| Entry |
|
|---|
| Name |
Bepridil hydrochloride (USAN);
Bepridil hydrochloride hydrate (JAN);
Vascor (TN) |
|---|
| Formula |
C24H34N2O. HCl. H2O
|
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| Exact mass |
420.2544
|
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| Mol weight |
421.01
|
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| Structure |
|
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| Simcomp |
|
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| Class |
Cardiovascular agent
DG01575 Calcium channel blocker
DG01496 Calcium channel L type blocker
DG01653 Antiarrhythmics
DG01807 Phenylalkylamine derivative
Metabolizing enzyme substrate
DG01642 CYP2C9 substrate
DG01644 CYP2D6 substrate
DG01633 CYP3A/CYP3A4 substrate
DG02913 CYP3A4 substrate
Metabolizing enzyme inhibitor
DG01645 CYP2D6 inhibitor
|
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| Remark |
| Therapeutic category: | 2129 |
| Product (DG00333): | D00631<JP> |
|
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| Efficacy |
Antiarrhythmic, Vasodilator (coronary), Calcium channel blocker, Sodium channel blocker, Potassium channel blocker |
|---|
| Target |
|
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| Pathway |
| hsa04270 | Vascular smooth muscle contraction |
|
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| Metabolism |
Enzyme: CYP2D6 [HSA: 1565], CYP2C9 [HSA: 1559], CYP3A4 [HSA: 1576]
|
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| Interaction |
CYP inhibition: CYP2D6 [HSA: 1565]
|
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| Structure map |
|
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| Brite |
Anatomical Therapeutic Chemical (ATC) classification [BR:br08303]
C CARDIOVASCULAR SYSTEM
C08 CALCIUM CHANNEL BLOCKERS
C08E NON-SELECTIVE CALCIUM CHANNEL BLOCKERS
C08EA Phenylalkylamine derivatives
C08EA02 Bepridil
D00631 Bepridil hydrochloride (USAN) <JP>
Therapeutic category of drugs in Japan [BR:br08301]
2 Agents affecting individual organs
21 Cardiovascular agents
212 Antiarrhythmic agents
2129 Others
D00631 Bepridil hydrochloride (USAN); Bepridil hydrochloride hydrate (JAN)
Drug groups [BR:br08330]
Cardiovascular agent
DG01575 Calcium channel blocker
DG01496 Calcium channel L type blocker
DG00333 Bepridil
D00631 Bepridil hydrochloride
DG01653 Antiarrhythmics
DG01807 Phenylalkylamine derivative
DG00333 Bepridil
D00631 Bepridil hydrochloride
Metabolizing enzyme substrate
DG01642 CYP2C9 substrate
DG00333 Bepridil
D00631 Bepridil hydrochloride
DG01644 CYP2D6 substrate
DG00333 Bepridil
D00631 Bepridil hydrochloride
DG01633 CYP3A/CYP3A4 substrate
DG02913 CYP3A4 substrate
DG00333 Bepridil
D00631 Bepridil hydrochloride
Metabolizing enzyme inhibitor
DG01645 CYP2D6 inhibitor
DG00333 Bepridil
D00631 Bepridil hydrochloride
Drug classes [BR:br08332]
Cardiovascular agent
DG01653 Antiarrhythmics
D00631 Bepridil hydrochloride
Target-based classification of drugs [BR:br08310]
Ion channels
Voltage-gated ion channels
Calcium channels
CACNA1-T
D00631 Bepridil hydrochloride (USAN) <JP>
CACNA1-L
D00631 Bepridil hydrochloride (USAN) <JP>
Potassium channels
KCNA5
D00631 Bepridil hydrochloride (USAN) <JP>
KCND3
D00631 Bepridil hydrochloride (USAN) <JP>
KCNH2
D00631 Bepridil hydrochloride (USAN) <JP>
KCNQ1
D00631 Bepridil hydrochloride (USAN) <JP>
Inward rectifier channels (Kir)
KCNJ3
D00631 Bepridil hydrochloride (USAN) <JP>
KCNJ5
D00631 Bepridil hydrochloride (USAN) <JP>
KCNJ8
D00631 Bepridil hydrochloride (USAN) <JP>
KCNJ11
D00631 Bepridil hydrochloride (USAN) <JP>
KCNJ12
D00631 Bepridil hydrochloride (USAN) <JP>
Enzymes
Hydrolases (EC3)
ATPase
ATP1A
D00631 Bepridil hydrochloride (USAN) <JP>
Drug metabolizing enzymes and transporters [br08309.html]
Drug metabolizing enzymes
D00631
Drug groups [BR:br08330]
Cardiovascular agent
DG01575 Calcium channel blocker
DG01496 Calcium channel L type blocker
DG00333 Bepridil
DG01653 Antiarrhythmics
DG01807 Phenylalkylamine derivative
DG00333 Bepridil
Metabolizing enzyme substrate
DG01642 CYP2C9 substrate
DG00333 Bepridil
DG01644 CYP2D6 substrate
DG00333 Bepridil
DG01633 CYP3A/CYP3A4 substrate
DG02913 CYP3A4 substrate
DG00333 Bepridil
Metabolizing enzyme inhibitor
DG01645 CYP2D6 inhibitor
DG00333 Bepridil
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| Other DBs |
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| LinkDB |
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| KCF data |
ATOM 29
1 N1c N 23.4624 -19.3400
2 C1b C 24.6731 -20.0358
3 C1b C 22.2518 -20.0418
4 C1c C 25.8837 -19.3400
5 C8y C 21.0411 -19.3400
6 N1y N 27.1003 -20.0358
7 C1b C 25.8837 -17.9363
8 C8x C 19.8305 -20.0418
9 C8x C 21.0411 -17.9421
10 C1x C 28.2348 -19.2112
11 C1x C 27.5330 -21.3693
12 O2a O 27.0944 -17.2402
13 C8x C 18.6141 -19.3400
14 C8x C 19.8305 -17.2402
15 C1x C 29.3695 -20.0358
16 C1x C 28.9309 -21.3693
17 C1b C 28.3108 -17.9363
18 C8x C 18.6141 -17.9421
19 C1c C 29.5214 -17.2345
20 C1a C 30.7321 -17.9363
21 C1a C 29.5214 -15.8367
22 C8y C 23.4599 -17.9200
23 C8x C 24.6637 -17.2222
24 C8x C 24.6612 -15.8222
25 C8x C 23.4475 -15.1243
26 C8x C 22.2437 -15.8222
27 C8x C 22.2462 -17.2222
28 O0 O 36.0999 -19.7939
29 X Cl 33.2761 -19.7939
BOND 29
1 1 2 1
2 1 3 1
3 2 4 1
4 3 5 1
5 4 6 1
6 4 7 1
7 5 8 2
8 5 9 1
9 6 10 1
10 6 11 1
11 7 12 1
12 8 13 1
13 9 14 2
14 10 15 1
15 11 16 1
16 12 17 1
17 13 18 2
18 17 19 1
19 19 20 1
20 19 21 1
21 14 18 1
22 15 16 1
23 1 22 1
24 22 23 2
25 23 24 1
26 24 25 2
27 25 26 1
28 26 27 2
29 22 27 1
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