| Entry |
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| Name |
Quinidine sulfate (USP);
Quinidine sulfate hydrate (JP18);
Quinidex (TN) |
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| Product |
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| Generic |
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| Formula |
(C20H24N2O2)2. H2SO4. 2H2O
|
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| Exact mass |
782.3561
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| Mol weight |
782.94
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| Structure |
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| Simcomp |
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| Class |
Cardiovascular agent
DG01653 Antiarrhythmics
DG01652 Class I antiarrhythmic agent
DG01649 Class Ia antiarrhythmic agent
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| Remark |
| Therapeutic category: | 2122 |
| Product (DG00192): | D00642<US> D02272<JP/US> |
| Product (mixture): | D10208<US> |
|
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| Efficacy |
Antiarrhythmic, Sodium channel blocker |
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| Disease |
Atrial fibrillation [DS: H00731] |
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| Target |
|
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| Pathway |
| hsa04261 | Adrenergic signaling in cardiomyocytes |
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| Interaction |
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| Structure map |
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| Brite |
Anatomical Therapeutic Chemical (ATC) classification [BR:br08303]
C CARDIOVASCULAR SYSTEM
C01 CARDIAC THERAPY
C01B ANTIARRHYTHMICS, CLASS I AND III
C01BA Antiarrhythmics, class Ia
C01BA01 Quinidine
D02272 Quinidine sulfate (USP) <JP/US>
USP drug classification [BR:br08302]
Cardiovascular Agents
Antiarrhythmics
Vaughn Williams-Class I
Quinidine
D02272 Quinidine sulfate (USP)
Therapeutic category of drugs in Japan [BR:br08301]
2 Agents affecting individual organs
21 Cardiovascular agents
212 Antiarrhythmic agents
2122 Quinidines
D02272 Quinidine sulfate (USP); Quinidine sulfate hydrate (JP18)
Drug groups [BR:br08330]
Cardiovascular agent
DG01653 Antiarrhythmics
DG01652 Class I antiarrhythmic agent
DG01649 Class Ia antiarrhythmic agent
DG00192 Quinidine
D02272 Quinidine sulfate
Drug classes [BR:br08332]
Cardiovascular agent
DG01653 Antiarrhythmics
D02272 Quinidine sulfate
Target-based classification of drugs [BR:br08310]
Ion channels
Voltage-gated ion channels
Sodium channels
SCN1A
D02272 Quinidine sulfate (USP) <JP/US>
SCN2A
D02272 Quinidine sulfate (USP) <JP/US>
SCN3A
D02272 Quinidine sulfate (USP) <JP/US>
SCN4A
D02272 Quinidine sulfate (USP) <JP/US>
SCN5A
D02272 Quinidine sulfate (USP) <JP/US>
SCN8A
D02272 Quinidine sulfate (USP) <JP/US>
SCN9A
D02272 Quinidine sulfate (USP) <JP/US>
SCN10A
D02272 Quinidine sulfate (USP) <JP/US>
SCN11A
D02272 Quinidine sulfate (USP) <JP/US>
