| Entry |
|
|---|
| Name |
Fosamprenavir (INN) |
|---|
| Formula |
C25H36N3O9PS
|
|---|
| Exact mass |
585.1910
|
|---|
| Mol weight |
585.61
|
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| Structure |
|
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| Simcomp |
|
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| Class |
Antiviral
DG03107 Anti-HIV agent
DG01647 HIV protease inhibitor
Metabolizing enzyme substrate
DG01633 CYP3A/CYP3A4 substrate
DG02913 CYP3A4 substrate
Metabolizing enzyme inhibitor
DG02852 CYP3A/CYP3A4 inhibitor
DG01522 CYP3A4 inhibitor
|
|---|
| Remark |
| Product (DG00656): | D03835<US> |
|
|---|
| Efficacy |
Antiviral, HIV protease inhibitor |
|---|
| Comment |
Active form of prodrug: Amprenavir [DR: D00894]
|
|---|
| Target |
|
|---|
| Pathway |
|
|---|
| Metabolism |
Enzyme: CYP3A4 [HSA: 1576]
|
|---|
| Interaction |
CYP inhibition: CYP3A4 [HSA: 1576]
|
|---|
| Structure map |
|
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| Brite |
Anatomical Therapeutic Chemical (ATC) classification [BR:br08303]
J ANTIINFECTIVES FOR SYSTEMIC USE
J05 ANTIVIRALS FOR SYSTEMIC USE
J05A DIRECT ACTING ANTIVIRALS
J05AE Protease inhibitors
J05AE07 Fosamprenavir
D02497 Fosamprenavir (INN)
Drug groups [BR:br08330]
Antiviral
DG03107 Anti-HIV agent
DG01647 HIV protease inhibitor
DG00656 Fosamprenavir
D02497 Fosamprenavir
Metabolizing enzyme substrate
DG01633 CYP3A/CYP3A4 substrate
DG02913 CYP3A4 substrate
DG00656 Fosamprenavir
D02497 Fosamprenavir
Metabolizing enzyme inhibitor
DG02852 CYP3A/CYP3A4 inhibitor
DG01522 CYP3A4 inhibitor
DG00656 Fosamprenavir
D02497 Fosamprenavir
Antimicrobials [BR:br08307]
Antivirals
Polyprotein cleavage inhibitor
HIV protease inhibitor
D02497 Fosamprenavir (INN)
Drug metabolizing enzymes and transporters [br08309.html]
Drug metabolizing enzymes
D02497
Prodrugs [br08324.html]
D02497
Drug groups [BR:br08330]
Antiviral
DG03107 Anti-HIV agent
DG01647 HIV protease inhibitor
DG00656 Fosamprenavir
Metabolizing enzyme substrate
DG01633 CYP3A/CYP3A4 substrate
DG02913 CYP3A4 substrate
DG00656 Fosamprenavir
Metabolizing enzyme inhibitor
DG02852 CYP3A/CYP3A4 inhibitor
DG01522 CYP3A4 inhibitor
DG00656 Fosamprenavir
Antimicrobials abbreviations [BR:br08327]
Antivirals
Polyprotein cleavage inhibitor
HIV protease inhibitor
DG00656 Fosamprenavir
Prodrugs [br08324.html]
DG00656
|
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| Other DBs |
|
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| LinkDB |
|
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| KCF data |
ATOM 39
1 N1c N 16.3800 -7.8400
2 C1b C 15.2600 -7.1400
3 S4a S 17.9200 -7.1400
4 C1c C 14.0700 -7.8400
5 C8y C 19.3200 -7.8400
6 C1c C 12.8800 -7.1400
7 N1b N 11.7600 -7.8400
8 C7a C 10.5700 -7.1400
9 O7a O 9.3800 -7.8400
10 O6a O 10.5700 -5.8100
11 C1y C 8.1900 -7.2100
12 C8x C 19.3200 -9.2400
13 C8x C 20.5100 -9.8700
14 C8y C 21.6300 -9.2400
15 C8x C 21.6300 -7.8400
16 C8x C 20.5100 -7.1400
17 N1a N 22.8900 -9.9400
18 O2b O 14.0700 -9.8700
19 P1b P 12.8800 -10.6400
20 O1c O 11.7600 -11.2700
21 O3c O 16.9400 -6.2300
22 O3c O 18.8300 -6.2300
23 O1c O 13.5800 -11.8300
24 O1c O 12.1800 -9.4500
25 C1x C 8.1900 -5.8800
26 C1x C 6.9300 -7.6300
27 C1x C 6.0900 -6.5800
28 O2x O 6.9300 -5.4600
29 C1b C 16.3577 -9.2370
30 C1c C 17.5765 -9.9669
31 C1a C 18.8063 -9.2830
32 C1a C 17.5543 -11.3399
33 C1b C 12.8612 -5.7401
34 C8y C 14.0780 -5.0156
35 C8x C 15.3039 -5.7014
36 C8x C 16.5068 -4.9850
37 C8x C 16.4878 -3.5852
38 C8x C 15.2619 -2.8993
39 C8x C 14.0590 -3.6157
BOND 41
1 1 2 1
2 1 3 1
3 2 4 1
4 3 5 1
5 4 6 1
6 6 7 1
7 7 8 1
8 8 9 1
9 8 10 2
10 11 9 1 #Up
11 5 12 2
12 12 13 1
13 13 14 2
14 14 15 1
15 15 16 2
16 5 16 1
17 14 17 1
18 4 18 1 #Up
19 18 19 1
20 19 20 1
21 3 21 2
22 3 22 2
23 19 23 1
24 19 24 2
25 11 25 1
26 11 26 1
27 26 27 1
28 27 28 1
29 25 28 1
30 1 29 1
31 29 30 1
32 30 31 1
33 30 32 1
34 6 33 1 #Up
35 33 34 1
36 34 35 2
37 35 36 1
38 36 37 2
39 37 38 1
40 38 39 2
41 34 39 1
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