 | | DRUG: Diclofenac sodium | |
| Entry |
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| Name |
Diclofenac sodium (JP18/USP);
Solaraze (TN);
Voltaren (TN) |
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| Product |
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| Generic |
DICLOFENAC (Advanced Rx of Tennessee), DICLOFENAC (Altaire Pharmaceuticals), DICLOFENAC SODIUM (A-S Medication Solutions), DICLOFENAC SODIUM (A-S Medication Solutions), DICLOFENAC SODIUM (A-S Medication Solutions), DICLOFENAC SODIUM (A-S Medication Solutions), DICLOFENAC SODIUM (A-S Medication Solutions), DICLOFENAC SODIUM (A-S Medication Solutions), DICLOFENAC SODIUM (A-S Medication Solutions), DICLOFENAC SODIUM (A-S Medication Solutions), DICLOFENAC SODIUM (A-S Medication Solutions), DICLOFENAC SODIUM (A-S Medication Solutions), DICLOFENAC SODIUM (A-S Medication Solutions), DICLOFENAC SODIUM (A-S Medication Solutions), DICLOFENAC SODIUM (ATLANTIC BIOLOGICALS CORP.), DICLOFENAC SODIUM (Actavis Pharma), DICLOFENAC SODIUM (Actavis Pharma), DICLOFENAC SODIUM (Advagen Pharma), DICLOFENAC SODIUM (Advanced Rx Pharmacy of Tennessee), DICLOFENAC SODIUM (Advanced Rx Pharmacy of Tennessee), DICLOFENAC SODIUM (Advanced Rx Pharmacy of Tennessee), DICLOFENAC SODIUM (Advanced Rx Pharmacy of Tennessee), DICLOFENAC SODIUM (Advanced Rx Pharmacy of Tennessee), DICLOFENAC SODIUM (Advanced Rx Pharmacy of Tennessee), DICLOFENAC SODIUM (Advanced Rx Pharmacy of Tennessee), DICLOFENAC SODIUM (Advanced Rx Pharmacy of Tennessee), DICLOFENAC SODIUM (Advanced Rx Pharmacy of Tennessee), DICLOFENAC SODIUM (Advanced Rx Pharmacy of Tennessee), DICLOFENAC SODIUM (Advanced Rx Pharmacy of Tennessee), DICLOFENAC SODIUM (Advanced Rx Pharmacy of Tennessee), DICLOFENAC SODIUM (Advanced Rx of Tennessee), DICLOFENAC SODIUM (Advanced Rx of Tennessee), DICLOFENAC SODIUM (Advanced Rx of Tennessee), DICLOFENAC SODIUM (Advanced Rx of Tennessee), DICLOFENAC SODIUM (Advanced Rx of Tennessee), DICLOFENAC SODIUM (Advanced Rx of Tennessee), DICLOFENAC SODIUM (Alembic Pharmaceuticals Limited), DICLOFENAC SODIUM (Alembic Pharmaceuticals Limited), DICLOFENAC SODIUM (Alembic Pharmaceuticals), DICLOFENAC SODIUM (Alembic Pharmaceuticals), DICLOFENAC SODIUM (American Health Packaging), DICLOFENAC SODIUM (American Health Packaging), DICLOFENAC SODIUM (Amneal Pharmaceuticals LLC), DICLOFENAC SODIUM (Amneal Pharmaceuticals LLC), DICLOFENAC SODIUM (Amneal Pharmaceuticals of New York LLC), DICLOFENAC SODIUM (Aphena Pharma Solutions - Tennessee), DICLOFENAC SODIUM (Apotex Corp.), DICLOFENAC SODIUM (Asclemed USA), DICLOFENAC SODIUM (Asclemed USA), DICLOFENAC SODIUM (Asclemed USA), DICLOFENAC SODIUM (Asclemed USA), DICLOFENAC SODIUM (Asclemed USA), DICLOFENAC SODIUM (Asclemed USA), DICLOFENAC SODIUM (Asclemed USA), DICLOFENAC SODIUM (Asclemed USA), DICLOFENAC SODIUM (Asclemed USA), DICLOFENAC SODIUM (Asclemed USA), DICLOFENAC SODIUM (Asclemed USA), DICLOFENAC SODIUM (Asclemed USA), DICLOFENAC SODIUM (Aurolife Pharma LLC), DICLOFENAC SODIUM (AvKARE), DICLOFENAC SODIUM (AvKARE), DICLOFENAC SODIUM (Bausch & Lomb Incorporated), DICLOFENAC SODIUM (BluePoint Laboratories), DICLOFENAC SODIUM (BluePoint Laboratories), DICLOFENAC SODIUM (Bryant Ranch Prepack), DICLOFENAC SODIUM (Bryant Ranch Prepack), DICLOFENAC SODIUM (Bryant Ranch Prepack), DICLOFENAC SODIUM (Bryant Ranch Prepack), DICLOFENAC SODIUM (Bryant Ranch Prepack), DICLOFENAC SODIUM (Bryant Ranch Prepack), DICLOFENAC SODIUM (Bryant Ranch Prepack), DICLOFENAC SODIUM (Bryant Ranch Prepack), DICLOFENAC SODIUM (Bryant Ranch Prepack), DICLOFENAC SODIUM (Bryant Ranch Prepack), DICLOFENAC SODIUM (Bryant Ranch Prepack), DICLOFENAC SODIUM (Bryant Ranch Prepack), DICLOFENAC SODIUM (Bryant Ranch Prepack), DICLOFENAC SODIUM (Bryant Ranch Prepack), DICLOFENAC SODIUM (Bryant Ranch Prepack), DICLOFENAC SODIUM (Bryant Ranch Prepack), DICLOFENAC SODIUM (Bryant Ranch Prepack), DICLOFENAC SODIUM (Bryant Ranch Prepack), DICLOFENAC SODIUM (Bryant Ranch Prepack), DICLOFENAC SODIUM (Bryant Ranch Prepack), DICLOFENAC SODIUM (Carlsbad Technology), DICLOFENAC SODIUM (Cipla USA), DICLOFENAC SODIUM (Coupler LLC), DICLOFENAC SODIUM (DIRECT RX), DICLOFENAC SODIUM (Denton Pharma), DICLOFENAC SODIUM (DirectRx), DICLOFENAC SODIUM (Direct_Rx), DICLOFENAC SODIUM (Direct_Rx), DICLOFENAC SODIUM (EXELAN PHARMACEUTICALS), DICLOFENAC SODIUM (Edenbridge Pharmaceuticals LLC.), DICLOFENAC SODIUM (GLENMARK PHARMACEUTICALS), DICLOFENAC SODIUM (Gabar Health Sciences Corp), DICLOFENAC SODIUM (Golden State Medical Supply), DICLOFENAC SODIUM (IPG PHARMACEUTICALS), DICLOFENAC SODIUM (Ingenus Pharmaceuticals), DICLOFENAC SODIUM (Lannett Company), DICLOFENAC SODIUM (Lupin Pharmaceuticals), DICLOFENAC SODIUM (Lupin Pharmaceuticals), DICLOFENAC SODIUM (Medsource Pharmaceuticals), DICLOFENAC SODIUM (Medsource Pharmaceuticals), DICLOFENAC SODIUM (Medsource Pharmaceuticals), DICLOFENAC SODIUM (NorthStar Rx LLC), DICLOFENAC SODIUM (Northwind Pharmaceuticals), DICLOFENAC SODIUM (Northwind Pharmaceuticals), DICLOFENAC SODIUM (Novel Laboratories), DICLOFENAC SODIUM (NuCare Pharmaceuticals), DICLOFENAC SODIUM (NuCare Pharmaceuticals), DICLOFENAC SODIUM (NuCare Pharmaceuticals), DICLOFENAC SODIUM (NuCare Pharmaceuticals), DICLOFENAC SODIUM (NuCare Pharmaceuticals), DICLOFENAC SODIUM (NuCare Pharmaceuticals), DICLOFENAC SODIUM (NuCare Pharmaceuticals), DICLOFENAC SODIUM (NuCare Pharmaceuticals), DICLOFENAC SODIUM (NuCare Pharmaceuticals), DICLOFENAC SODIUM (NuCare Pharmaceuticals), DICLOFENAC SODIUM (NuCare Pharmaceuticals), DICLOFENAC SODIUM (NuCare Pharmaceuticals), DICLOFENAC SODIUM (NuCare Pharmaceuticals), DICLOFENAC SODIUM (Oceanside Pharmaceuticals), DICLOFENAC SODIUM (PD-Rx Pharmaceuticals), DICLOFENAC SODIUM (PD-Rx Pharmaceuticals), DICLOFENAC SODIUM (Padagis Israel Pharmaceuticals), DICLOFENAC SODIUM (Padagis Israel Pharmaceuticals), DICLOFENAC SODIUM (Preferred Pharmaceuticals), DICLOFENAC SODIUM (Preferred Pharmaceuticals), DICLOFENAC SODIUM (Preferred Pharmaceuticals), DICLOFENAC SODIUM (Preferred Pharmaceuticals), DICLOFENAC SODIUM (Preferred Pharmaceuticals), DICLOFENAC SODIUM (Preferred Pharmaceuticals), DICLOFENAC SODIUM (Preferred Pharmaceuticals), DICLOFENAC SODIUM (Preferred Pharmaceuticals), DICLOFENAC