Drugs listed in the Japanese Pharmacopoeia [BR:br08311]
Chemicals
D02272 Quinidine sulfate hydrate
Pharmacogenomic biomarkers [br08341.html]
Polymorphisms and mutations affecting drug response
D02272
Drug groups [BR:br08330]
Cardiovascular agent
DG01653 Antiarrhythmics
DG01652 Class I antiarrhythmic agent
DG01649 Class Ia antiarrhythmic agent
DG00192 Quinidine
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| Other DBs |
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| LinkDB |
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| KCF data |
ATOM 55
1 C8y C 19.1695 -25.8213
2 C8y C 20.3898 -25.1264
3 C8y C 19.1636 -27.2226
4 C8x C 17.9666 -25.1206
5 C1c C 20.3956 -23.7251
6 C8x C 21.6100 -25.8330
7 C8x C 17.9666 -27.9291
8 N5x N 20.3782 -27.9348
9 C8y C 16.7463 -25.8213
10 C1y C 21.6217 -23.0186
11 O1a O 19.1812 -23.0070
12 C8x C 21.6042 -27.2342
13 C8x C 16.7463 -27.2226
14 O2a O 15.5319 -25.1206
15 N1y N 23.0581 -22.1429
16 C1x C 20.8919 -21.9734
17 C1a C 15.5319 -23.7193
18 C1x C 23.0581 -20.9050
19 C1x C 24.5586 -22.9485
20 C1y C 22.3049 -21.1385
21 C1y C 22.3107 -20.1518
22 C1x C 23.8639 -21.8391
23 C2b C 21.7736 -18.8497
24 C2a C 22.6376 -17.7405
25 S4a S 28.9727 -21.0527
26 O1d O 30.3683 -21.0584
27 O1d O 27.5773 -21.0527
28 O1d O 28.9670 -22.4481
29 O1d O 28.9670 -19.6514
30 O0 O 29.7500 -25.6200
31 C8y C 19.1695 -25.8213
32 C8y C 20.3898 -25.1264
33 C1c C 20.3956 -23.7251
34 C1y C 21.6217 -23.0186
35 N1y N 23.0581 -22.1429
36 C1x C 23.0581 -20.9050
37 C1y C 22.3107 -20.1518
38 C2b C 21.7736 -18.8497
39 C2a C 22.6376 -17.7405
40 C1y C 22.3049 -21.1385
41 C1x C 20.8919 -21.9734
42 C1x C 23.8639 -21.8391
43 C1x C 24.5586 -22.9485
44 O1a O 19.1812 -23.0070
45 C8x C 21.6100 -25.8330
46 C8x C 21.6042 -27.2342
47 N5x N 20.3782 -27.9348
48 C8y C 19.1636 -27.2226
49 C8x C 17.9666 -27.9291
50 C8x C 16.7463 -27.2226
51 C8y C 16.7463 -25.8213
52 C8x C 17.9666 -25.1206
53 O2a O 15.5319 -25.1206
54 C1a C 15.5319 -23.7193
55 O0 O 29.7500 -25.6200
BOND 58
1 25 26 1
2 25 27 1
3 25 28 2
4 25 29 2
5 1 2 1
6 1 3 1
7 1 4 2
8 2 5 1
9 2 6 2
10 3 7 2
11 3 8 1
12 4 9 1
13 5 10 1
14 5 11 1 #Down
15 6 12 1
16 7 13 1
17 9 14 1
18 10 15 1
19 10 16 1
20 14 17 1
21 15 18 1
22 15 19 1
23 16 20 1
24 18 21 1
25 19 22 1
26 21 23 1 #Up
27 23 24 2
28 8 12 2
29 9 13 2
30 20 21 1
31 20 22 1
32 31 32 1
33 31 48 1
34 31 52 2
35 32 33 1
36 32 45 2
37 48 49 2
38 48 47 1
39 52 51 1
40 33 34 1
41 33 44 1 #Down
42 45 46 1
43 49 50 1
44 51 53 1
45 34 35 1
46 34 41 1
47 53 54 1
48 35 36 1
49 35 43 1
50 41 40 1
51 36 37 1
52 43 42 1
53 37 38 1 #Up
54 38 39 2
55 47 46 2
56 51 50 2
57 40 37 1
58 40 42 1
BRACKET 1 14.7000 -28.9100 14.7000 -16.8700
1 25.2700 -16.8700 25.2700 -28.9100
1 2
ORIGINAL 1 1 2 5 10 15 18 21 23 24 20 16 22 19 25 11 6
1 12 8 3 7 13 9 4 14 17
REPEAT 1 32 33 34 35 36 37 38 39 40 41 42 43 44 45 46 47
1 48 49 50 51 52 53 54 55 56
2 27.5800 -26.5300 27.5800 -24.7800
2 30.3800 -24.7800 30.3800 -26.5300
2 2
ORIGINAL 2 31
REPEAT 2 57
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