| Entry |
|
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| Name |
Dihydrocodeine bitartrate (USP) |
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| Formula |
C18H23NO3. C4H6O6
|
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| Exact mass |
451.1842
|
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| Mol weight |
451.47
|
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| Structure |
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| Simcomp |
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| Class |
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| Remark |
| Product (DG00814): | D01481<JP> |
| Product (mixture): | D12295<US> |
|
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| Efficacy |
Analgesic (narcotic), Antitussive, Opioid receptor agonist |
|---|
| Comment |
Component of DHC plus (TN)
Opium alkaloid
|
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| Target |
|
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| Pathway |
| hsa04080 | Neuroactive ligand-receptor interaction |
|
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| Metabolism |
Enzyme: UGT2B7 [HSA: 7364], UGT2B4 [HSA: 7363]; CYP3A4 [HSA: 1576], CYP2D6 [HSA: 1565]
|
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| Interaction |
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| Structure map |
| map07224 | Opioid receptor agonists/antagonists |
|
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| Brite |
Anatomical Therapeutic Chemical (ATC) classification [BR:br08303]
N NERVOUS SYSTEM
N02 ANALGESICS
N02A OPIOIDS
N02AA Natural opium alkaloids
N02AA08 Dihydrocodeine
D03825 Dihydrocodeine bitartrate (USP)
Drug groups [BR:br08330]
Neuropsychiatric agent
DG01564 Opioid receptor agonist
DG01563 mu-Opioid receptor agonist
DG00814 Dihydrocodeine
D03825 Dihydrocodeine bitartrate
Analgesic
DG01984 Opioid analgesics
DG00814 Dihydrocodeine
D03825 Dihydrocodeine bitartrate
Metabolizing enzyme substrate
DG01644 CYP2D6 substrate
DG00814 Dihydrocodeine
D03825 Dihydrocodeine bitartrate
DG01633 CYP3A/CYP3A4 substrate
DG02913 CYP3A4 substrate
DG00814 Dihydrocodeine
D03825 Dihydrocodeine bitartrate
DG02924 UGT substrate
DG03189 UGT2B4 substrate
DG00814 Dihydrocodeine
D03825 Dihydrocodeine bitartrate
DG03190 UGT2B7 substrate
DG00814 Dihydrocodeine
D03825 Dihydrocodeine bitartrate
Target-based classification of drugs [BR:br08310]
G Protein-coupled receptors
Rhodopsin family
Opioid
OPRM1
D03825 Dihydrocodeine bitartrate (USP)
Drug metabolizing enzymes and transporters [br08309.html]
Drug metabolizing enzymes
D03825
Drug groups [BR:br08330]
Neuropsychiatric agent
DG01564 Opioid receptor agonist
DG01563 mu-Opioid receptor agonist
DG00814 Dihydrocodeine
Analgesic
DG01984 Opioid analgesics
DG00814 Dihydrocodeine
Metabolizing enzyme substrate
DG01644 CYP2D6 substrate
DG00814 Dihydrocodeine
DG01633 CYP3A/CYP3A4 substrate
DG02913 CYP3A4 substrate
DG00814 Dihydrocodeine
DG02924 UGT substrate
DG03189 UGT2B4 substrate
DG00814 Dihydrocodeine
DG03190 UGT2B7 substrate
DG00814 Dihydrocodeine
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| Other DBs |
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| LinkDB |
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| KCF data |
ATOM 32
1 C1z C 24.6296 -16.0491
2 C8y C 24.6354 -14.7521
3 C1y C 25.7515 -16.7095
4 C1y C 23.5019 -16.7095
5 C1x C 25.5587 -15.1377
6 C8y C 23.5253 -14.0919
7 C8y C 25.7690 -14.1153
8 C1y C 26.8908 -16.0667
9 C1x C 25.7573 -18.0125
10 O2x O 22.2457 -15.3889
11 C1y C 23.5019 -18.0125
12 C1x C 27.9951 -15.1260
13 C8y C 23.5310 -12.7947
14 C1x C 26.8966 -14.7638
15 C8x C 25.7806 -12.8179
16 N1y N 28.0186 -16.7270
17 C1x C 24.6296 -18.6610
18 C8x C 24.6647 -12.1519
19 O2a O 22.4092 -12.1345
20 O1a O 22.3739 -18.6649
21 C1a C 21.1969 -12.8212
22 C1a C 29.4186 -16.7270
23 C1c C 35.4128 -15.8474
24 C1c C 36.6002 -15.1490
25 C6a C 34.1556 -15.1490
26 O1a O 35.4128 -17.2443
27 C6a C 37.7875 -15.8474
28 O1a O 36.6002 -13.7521
29 O6a O 32.9683 -15.8474
30 O6a O 34.1556 -13.7521
31 O6a O 39.0447 -15.1490
32 O6a O 37.7875 -17.2443
BOND 35
1 4 10 1 #Down
2 4 11 1
3 5 12 1
4 6 13 2
5 7 14 1
6 7 15 1
7 8 16 1 #Up
8 9 17 1
9 13 18 1
10 13 19 1
11 6 10 1
12 8 14 1
13 11 17 1
14 12 16 1
15 15 18 2
16 11 20 1 #Down
17 1 2 1
18 1 3 1
19 1 4 1
20 1 5 1 #Up
21 2 6 1
22 2 7 2
23 3 8 1
24 3 9 1
25 19 21 1
26 16 22 1
27 23 24 1
28 23 25 1
29 23 26 1 #Up
30 24 27 1
31 24 28 1 #Up
32 25 29 1
33 25 30 2
34 27 31 1
35 27 32 2
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