SODIUM (Preferred Pharmaceuticals), DICLOFENAC SODIUM (Preferred Pharmaceuticals), DICLOFENAC SODIUM (Preferred Pharmaceuticals), DICLOFENAC SODIUM (Preferred Pharmaceuticals), DICLOFENAC SODIUM (Preferred Pharmaceuticals), DICLOFENAC SODIUM (Preferred Pharmaceuticals), DICLOFENAC SODIUM (Proficient Rx LP), DICLOFENAC SODIUM (Proficient Rx LP), DICLOFENAC SODIUM (Proficient Rx LP), DICLOFENAC SODIUM (Proficient Rx LP), DICLOFENAC SODIUM (Proficient Rx LP), DICLOFENAC SODIUM (Proficient Rx LP), DICLOFENAC SODIUM (Proficient Rx LP), DICLOFENAC SODIUM (Proficient Rx LP), DICLOFENAC SODIUM (Proficient Rx LP), DICLOFENAC SODIUM (Proficient Rx LP), DICLOFENAC SODIUM (Proficient Rx LP), DICLOFENAC SODIUM (Proficient Rx LP), DICLOFENAC SODIUM (Proficient Rx LP), DICLOFENAC SODIUM (Proficient Rx LP), DICLOFENAC SODIUM (Proficient Rx LP), DICLOFENAC SODIUM (Proficient Rx LP), DICLOFENAC SODIUM (Proficient Rx LP), DICLOFENAC SODIUM (Proficient Rx LP), DICLOFENAC SODIUM (Proficient Rx LP), DICLOFENAC SODIUM (Proficient Rx LP), DICLOFENAC SODIUM (Proficient Rx LP), DICLOFENAC SODIUM (Proficient Rx LP), DICLOFENAC SODIUM (Proficient Rx LP), DICLOFENAC SODIUM (Proficient Rx LP), DICLOFENAC SODIUM (Proficient Rx LP), DICLOFENAC SODIUM (Proficient Rx LP), DICLOFENAC SODIUM (Proficient Rx LP), DICLOFENAC SODIUM (PureTek Corporation), DICLOFENAC SODIUM (Quality Care Products LLC), DICLOFENAC SODIUM (Quality Care Products LLC), DICLOFENAC SODIUM (Quality Care Products), DICLOFENAC SODIUM (Quality Care Products), DICLOFENAC SODIUM (Quality Care Products), DICLOFENAC SODIUM (Quality Care Products), DICLOFENAC SODIUM (Quality Care Products), DICLOFENAC SODIUM (Quality Care Products), DICLOFENAC SODIUM (Quality Care Products), DICLOFENAC SODIUM (REMEDYREPACK), DICLOFENAC SODIUM (REMEDYREPACK), DICLOFENAC SODIUM (REMEDYREPACK), DICLOFENAC SODIUM (REMEDYREPACK), DICLOFENAC SODIUM (REMEDYREPACK), DICLOFENAC SODIUM (REMEDYREPACK), DICLOFENAC SODIUM (REMEDYREPACK), DICLOFENAC SODIUM (REMEDYREPACK), DICLOFENAC SODIUM (REMEDYREPACK), DICLOFENAC SODIUM (REMEDYREPACK), DICLOFENAC SODIUM (REPHARM LLC), DICLOFENAC SODIUM (RedPharm Drug), DICLOFENAC SODIUM (RedPharm Drug), DICLOFENAC SODIUM (RedPharm Drug), DICLOFENAC SODIUM (RedPharm Drug), DICLOFENAC SODIUM (Rising Pharma Holdings), DICLOFENAC SODIUM (Sandoz), DICLOFENAC SODIUM (St. Mary's Medical Park Pharmacy), DICLOFENAC SODIUM (St. Mary's Medical Park Pharmacy), DICLOFENAC SODIUM (St. Mary's Medical Park Pharmacy), DICLOFENAC SODIUM (Taro Pharmaceuticals U.S.A.), DICLOFENAC SODIUM (Taro Pharmaceuticals U.S.A.), DICLOFENAC SODIUM (Taro Pharmaceuticals U.S.A.), DICLOFENAC SODIUM (Viona Pharmaceuticals), DICLOFENAC SODIUM (Zydus Lifesciences Limited), DICLOFENAC SODIUM 1.5% (Proficient Rx LP), DICLOFENAC SODIUM 1.5% (Proficient Rx LP), DICLOFENAC SODIUM 1.5% (SOLA Pharmaceuticals), DICLOFENAC SODIUM DELAYED RELEASE (A-S Medication Solutions), DICLOFENAC SODIUM DELAYED RELEASE (Cambridge Therapeutics Technologies), DICLOFENAC SODIUM GEL (Direct_Rx), DICLOFENAC SODIUM GEL (Direct_Rx), DICLOFENAC SODIUM GEL (Direct_Rx), DICLOFENAC SODIUM TOPICAL SOLUTION (Direct_Rx), DICLOFENAC SODIUM TOPICAL SOLUTION (Direct_Rx), VAROPHEN (V2 Pharma) |
