred Pharmaceuticals), MIRTAZAPINE (Preferred Pharmaceuticals), MIRTAZAPINE (Proficient Rx LP), MIRTAZAPINE (Proficient Rx LP), MIRTAZAPINE (Proficient Rx LP), MIRTAZAPINE (Proficient Rx LP), MIRTAZAPINE (Quality Care Products LLC), MIRTAZAPINE (Quality Care Products), MIRTAZAPINE (REMEDYREPACK), MIRTAZAPINE (REMEDYREPACK), MIRTAZAPINE (REMEDYREPACK), MIRTAZAPINE (REMEDYREPACK), MIRTAZAPINE (REMEDYREPACK), MIRTAZAPINE (REMEDYREPACK), MIRTAZAPINE (REMEDYREPACK), MIRTAZAPINE (Rising Pharma Holdings), MIRTAZAPINE (Rising Pharma Holdings), MIRTAZAPINE (SQUARE PHARMACEUTICALS LIMITED), MIRTAZAPINE (Sun Pharmaceutical Industries), MIRTAZAPINE (Viona Pharmaceuticals) |
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| Formula |
C17H19N3
|
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| Exact mass |
265.1579
|
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| Mol weight |
265.35
|
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| Structure |
|
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| Simcomp |
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| Class |
Cardiovascular agent
DG01466 Adrenergic receptor antagonist
DG01465 alpha-Adrenergic receptor antagonist
DG01460 alpha2-Adrenergic receptor antagonist
Neuropsychiatric agent
DG01729 Tetracyclic antidepressant
DG03077 Noradrenergic and specific serotonergic antidepressant (NaSSA)
Gastrointestinal agent
DG01489 5-HT3-receptor antagonist
Metabolizing enzyme substrate
DG01892 CYP1A2 substrate
DG01644 CYP2D6 substrate
DG01633 CYP3A/CYP3A4 substrate
DG02913 CYP3A4 substrate
|
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| Remark |
| Therapeutic category: | 1179 |
| Product (DG02838): | D00563<JP/US> |
|
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| Efficacy |
Antidepressant, Serotonin receptor antagonist |
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| Disease |
Major depressive disorder [DS: H01646] |
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| Comment |
NaSSA: Noradrenergic and specific serotonergic antidepressant
|
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| Target |
|
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| Pathway |
| hsa04080 | Neuroactive ligand-receptor interaction |
|
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| Metabolism |
Enzyme: CYP1A2 [HSA: 1544], CYP2D6 [HSA: 1565], CYP3A4 [HSA: 1576]
|
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| Interaction |
|
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| Structure map |
|
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| Brite |
Anatomical Therapeutic Chemical (ATC) classification [BR:br08303]
N NERVOUS SYSTEM
N06 PSYCHOANALEPTICS
N06A ANTIDEPRESSANTS
N06AX Other antidepressants
N06AX11 Mirtazapine
D00563 Mirtazapine (JAN/USP/INN) <JP/US>
USP drug classification [BR:br08302]
Antidepressants
Antidepressants, Other
Mirtazapine
D00563 Mirtazapine (JAN/USP/INN)
Therapeutic category of drugs in Japan [BR:br08301]
1 Agents affecting nervous system and sensory organs
11 Agents affecting central nervous system
117 Psychotropics
1179 Others
D00563 Mirtazapine (JAN/USP/INN)
Drug groups [BR:br08330]
Cardiovascular agent
DG01466 Adrenergic receptor antagonist
DG01465 alpha-Adrenergic receptor antagonist
DG01460 alpha2-Adrenergic receptor antagonist
DG02838 Mirtazapine
D00563 Mirtazapine
Neuropsychiatric agent
DG01729 Tetracyclic antidepressant
DG02838 Mirtazapine
D00563 Mirtazapine
DG03077 Noradrenergic and specific serotonergic antidepressant (NaSSA)
DG02838 Mirtazapine
D00563 Mirtazapine
Gastrointestinal agent
DG01489 5-HT3-receptor antagonist
DG02838 Mirtazapine
D00563 Mirtazapine
Metabolizing enzyme substrate
DG01892 CYP1A2 substrate
DG02838 Mirtazapine
D00563 Mirtazapine
DG01644 CYP2D6 substrate
DG02838 Mirtazapine
D00563 Mirtazapine
DG01633 CYP3A/CYP3A4 substrate
DG02913 CYP3A4 substrate
DG02838 Mirtazapine
D00563 Mirtazapine
Target-based classification of drugs [BR:br08310]
G Protein-coupled receptors
Rhodopsin family
Adrenaline
ADRA2
D00563 Mirtazapine (JAN/USP/INN) <JP/US>
Serotonin
HTR2
D00563 Mirtazapine (JAN/USP/INN) <JP/US>
Ion channels
Ligand-gated ion channels
Serotonin
HTR3
D00563 Mirtazapine (JAN/USP/INN) <JP/US>
New drug approvals in Japan [br08318.html]
Drugs with new active ingredients
D00563
Drug metabolizing enzymes and transporters [br08309.html]
Drug metabolizing enzymes
D00563
Drug groups [BR:br08330]
Cardiovascular agent
DG01466 Adrenergic receptor antagonist
DG01465 alpha-Adrenergic receptor antagonist
DG01460 alpha2-Adrenergic receptor antagonist
DG02838 Mirtazapine
Neuropsychiatric agent
DG01729 Tetracyclic antidepressant
DG02838 Mirtazapine
DG03077 Noradrenergic and specific serotonergic antidepressant (NaSSA)
DG02838 Mirtazapine
Gastrointestinal agent
DG01489 5-HT3-receptor antagonist
DG02838 Mirtazapine
Metabolizing enzyme substrate
DG01892 CYP1A2 substrate
DG02838 Mirtazapine
DG01644 CYP2D6 substrate
DG02838 Mirtazapine
DG01633 CYP3A/CYP3A4 substrate
DG02913 CYP3A4 substrate
DG02838 Mirtazapine
|
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| Other DBs |
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| LinkDB |
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| KCF data |
ATOM 20
1 C1y C 9.7476 -8.2180
2 N1y N 11.1496 -8.2180
3 C8y C 11.9909 -7.1665
4 C8y C 11.7105 -5.7644
5 C8y C 8.9064 -7.1665
6 C1x C 10.4486 -5.2036
7 C8y C 9.1868 -5.7644
8 C8x C 7.5744 -7.5871
9 C8x C 6.5229 -6.6056
10 C8x C 6.8033 -5.2737
11 C8x C 8.1353 -4.8531
12 C8x C 12.6919 -4.8531
13 C8x C 14.0238 -5.2737
14 C8x C 14.3743 -6.6056
15 N5x N 13.3228 -7.5170
16 C1x C 11.8507 -9.4097
17 C1x C 11.1496 -10.6715
18 N1y N 9.8177 -10.6715
19 C1x C 9.0466 -9.4798
20 C1a C 9.1167 -11.9334
BOND 23
1 3 4 1
2 1 5 1
3 4 6 1
4 2 3 1
5 5 7 2
6 1 2 1
7 6 7 1
8 5 8 1
9 8 9 2
10 9 10 1
11 10 11 2
12 7 11 1
13 4 12 2
14 12 13 1
15 13 14 2
16 14 15 1
17 3 15 2
18 2 16 1
19 16 17 1
20 17 18 1
21 18 19 1
22 1 19 1
23 18 20 1
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