| Entry |
|
|---|
| Name |
Bromperidol (JAN/USAN/INN);
Impromen (TN) |
|---|
| Formula |
C21H23BrFNO2
|
|---|
| Exact mass |
419.0896
|
|---|
| Mol weight |
420.31
|
|---|
| Structure |
|
|---|
| Simcomp |
|
|---|
| Class |
Neuropsychiatric agent
DG01478 Dopamine antagonist
DG01474 Dopamine D2-receptor antagonist
DG03200 Antipsychotic agent
DG01940 Butyrophenone derivative
Metabolizing enzyme substrate
DG01633 CYP3A/CYP3A4 substrate
DG02913 CYP3A4 substrate
|
|---|
| Remark |
| Therapeutic category: | 1179 |
| Product (DG00890): | D01101<JP> |
|
|---|
| Efficacy |
Antipsychotic, Dopamine D2 receptor antagonist |
|---|
| Comment |
Butyrophenone derivative
|
|---|
| Target |
|
|---|
| Pathway |
| hsa04080 | Neuroactive ligand-receptor interaction |
|
|---|
| Metabolism |
Enzyme: CYP3A4 [HSA: 1576]
|
|---|
| Interaction |
|
|---|
| Structure map |
| map07031 | Antipsychotics - butyrophenones |
|
|---|
| Brite |
Anatomical Therapeutic Chemical (ATC) classification [BR:br08303]
N NERVOUS SYSTEM
N05 PSYCHOLEPTICS
N05A ANTIPSYCHOTICS
N05AD Butyrophenone derivatives
N05AD06 Bromperidol
D01101 Bromperidol (JAN/USAN/INN) <JP>
Therapeutic category of drugs in Japan [BR:br08301]
1 Agents affecting nervous system and sensory organs
11 Agents affecting central nervous system
117 Psychotropics
1179 Others
D01101 Bromperidol (JAN/USAN/INN)
Drug groups [BR:br08330]
Neuropsychiatric agent
DG01478 Dopamine antagonist
DG01474 Dopamine D2-receptor antagonist
DG00890 Bromperidol
D01101 Bromperidol
DG03200 Antipsychotic agent
DG01940 Butyrophenone derivative
DG00890 Bromperidol
D01101 Bromperidol
Metabolizing enzyme substrate
DG01633 CYP3A/CYP3A4 substrate
DG02913 CYP3A4 substrate
DG00890 Bromperidol
D01101 Bromperidol
Target-based classification of drugs [BR:br08310]
G Protein-coupled receptors
Rhodopsin family
Dopamine
DRD2
D01101 Bromperidol (JAN/USAN/INN) <JP>
Drug metabolizing enzymes and transporters [br08309.html]
Drug metabolizing enzymes
D01101
Drug groups [BR:br08330]
Neuropsychiatric agent
DG01478 Dopamine antagonist
DG01474 Dopamine D2-receptor antagonist
DG00890 Bromperidol
DG03200 Antipsychotic agent
DG01940 Butyrophenone derivative
DG00890 Bromperidol
Metabolizing enzyme substrate
DG01633 CYP3A/CYP3A4 substrate
DG02913 CYP3A4 substrate
DG00890 Bromperidol
|
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| Other DBs |
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| LinkDB |
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| KCF data |
ATOM 26
1 C1b C 19.8100 -17.5700
2 C1b C 21.0000 -16.8700
3 C1b C 22.1900 -17.5700
4 N1y N 23.4500 -16.8700
5 C1x C 23.4500 -15.4700
6 C1x C 24.6400 -17.5700
7 C1x C 24.6400 -14.7700
8 C1x C 25.8300 -16.8700
9 C1z C 25.8300 -15.4700
10 C8y C 27.0200 -14.7700
11 C8x C 27.0200 -13.4400
12 C8x C 28.2100 -15.4700
13 C8x C 28.2100 -12.7400
14 C8x C 29.4000 -14.7700
15 C8y C 29.4000 -13.4400
16 X Br 30.6600 -12.7400
17 C5a C 18.5500 -16.8700
18 C8y C 17.3600 -17.5700
19 O5a O 18.5500 -15.4000
20 C8x C 17.3600 -18.9700
21 C8x C 16.1000 -19.6700
22 C8y C 14.9100 -18.9700
23 C8x C 14.9100 -17.5700
24 C8x C 16.1000 -16.8700
25 X F 13.6500 -19.6700
26 O1a O 27.0424 -16.1700
BOND 28
1 9 10 1
2 10 11 1
3 10 12 2
4 11 13 2
5 12 14 1
6 13 15 1
7 15 16 1
8 8 9 1
9 14 15 2
10 1 17 1
11 1 2 1
12 17 18 1
13 2 3 1
14 17 19 2
15 3 4 1
16 4 5 1
17 4 6 1
18 5 7 1
19 6 8 1
20 18 20 1
21 20 21 2
22 21 22 1
23 22 23 2
24 23 24 1
25 24 18 2
26 7 9 1
27 22 25 1
28 9 26 1
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