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| Formula |
C14H10Cl2NO2. Na
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| Exact mass |
316.9986
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| Mol weight |
318.13
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| Structure |
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| Simcomp |
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| Class |
Anti-inflammatory
DG01504 Nonsteroidal anti-inflammatory drug (NSAID)
DG01906 Anti-inflammatory drug, acetic acid derivatives
DG01898 Anti-inflammatory drug, phenylacetic acid derivatives
Metabolizing enzyme substrate
DG01642 CYP2C9 substrate
Transporter inhibitor
DG02866 SLC22A8 inhibitor
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| Remark |
| Product (DG00441): | D00903<US> D00904<JP/US> D07818<US> |
| Product (mixture): | D11091<US> |
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| Efficacy |
Analgesic, Anti-inflammatory, Antipyretic, COX inhibitor |
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| Target |
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| Pathway |
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| Metabolism |
Enzyme: CYP2C9 [HSA: 1559]
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| Interaction |
Transporter inhibition: SLC22A8 [HSA: 9376]
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| Structure map |
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| Brite |
Anatomical Therapeutic Chemical (ATC) classification [BR:br08303]
D DERMATOLOGICALS
D11 OTHER DERMATOLOGICAL PREPARATIONS
D11A OTHER DERMATOLOGICAL PREPARATIONS
D11AX Other dermatologicals
D11AX18 Diclofenac
D00904 Diclofenac sodium (JP18/USP) <JP/US>
M MUSCULO-SKELETAL SYSTEM
M01 ANTIINFLAMMATORY AND ANTIRHEUMATIC PRODUCTS
M01A ANTIINFLAMMATORY AND ANTIRHEUMATIC PRODUCTS, NON-STEROIDS
M01AB Acetic acid derivatives and related substances
M01AB05 Diclofenac
D00904 Diclofenac sodium (JP18/USP) <JP/US>
M02 TOPICAL PRODUCTS FOR JOINT AND MUSCULAR PAIN
M02A TOPICAL PRODUCTS FOR JOINT AND MUSCULAR PAIN
M02AA Antiinflammatory preparations, non-steroids for topical use
M02AA15 Diclofenac
D00904 Diclofenac sodium (JP18/USP) <JP/US>
S SENSORY ORGANS
S01 OPHTHALMOLOGICALS
S01B ANTIINFLAMMATORY AGENTS
S01BC Antiinflammatory agents, non-steroids
S01BC03 Diclofenac
D00904 Diclofenac sodium (JP18/USP) <JP/US>
USP drug classification [BR:br08302]
Analgesics
Nonsteroidal Anti-inflammatory Drugs
Diclofenac
D00904 Diclofenac sodium (JP18/USP)
Dermatological Agents
Dermatological Agents, Other
Warts and Actinic Keratosis Agents
Diclofenac
D00904 Diclofenac sodium (JP18/USP)
Ophthalmic Agents
Ophthalmic Anti-inflammatories
Nonsteroidal Anti-Inflammatory Drugs, Ophthalmic
Diclofenac
D00904 Diclofenac sodium (JP18/USP)
Therapeutic category of drugs in Japan [BR:br08301]
1 Agents affecting nervous system and sensory organs
11 Agents affecting central nervous system
114 Antipyretics and analgesics, anti-inflammatory agents
1147 Phenylacetates
D00904 Diclofenac sodium (JP18/USP)
