| Entry |
|
|---|
| Name |
Scopolamine hydrobromide (USP);
Scopolamine hydrobromide hydrate (JP18);
Scopolamine hydrobromide trihydrate;
Hysco (TN);
Isopto hyoscine (TN) |
|---|
| Formula |
C17H21NO4. 3H2O. HBr
|
|---|
| Exact mass |
437.1049
|
|---|
| Mol weight |
438.31
|
|---|
| Structure |
|
|---|
| Simcomp |
|
|---|
| Class |
Neuropsychiatric agent
DG01491 Muscarinic cholinergic receptor antagonist
Gastrointestinal agent
DG01762 Antiemetic
|
|---|
| Remark |
| Product (DG00065): | D00138<US> |
|
|---|
| Efficacy |
Antispasmodic, Midriatic, Muscarinic acetylcholine receptor antagonist |
|---|
| Comment |
Tropane derivative
|
|---|
| Target |
|
|---|
| Pathway |
| hsa04080 | Neuroactive ligand-receptor interaction |
|
|---|
| Interaction |
|
|---|
| Structure map |
| map07220 | Cholinergic and anticholinergic drugs |
|
|---|
| Brite |
Anatomical Therapeutic Chemical (ATC) classification [BR:br08303]
A ALIMENTARY TRACT AND METABOLISM
A04 ANTIEMETICS AND ANTINAUSEANTS
A04A ANTIEMETICS AND ANTINAUSEANTS
A04AD Other antiemetics
A04AD01 Scopolamine
D02071 Scopolamine hydrobromide (USP)
N NERVOUS SYSTEM
N05 PSYCHOLEPTICS
N05C HYPNOTICS AND SEDATIVES
N05CM Other hypnotics and sedatives
N05CM05 Scopolamine
D02071 Scopolamine hydrobromide (USP)
S SENSORY ORGANS
S01 OPHTHALMOLOGICALS
S01F MYDRIATICS AND CYCLOPLEGICS
S01FA Anticholinergics
S01FA02 Scopolamine
D02071 Scopolamine hydrobromide (USP)
USP drug classification [BR:br08302]
Gastrointestinal Agents
Antispasmodics, Gastrointestinal
Scopolamine
D02071 Scopolamine hydrobromide (USP)
Classification of Japanese OTC drugs [BR:br08313]
Agents for nervous and sensory systems
06 Antivertigo drugs (incl. motion/morning sickness remedies)
D02071 Scopolamine hydrobromide (USP)
Agents for digestive organs
15 Stomach pain and cramp relievers
D02071 Scopolamine hydrobromide (USP)
Risk category of Japanese OTC drugs [BR:br08312]
Second-class OTC drugs
Inorganic and organic chemicals
Scopolamine
D02071 Scopolamine hydrobromide (USP)
Drug groups [BR:br08330]
Neuropsychiatric agent
DG01491 Muscarinic cholinergic receptor antagonist
DG00065 Scopolamine
D02071 Scopolamine hydrobromide
Gastrointestinal agent
DG01762 Antiemetic
DG00065 Scopolamine
D02071 Scopolamine hydrobromide
Target-based classification of drugs [BR:br08310]
G Protein-coupled receptors
Rhodopsin family
Acetylcholine (muscarinic)
CHRM
D02071 Scopolamine hydrobromide (USP)
Drugs listed in the Japanese Pharmacopoeia [BR:br08311]
Chemicals
D02071 Scopolamine hydrobromide hydrate
Drug groups [BR:br08330]
Neuropsychiatric agent
DG01491 Muscarinic cholinergic receptor antagonist
DG00065 Scopolamine
Gastrointestinal agent
DG01762 Antiemetic
DG00065 Scopolamine
|
|---|
| Other DBs |
|
|---|
| LinkDB |
|
|---|
| KCF data |
ATOM 26
1 X Br 38.4301 -16.1700
2 O0 O 38.8500 -18.6900
3 C1y C 24.3600 -17.8500
4 C1y C 24.6400 -16.6600
5 C1y C 25.4800 -17.5700
6 O2x O 23.3100 -16.4500
7 C1y C 25.8300 -16.3800
8 N1y N 24.5700 -15.0500
9 C1x C 27.3700 -17.5700
10 C1x C 27.0900 -16.3800
11 C1a C 24.5700 -13.7200
12 C1y C 28.3500 -18.0600
13 O7a O 29.4000 -18.9700
14 C7a C 30.8000 -18.9700
15 O6a O 31.5000 -20.1600
16 C1c C 31.5000 -17.7800
17 C8y C 32.9000 -17.7800
18 C8x C 33.6000 -18.9700
19 C8x C 35.0000 -18.9700
20 C8x C 35.7000 -17.7800
21 C8x C 35.0000 -16.5900
22 C8x C 33.6000 -16.5900
23 C1b C 30.8000 -16.5200
24 O1a O 31.5000 -15.3300
25 O0 O 38.8500 -18.6900
26 O0 O 38.8500 -18.6900
BOND 25
1 3 4 1
2 3 5 1
3 3 6 1
4 4 7 1
5 5 8 1
6 5 9 1
7 7 10 1
8 8 11 1
9 9 12 1
10 12 13 1 #Down
11 4 6 1
12 7 8 1
13 10 12 1
14 13 14 1
15 14 15 2
16 14 16 1
17 16 17 1
18 17 18 2
19 18 19 1
20 19 20 2
21 20 21 1
22 21 22 2
23 17 22 1
24 16 23 1 #Down
25 23 24 1
BRACKET 1 36.8200 -19.8100 36.8200 -17.6400
1 39.4100 -17.6400 39.4100 -19.8100
1 3
ORIGINAL 1 2
REPEAT 1 27 28
|
|---|
