| Entry |
|
|---|
| Name |
Morphine hydrochloride hydrate (JP18);
Morphine hydrochloride trihydrate;
Anpec (TN) |
|---|
| Formula |
C17H19NO3. 3H2O. HCl
|
|---|
| Exact mass |
375.1449
|
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| Mol weight |
375.84
|
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| Structure |
|
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| Simcomp |
|
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| Class |
Neuropsychiatric agent
DG01564 Opioid receptor agonist
DG01563 mu-Opioid receptor agonist
Analgesic
DG01984 Opioid analgesics
Metabolizing enzyme substrate
DG02924 UGT substrate
|
|---|
| Remark |
| Therapeutic category: | 8114 |
| Product (DG00810): | D00842<JP/US> D02271<JP> |
|
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| Efficacy |
Analgesic (narcotic), Opioid receptor agonist |
|---|
| Comment |
Opium alkaloid
|
|---|
| Target |
|
|---|
| Pathway |
| hsa04080 | Neuroactive ligand-receptor interaction |
|
|---|
| Metabolism |
|
|---|
| Interaction |
|
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| Structure map |
| map07224 | Opioid receptor agonists/antagonists |
|
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| Other map |
|
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| Brite |
Anatomical Therapeutic Chemical (ATC) classification [BR:br08303]
N NERVOUS SYSTEM
N02 ANALGESICS
N02A OPIOIDS
N02AA Natural opium alkaloids
N02AA01 Morphine
D02271 Morphine hydrochloride hydrate (JP18) <JP>
USP drug classification [BR:br08302]
Analgesics
Opioid Analgesics, Long-acting
Morphine
D02271 Morphine hydrochloride hydrate (JP18)
Opioid Analgesics, Short-acting
Morphine
D02271 Morphine hydrochloride hydrate (JP18)
Therapeutic category of drugs in Japan [BR:br08301]
8 Narcotics
81 Alkaloidal narcotics
811 Opium alkaloids
8114 Morphines
D02271 Morphine hydrochloride hydrate (JP18)
Drug groups [BR:br08330]
Neuropsychiatric agent
DG01564 Opioid receptor agonist
DG01563 mu-Opioid receptor agonist
DG00810 Morphine
D02271 Morphine hydrochloride hydrate
Analgesic
DG01984 Opioid analgesics
DG00810 Morphine
D02271 Morphine hydrochloride hydrate
Metabolizing enzyme substrate
DG02924 UGT substrate
DG00810 Morphine
D02271 Morphine hydrochloride hydrate
Target-based classification of drugs [BR:br08310]
G Protein-coupled receptors
Rhodopsin family
Opioid
OPRM1
D02271 Morphine hydrochloride hydrate (JP18) <JP>
Drugs listed in the Japanese Pharmacopoeia [BR:br08311]
Chemicals
D02271 Morphine hydrochloride hydrate
D02271 Morphine hydrochloride tablets
D02271 Morphine hydrochloride injection
Drug metabolizing enzymes and transporters [br08309.html]
Drug metabolizing enzymes
D02271
Drug groups [BR:br08330]
Neuropsychiatric agent
DG01564 Opioid receptor agonist
DG01563 mu-Opioid receptor agonist
DG00810 Morphine
Analgesic
DG01984 Opioid analgesics
DG00810 Morphine
Metabolizing enzyme substrate
DG02924 UGT substrate
DG00810 Morphine
|
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| Other DBs |
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| LinkDB |
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| KCF data |
ATOM 25
1 X Cl 27.0190 -23.0527
2 O0 O 27.2299 -20.5437
3 C1z C 19.1395 -23.6495
4 C8y C 19.1395 -22.3255
5 C1y C 20.3241 -24.3462
6 C1y C 18.0246 -24.2766
7 C1x C 20.3241 -23.0224
8 C8y C 18.0246 -21.6984
9 C8y C 20.3241 -21.6984
10 C1y C 21.4390 -23.6495
11 C2x C 20.3241 -25.6005
12 O2x O 16.7007 -22.9526
13 C1y C 18.0246 -25.6005
14 C1x C 22.5538 -23.0224
15 C8y C 18.0246 -20.3745
16 C1x C 21.4390 -22.3952
17 C8x C 20.3241 -20.3745
18 N1y N 22.5538 -24.3462
19 C2x C 19.1395 -26.2973
20 O1a O 16.9098 -26.2973
21 C8x C 19.2092 -19.7474
22 O1a O 16.9098 -19.7474
23 C1a C 23.9527 -24.3462
24 O0 O 27.2299 -20.5437
25 O0 O 27.2299 -20.5437
BOND 25
1 3 4 1
2 3 5 1
3 3 6 1
4 3 7 1 #Up
5 4 8 2
6 4 9 1
7 5 10 1
8 5 11 1
9 6 12 1 #Down
10 6 13 1
11 7 14 1
12 8 15 1
13 9 16 1
14 9 17 2
15 10 18 1 #Up
16 11 19 2
17 13 20 1 #Down
18 15 21 2
19 15 22 1
20 8 12 1
21 10 16 1
22 13 19 1
23 14 18 1
24 17 21 1
25 18 23 1
BRACKET 1 25.0600 -21.4200 25.0600 -19.5300
1 27.9300 -19.5300 27.9300 -21.4200
1 3
ORIGINAL 1 2
REPEAT 1 25 26
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