| Entry |
|
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| Name |
Fosamprenavir sodium (USAN) |
|---|
| Formula |
C25H34N3O9PS. 2Na
|
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| Exact mass |
629.1549
|
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| Mol weight |
629.57
|
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| Structure |
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| Simcomp |
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| Class |
Antiviral
DG03107 Anti-HIV agent
DG01647 HIV protease inhibitor
Metabolizing enzyme substrate
DG01633 CYP3A/CYP3A4 substrate
DG02913 CYP3A4 substrate
Metabolizing enzyme inhibitor
DG02852 CYP3A/CYP3A4 inhibitor
DG01522 CYP3A4 inhibitor
|
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| Remark |
| Product (DG00656): | D03835<US> |
|
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| Efficacy |
Antiviral, HIV protease inhibitor |
|---|
| Comment |
Active form of prodrug: Amprenavir [DR: D00894]
|
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| Target |
|
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| Pathway |
|
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| Metabolism |
Enzyme: CYP3A4 [HSA: 1576]
|
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| Interaction |
CYP inhibition: CYP3A4 [HSA: 1576]
|
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| Structure map |
|
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| Brite |
Anatomical Therapeutic Chemical (ATC) classification [BR:br08303]
J ANTIINFECTIVES FOR SYSTEMIC USE
J05 ANTIVIRALS FOR SYSTEMIC USE
J05A DIRECT ACTING ANTIVIRALS
J05AE Protease inhibitors
J05AE07 Fosamprenavir
D03837 Fosamprenavir sodium (USAN)
Drug groups [BR:br08330]
Antiviral
DG03107 Anti-HIV agent
DG01647 HIV protease inhibitor
DG00656 Fosamprenavir
D03837 Fosamprenavir sodium
Metabolizing enzyme substrate
DG01633 CYP3A/CYP3A4 substrate
DG02913 CYP3A4 substrate
DG00656 Fosamprenavir
D03837 Fosamprenavir sodium
Metabolizing enzyme inhibitor
DG02852 CYP3A/CYP3A4 inhibitor
DG01522 CYP3A4 inhibitor
DG00656 Fosamprenavir
D03837 Fosamprenavir sodium
Antimicrobials [BR:br08307]
Antivirals
Polyprotein cleavage inhibitor
HIV protease inhibitor
D03837 Fosamprenavir sodium (USAN)
Drug metabolizing enzymes and transporters [br08309.html]
Drug metabolizing enzymes
D03837
Drug groups [BR:br08330]
Antiviral
DG03107 Anti-HIV agent
DG01647 HIV protease inhibitor
DG00656 Fosamprenavir
Metabolizing enzyme substrate
DG01633 CYP3A/CYP3A4 substrate
DG02913 CYP3A4 substrate
DG00656 Fosamprenavir
Metabolizing enzyme inhibitor
DG02852 CYP3A/CYP3A4 inhibitor
DG01522 CYP3A4 inhibitor
DG00656 Fosamprenavir
Antimicrobials abbreviations [BR:br08327]
Antivirals
Polyprotein cleavage inhibitor
HIV protease inhibitor
DG00656 Fosamprenavir
Prodrugs [br08324.html]
DG00656
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| Other DBs |
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| LinkDB |
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| KCF data |
ATOM 41
1 Z Na 17.7733 -24.9426 #+
2 Z Na 11.5601 -24.5153 #+
3 N1c N 18.9700 -21.0000
4 C1b C 17.8500 -20.3000
5 S4a S 20.5100 -20.3000
6 C1c C 16.6600 -21.0000
7 C8y C 21.9100 -21.0000
8 C1c C 15.4700 -20.3000
9 N1b N 14.3500 -21.0000
10 C7a C 13.1600 -20.3000
11 O7a O 11.9700 -21.0000
12 O6a O 13.1600 -18.9700
13 C1y C 10.7800 -20.3700
14 C8x C 21.9100 -22.4000
15 C8x C 23.1000 -23.0300
16 C8y C 24.2200 -22.4000
17 C8x C 24.2200 -21.0000
18 C8x C 23.1000 -20.3000
19 N1a N 25.4800 -23.1000
20 O2b O 16.6600 -23.0300
21 P1b P 15.4700 -23.8000
22 O1c O 13.9300 -24.5700 #-
23 O3c O 19.5300 -19.3900
24 O3c O 21.4200 -19.3900
25 O1c O 16.1700 -24.9900 #-
26 O1c O 14.7700 -22.6100
27 C1x C 10.7800 -19.0400
28 C1x C 9.5200 -20.7900
29 C1x C 8.6800 -19.7400
30 O2x O 9.5200 -18.6200
31 C1b C 18.9700 -22.4000
32 C1c C 20.1600 -23.1700
33 C1a C 21.4200 -22.4700
34 C1a C 20.1600 -24.5000
35 C1b C 15.4700 -18.9000
36 C8y C 16.6600 -18.2000
37 C8x C 17.9200 -18.9000
38 C8x C 19.1100 -18.1300
39 C8x C 19.1100 -16.7300
40 C8x C 17.8500 -16.0300
41 C8x C 16.6600 -16.8000
BOND 41
1 3 4 1
2 3 5 1
3 4 6 1
4 5 7 1
5 6 8 1
6 8 9 1
7 9 10 1
8 10 11 1
9 10 12 2
10 13 11 1 #Up
11 7 14 2
12 14 15 1
13 15 16 2
14 16 17 1
15 17 18 2
16 7 18 1
17 16 19 1
18 6 20 1 #Up
19 20 21 1
20 21 22 1
21 5 23 2
22 5 24 2
23 21 25 1
24 21 26 2
25 13 27 1
26 13 28 1
27 28 29 1
28 29 30 1
29 27 30 1
30 3 31 1
31 31 32 1
32 32 33 1
33 32 34 1
34 8 35 1 #Up
35 35 36 1
36 36 37 2
37 37 38 1
38 38 39 2
39 39 40 1
40 40 41 2
41 36 41 1
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