13 Agents affecting sensory organs
131 Ophthalmic agents
1319 Others
D00904 Diclofenac sodium (JP18/USP)
2 Agents affecting individual organs
26 Epidermides
264 Analgesics, anti-itchings, astringents, anti-inflammatory agents
2649 Others
D00904 Diclofenac sodium (JP18/USP)
Classification of Japanese OTC drugs [BR:br08313]
Agents for integumentary system
57 Analgesic, antipruritic, astringent, and anti-inflammatory remedies (incl. gel patches)
D00904 Diclofenac sodium (JP18/USP)
Risk category of Japanese OTC drugs [BR:br08312]
Second-class OTC drugs
Inorganic and organic chemicals
Diclofenac
D00904 Diclofenac sodium (JP18/USP)
Drug groups [BR:br08330]
Anti-inflammatory
DG01504 Nonsteroidal anti-inflammatory drug (NSAID)
DG01906 Anti-inflammatory drug, acetic acid derivatives
DG01898 Anti-inflammatory drug, phenylacetic acid derivatives
DG00441 Diclofenac
D00904 Diclofenac sodium
Metabolizing enzyme substrate
DG01642 CYP2C9 substrate
DG00441 Diclofenac
D00904 Diclofenac sodium
Transporter inhibitor
DG02866 SLC22A8 inhibitor
DG00441 Diclofenac
D00904 Diclofenac sodium
Drug classes [BR:br08332]
Anti-inflammatory
DG01504 Nonsteroidal anti-inflammatory drug (NSAID)
D00904 Diclofenac sodium
Target-based classification of drugs [BR:br08310]
Enzymes
Oxidoreductases (EC1)
Prostaglandin synthase
PTGS1 (COX1)
D00904 Diclofenac sodium (JP18/USP) <JP/US>
PTGS2 (COX2)
D00904 Diclofenac sodium (JP18/USP) <JP/US>
Drugs listed in the Japanese Pharmacopoeia [BR:br08311]
Chemicals
D00904 Diclofenac sodium
D00904 Diclofenac sodium suppositories
Drug metabolizing enzymes and transporters [br08309.html]
Drug metabolizing enzymes
D00904
Drug transporters
D00904
Rx-to-OTC switch list in the USA [br08315.html]
D00904
Rx-to-OTC switch list in Japan [br08314.html]
D00904
Drug groups [BR:br08330]
Anti-inflammatory
DG01504 Nonsteroidal anti-inflammatory drug (NSAID)
DG01906 Anti-inflammatory drug, acetic acid derivatives
DG01898 Anti-inflammatory drug, phenylacetic acid derivatives
DG00441 Diclofenac
Metabolizing enzyme substrate
DG01642 CYP2C9 substrate
DG00441 Diclofenac
Transporter inhibitor
DG02866 SLC22A8 inhibitor
DG00441 Diclofenac
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| Other DBs |
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| LinkDB |
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| KCF data |
ATOM 20
1 Z Na 34.1141 -25.5138 #+
2 C8x C 26.2972 -26.1573
3 C8x C 26.2972 -27.5565
4 C8x C 27.5089 -28.2561
5 C8x C 28.7206 -27.5565
6 C8y C 28.7206 -26.1573
7 C8y C 27.5089 -25.4578
8 C1b C 29.9510 -25.4468
9 C6a C 31.1554 -26.1420
10 O6a O 32.3370 -25.4597 #-
11 O6a O 31.1558 -27.5561
12 N1b N 27.5089 -24.0588
13 C8y C 26.2804 -23.3494
14 C8y C 26.2807 -21.9600
15 C8x C 25.0692 -21.2602
16 C8x C 23.8573 -21.9595
17 C8x C 23.8570 -23.3489
18 C8y C 25.0686 -24.0487
19 X Cl 27.5049 -21.2534
20 X Cl 25.0686 -25.4575
BOND 20
1 2 3 2
2 3 4 1
3 4 5 2
4 5 6 1
5 6 7 2
6 2 7 1
7 6 8 1
8 8 9 1
9 9 10 1
10 9 11 2
11 7 12 1
12 12 13 1
13 13 14 2
14 14 15 1
15 15 16 2
16 16 17 1
17 17 18 2
18 13 18 1
19 14 19 1
20 18 20 1
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