| Entry |
|
|---|
| Name |
Ampiroxicam (JP18/INN);
Flucam (TN) |
|---|
| Formula |
C20H21N3O7S
|
|---|
| Exact mass |
447.1100
|
|---|
| Mol weight |
447.46
|
|---|
| Structure |
|
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| Class |
Anti-inflammatory
DG01504 Nonsteroidal anti-inflammatory drug (NSAID)
DG01910 Anti-inflammatory drug, oxicams
Metabolizing enzyme substrate
DG01642 CYP2C9 substrate
|
|---|
| Efficacy |
Analgesic, Anti-inflammatory, Antirheumatic, COX inhibitor |
|---|
| Comment |
Oxicams
Active form of prodrug: Piroxicam [DR: D00127]
|
|---|
| Target |
|
|---|
| Pathway |
|
|---|
| Metabolism |
Enzyme: CYP2C9 [HSA: 1559]
|
|---|
| Interaction |
|
|---|
| Structure map |
|
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| Brite |
Drug groups [BR:br08330]
Anti-inflammatory
DG01504 Nonsteroidal anti-inflammatory drug (NSAID)
DG01910 Anti-inflammatory drug, oxicams
D01397 Ampiroxicam
Metabolizing enzyme substrate
DG01642 CYP2C9 substrate
D01397 Ampiroxicam
Target-based classification of drugs [BR:br08310]
Enzymes
Oxidoreductases (EC1)
Prostaglandin synthase
PTGS1 (COX1)
D01397 Ampiroxicam (JP18/INN)
PTGS2 (COX2)
D01397 Ampiroxicam (JP18/INN)
Drugs listed in the Japanese Pharmacopoeia [BR:br08311]
Chemicals
D01397 Ampiroxicam
D01397 Ampiroxicam capsules
Drug metabolizing enzymes and transporters [br08309.html]
Drug metabolizing enzymes
D01397
Prodrugs [br08324.html]
D01397
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| Other DBs |
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| LinkDB |
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| KCF data |
ATOM 31
1 C8y C 27.9963 -14.0121
2 N5x N 29.1858 -14.6984
3 C8x C 30.3750 -14.0113
4 C8x C 30.3745 -12.6380
5 C8x C 29.1849 -11.9517
6 C8x C 27.9959 -12.6388
7 C8y C 22.0186 -14.7322
8 C8y C 22.0186 -16.1207
9 C8y C 23.2177 -14.0254
10 C8x C 20.8133 -14.0445
11 S2x S 23.2303 -16.8149
12 C8x C 20.8133 -16.8211
13 C8y C 24.4294 -14.7260
14 O2a O 23.2115 -12.6560
15 C8x C 19.6269 -14.7322
16 N4y N 24.4420 -16.1269
17 C8x C 19.6269 -16.1207
18 C5a C 25.6157 -14.0318
19 C1a C 25.6283 -16.8085
20 O5a O 25.6094 -12.6624
21 C1c C 22.0256 -11.9761
22 O7a O 20.8437 -12.6549
23 C7a C 19.6616 -11.9761
24 O7a O 18.4798 -12.6549
25 C1b C 17.2979 -11.9761
26 C1a C 16.1158 -12.6549
27 O6a O 19.6541 -10.6112
28 C1a C 22.0250 -10.6132
29 N1b N 26.8096 -14.7130
30 O3c O 22.2404 -17.8048
31 O3c O 24.2203 -17.8048
BOND 33
1 7 10 1
2 8 11 1
3 8 12 1
4 9 13 2
5 9 14 1
6 10 15 2
7 11 16 1
8 12 17 2
9 13 18 1
10 16 19 1
11 18 20 2
12 13 16 1
13 15 17 1
14 2 3 1
15 14 21 1
16 3 4 2
17 21 22 1
18 4 5 1
19 22 23 1
20 5 6 2
21 23 24 1
22 6 1 1
23 24 25 1
24 25 26 1
25 1 2 2
26 23 27 2
27 7 8 2
28 21 28 1
29 7 9 1
30 18 29 1
31 29 1 1
32 11 30 2
33 11 31 2
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