KEGG   DRUG: Naproxen sodium
Entry
D00970                      Drug                                   
Name
Naproxen sodium (USP);
Anaprox (TN)
Product
  Generic
Formula
C14H13O3. Na
Exact mass
252.0762
Mol weight
252.24
Structure
Simcomp
Class
Anti-inflammatory
 DG01504  Nonsteroidal anti-inflammatory drug (NSAID)
  DG01908  Anti-inflammatory drug, propionic acid derivatives
Remark
ATC code: G02CC02 M01AE02 M02AA12
Chemical structure group: DG00455
Product (DG00455): D00118<JP/US> D00970<US>
Product (mixture): D11577<US>
Efficacy
Analgesic, Anti-inflammatory, Antipyretic, COX inhibitor
  Disease
Rheumatoid arthritis [DS:H00630]
Ankylosing spondylitis [DS:H01674]
Polyarticular juvenile idiopathic arthritis [DS:H01672]
Acute gout [DS:H01532]
Comment
Propionic acid derivative
Target
PTGS1 (COX1) [HSA:5742] [KO:K00509]
PTGS2 (COX2) [HSA:5743] [KO:K11987]
  Pathway
hsa00590  Arachidonic acid metabolism
Interaction
Structure map
map07048  Antimigraines
map07114  Naphthalene family
map07219  Cyclooxygenase inhibitors
Brite
Anatomical Therapeutic Chemical (ATC) classification [BR:br08303]
 G GENITO URINARY SYSTEM AND SEX HORMONES
  G02 OTHER GYNECOLOGICALS
   G02C OTHER GYNECOLOGICALS
    G02CC Antiinflammatory products for vaginal administration
     G02CC02 Naproxen
      D00970  Naproxen sodium (USP) <US>
 M MUSCULO-SKELETAL SYSTEM
  M01 ANTIINFLAMMATORY AND ANTIRHEUMATIC PRODUCTS
   M01A ANTIINFLAMMATORY AND ANTIRHEUMATIC PRODUCTS, NON-STEROIDS
    M01AE Propionic acid derivatives
     M01AE02 Naproxen
      D00970  Naproxen sodium (USP) <US>
  M02 TOPICAL PRODUCTS FOR JOINT AND MUSCULAR PAIN
   M02A TOPICAL PRODUCTS FOR JOINT AND MUSCULAR PAIN
    M02AA Antiinflammatory preparations, non-steroids for topical use
     M02AA12 Naproxen
      D00970  Naproxen sodium (USP) <US>
USP drug classification [BR:br08302]
 Analgesics
  Nonsteroidal Anti-inflammatory Drugs
   Naproxen
    D00970  Naproxen sodium (USP)
Drug groups [BR:br08330]
 Anti-inflammatory
  DG01504  Nonsteroidal anti-inflammatory drug (NSAID)
   DG01908  Anti-inflammatory drug, propionic acid derivatives
    DG00455  Naproxen
     D00970  Naproxen sodium
Drug classes [BR:br08332]
 Anti-inflammatory
  DG01504  Nonsteroidal anti-inflammatory drug (NSAID)
   D00970  Naproxen sodium
Target-based classification of drugs [BR:br08310]
 Enzymes
  Oxidoreductases (EC1)
   Prostaglandin synthase
    PTGS1 (COX1)
     D00970  Naproxen sodium (USP) <US>
    PTGS2 (COX2)
     D00970  Naproxen sodium (USP) <US>
Rx-to-OTC switch list in the USA [br08315.html]
 D00970
Drug groups [BR:br08330]
 Anti-inflammatory
  DG01504  Nonsteroidal anti-inflammatory drug (NSAID)
   DG01908  Anti-inflammatory drug, propionic acid derivatives
    DG00455  Naproxen
Other DBs
CAS: 26159-34-2
PubChem: 7848033
ChEBI: 7477
LigandBox: D00970
NIKKAJI: J17.059C
LinkDB
KCF data

ATOM        18
            1   C8y C    23.5997  -20.0988
            2   C8y C    23.5997  -21.4993
            3   C8x C    24.7901  -19.3985
            4   C8x C    22.3393  -19.3985
            5   C8x C    22.3393  -22.1995
            6   C8x C    24.7901  -22.1995
            7   C8y C    25.9806  -20.0988
            8   C8x C    21.1489  -20.0988
            9   C8y C    21.1489  -21.4993
            10  C8x C    25.9806  -21.4993
            11  C1c C    27.2410  -19.3985
            12  O2a O    19.9584  -22.1995
            13  C6a C    28.4314  -20.0988
            14  C1a C    27.2410  -17.9980
            15  C1a C    18.6980  -21.4993
            16  O6a O    28.4314  -21.4993
            17  O6a O    29.6219  -19.3985 #-
            18  Z   Na   31.5125  -19.3985 #+
BOND        18
            1     1   2 2
            2     1   3 1
            3     1   4 1
            4     2   5 1
            5     2   6 1
            6     3   7 2
            7     4   8 2
            8     5   9 2
            9     6  10 2
            10    7  11 1
            11    9  12 1
            12   11  13 1
            13   11  14 1 #Down
            14   12  15 1
            15   13  16 2
            16   13  17 1
            17    7  10 1
            18    8   9 1

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